Pathogenesis and establishment of new diagnosis and treatment of Chronic pulmonary aspergillosis

• Project/Area Number: 20591205
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Infectious disease medicine
• Research Institution: Nagasaki University
• Principal Investigator: IZUMIKAWA Koichi 長崎大学, 医歯薬学総合研究科, 講師 (20404212)
• Co-Investigator(Kenkyū-buntansha): KOHNO Shigeru 長崎大学, 医歯薬学総合研究科, 教授 (80136647)
• Project Period (FY): 2008 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2008: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
• Keywords: 日和見感染症 / 慢性肺アスペルギルス症 / 侵襲性肺アスペルギルス症 / バイオフィルム / 併用療法 / カテーテル留置モデル / 菌糸 / 吸入療法 / 病態解析 / COPDマウス

Research Abstract

Pathogenesis of chronic pulmonary aspergillosis (CPA) and complex and related to delayed diagnosis followed by delayed treatment. Aim of this study to establish the mouse CPA model and develop newer diagnosis method and treatment. CPA mouse model developed in COPD mice revealed the longer existence of Aspergillus fumigatus for three weeks compared to non-COPD mice (less than a week). Inhalation of liposomal amphotericin B was proved to be effective in pulmonary aspergillosis mouse model.

Research Products

• [Journal Article] Management of chronic pulmonary aspergillosis (2012)
  • Author(s): Izumikawa K, Tashiro M, Kohno S
  • Journal Title: Ann N Y Acad Sci Volume: 1272:40-8
  • Peer Reviewed
• [Journal Article] double-blind comparative study of the safety and efficacy of caspofungin versus micafungin in the treatment of candidiasis and aspergillosis (2012)
  • Author(s): Kohno S, Izumikawa K, Yoshida M, Takesue Y, Oka S, Kamei K, Miyazaki Y, Yoshinari T, Kartsonis NA, Niki Y
  • Journal Title: Eur J Clin Microbiol Infect Dis
  • NAID: 120006985737
  • Peer Reviewed
• [Journal Article] Correlation between triazole treatment history and susceptibility in clinically isolated Aspergillus fumigatus (2012)
  • Author(s): Tashiro M, Izumikawa K, Hirano K, Ide S, Mihara T, Hosogaya N, Takazono T, Morinaga Y, Nakamura S, Kurihara S, Imamura Y, Miyazaki T, Nishino T, Tsukamoto M, Kakeya H, Yamamoto Y, Yanagihara K, Yasuoka A, Tashiro T, Kohno S
  • Journal Title: Antimicrob Agents Chemother Volume: 56(9):4870-5
  • NAID: 120006985531
  • Peer Reviewed
• [Journal Article] Bronchoalveolar lavage galactomannan for the diagnosis of chronic pulmonary aspergillosis (2012)
  • Author(s): Izumikawa K, Yamamoto Y, Mihara T, Takazono T, Morinaga Y, Kurihara S, Nakamura S, Imamura Y, Miyazaki T, Nishino T, Tsukamoto M, Kakeya H, Yanagihara K, Mine M, Yasuoka A, Tashiro T, Kohno S
  • Journal Title: Med Mycol Volume: 50(8):811-7
  • NAID: 120006985848
  • Peer Reviewed
• [Journal Article] Antifungal susceptibilities of Aspergillus fumigatusclinical isolates in Nagasaki (2012)
  • Author(s): Tashiro M, Izumikawa K, Minematsu A, Hirano K, Iwanaga N, Ide S, Mihara T, Hosogaya N, Takazono T, Morinaga Y, Nakamura S, Kurihara S, Imamura Y, Miyazaki T, Nishino T, Tsukamoto M, Kakeya H, Yamamoto Y, Yanagihara K, Yasuoka A, Tashiro T, Kohno S
  • Journal Title: Japan. Antimicrob Agents Chemother. Volume: 6(1):584-587
  • Peer Reviewed
• [Journal Article] A double-blind comparative study of the safety and efficacy of caspofungin versus micafungin in the treatment of candidiasis and aspergillosis (2012)
  • Author(s): Kohno S, Izumikawa K, et al.
  • Journal Title: Eur J Clin Microbiol Infect Dis Volume: 32 Issue: 3 Pages: 387
  • DOI: 10.1007/s10096-012-1754-z
  • NAID: 120006985737
  • Peer Reviewed
• [Journal Article] Correlation between triazole treatment history and susceptibility in clinically isolated Aspergillus fumigatus. (2012)
  • Author(s): Tashiro M, Izumikawa K, et al.
