| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
|---|
| Research Abstract |
The signal transduction from complex of ATM, Mre11, and NBS1 are important for brain development during embryonic period. We searched the common target of protein complex of Rad50, Mre11 and NBS1. We tried to find the important proteins for brain development and cerebellar degeneration. We found several proteins which interact with Mre11-NBS1-Rad50 complex. We studied those protein function in the cells using overexpressing system, siRNA system and so on. We also found the binding sites which were important for interacting with the Mre11-NBS1-Rad50 complex. We used those data for protein structure analysis to understand about protein functions.
|
