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Analysis of the mechanism of infantile allergic diseases using the system to differentiate human ES cells into immune cells

Research Project

Project/Area Number 20591244
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Pediatrics
Research InstitutionThe University of Tokyo

Principal Investigator

MA Hou  The University of Tokyo, 医科学研究所, 特任研究員 (20378748)

Co-Investigator(Kenkyū-buntansha) TSUJI Kohichiro  東京大学, 医科学研究所, 准教授 (50179991)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsヒト胚性幹細胞(ES細胞) / 乳児アレルギー疾患 / 肥満細胞 / 好酸球 / 乳児アレルギー / 結合組織型肥満細胞 / ES細胞 / アレルギー / ヒトES細胞 / アトピー性皮膚炎 / 胎仔肝 / ストローマ細胞 / 多能性造血細胞 / 胎生期造血
Research Abstract

We succeeded the production of human mast cells and eosinophils, major immune effecter cells in allergic diseases, from hematopoietic cells derived human ES cells by coculture with AGMs-3 cells which are stromal cell line established from murine embryonic AGM region. Since this system reflect the generation and development of these immune cells in human embryo, it is expected to be a useful tool for analysis of the mechanism causing infantile allergic diseases.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (101 results)

All 2011 2010 2009 2008 Other

All Journal Article (29 results) (of which Peer Reviewed: 24 results) Presentation (49 results) Book (11 results) Remarks (5 results) Patent(Industrial Property Rights) (7 results) (of which Overseas: 2 results)

  • [Journal Article] Sero-prevalence of pandemic (H1N1) 2009 influenza A virus among schoolchildren and their parents inTokyo, Japan.2011

    • Author(s)
      Iwatsuki-Horimoto K, Horimoto T, Tamura D, Kiso M, Kawakami E, Hatakeyama S, Ebihara Y, Koibuchi T, Fujii T, Takahashi K, Shimojima M, Sakai-Tagawa Y, Ito M, Sakabe S, Iwasa A, Takahashi K, Ishii T, Gorai T, Tsuji K, Iwamoto A, Kawaoka Y
    • Journal Title

      J Clinic Microbiol (掲載確定)

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Reduced dose chemotherapy for acute promyelocytic leukemia with adult Down syndrome.2011

    • Author(s)
      Tsuda M, Ebihara Y, Mochizuki S, Uchimaru K, Tojo A, Tsuji K
    • Journal Title

      Br J Haematol (掲載確定)

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] ヒトES細胞から血液細胞への分化誘導2011

    • Author(s)
      辻浩一郎
    • Journal Title

      Cytometry Research (掲載確定)

    • NAID

      10028165325

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Sero-prevalence of pandemic (H1N1) 2009 influenza A virus among schoolchildren and their parents in Tokyo, Japan.2011

    • Author(s)
      Iwatsuki-Horimoto K, et al.
    • Journal Title

      J Clinic Microbiol

      Volume: (掲載確定in press, in press掲載確定)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reduced dose chemotherapy for acute promyelocytic leukemia with adult Down syndrome.2011

    • Author(s)
      Tsuda M, et al.
    • Journal Title

      Br J Haematol

      Volume: (掲載確定in press, in press掲載確定)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ヒトES細胞から血液細胞への分化誘導2011

    • Author(s)
      辻浩一郎
    • Journal Title

      Cytometry Research

      Volume: (掲載確定in press,印刷中 掲載確定)

    • NAID

      10028165325

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Adhesion-mediated self-renewal abilities of Ph+ blastoma cells.2010

    • Author(s)
      Funayama K, Saito-Kurimoto Y, Ebihara Y, Shimane Y, Nomura H, Tsuji K, Asano S
    • Journal Title

      Biochem Biophys Res Commun 396

      Pages: 193-198

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] A 5' untranslated region containing the IRES element in the Runx1 gene is required for angiogenesis, hematopoiesis and leukemogenesis in a knock-in mouse model.2010

    • Author(s)
      Nagamachi A, Htun PW, Ma F, Miyazaki K, Yamasaki N, Kanno M, Inaba T, Honda Z, Okuda T, Oda H, Tsuji K, Honda H H
    • Journal Title

      Dev Biol 345

      Pages: 226-236

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Adhesion-mediated self-renewal abilities of Ph+ blastoma cells.2010

