The association of IGFBP-1 gene polymorphism with height growth and insulin sensitivity

• Project/Area Number: 20591216
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Pediatrics
• Research Institution: University of Tsukuba
• Principal Investigator: KAMODA Tomohiro University of Tsukuba, 大学院・人間総合科学研究科, 准教授 (50224704)
• Co-Investigator(Kenkyū-buntansha): MIYAZONO Yayoi 筑波大学, 大学院・人間総合科学研究科, 講師 (30400675)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000); Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 遺伝子 / 内科 / 臨床

Research Abstract

IGFBP-1 gene polymorphism (A4403G) was analyzed in children with idiopathic short stature and the association of its genotype with blood IGFBP-1 or free IGF-I levels was evaluated. The results showed no significant association between A4403G genotype and blood free IGF-I levels, suggesting that the differences in the binding ability of IGFBP-1 for circulating IGF-I was unlikely to explain the etiology of idiopathic short children.

Research Products

• [Journal Article] 低出生体重のSGA 性低身長児におけるGH 補充療法のインスリン感受性に及ぼす影響に関する研究 (2010)
  • Author(s): 鴨田知博、岩淵敦、齋藤誠、宮園弥生、野末裕紀
  • Journal Title: 成長科学協会研究年報 第33号 Pages: 103-107
• [Journal Article] 特発性低身長症におけるIGFBP-1遺伝子多型に関する研究 (2008)
  • Author(s): 鴨田知博
  • Journal Title: 成長科学協会研究年報 第31号 Pages: 97-100
• [Presentation] 低出生体重のSGA性低身長児におけるGH 補充療法のインスリン感受性に及ぼす影響 (2010)
  • Author(s): 野末裕紀、鴨田知博、岩淵敦、齋藤誠、宮園弥生
  • Organizer: 第44回日本小児内分泌学会
  • Place of Presentation: 大阪
  • Year and Date: 2010-10-08
• [Presentation] 低出生体重のSGA性低身長児におけるGH補充療法のインスリン感受性に及ぼす影響 (2010)
  • Author(s): 野末裕紀、鴨田知博、岩淵敦、齊藤誠、宮園弥生
  • Organizer: 第44回日本小児内分泌学会
  • Place of Presentation: 大阪市中央公会堂(大阪)
  • Year and Date: 2010-10-08
• [Presentation] 早産時における生後早期の血中アディポネクチンに関する研究 (2010)
  • Author(s): 齋藤誠、鴨田知博、宮園弥生、日高大介、西村一記、中尾厚、須磨崎亮
  • Organizer: 第113回日本小児科学会学術集会
  • Place of Presentation: 盛岡
  • Year and Date: 2010-04-23