  • Journal Title: Antimicrob Agents Chemother Volume: 56 Issue: 9 Pages: 4870-4875
  • DOI: 10.1128/aac.00514-12
  • NAID: 120006985531
  • Peer Reviewed
• [Journal Article] Bronchoalveolar lavage galactomannan for the diagnosis of chronic pulmonary aspergillosis (2012)
  • Author(s): Izumikawa K, Yamamoto Y,et al.
  • Journal Title: Med Mycol Volume: 50 Issue: 8 Pages: 811-817
  • DOI: 10.3109/13693786.2012.682228
  • NAID: 120006985848
  • Peer Reviewed
• [Journal Article] Antifungal susceptibilities of Aspergillus fumigatus clinical isolates in Nagasaki, Japan. (2012)
  • Author(s): Tashiro M, Izumikawa K, et al.
  • Journal Title: Antimicrob Agents Chemother Volume: 56 Issue: 1 Pages: 584-587
  • DOI: 10.1128/aac.05394-11
  • Peer Reviewed
• [Journal Article] Antifungal susceptibilities of Aspergillus fumigatus clinical isolates in Nagasaki, Japan (2012)
  • Author(s): Tashiro M, Izumikawa K, Kohno S, et al
  • Journal Title: Antimicrobial Agents and Chemotherapy Volume: Vol.56 Pages: 584-587
  • Peer Reviewed
• [Journal Article] A case of bronchial aspergillosis caused by Aspergillus udagawae and its mycological features (2011)
  • Author(s): Gyotoku H, Izumikawa K, Ikeda H, Takazono T, Morinaga Y, Nakamura S, Imamura Y, Nishino T, Miyazaki T, Kakeya H, Yamamoto Y, Yanagihara K, Yasuoka A, Yaguchi T, Ohno H, Miyazaki Y, Kamei K, Kanda T, Kohno S
  • Journal Title: Med Mycol
  • NAID: 120006985656
  • Peer Reviewed
• [Journal Article] Clinical efficacy and safety ofMicafungin in Japanese patients with chronic pulmonary aspergillosis: a prospective observational study (2011)
  • Author(s): Kohno S, Izumikawa K, Kakeya H, Miyazaki Y, Ogawa K, Amitani R, Niki Y, Kurashima A
  • Journal Title: Med Mycol Volume: 49(7):688-93
  • Peer Reviewed
• [Journal Article] Diagnostic significance of Aspergillus species isolated from respiratory samples in an adult pneumology ward (2011)
  • Author(s): Tashiro T, Izumikawa K, Tashiro M, Takazono T, Morinaga Y, Yamamoto K, Imamura Y, Miyazaki T, Seki M, Kakeya H, Yamamoto Y, Yanagihara K, Yasuoka A, Kohno S
  • Journal Title: Med Mycol Volume: 49(6):581-7
  • NAID: 120006985275
  • Peer Reviewed
• [Journal Article] Clinical efficacy and safety of micafungin in Japanese patients with chronic pulmonary aspergillosis : a prospective observational study (2011)
  • Author(s): Kohno S, Izumikawa K, et al
  • Journal Title: Medical Mycology Volume: Vol.49 Pages: 688-693
  • NAID: 120006985289
  • Peer Reviewed
• [Journal Article] Diagnostic significance of Aspergillus species isolated from respiratory samples in an adult pneumology ward (2011)
  • Author(s): Tashiro T, Izumikawa K, Kohno S, et al
  • Journal Title: Medical Mycology Volume: Vol.49 Pages: 581-587
  • NAID: 120006985275
  • Peer Reviewed
• [Journal Article] Evaluation of the Cica Fungi Test Candida, a novel serum Candida mannan antigen kit, and its comparison with Cand-Tec in candidemia patients (2011)
  • Author(s): Takazono T, Izumikawa K, Kohno S, et al
  • Journal Title: Japanese Journal of Infectious Diseases Volume: Vol.64 Pages: 116-120
  • NAID: 120006985095
  • Peer Reviewed
• [Journal Article] A case of bronchial aspergillosis caused by Aspergillus udagawae and its mycological features (2011)
  • Author(s): Gyotoku H, Izumikawa K, Kohno S, et al
  • Journal Title: Medical Mycology Volume: (E-pub)
  • NAID: 120006985656
  • Peer Reviewed
• [Journal Article] アスペルギルスの薬剤耐性機序に関する疫学研究と治療法の最適化研究 (2011)
  • Author(s): 泉川公一
  • Journal Title: The Japanese journal of antibiotics Volume: Vol.64 Pages: 22-34
  • NAID: 10028255256
  • Peer Reviewed
• [Journal Article] 肺アスペルギルス症の新しい試み (2011)
  • Author(s): 泉川公一
  • Journal Title: 呼吸 Volume: Vol.8 Pages: 692-699