    • Author(s)
      Funayama K, et al.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 396 Pages: 193-198

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A 5'untranslated region containing the IRES element in the Runxl gene isrequired for angiogenesis, hematopoiesis and leukemogenesis in a knock-in mouse model.2010

    • Author(s)
      Nagamachi A*, et al.(*equally contributed)
    • Journal Title

      Dev Biol

      Volume: 345 Pages: 226-236

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IRES-dependent expression is required for AML 1-mediated angiogenesis and hematopoiesis and for AML 1 fusion protein-induced leukemogenesis.2010

    • Author(s)
      Miyazaki K, Ma F, Yamasaki N, Oda H, Miyazaki M, Honda Z, Okuda T, Tsuji K, Honda H
    • Journal Title

      Dev Biol. (in press.)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Adhesion-mediated self-renewal abilities of Ph+ blastoma cells.2010

    • Author(s)
      Funayama K, Saito-Kurimoto Y, Ebihara Y, Shimane Y, Nomura H, Tsuji K, Asano S
    • Journal Title

      Biochem Biophys Res Commun (in press.)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Generation of blood cells from human ES cells and embryonic hematopoiesis.2010

    • Author(s)
      Ma F, Yang W, Tsuji K
    • Journal Title

      J Pedatir Biochem (in press.)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Application of whole mouse embryo culture system on stem cell research2009

    • Author(s)
      Kulkeaw K, Mizuochi C, Horio Y, Osumi N, Tsuji K, Sugiyama D.
    • Journal Title

      Stem Cell Rev & Rep. 5

      Pages: 175-180

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ヒトES細胞からの血液細胞の産生2009

    • Author(s)
      辻浩一郎
    • Journal Title

      人工血液 17

      Pages: 29-36

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] iPS細胞からの血液誘導2009

    • Author(s)
      辻浩一郎
    • Journal Title

      臨床検査

      Pages: 737-743

    • Related Report
      2009 Annual Research Report
  • [Journal Article]2009

    • Author(s)
      海老原康博
    • Journal Title

      小児がん. がん患者の心に寄り添うためのサイコオンコロジーの基礎と実践.(大木桃代編)(真興交易医書出版部)

      Pages: 43-47

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Homeostatic erythropoiesis by the transcription factor IRF2 through attenuation of type I interferon signaling.2008

    • Author(s)
      Mizutani T, Mizutani T, Tsuji K, Ebihara Y, Ohba Y, Taniguchi T, Honda K
    • Journal Title

      Exp Hematol 36

      Pages: 255-264

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cardiovascular toxicity of cryopreserved cord blood cell infusion.2008

    • Author(s)
      Konuma T, Konuma T, Ooi J, Takahashi S, Tomonari A, Tsukada N, Kobayashi T, Sato A, Kato S, Kasahara S, Ebihara Y, Nagamura-Inoue T, Tsuji K, Tojo A, Asano S
    • Journal Title

      Bone Marrrow Transplant 41

      Pages: 861-865

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Direct development of functionally mature tryptase/chymase double positive connective tissue-type mast cells from primate ES cells.2008

    • Author(s)
      Ma F, Kambe N, Wang D, Shinoda G, Fujino H, Umeda K, Fujisawa A, Ma L, Suemori H, Nakatsuji N, Miyachi Y, Torii R, Tsuji K, Heike T, Nakahata T
    • Journal Title

      Stem Cells 26(3)

      Pages: 706-714

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Generation of functional erythroid cells from human embryonic stem cell-derived definitive hematopoiesis.2008

    • Author(s)
      Ma F, Ebihara Y, Umeda K, Sakai H, Hanada S, Zhang H, Tsuchida E, Nakahata T, Nakauchi H, Tsuji K
    • Journal Title

      Proc Natl Acad Sci USA 105(35)

      Pages: 13087-13092

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Generation of functional erythrocytes from human embryonic stem cell-derived definitive hematopoiesis.2008

    • Author(s)
      Ma F et al.
    • Journal Title

      Proc Natl Acad Sci USA 105

      Pages: 13087-13092

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Direct development of functionally mature tryptase/chymase double positive tissue-type mastc ells from primate ES cells.2008

