| Project/Area Number |
20591224
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Kochi University |
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Principal Investigator |
MITSUI Shinichi Kochi University, 教育研究部・医療学系, 准教授 (20295661)
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| Co-Investigator(Kenkyū-buntansha) |
YURI Kazunari 高知大学, 教育研究部・医療学系, 教授 (10220534)
OSAKO Yoji 高知大学, 教育研究部・医療学系, 助教 (40335922)
HOSOKAWA Sadatoshi 高知大学, 教育研究部・医療学系, 助教 (10380312)
ADACHI Kiyomi 高知大学, 教育研究部・医療学系, 助教 (60335932)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 発達小児科学 / 精神遅滞 / 発達障害 / motopsin / neurotrypsin / プロテアーゼ / 神経科学 / 脳神経疾患 / neurotrysin |
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| Research Abstract |
Our data suggested the following subjects. Abnormal response to social stimulation at the hippocampus of motopsin-deficient mice, known as a model for developmental disorder, appears to be derived from the cognitive deficit to olfactory stimulation. The interaction between motopsin and sez-6 may modulate the development of neuronal processes. Further, proteomic analysis of hippocampus in motopsin-deficient mice identified some candidates for motopsin substrates.
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