• [Journal Article] Posaconazole for chronic pulmonary aspergillosis: The next strategy against the threat of azole-resistantAspergillus infection (2010)
  • Author(s): Kohno S, Izumikawa K
  • Journal Title: Clin Infect Dis Volume: 51(12):1392-4
  • Peer Reviewed
• [Journal Article] Chronic aspergillus infections of the respiratory tract: diagnosis, management and antifungal resistance (2010)
  • Author(s): Izumikawa K, Takazono T, Kohno S
  • Journal Title: Curr Opin Infect Dis Volume: 23(6):584-9
  • NAID: 120006984888
  • Peer Reviewed
• [Journal Article] Intravenous micafungin versus voriconazole for chronic pulmonary aspergillosis: a multicenter trial in Japan (2010)
  • Author(s): Kohno S, Izumikawa K, Ogawa K, Kurashima A, Okimoto N, Amitani R, Kakeya H, Niki Y, Miyazaki Y
  • Journal Title: J Infection Volume: 61(5):410-8
  • NAID: 120006984951
  • Peer Reviewed
• [Journal Article] Diffuse alveolar hemorrhage following itraconazole injection (2010)
  • Author(s): Izumikawa K, Nakano K, Kurihara S, Imamura Y, Yamamoto K, Miyazaki T, Sakamoto N, Seki M, Ishimatsu Y, Kakeya H, Yamamoto Y, Yanagihara K, Tsuchiya T, Yamasaki N, Tagawa T, Mukae H, Nagayasu T, Kohno S
  • Journal Title: Intern Med Volume: 49(5):497-500
  • NAID: 130000251704
  • Peer Reviewed
• [Journal Article] Posaconazole for chronic pulmonary aspergillosis : The next strategy against the threat of azole-resistant Aspergillus infection. (2010)
  • Author(s): Kohno S, Izumikawa K.
  • Journal Title: Clin Infect Dis 51 Pages: 1392-1394
  • NAID: 120006984856
  • Peer Reviewed
• [Journal Article] Intravenous micafungin versus voriconazole for chronic pulmonary aspergillosis : a multicenter trial in Japan. (2010)
  • Author(s): Kohno S, Izumikawa K, Ogawa K, Kurashima A, Okimoto N, Amitani R, Kakeya H, Niki Y, Miyazaki Y.
  • Journal Title: J Infecion. 61 Pages: 410-418
  • NAID: 120006984951
  • Peer Reviewed
• [Journal Article] Chronic aspergillus infections of the respiratory tract : diagnosis, management and antifungal resistance. (2010)
  • Author(s): Izumikawa K, Takazono T, Kohno S.
  • Journal Title: Curr Opin Infect Dis 23 Pages: 584-589
  • NAID: 120006984888
  • Peer Reviewed
• [Journal Article] Posaconazole for chronic pulmonary aspergillosis : The next strategy against the threat of azole-resistant Aspergillus infection (2010)
  • Author(s): Kohno S, Izumikawa K
  • Journal Title: Clin Infect Dis Volume: 51 Pages: 1392-1394
  • NAID: 120006984856
  • Peer Reviewed
• [Journal Article] Intravenous micafungin versus voriconazole for chronic pulmonary aspergillosis : a multicenter trial in Japan. (2010)
  • Author(s): Kohno S, Izumikawa K, Ogawa K, Kurashima A, Okimoto N, Amitani R, Kakeya H, Niki Y, Miyazaki Y
  • Journal Title: J Infecion Volume: 61 Pages: 410-418
  • NAID: 120006984951
  • Peer Reviewed
• [Journal Article] Chronic aspergillus infections of the respiratory tract : diagnosis, management and antifungal resistance (2010)
  • Author(s): Izumikawa K, Takazono T, Kohno S
  • Journal Title: Curr Opin Infect Dis Volume: 23 Pages: 584-589
  • NAID: 120006984888
  • Peer Reviewed
• [Journal Article] Efficacy of combination antifungal therapy with intraperitoneally administered micafungin and aerosolized liposomal amphotericin B against murine invasive pulmonary aspergillosis (2009)
  • Author(s): Takazono T, Izumikawa K, Mihara T, Kosai K, Saijo T, Imamura Y, Miyazaki T, Seki M, Kakeya H, Yamamoto Y, Yanagihara K, Kohno S
  • Journal Title: Antimicrob Agents Chemother Volume: 53(8):3508-10
  • NAID: 120006983921
  • Peer Reviewed
• [Journal Article] Efficacy of combination antifungal therapy with intraperitoneally administered micafungin and aerosolized liposomal amphotericin B against murine invasive pulmonary aspergillosis. (2009)
  • Author(s): Takazono T, Izumikawa K.