    • Author(s)
      Ma F et aL
    • Journal Title

      Stem Cells 26

      Pages: 706-714

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Homeostatic erythropoiesis by the transcription factor IRF2 through attenuation of type I interferon signaling.2008

    • Author(s)
      Mizutani T et al.
    • Journal Title

      Exp Hematol 36

      Pages: 255-264

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cardiovascular toxidty of cryopreserved cord blood cell infusion.2008

    • Author(s)
      Konuma T et al.
    • Journal Title

      Bone Marrrow Transplant 41

      Pages: 861-865

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 胎児造血とヒトES細胞からの血液の産生2008

    • Author(s)
      辻浩一郎
    • Journal Title

      日本小児科学会雑誌 112

      Pages: 1654-1662

    • NAID

      10024842380

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Application of whole mouse embryo culture system on stem cell research.

    • Author(s)
      Kulkeaw K et al.
    • Journal Title

      Stem Cell Rev & Rep (掲載確定)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ヒトES細胞からの血液細胞の産生

    • Author(s)
      辻浩一郎
    • Journal Title

      人工血液 (掲載確定)

    • Related Report
      2008 Annual Research Report
  • [Journal Article] iPS細胞からの血液誘導

    • Author(s)
      辻浩一郎
    • Journal Title

      臨床検査 (掲載確定)

    • Related Report
      2008 Annual Research Report
  • [Presentation] ヒトiPS細胞から血液細胞への動物血清・細胞非依存的分化誘導:自己iPS細胞由来 間葉系幹細胞との共培養2011

    • Author(s)
      海老原康博, 他
    • Organizer
      第10回日本再生医療学会総会
    • Place of Presentation
      東京:京王プラザホテル
    • Related Report
      2010 Final Research Report
  • [Presentation] ヒトips細胞から血液細胞への動物血清・細胞非依存的分化誘導:自己iPS細胞由来間葉系幹細胞との共培養.2011

    • Author(s)
      海老原康博, 他
    • Organizer
      第10回日本再生医療学会総会
    • Place of Presentation
      東京京王プラザホテル
    • Related Report
      2010 Annual Research Report
  • [Presentation] 15-20歳の思春期症例に対する臍帯血移植の検討2010

    • Author(s)
      海老原康博, 他
    • Organizer
      第52回日本小児血液学会総会
    • Place of Presentation
      大阪:大阪国際会議場
    • Related Report
      2010 Final Research Report
  • [Presentation] Differentiation of mature eosinophils derived from human embryonic and induced pluripotent stem cells.2010

    • Author(s)
      Yang W, et al.
    • Organizer
      52^<nd> ASH Annual Meeting
    • Place of Presentation
      Orange County Convention Center, Orlando, Florida, USA
    • Related Report
      2010 Final Research Report
  • [Presentation] Hematopoiesis of human induced pluripotent stem cells derived from patients with Down syndrome.2010

    • Author(s)
      Nishihama N, et al.
    • Organizer
      52^<nd> ASH Annual Meeting
    • Place of Presentation
      Orange County Convention Center, Orlando, Florida, USA
    • Related Report
      2010 Final Research Report
  • [Presentation] Generation of functionally mature blood cells from human ES/iPS cells and their possible clinical utilization.2010

    • Author(s)
      Ma F.
    • Organizer
      BIT's 3^<rd> Annual World Congress of RegenerativeMedicine & Stem Cells (RMSC-2010)
    • Place of Presentation
      Shanghai Everbright Convention and Exhibition Center Shanghai, China
    • Related Report
      2010 Final Research Report
  • [Presentation] Generation of functionally mature blood cells from human pluripotent stem cells.2010

    • Author(s)
      Ma F.
    • Organizer
      International Forum on Stem Cells 2010
    • Place of Presentation
      Chinese Academy of Medical Sciences Tianjin, China
    • Related Report
      2010 Final Research Report
  • [Presentation] The novel transfusion and cellular therapies based on human ES and iPScells.2010

    • Author(s)
      Ma F.
    • Organizer
      5^<th> National Congress of the China Society of Blood Transfusion
    • Place of Presentation
      The Century City New International Convention & Exhibition Center, Chengdu, China
    • Related Report
      2010 Final Research Report
  • [Presentation] The impact of steroid use as a GVHD treatment or prophylaxis within100 days after CBT.2010

