Association of gene polymorphism with vitamin D deficiency.
| Project/Area Number |
20591215
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Yamagata University |
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Principal Investigator |
KITANAKA Sachiko Yamagata University, 医学部附属病院, 准教授 (30431638)
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| Co-Investigator(Kenkyū-buntansha) |
NUMAKURA Chikahiko 山形大学, 医学部, 助教 (00400549)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | ビタミンD欠乏症 / くる病 / 疾患感受性遺伝子 / ゲノム / 遺伝子多型 / ビタミンD受容体 / 代謝酵素 |
|---|
| Research Abstract |
Vitamin D deficiency resulting in hypocalcemic seizures or rickets in children is increasing worldwide, due to an insufficient intake of vitamin D and a lack of sunshine exposure. Since the prevalence of vitamin D deficiency is low compared to the large number of breastfed children with low serum levels of 25OHD, we speculated that some genetic predisposition may be concerned with the onset of vitamin D deficiency. In this study, we analyzed polymorphisms in vitamin D related genes in patients with vitamin D deficiency and controls in Japan. We found differences in the polymorphisms, suggesting that genetic factors may predispose to vitamin D deficiency to some extent.
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Report
(4 results)
Research Products
(32 results)