  • Journal Title: Antimicrob Agents Chemother 53 Pages: 3508-3510
  • NAID: 120006983921
  • Peer Reviewed
• [Journal Article] Efficacy of combination antifungal therapy with intraperitoneally administered micafungin and aerosolized liposomal amphotericin B against murine invasive pulmonary aspergillosis (2009)
  • Author(s): Takazono T, Izumikawa K
  • Journal Title: Antimicrob Agents Chemother 53 Pages: 3508-3510
  • NAID: 120006983921
  • Peer Reviewed
• [Presentation] Management of chronic pulmonary aspergillosis (2012)
  • Author(s): Izumikawa K, Kohno S
  • Organizer: 5th Advanced against Aspergillosis
  • Place of Presentation: Istanbul, Turkey
  • Year and Date: 2012-01-26
• [Presentation] Bronchial Aspergillosis due to Aspergillus udagawae: a rare case report (2012)
  • Author(s): Ide S, Izumikawa K, Kohno S
  • Organizer: 5th Advanced against Aspergillosis
  • Place of Presentation: Istanbul, Turkey
  • Year and Date: 2012-01-26
• [Presentation] Antifungal susceptibility of Aspergillus fumigatus and relationship with azole exposure in Nagasaki (2012)
  • Author(s): Tashiro M, Izumikawa K, Kohno S
  • Organizer: JAPAN, 5th Advanced against Aspergillosis
  • Place of Presentation: Istanbul, Turkey
  • Year and Date: 2012-01-26
• [Presentation] A case of chronic pulmonary aspergillosis due to itraconazole low-susceptible Aspergillus fumigatus of which resistance acquired during long-term administration of itraconazole (2012)
  • Author(s): Hirano K, Izumikawa K, Kohno S
  • Organizer: 5th Advanced against Aspergillosis
  • Place of Presentation: Istanbul, Turkey
  • Year and Date: 2012-01-26
• [Presentation] Bronchial Aspergillosis due to Aspergillus udagawae : a rare case report (2012)
  • Author(s): Ide S, Izumikawa K, Kohno S
  • Organizer: 5th Advanced against Aspergillosis
  • Place of Presentation: Istanbul, Turkey
  • Year and Date: 2012-01-26
• [Presentation] Antifungal susceptibility of Aspergillus fumigatus and relationship with azole exposure in Nagasaki, JAPAN (2012)
  • Author(s): Tashiro M, Izumikawa K, Kohno S
  • Organizer: 5th Advanced against Aspergillosis
  • Place of Presentation: Istanbul, Turkey
  • Year and Date: 2012-01-26
• [Presentation] A case of chronic pulmonary aspergillosis due to itraconazole low-suscep tible Aspergillus fumigatus of which resistance acquired during long-term administration of itraconazole (2012)
  • Author(s): Hirano K, Izumikawa K, Kohno S
  • Organizer: 5th Advanced against Aspergillosis
  • Place of Presentation: Istanbul, Turkey
  • Year and Date: 2012-01-26
• [Presentation] 呼吸器真菌症の治療戦略 ~アスペルギルス症について~ (2012)
  • Author(s): 泉川公一
  • Organizer: 第52回 日本呼吸器学会総会
  • Place of Presentation: 神戸
• [Presentation] アスペルギルス症治療におけるカスポファンギンの位置づけ (2012)
  • Author(s): 泉川公一
  • Organizer: 第60回化学療法学会総会
  • Place of Presentation: 長崎
• [Presentation] 難治性肺真菌症 特にアスペルギルス症を取り巻く問題点 (2012)
  • Author(s): 泉川公一
  • Organizer: 第86回日本感染症学会総会
  • Place of Presentation: 長崎
• [Presentation] 真菌感染症の治療戦略 (2012)
  • Author(s): 泉川公一