    • Author(s)
      Kawakita T, et al.
    • Organizer
      第72回日本血液学会学術集会
    • Place of Presentation
      神奈川:パシフィコ横浜
    • Related Report
      2010 Final Research Report
  • [Presentation] Acute promyelocytic leukemia with adult Down syndrome : a case report.2010

    • Author(s)
      Tsuda M, et al.
    • Organizer
      第72回日本血液学会学術集会
    • Place of Presentation
      神奈川:パシフィコ横浜
    • Related Report
      2010 Final Research Report
  • [Presentation] Generation of mature eosinophils from human embryonic and induced pluripotent stem cells.2010

    • Author(s)
      Ma F, et al.
    • Organizer
      39^<th> Annual Scientific Meeting of ISEH
    • Place of Presentation
      Melbourne Convention & Exhibition Centre, Melbourne Australia
    • Related Report
      2010 Final Research Report
  • [Presentation] ヒトES細胞から血液細胞への分化誘導2010

    • Author(s)
      辻浩一郎
    • Organizer
      第20回日本サイトメトリー学会学術集会
    • Place of Presentation
      東京:東京慈恵会医科大学
    • Related Report
      2010 Final Research Report
  • [Presentation] 慢性骨髄性白血病に対する骨髄破壊的前処置を用いた臍帯血移植2010

    • Author(s)
      河北敏郎, 他
    • Organizer
      第32回日本造血細胞移植学会
    • Place of Presentation
      静岡:アクトシティ浜松
    • Related Report
      2010 Final Research Report
  • [Presentation] Generation of mature eosinophils from human embryonic and induced pluripotent stem cells.2010

    • Author(s)
      Ma F, et al.
    • Organizer
      39^<th> Annual Scientific Meeting of ISEH
    • Place of Presentation
      Melbourne, Australia
    • Related Report
      2010 Annual Research Report
  • [Presentation] Hematopoiesis of human induced pluripotent stem cells derived from patients with Down syndrome.2010

    • Author(s)
      Nishihama N, et al.
    • Organizer
      52^<nd> ASH Annual Meeting
    • Place of Presentation
      Orlando, Florida, USA
    • Related Report
      2010 Annual Research Report
  • [Presentation] Differentiation of mature eosinophils derived from human embryonic and induced pluripotent stem cells.2010

    • Author(s)
      Yang W, et al.
    • Organizer
      52nd ASH Annual Meeting
    • Place of Presentation
      Orlando, Florida, USA
    • Related Report
      2010 Annual Research Report
  • [Presentation] The novel transfusion and cellular therapies based on human ES and iPS cells.2010

    • Author(s)
      Ma F.
    • Organizer
      5^<th> National Congress of the China Society of Blood Transfusion.
    • Place of Presentation
      Chengdu, China
    • Related Report
      2010 Annual Research Report
  • [Presentation] Generation of functionally mature blood cells from human pluripotent stem cells.2010

    • Author(s)
      Ma F.
    • Organizer
      International Forum on Stem Cells 2010
    • Place of Presentation
      Tianjin, China
    • Related Report
      2010 Annual Research Report
  • [Presentation] Generation of functionally mature blood cells from human ES/iPS cells and their possible clinical utilization.2010

    • Author(s)
      Ma F.
    • Organizer
      BIT's 3^<rd> Annual World Congress of Regenerative Medicine & Stem Cells (RMSC-2010)
    • Place of Presentation
      Shanghai, China
    • Related Report
      2010 Annual Research Report
  • [Presentation] ヒトES細胞から血液細胞への分化誘導2010

    • Author(s)
      辻浩一郎
    • Organizer
      第20回日本サイトメトリー学会学術集会
    • Place of Presentation
      東京慈恵医科大学
    • Related Report
      2010 Annual Research Report
  • [Presentation] Acute promyelocytic leukemia with adult Down syndrome : a case report.2010

    • Author(s)
      Tsuda M, et al.
    • Organizer
      第72回日本血液学会学術集会
    • Place of Presentation
      横浜パシスコ横浜
    • Related Report
      2010 Annual Research Report
  • [Presentation] The impact of steroid use as a GVHD treatment or prophylaxis within 100 days after CBT.2010

