Experimental study of immune responses in cell transplantation therapy for genetic neurodegenerative disorders
| Project/Area Number |
20591229
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Osaka City University |
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Principal Investigator |
TANAKA Akemi Osaka City University, 大学院・医学研究科, 准教授 (30145776)
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| Co-Investigator(Kenkyū-buntansha) |
MAEDA Mitsuyo 大阪歯科大学, 大学院・医学研究科, 助教 (40122080)
SETO Toshiyuki 大阪市立大学, 大学院・医学研究科, 講師 (60423878)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 神経遺伝性疾患 / 細胞移植 / 免疫応答 / 移植免疫 / 再生医療 / 遺伝性神経疾患 |
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| Research Abstract |
We performed cell transplantation therapy to treat the brain involvement of lysosomal storage diseases. The grafted cells were gradually depleted because of immunological rejection by the host animals. To avoid deleterious immune attack and to achieve sufficient long-term efficacy in brain, development of methods to steer the immune response away from cytotoxic responses or to induce tolerance to the products of therapeutic genes is needed. To overcome this immunological rejection, we carried out brain injection and intravenous administration of mesenchymal stem cells simultaneously to a model mouse of β-galactosidase deficiency. However, we could not show a significant deference in the duration of engrafting between the brain injection only and the simultaneous injection of brain and vein.
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Report
(4 results)
Research Products
(46 results)
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[Journal Article] Mucolipidosis II and III alpha/beta : mutation analysis of 40 Japanese patients showed genot ype-phenotype correlation.2009
Author(s)
Otomo T, Muramatu T, Yorifuji T, Oku yama T, Nakabayashi H, Fukao T, Oh ura T, Yoshino M, Tanaka A, Okamoto N, Ozono K, Sakai N.
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Journal Title
J Hum Ge net 54
Pages: 145-151
Related Report
Peer Reviewed
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[Journal Article] Mucolipidosis II and III alpha/beta : mutation analysis of 40 Japanese patients showed genotype-phenotype correlation.2009
Author(s)
Otomo T, Muramatu T, Yorifuji T, Okuyama T, Nakabayashi H, Fukao T, Ohura T, Yoshino M, Tanaka A, Okamoto N, Ozono K, Sakai N
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Journal Title
J Hum Genet 54
Pages: 145-151
NAID
Related Report
Peer Reviewed
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[Journal Article] Mucolipidosis II and III alpha/beta : mutation analysis of 40 Japanese patients showed genotype-phenotype correlation.2009
Author(s)
Otomo T, Muramatu T, Yorifuji T, Okuyama T, Nakabayashi H, Fukao T, Ohura T, Yoshino M, Tanaka A, Okamoto N, Ozono K, Sakai N.
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Journal Title
J Hum Genet 54
Pages: 145-151
NAID
Related Report
Peer Reviewed
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[Presentation] Efficacy of hematopoietic cell transplantation on the patients with mucopolysaccharidosis type II : Multicenter survey in Japan.2010
Author(s)
Tanaka A, Okuyama T, Suzuki Y, Sakai N, Sawada T, Tanaka T, Takakura H, Ohashi T, Wada M, Yabe H, Ohura T, Suzuki N, Kato K, Adachi S, Mugishima H, Kato S
Organizer
11^<th> International Symposium on Mucopolysaccharide and Related Diseases
Place of Presentation
Adelaide, Australia
Related Report
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[Presentation] Efficacy of hematopoietic cell transplantation on the patients with mucopolysaccharidosis type II : Multicenter survey in Japan2010
Author(s)
Tanaka A, Okuyama T, SuzukiY, Sakai N, Sawada T, Tanaka T, Takakura H, Ohashi T, Wada M, Yabe H, Ohura T, Suzuki N, Kato K, Adachi S, Mugishima H, Kato S
Organizer
11^<th> International Symposium on Mucopolysaccharide and Related Diseases
Place of Presentation
アデレード・オーストラリアアデレードコンベンションセンター
Related Report
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[Presentation] Efficacy of enzyme replacement therapy on the patients with late stage of mucopolysaccharidoses Type I and II.2009
Author(s)
Sawada T, Tanaka A, Aso K, Tsuruhara A, Morita K, Takeda T, Tada A, Hozumi T, Yokoi T, Hattori H, Yamano T
Organizer
11^<th> International Congress of Inborn Errors of Metabolism
Place of Presentation
サンディエゴ・アメリカ合衆国
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[Book] Neurochemistry of Metabolic Disease, Chaptor 8: Enzyme Replacement Therapy for Lysosomal Storage Dseases. Editors: Sanker Surendran2011
Author(s)
Tomatsu S, Montano AM, Molano ACS, Roman D, Hintze J, Carvalho CG, Federhen A, Vieira TA, Giugliani R, Wegrzyn G, Tanaka A, Suzuki Y, Orii T.
Publisher
Nova Science Publishers, Inc. in press
Related Report
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[Book] Neurochemistry of Metabolic Disease2011
Author(s)
Tomatsu S, Montano AM, Molano ACS, Roman D, Hintze J, Carvalho CG, Federhen A, Vieira TA, Giugliani R, Wegrzyn G, Tanaka A, Suzuki Y, Orii T
Publisher
Chaptor 8 : Enzyme Replacement Therapy for Lysosomal Storage Dseases(In press)
Related Report
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