Pathogenesis of premature brain damage and plasticity
| Project/Area Number |
20591217
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | The University of Tokyo |
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Principal Investigator |
OKA Akira The University of Tokyo, 医学部, 教授 (00251273)
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| Co-Investigator(Kenkyū-buntansha) |
ITOH Masayuki 国立精神・神経医療研究センター, 神経研究所, 室長 (50243407)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 周産期脳障害 / 脳室周囲白質軟化症 / 脳性麻痺 / 可塑性 / 感染 / 発達障害 / 絨毛羊膜炎 / アストロサイト |
|---|
| Research Abstract |
We developed an inflammatory rat model of periventricular leukomalacia (PVL), the most important pathology as a cause of cerebral palsy. Rat models using chorioamnionitis and neonatal sepsis, which were epidemiologically linked to cerebral palsy, have lead to brain injury specifically in periventricular white matter, including cystic formation with rarefaction of white matter, and subsequent histologic reaction of tissue repair. These pathologic changes were similar to human PVL, indicating the significant role of infection and inflammation in the pathogenesis of human PVL, and these models were suitable to the investigation for the development of therapeutic intervention.
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Report
(4 results)
Research Products
(51 results)
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[Journal Article] Neocortical layer formation of human developing brains and lissencephalies : consideration of layer-specific marker expression.2011
Author(s)
Saito T, Hanai S, Takashima S, Nakagawa E, Okazaki S, Inoue T, Miyata R, Hoshino K, Akashi T, Sasaki M, Goto Y, Hayashi M, Itoh M
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Journal Title
Cereb Cortex 21
Pages: 588-596
Related Report
Peer Reviewed
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[Journal Article] Neocortical layer formation of human developing brains and lissencephalies : consideration of layer-specific marker expression.2011
Author(s)
Saito T, Hanai S, Takashima S, Nakagawa E, Okazaki S, Inoue T, Miyata R, Hoshino K, Akashi T, Sasaki M, Goto Y, Hayashi M, Itoh M.
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Journal Title
Cereb Cortex.
Volume: 21
Pages: 588-96
Related Report
Peer Reviewed
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[Journal Article] EYA4, deleted in a case with middle interhemisheric variant of holoprosencephaly, interacts with SIX3 both physically and functionally.2009
Author(s)
Abe Y, Oka A, Mizuguchi M, Igarashi T, Ishikawa S, Aburatani H, Yokoyama S, Asahara H, Nagao K, Yamada M, Miyashita T
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Hepatoblastoma in a patient with Sotos syndrome.2009
Author(s)
Kato M, Takita J, Takahashi K, Mimaki M, Chen Y, Koh K, Ida K, Oka A, Mizuguchi M, Ogawa S, Igarashi T
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Journal Title
J Pediatr 155
Pages: 937-939
Related Report
Peer Reviewed
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[Journal Article] EYA4, deleted in a case with middle interhemisheric variant of holoprosencephaly, interacts with SIX3 both physically and functionally.2009
Author(s)
Abe Y, Oka A, Mizuguchi M, Igarashi T, Ishikawa S, Aburatani H, Yokoyama S, Asahara H, Nagao K, Yamada M, Miyashita T.
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Hepatoblastoma in a patient with Sotos syndrome.2009
Author(s)
Kato M, Takita J, Takahashi K, Mimaki M, Chen Y, Koh K, Ida K, Oka A, Mizuguchi M, Ogawa S, Igarashi T.
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Journal Title
Journal of Pediatrics 155
Pages: 937-939
Related Report
Peer Reviewed
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[Journal Article] Mental retardation, spasticity, basal ganglia calcification, cerebral white matter lesions, multiple endocrine defects, telangiectasia and atrophic skin: A new syndrome?2008
Author(s)
Saito Y, Toyoshima M, Oka A, Zhuo L, Moriwaki SI, Yamamoto O, Kanzaki S, Hanaki KI, Ninomiya H, Nanba E, Kondo A, Maegaki Y, Ohno K.
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Journal Title
Brain and Development 30
Pages: 221-225
NAID
Related Report
Peer Reviewed
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