    • Author(s)
      Kawakita T, et al.
    • Organizer
      第72回日本血液学会学術集会
    • Place of Presentation
      横浜パシスコ横浜
    • Related Report
      2010 Annual Research Report
  • [Presentation] 15-20歳の思春期症例に対する臍帯血移植の検討2010

    • Author(s)
      海老原康博, 他
    • Organizer
      第52回日本小児血液学会総会
    • Place of Presentation
      大阪国際会議場
    • Related Report
      2010 Annual Research Report
  • [Presentation] 慢性骨髄性白血病に対する骨髄破壊的前処置を用いた臍帯血移植2010

    • Author(s)
      河北敏郎, 大井淳, 高橋聡, 塚田信弘, 加藤せい子, 佐藤亜紀, 永田泰之, 海老原康博, 辻浩一郎, 浅野茂隆, 東條有伸
    • Organizer
      第32回日本造血細胞移植学会
    • Place of Presentation
      浜松
    • Related Report
      2009 Annual Research Report
  • [Presentation] Regenerative medicine and hematopoietic stem cells.2009

    • Author(s)
      辻浩一郎
    • Organizer
      Educational Symposium for Current Pediatric Hematology
    • Place of Presentation
      中国医科学研究院/天津血液研究所病院 Tianjin, China
    • Year and Date
      2009-09-18
    • Related Report
      2010 Final Research Report
  • [Presentation] Regenerative medicine and hematopoietic stem cells.2009

    • Author(s)
      Tsuji K.(Invited Speaker)
    • Organizer
      Educational Symposium for Current Pediatric Hematology
    • Place of Presentation
      Tianjin, China
    • Year and Date
      2009-09-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] Regenerative medicine based on human ES/iPS cells.2009

    • Author(s)
      Ma F
    • Organizer
      Educational Symposium for Current Pediatric Hematology
    • Place of Presentation
      Tianjin, China
    • Year and Date
      2009-09-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] ヒトES細胞維持機能を有するヒトES細胞由来ストローマ細胞2009

    • Author(s)
      海老原康博, 他
    • Organizer
      第8回日本再生医療学会
    • Place of Presentation
      東京:東京国際フォーラム
    • Year and Date
      2009-03-05
    • Related Report
      2010 Final Research Report
  • [Presentation] ヒトES細胞維持能を有するヒトES細胞由来ストローマ細胞2009

    • Author(s)
      海老原康博他
    • Organizer
      第8回日本再生医療学会
    • Place of Presentation
      東京
    • Year and Date
      2009-03-05
    • Related Report
      2008 Annual Research Report
  • [Presentation] 15-20歳の思春期奨励に対する臍帯血移植の検討2009

    • Author(s)
      海老原康博, 他
    • Place of Presentation
      北海道:ロイトン札幌
    • Year and Date
      2009-02-05
    • Related Report
      2010 Final Research Report
  • [Presentation] 15-20歳の思春期症例に対する臍帯血移植の検討2009

    • Author(s)
      海老原康博他
    • Organizer
      第31回日本造血細胞移植学会
    • Place of Presentation
      札幌
    • Year and Date
      2009-02-05
    • Related Report
      2008 Annual Research Report
  • [Presentation] 再発・難治性白血病4例に対するIDA-FLAG療法の効果および有効性2009

    • Author(s)
      渡辺温子, 他
    • Organizer
      第51回日本小児血液学会
    • Place of Presentation
      千葉:東京ベイホテル東急
    • Related Report
      2010 Final Research Report
  • [Presentation] Second or third myeloablative allo-SCT using cord blood for adult leukemia.2009

    • Author(s)
      Kato S, et al
    • Organizer
      第71回日本血液学会総会
    • Place of Presentation
      京都:国立京都国際会館
    • Related Report
      2010 Final Research Report
  • [Presentation] Human ES cell-derived MSC maintining human ES and iPS cells under animal serum-free conditions.2009

    • Author(s)
      Ebihara Y, et al
    • Organizer
      第71回日本血液学会総会
    • Place of Presentation
      京都:国立京都国際会館
    • Related Report
      2010 Final Research Report
  • [Presentation] Derivation of mature blood cells from human induced pluripotent stem cells.2009

