Pathogenesis and establishment of new diagnosis and treatment of Chronic pulmonary aspergillosis
| Project/Area Number |
20591205
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Infectious disease medicine
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| Research Institution | Nagasaki University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KOHNO Shigeru 長崎大学, 医歯薬学総合研究科, 教授 (80136647)
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| Project Period (FY) |
2008 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
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| Keywords | 日和見感染症 / 慢性肺アスペルギルス症 / 侵襲性肺アスペルギルス症 / バイオフィルム / 併用療法 / カテーテル留置モデル / 菌糸 / 吸入療法 / 病態解析 / COPDマウス |
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| Research Abstract |
Pathogenesis of chronic pulmonary aspergillosis (CPA) and complex and related to delayed diagnosis followed by delayed treatment. Aim of this study to establish the mouse CPA model and develop newer diagnosis method and treatment. CPA mouse model developed in COPD mice revealed the longer existence of Aspergillus fumigatus for three weeks compared to non-COPD mice (less than a week). Inhalation of liposomal amphotericin B was proved to be effective in pulmonary aspergillosis mouse model.
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Report
(7 results)
Research Products
(72 results)
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[Journal Article] Correlation between triazole treatment history and susceptibility in clinically isolated Aspergillus fumigatus2012
Author(s)
Tashiro M, Izumikawa K, Hirano K, Ide S, Mihara T, Hosogaya N, Takazono T, Morinaga Y, Nakamura S, Kurihara S, Imamura Y, Miyazaki T, Nishino T, Tsukamoto M, Kakeya H, Yamamoto Y, Yanagihara K, Yasuoka A, Tashiro T, Kohno S
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Journal Title
Antimicrob Agents Chemother
Volume: 56(9):4870-5
NAID
Related Report
Peer Reviewed
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[Journal Article] Bronchoalveolar lavage galactomannan for the diagnosis of chronic pulmonary aspergillosis2012
Author(s)
Izumikawa K, Yamamoto Y, Mihara T, Takazono T, Morinaga Y, Kurihara S, Nakamura S, Imamura Y, Miyazaki T, Nishino T, Tsukamoto M, Kakeya H, Yanagihara K, Mine M, Yasuoka A, Tashiro T, Kohno S
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Journal Title
Med Mycol
Volume: 50(8):811-7
NAID
Related Report
Peer Reviewed
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[Journal Article] Antifungal susceptibilities of Aspergillus fumigatusclinical isolates in Nagasaki2012
Author(s)
Tashiro M, Izumikawa K, Minematsu A, Hirano K, Iwanaga N, Ide S, Mihara T, Hosogaya N, Takazono T, Morinaga Y, Nakamura S, Kurihara S, Imamura Y, Miyazaki T, Nishino T, Tsukamoto M, Kakeya H, Yamamoto Y, Yanagihara K, Yasuoka A, Tashiro T, Kohno S
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Journal Title
Japan. Antimicrob Agents Chemother.
Volume: 6(1):584-587
Related Report
Peer Reviewed
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[Journal Article] A case of bronchial aspergillosis caused by Aspergillus udagawae and its mycological features2011
Author(s)
Gyotoku H, Izumikawa K, Ikeda H, Takazono T, Morinaga Y, Nakamura S, Imamura Y, Nishino T, Miyazaki T, Kakeya H, Yamamoto Y, Yanagihara K, Yasuoka A, Yaguchi T, Ohno H, Miyazaki Y, Kamei K, Kanda T, Kohno S
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Journal Title
NAID
Related Report
Peer Reviewed
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[Journal Article] Diagnostic significance of Aspergillus species isolated from respiratory samples in an adult pneumology ward2011
Author(s)
Tashiro T, Izumikawa K, Tashiro M, Takazono T, Morinaga Y, Yamamoto K, Imamura Y, Miyazaki T, Seki M, Kakeya H, Yamamoto Y, Yanagihara K, Yasuoka A, Kohno S
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Journal Title
Med Mycol
Volume: 49(6):581-7
NAID
Related Report
Peer Reviewed
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[Journal Article] Diffuse alveolar hemorrhage following itraconazole injection2010
Author(s)
Izumikawa K, Nakano K, Kurihara S, Imamura Y, Yamamoto K, Miyazaki T, Sakamoto N, Seki M, Ishimatsu Y, Kakeya H, Yamamoto Y, Yanagihara K, Tsuchiya T, Yamasaki N, Tagawa T, Mukae H, Nagayasu T, Kohno S
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Journal Title
Intern Med
Volume: 49(5):497-500
NAID
Related Report
Peer Reviewed
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[Journal Article] Efficacy of combination antifungal therapy with intraperitoneally administered micafungin and aerosolized liposomal amphotericin B against murine invasive pulmonary aspergillosis2009
Author(s)
Takazono T, Izumikawa K, Mihara T, Kosai K, Saijo T, Imamura Y, Miyazaki T, Seki M, Kakeya H, Yamamoto Y, Yanagihara K, Kohno S
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Journal Title
Antimicrob Agents Chemother
Volume: 53(8):3508-10
NAID
Related Report
Peer Reviewed
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