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Epileptogenesis of refractory epilepsy in acute and chronic child-onset neurological disorders

Research Project

Project/Area Number 20591238
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Pediatrics
Research InstitutionTokyo Metropolitan Organization for Medical Research

Principal Investigator

HAYASHI Masaharu  Tokyo Metropolitan Organization for Medical Research, 東京都神経科学総合研究所, 副参事研究員 (00280777)

Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords難治てんかん / 髄液マーカー / ELISA / 剖検脳 / 免疫組織化学染色 / 脳炎・脳症 / 酸化ストレス / アセチルコリン神経 / 脳梁膨大部 / MERS / サイトカイン / 進行性ミオクローヌスてんかん / DRPLA / 脚橋被蓋核 / けいれん重積型脳症 / 軸索障害 / 髄液総タウ蛋白値 / West症候群 / 大脳皮質形成異常症 / GABA系抑制性神経 / ムロ多糖症 / GABA系抑制性介在神経 / 周産期障害 / 神経線維腫症 / アストロサイト
Research Abstract

In order to clarify the pathogenesis of child-onset intractable epilepsy, we performed ELISA analysis in the cerebrospinal fluid (CSF), and immunohistochemical study in the autopsy brains. We identified the involvements of axonal damage and oxidative stress in patients with acute encephalopathy with biphasic seizures and clinically mild encephalopathy with a reversible splenial lesion, respectively. We found the lesion of acetylcholine neurons in the pedunculopontine tegmental nucleus in cases of perinatal disorders, sequels of West syndromes, and dentatorubropallidoluysian atrophy. We also discovered the impairment of the cortical GABAergic interneurons in cases of mucopolysaccharidosis and diffuse cortical dysplasia.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (34 results)

All 2010 2009 2008

All Journal Article (16 results) (of which Peer Reviewed: 16 results) Presentation (12 results) Book (6 results)

  • [Journal Article] Autoimmune focal encephalitis shows marked hypermetabolism on positron emission tomography2010

    • Author(s)
      Sekigawa M, Okumura A, Niijima S, Hayashi M, Tanaka K, Shimizu T
    • Journal Title

      J Pediatrics Vol.156

      Pages: 158-160

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] The axonal damage marker tau protein in the cerebrospinal fluid is increased in patients with acute encephalopathy with biphasic seizures and late reduced diffusion2010

    • Author(s)
      Tanuma N, Hayashi M, et al
    • Journal Title

      Brain Dev Vol.32

      Pages: 435-439

    • NAID

      10027491589

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] The axonal damage marker tau protein in the cerebrospinal fluid is increased in patients with acute encephalopathy with biphasic seizures and late reduced diffusion.2010

    • Author(s)
      Tanuma N, Miyata R, Kumada S, Kubota M, Takanashi J, Okumura A, Hayashi M.
    • Journal Title

      Brain and Development

      Volume: 32 Pages: 435-439

    • NAID

      10027491589

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Autoimmune focal encephalitis shows marked hypermetabolism on positron emission tomography.2010

    • Author(s)
      Sekigawa M, Okumura A, Niijima S, Hayashi M, et al.
    • Journal Title

      Journal of Pediatrics

      Volume: 156 Pages: 158-160

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An autopsy report of case showing repetitive hypoglycemia and unique cortical dysplasia2010

    • Author(s)
      Hayashi M, Hachiya Y, Arai N.
    • Journal Title

      Brain and Development 32

      Pages: 289-292

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An autopsy report of case showing repetitive hypoglycemia and unique cortical dysplasia2009

    • Author(s)
      Hayashi M, Hachiya Y, Arai N
    • Journal Title

      Brain Dev Vol.32

      Pages: 289-292

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Accumulation of oxidative stress around the stroke-like lesions of MELAS patients2009

    • Author(s)
      Katayama Y, Maeda K, Iizuka T, Hayashi M, et al
    • Journal Title

      Mitochondrion Vol.9

      Pages: 306-313

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Oxidative stress in developmental brain disorders2009

    • Author(s)
      Hayashi M
    • Journal Title

      Neuropathology Vol.29

      Pages: 1-8

    • NAID

      10025824645

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Oxidative stress in developmental brain disorders2009

    • Author(s)
      Hayashi M.
    • Journal Title

      Neuropathology 29

      Pages: 1-8

    • NAID

      10025824645

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Accumulation of oxidative stress around the stroke-like lesions of MELAS patients2009

    • Author(s)
      Katayama Y, Maeda K, Iizuka T, Hayashi M, et al.
    • Journal Title

      Mitochondrion 9

      Pages: 306-313

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Glial clusters and perineuronal glial satellitosis in the basal ganglia of neurofibromatosis type 12008

    • Author(s)
      Yokota O, Tsuchiya K, Hayashi M, et al
    • Journal Title

      Acta Neuropathol Vol.116

      Pages: 57-66

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] The pedunculopontine nucleus in developmental disorders of the basal ganglia2008

    • Author(s)
      Anzai Y, Hayashi M, Ohya T, Yokota S
    • Journal Title

      Neuropathology Vol.28

      Pages: 258-263

    • NAID

      10029319420

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mechanisms of neurodegeneration in mucopolysaccharidoses II and IIIB : analysis of human brain tissue2008

    • Author(s)
      Hamano K, Hayashi M, Shioda K, FukatsuR, Mizutani S
    • Journal Title

      Acta Neuropathol Vol.115

      Pages: 547-559

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mechanisms of neurodegeneration in mucopolysaccharidoses II and IIIB : analysis of human brain tissue2008

    • Author(s)
      Hamano K, Hayashi M, Shioda K, et al.
    • Journal Title

      Acta Neuropathol 115

      Pages: 547-549

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The pedunculopontine nucleus in developmental disorders of the basal ganglia2008