    • Author(s)
      Ma F, et al
    • Organizer
      38th Annual Scientific Meeting of the International Society of Experimental Hematology
    • Place of Presentation
      Horel Divani Caravel, Athens, Greece
    • Related Report
      2010 Final Research Report
  • [Presentation] Human embryonic stem (ES) cell-derived mesenchymal stem cells capable of efficiently maintaining human ES and induced pluripotent stem cells under animal serum-free conditions.2009

    • Author(s)
      Ebihara Y, et al
    • Organizer
      7th Annual Meeting of the International Society of Stem Cell Research
    • Place of Presentation
      Centre convencions Internacional, Barcelona, Spain
    • Related Report
      2010 Final Research Report
  • [Presentation] Derivation of multipotential hematopoietic progenitors and mature blood cells from human induced pluripotent stem cells.2009

    • Author(s)
      Ma F, et al
    • Organizer
      7th Keio Stem Cell Research Symposium
    • Place of Presentation
      東京:慶応義塾大学
    • Related Report
      2010 Final Research Report
  • [Presentation] 15-20歳の思春期症例に対する臍帯血移植の検討2009

    • Author(s)
      海老原康博, 他
    • Organizer
      第112回日本小児科学会学術集会
    • Place of Presentation
      奈良:奈良県文化会館
    • Related Report
      2010 Final Research Report
  • [Presentation] Human embryonic stem(ES)cell-derived mesenchymal stem cells capable of efficiently maintaining human ES and induced pluripotent stem cells under animal serum-free conditions2009

    • Author(s)
      Ebihara Y, Ma F, Hanada S, Tomizawa D, Tsuji K, Ononda H, Oyaizu N.
    • Organizer
      7th Annual Meeting of the International Society of Stem Cell Research
    • Place of Presentation
      Barcelona, Spain
    • Related Report
      2009 Annual Research Report
  • [Presentation] Derivation of mature blood cells from humam induced pluripotent stem cells.2009

    • Author(s)
      Ma F, Ebihara Y, Nakauchi H, Tsuji K.
    • Organizer
      38th Annual Scientific Meeting of the International Society of Experimental Hematology
    • Place of Presentation
      Athens, Greece
    • Related Report
      2009 Annual Research Report
  • [Presentation] Derivation of multipotential hematopoietic progenitors and mature blood cells from human induced pluripotent stem cells.2009

    • Author(s)
      Ma F, Ebihara Y, Nakauchi H, Tsuji K.
    • Organizer
      7th Keio Stem Cell Research Symposium
    • Place of Presentation
      Tokyo, Japan
    • Related Report
      2009 Annual Research Report
  • [Presentation] Second or third myeloblative allo-SCT using cord blood for adult leukemia.2009

    • Author(s)
      Kato S, Ooi J, Tahashi S, Tsukada N, Sato A, Konuma T, Kawakita T, Nagata Y, Ebihara Y Tsuji K, Tojo A, Asano S.
    • Organizer
      第71回日本血液学会総会
    • Place of Presentation
      京都
    • Related Report
      2009 Annual Research Report
  • [Presentation] Human ES cell-derived MSC maintining human ES and iPS cells under animal serum-free conditions.2009

    • Author(s)
      Ebihara Y, Ma F, Hanada S, Tomizawa D, Tsuji K, Oyaizu N.
    • Organizer
      第71回日本血液学会総会
    • Place of Presentation
      京都
    • Related Report
      2009 Annual Research Report
  • [Presentation] 15-20歳の思春期症例に対する臍帯血移植の検討2009

    • Author(s)
      海老原康博, 辻浩一郎
    • Organizer
      第112回日本小児科学会学術集会
    • Place of Presentation
      奈良
    • Related Report
      2009 Annual Research Report
  • [Presentation] 再発・難治性白血病4例に対するIDA-FLAG療法の効果および有効性2009

    • Author(s)
      渡辺温子, 田中竜平, 正田絵里子, 水野圭子, 森脇浩一, 海老原康博
    • Organizer
      第51回日本小児血液学会
    • Place of Presentation
      舞浜
    • Related Report
      2009 Annual Research Report
  • [Presentation] Myelodysplastic Syndrome (MDS) and Myeloproliferative Disease (MPD) in Children : A prospective Resistration of 222 Cases.2008

