| Project/Area Number |
20591237
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | University of Occupational and Environmental Health, Japan |
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Principal Investigator |
UENO Susumu University of Occupational and Environmental Health, Japan, 医学部, 准教授 (00279324)
|
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| Co-Investigator(Kenkyū-buntansha) |
FUETA Yukiko 産業医科大学, 産業保健学部, 助教 (10132482)
YUHI Tomoaki 産業医科大学, 医学部, 助教 (60330982)
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| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 小児神経学 / フロン代替物質 / 1-ブロモプロパン / 胎児期曝露 / 次世代影響 / 神経行動学的表現型 / オープンフィールド試験 / 海馬神経回路 / 受動的回避試験 / 高架式十字迷路試験 / 新奇物体探索試験 / AMPA受容体 / Na^+チャネル / 海馬スライス標本 / 中枢神経毒性 |
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| Research Abstract |
In this research project, we investigated the effect of prenatal exposure to 1-bromopropane (1BP), an alternative to chlorofluorocarbons, on the neurofunctions at the CNS-formation stage and neurobehavior at juvenile period, using rat animal models. As a result, we found that prenatal exposure to 1BP may alter hippocampal stimulus-responsive relationship at the CNS-formation stage, and exploration and short-term memory function at the juvenile period, suggesting that the prenatal exposure to chemicals could induce a postgrowth abnormality of neurobehavior.
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