    • Author(s)
      Anzai Y, Hayashi M, Ohya T, Yokota S.
    • Journal Title

      Neuropathology 28

      Pages: 258-263

    • NAID

      10029319420

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Glial clusters and perineuronal glial satellitosis in the basal ganglia of neurofibromatosis type 12008

    • Author(s)
      Yokota O, Tsuchiya K, Hayashi M, et al.
    • Journal Title

      Acta Neuropathol 116

      Pages: 57-66

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] 歯状核赤核淡蒼球ルイ体萎縮症での脚橋被蓋核病変2010

    • Author(s)
      林雅晴、宮田理英、田沼直之
    • Organizer
      第44回日本てんかん学会
    • Place of Presentation
      岡山
    • Year and Date
      2010-10-15
    • Related Report
      2010 Final Research Report
  • [Presentation] 歯状核赤核淡蒼球ルイ体萎縮症での脚橋被蓋核病変2010

    • Author(s)
      林雅晴、宮田理英、田沼直之
    • Organizer
      第44回日本てんかん学会
    • Place of Presentation
      岡山コンベンションホール
    • Year and Date
      2010-10-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] 教育講演てんかん病理のトピックス2010

    • Author(s)
      林雅晴
    • Organizer
      Metropolitan Child Epilepsy Meeting
    • Place of Presentation
      東京
    • Year and Date
      2010-07-10
    • Related Report
      2010 Final Research Report
  • [Presentation] てんかん病理のトピックス2010

    • Author(s)
      林雅晴
    • Organizer
      Metropolitan Child Epilepsy Meeting
    • Place of Presentation
      東京医科大学(教育講演)
    • Year and Date
      2010-07-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] モーニングセミナー難治性てんかんの神経病理2009

    • Author(s)
      林雅晴
    • Organizer
      第36回日本小児臨床薬理学会
    • Place of Presentation
      高松
    • Year and Date
      2009-11-21
    • Related Report
      2010 Final Research Report
  • [Presentation] 難治性てんかんの神経病理(モーニングセミナー)2009

    • Author(s)
      林雅晴
    • Organizer
      第36回日本小児臨床薬理学会
    • Place of Presentation
      高松市
    • Year and Date
      2009-11-21
    • Related Report
      2009 Annual Research Report
  • [Presentation] Increase of oxidative stress markers in the urine in patients with xeroderma pigmentosum2009

    • Author(s)
      Hayashi M, Miyata R, Tanuma N
    • Organizer
      The 10th Asia Oceanian Congress of Child Neurology
    • Place of Presentation
      韓国・大邱
    • Year and Date
      2009-06-11
    • Related Report
      2010 Final Research Report
  • [Presentation] Increase of oxidative stress markers in the urine in patients with xero derma pigmentosum2009

    • Author(s)
      Hayashi M, Miyata R, Tanuma N.
    • Organizer
      The 10th Asia Oceanian Congress of Child Neurology
    • Place of Presentation
      韓国、大邱市
    • Year and Date
      2009-06-11
    • Related Report
      2009 Annual Research Report
  • [Presentation] West症候群剖検例での酸化ストレスに関する免疫組織化学的解析2008

    • Author(s)
      林雅晴、宮田理英、田沼直之
    • Organizer
      第111回日本小児科学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2008-04-25
    • Related Report
      2010 Final Research Report
  • [Presentation] West 症候群剖検例での酸化ストレスに関する免疫組織化学的解析2008

    • Author(s)
      林雅晴, 宮田理英, 田沼直之
    • Organizer
      第111回日本小児科学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2008-04-25
    • Related Report
      2008 Annual Research Report
  • [Presentation] Oxidative stress biomarkers in febrile seizures2008

    • Author(s)
      Tanuma N, Miyata R, Hayashi M, et al
    • Organizer
      The 11^<th> Annual Meeting of the Infantile Seizure Society
    • Place of Presentation
      大津
    • Year and Date
      2008-04-10
    • Related Report
      2010 Final Research Report
  • [Presentation] Oxidative stress biomarkers in febrile seizures2008

    • Author(s)
      Tanuma N, Miyata R, Hayashi M, et al.
    • Organizer
      The 11^<th> Annual Meeting of the Infantile Seizure Society
    • Place of Presentation
      Otsu, Japan
    • Year and Date
      2008-04-10
    • Related Report
      2008 Annual Research Report
  • [Book] Handbook of free radicals : formation, types and effects2010

    • Author(s)
      Hayashi M, Tanuma N, Miyata R
    • Total Pages
      642
    • Publisher
      Nova Science Publishers
    • Related Report
      2010 Final Research Report
  • [Book] Handbook of free radicals : formation, types and effects.2010

    • Author(s)
      Hayashi M, Tanuma N, Miyata R
    • Total Pages
      642
    • Publisher
      Nova Science Publishers
    • Related Report
      2010 Annual Research Report
  • [Book] 小児神経学の進歩第38集2009

    • Author(s)
      林雅晴
    • Total Pages
      136
    • Publisher
      診断と治療社
    • Related Report
      2010 Final Research Report
  • [Book] 小児神経学の進歩 第38集2009

    • Author(s)
      林雅晴, ら
    • Total Pages
      136
    • Publisher
      診断と治療社
    • Related Report
      2009 Annual Research Report
  • [Book] 症例から学ぶ神経疾患の画像と病理2008

    • Author(s)
      柳下章、林雅晴
    • Total Pages
      218
    • Publisher
      医学書院
    • Related Report
      2010 Final Research Report
  • [Book] 症例から学ぶ神経疾患の画像と病理2008

    • Author(s)
      柳下章, 林雅晴
    • Total Pages
      218
    • Publisher
      医学書院
    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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