Development of novel method to eliminate Helicobacter pylori using bacteriolytic activity of bacteriophage
| Project/Area Number |
20591203
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Infectious disease medicine
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| Research Institution | Kochi University |
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Principal Investigator |
MATSUZAKI Shigenobu Kochi University, 教育研究部・医療学系, 准教授 (00190439)
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| Co-Investigator(Kenkyū-buntansha) |
TAKEUCHI Hiroaki 高知大学, 教育研究部・医療学系 (90346560)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | ピロリ菌 / ファージ / 除菌法 |
|---|
| Research Abstract |
Helicobacter pylori is a causative agent of gastritis and the stomach ulcer, and is also a risk factor of the stomach cancer. If H.pylori is detected at the patient's stomach, the elimination of it with the antibiotic agents is recommended. However, recent progress of antibiotic-resistance in H.pylori threatens the future of the elimination method. Therefore, we tried to get phage to develop the bacteriophage (phage) therapy system against H.pylori infection. As a result, a novel phage, φHP33, was isolated successfully. Phage φHP33 had a broad-host-range to many H.pylori strains and had strong lytic acitivity against them. Therefore, φHP33 is expected to be a good candidate as therapeutic phage for H.pylori infection.
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Report
(4 results)
Research Products
(76 results)
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[Journal Article] Presence of Merkel cell polyomavirus in Japanese cutaneous squamous cell carcinoma.2011
Author(s)
Murakami M, Imajoh M, Ikawa T, Nakajima H, Kamioka M, Nemoto Y, Ujihara T, Uchiyama J, Matsuzaki S, Sano S, Daibata M.
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Journal Title
J Clin Virol. 50
Pages: 37-41
Related Report
Peer Reviewed
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[Journal Article] Presence of Merkel cell polyomavirus in Japanese cutaneous squamous cell carcinoma.2011
Author(s)
Murakami M, Imajoh M, Ikawa T, Nakajima H, Kamioka M, Nemoto Y, Ujihara T, Uchiyama J, Matsuzaki S, Sano S, Daibata M.
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Journal Title
J Clin Virol.
Volume: 50
Pages: 37-41
Related Report
Peer Reviewed
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[Journal Article]2009
Author(s)
Nishimori I, et al
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Journal Title
Chapter 17 : Inhibitors of Helicobacter pyloria and B-carbonic anhydrases as novel drugs for gastroduodenal diseases Drug Design of Zinc-Enzyme Inhibitors : Functional, Structural and Disease Applications(Wiley Hoboken press)
Related Report
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[Journal Article] Cloning, polymorphism, and inhibition of beta-carbonic anhydrase of Helicobacter pylori.2008
Author(s)
Morishita S, Nishimori I, Minakuchi T, Onishi S, Takeuchi H, Sugiura T, Vullo D, Scozzafava A, Supuran CT.
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Journal Title
J Gastroenterol. 43
Pages: 849-857
Related Report
Peer Reviewed
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