| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Research Abstract |
Neuroglycan C(NGC) is a transmembrane chondroitin sulfate proteoglycan that is expressed in the brain and predominantly localizes dendritic filopodia on neuron. Although it is revealed that presynaptic function of NGC-null mice was partially impaired in early stages of development, the molecular mechanisms of synapse formation modulated by NGC proteoglycan remains undefined. To address this question, we sought to determine the identity of proteins that interact with NGC. As the result of the analysis, we identified several members in the FGF family. In addition to a broad mitogenic and other biological processes including neural morphogenesis, some of members in FGF family were reported as a presynaptic organizer protein, which can induce a formation of functional synaptic vesicle aggregates on axon fiber. The result suggests a possibility that NGC on the dendrites functions to display FGF as a co-receptor for FGFR on the axons to form functional synapse at appropriate sites.
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