  • Organizer: 第82回日本感染症学会西日本地方会学術集会
  • Place of Presentation: 福岡
• [Presentation] 真菌の抗真菌薬耐性の現状と治療戦略 (2012)
  • Author(s): 泉川公一
  • Organizer: 第56回日本医真菌学会総会
  • Place of Presentation: 多摩
• [Presentation] Chronic pulmonary aspergillosis ~new treatment evidence and emergence of azole-resistant Aspergillus fumigatus in Japan~ (2011)
  • Author(s): Izumikawa K, Kohno S
  • Organizer: International Union of Microbiological Societies 2011 Congress
  • Place of Presentation: 札幌
  • Year and Date: 2011-09-09
• [Presentation] Chronic pulmonary aspergillosis～new treatment evidence and emergence of azole-resistant Aspersillus fumigatus in Japan～ (2011)
  • Author(s): Izumikawa K, Kohno S
  • Organizer: International Union of Microbiological Societies 2011 Congress
  • Place of Presentation: 札幌
  • Year and Date: 2011-09-09
• [Presentation] 当科で収集されたAspergillus fumigatusの臨床的抗真菌薬暴露歴と薬剤感受性の解析 (2011)
  • Author(s): 田代将人、泉川公一、河野茂
  • Organizer: 第5回アスペルギルス研究会
  • Place of Presentation: 東京
  • Year and Date: 2011-09-03
• [Presentation] 気管支拡張を伴ったアスペルギルス症の3例～病理学的検討を加えて～ (2011)
  • Author(s): 井手昇太郎、泉川公一、河野茂
  • Organizer: 第5回アスペルギルス研究会
  • Place of Presentation: 東京
  • Year and Date: 2011-09-03
• [Presentation] 慢性肺アスペルギルス症に対するイトラコナゾール長期投与中に、イトラコナゾール低感受性Aspergillus fumigatusが出現した症例 (2011)
  • Author(s): 平野勝治、泉川公一、河野茂
  • Organizer: 第5回アスペルギルス研究会
  • Place of Presentation: 東京
  • Year and Date: 2011-09-03
• [Presentation] Bronchoalveolar lavage galactomannan in diagnosis of chronic pulmonary aspergillosis (2010)
  • Author(s): Koichi Izumikawa, Takahiro Takazono, et al
  • Organizer: APSR2010
  • Place of Presentation: Manila, Philippine
  • Year and Date: 2010-11-26
• [Presentation] Bronchoalveolar lavage galactomannan in diagnosis of chronic pulmonary aspergillosis. (2010)
  • Author(s): Izumikawa K, Takazono T, et al.
  • Organizer: APSR2010
  • Place of Presentation: Manila, Philippine
  • Year and Date: 2010-11-26
• [Presentation] 呼吸器真菌症の病態、診断、治療のup to date～日本から何が発信できるか～ (2010)
  • Author(s): 泉川公一
  • Organizer: 第80回日本感染症学会西日本地方会
  • Place of Presentation: 松山
  • Year and Date: 2010-11-20
• [Presentation] 慢性肺アスペルギルス症 up to date (2010)
  • Author(s): 泉川公一
  • Organizer: 第54回日本医真菌学会総会
  • Place of Presentation: 東京
  • Year and Date: 2010-10-16
• [Presentation] 慢性肺アスペルギルス症up to date (2010)
  • Author(s): 泉川公一
  • Organizer: 第54回日本医真菌学会総会
  • Place of Presentation: 東京
  • Year and Date: 2010-10-16
• [Presentation] 慢性肺アスペルギルスマウスモデル作成の試み 2010 (2010)
  • Author(s): 高園貴弘、泉川公一
  • Organizer: 第4回アスペルギルス研究会
  • Place of Presentation: 千葉
  • Year and Date: 2010-07-24
• [Presentation] 慢性肺アスペルギルスマウスモデル作成の試み (2010)
  • Author(s): 高園貴弘、泉川公一
  • Organizer: 2010,第4回アスペルギルス研究会
  • Place of Presentation: 千葉
  • Year and Date: 2010-07-24
• [Presentation] 慢性肺アスペルギルスマウスモデル作成の試み、2010 (2010)
  • Author(s): 高園貴弘、泉川公一
  • Organizer: 第4回アスペルギルス研究会
  • Place of Presentation: 千葉
  • Year and Date: 2010-07-24
• [Presentation] 慢性肺アスペルギルス症の新知見 (2010)
  • Author(s): 泉川公一
  • Organizer: 第58回日本化学療法学会総会
