Screening of excreted proteins of Aspergillus fumigates for clinical application.
| Project/Area Number |
20591212
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Infectious disease medicine
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| Research Institution | National Institute of Infectious Diseases |
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Principal Investigator |
MIYAZAKI Yoshitsugu National Institute of Infectious Diseases, 生物活性物質部, 部長 (00311861)
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| Co-Investigator(Kenkyū-buntansha) |
IZUMIKAWA Kouichi 長崎大学, 医歯薬学総合研究科, 助教 (20404212)
YAMAGOE Satoshi 国立感染症研究所, 生物活性物質部, 主任研究官 (00212283)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | Aspergillus属 / 診断 / アスペルギルス症 / 治療 / シグナルペプチド / 細胞外分泌蛋白 / cDNAライブラリー |
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| Research Abstract |
We found some novel fungal proteins which natively exist on cell surface or are excreted out through cell membrane. Candidate proteins were chosen depending on levels of transcription for further experiments of gene cloning and of producing antibody, then confirmed that some proteins could be detected in culture medium. That showed those candidate, or at least a part of those, are excreted out to medium from fungal cell. We developed a preliminary diagnostic kit as an application of the study.
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Report
(4 results)
Research Products
(25 results)
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[Journal Article] Transcription factors CgUPC2A and CgUPC2B regulate ergosterol biosynthetic genes in Candida glabrata.2011
Author(s)
Nagi M, Nakayama H, Tanabe K, Bard M, Aoyama T, Okano M, Higashi S, Ueno K, Chibana H, Niimi M, Yamagoe S, Umeyama T, Kajiwara S, Ohno H, Miyazaki Y
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Journal Title
Genes Cells. 16
Pages: 80-89
Related Report
Peer Reviewed
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[Journal Article] An outbreak of histoplasmosis among healthy young Japanese women after traveling to Southeast Asia.2010
Author(s)
Ohno H, Ogata Y, Suguro H, Yokota S, Watanabe A, Kamei K, Yamagoe S, Ishida-Okawara A, Kaneko Y, Horino A, Yamane K, Tsuji T, Nagata N, Hasegawa H, Arakawa Y, Sata T, Miyazaki Y
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Journal Title
Inter Med. 49
Pages: 491-495
NAID
Related Report
Peer Reviewed
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