  • Place of Presentation: 長崎
  • Year and Date: 2010-06-04
• [Presentation] Development of murine chronic aspergillus colonization model (2010)
  • Author(s): Takahiro Takazono, Koichi Izumikawa, et al
  • Organizer: 4th Advances against Aspergillus and Aspergillosis
  • Place of Presentation: Rome, Italy
  • Year and Date: 2010-02-04
• [Presentation] Bronchoalveolar lavage galactomannan in diagnosis of chronic pulmonary aspergillosis (2010)
  • Author(s): Koichi Izumikawa, Takahiro Takazono, et al
  • Organizer: 4th Advances against Aspergillus and Aspergillosis
  • Place of Presentation: Rome, Italy
  • Year and Date: 2010-02-04
• [Presentation] Development of murine chronic aspergillus colonization model. (2010)
  • Author(s): Takazono T, Izumikawa K, et al.
  • Organizer: 4^<th> Advances against Aspergillus and Aspergillosis.
  • Place of Presentation: Rome, Italy
  • Year and Date: 2010-02-04
• [Presentation] Bronchoalveolar lavage galactomannan in diagnosis of chronic pulmonary aspergillosis. (2010)
  • Author(s): Izumikawa K, Takazono T, et al.
  • Organizer: 4^<th> Advances against Aspergillus and Aspergillosis.
  • Place of Presentation: Rome, Italy
  • Year and Date: 2010-02-04
• [Presentation] Development of murine chronic aspergillus colonization model (2010)
  • Author(s): Takahiro Takazono, Koichi Izumikawa, et al.
  • Organizer: 4^<th> Advances against Aspergillus and Aspergillosis
  • Place of Presentation: Rome, Italy
  • Year and Date: 2010-02-04
• [Presentation] Bronchoalveolar lavage galactomannan in diagnosis of chronic pulmonary aspergillosis (2010)
  • Author(s): Koichi Izumikawa, Takahiro Takazono, et al.
  • Organizer: 4^<th> Advances against Aspergillus and Aspergillosis
  • Place of Presentation: Rome, Italy
  • Year and Date: 2010-02-04
• [Presentation] 深在性真菌症の診断・治療を再考する 慢性肺アスペルギルス症 (2009)
  • Author(s): 泉川公一、河野 茂
  • Organizer: 第57回日本化学療法学会西日本支部総会・第52回日本感染症学会中日本支部総会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-11-28
• [Presentation] Fungal infections in non-neutropenic patients Chronic Pulmonary Aspergillosis (2009)
  • Author(s): Izumikawa K, Kohno S
  • Organizer: ISHAM 2009
  • Place of Presentation: 東京
  • Year and Date: 2009-05-26
• [Presentation] The Frontline of Respiratory Fungal Infections in JAPAN (2008)
  • Author(s): 泉川公一、河野 茂
  • Organizer: 第52回日本医真菌学会総
  • Place of Presentation: 長崎
  • Year and Date: 2008-09-11
• [Presentation] The Frontline of Respiratory Fungal Infect ions in JAPAN (2008)
  • Author(s): 泉川公一, 河野茂
  • Organizer: 第52回日本医真菌学会総会
  • Place of Presentation: 長崎
  • Year and Date: 2008-09-11
• [Book] 真菌性肺炎 (2011)
  • Author(s): 泉川公一
  • Total Pages: 506
  • Publisher: 最新医学社
• [Book] ガイドラインサポートブックIDSA GL:真菌症治療のUP-TO-DATE～2008～2010年のアスペルギルス、カンジダ、クリプトコックスIDSA GL改訂版を踏まえて～ (2010)
  • Author(s): 泉川公一
  • Total Pages: 322
  • Publisher: 医薬ジャーナル社
• [Remarks]
  • URL: http://www.med.nagasaki-u.ac.jp/intmed-2/index.html
• [Remarks]
  • URL: http://www.med.nagasaki-u.ac.jp/intmed-2/index.html