    • Author(s)
      Hirabayashi S, et al.
    • Organizer
      15th annual meeting of American Society of Hematology
    • Place of Presentation
      Moscone Convention Center, San Francisco, USA
    • Year and Date
      2008-12-07
    • Related Report
      2010 Final Research Report
  • [Presentation] Myelodysplastic Syndrome(MDS)and Myeloproliferative Disease(MPD)in Chidren: A prospective Resistration of 222 Cases.2008

    • Author(s)
      Hirabayashi S et a1.
    • Organizer
      15th annual meeting of American Society of Hematology
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2008-12-07
    • Related Report
      2008 Annual Research Report
  • [Presentation] 異種動物血清を用いないヒトembryonic stem cell(hESC)から間葉系幹細胞(MSC)への分化誘導2008

    • Author(s)
      海老原康博, 他
    • Organizer
      第70回日本血液学会
    • Place of Presentation
      京都:国立京都国際会館
    • Year and Date
      2008-10-10
    • Related Report
      2010 Final Research Report
  • [Presentation] 異種動物血清を用いないヒトembryonic stem cell(hESC)から間葉系幹細胞(MSC)への分化2008

    • Author(s)
      海老原康博他
    • Organizer
      第70回日本血液学会
    • Place of Presentation
      京都
    • Year and Date
      2008-10-10
    • Related Report
      2008 Annual Research Report
  • [Book] Stem Cell Therapy2011

    • Author(s)
      Ma F, Yang W, Tsuji K
    • Publisher
      Transworld Research Network, Kerala,
    • Related Report
      2010 Final Research Report
  • [Book] Embryonic stem cells2011

    • Author(s)
      Ma F, Ebihara Y, Tsuji K
    • Publisher
      Intech, Vienna(掲載確定)
    • Related Report
      2010 Final Research Report
  • [Book] Lineage-specific differentiation of human embryonic and induced pluripotent stem cells methods and protocols2011

    • Author(s)
      Ma F, Gu Y, Nishihama N, Ebihara Y, Tsuji K
    • Publisher
      Humana Press, New York(掲載確定)
    • Related Report
      2010 Final Research Report
  • [Book] 臍帯血移植の基礎と臨床2011

    • Author(s)
      辻浩一郎
    • Publisher
      医学書院(東京)(掲載確定)
    • Related Report
      2010 Final Research Report
  • [Book] Stem Cell Therapy2011

    • Author(s)
      Ma F, et al.
    • Publisher
      Transworld Research Network, Kerala
    • Related Report
      2010 Annual Research Report
  • [Book] Embryonic stem cells2011

    • Author(s)
      Ma F, et al.
    • Publisher
      Intech, Vienna(in press刊行確定)
    • Related Report
      2010 Annual Research Report
  • [Book] Lineage-specific differentiation of human embryonic and induced pluripotent stem cells methods and protocols2011

    • Author(s)
      Ma F, et al.
    • Publisher
      Humana Press, New York(刊行確定)
    • Related Report
      2010 Annual Research Report
  • [Book] 臍帯血移植の基礎と臨床2011

    • Author(s)
      辻浩一郎
    • Publisher
      医学書院(東京)(印刷中 刊行確定)
    • Related Report
      2010 Annual Research Report
  • [Book] Regenerative medicine based on human ES and iPS cells.2010

    • Author(s)
      Ma F, Yang W, Tsuji K.
    • Publisher
      Stem cells in medicine. edited by Isobe K(Transworld Research Network, Kerala)(in press)
    • Related Report
      2009 Annual Research Report
  • [Book] 胎生期の造血.臍帯血移植の基礎と臨床(浅野茂隆、谷口克編)2010

    • Author(s)
      辻浩一郎
    • Publisher
      医学書院(東京)(印刷中)
    • Related Report
      2009 Annual Research Report
  • [Book] 医学書院(東京)2010

    • Author(s)
      辻浩一郎
    • Publisher
      Myelodysplastic symdrome.今日の小児治療指針、大関武彦、古川漸、横田俊一郎、水口雅編(印刷中)
    • Related Report
      2009 Annual Research Report
  • [Remarks] ホームページ等

    • Related Report
      2010 Final Research Report
  • [Remarks] 東京大学医科学研究所 幹細胞治療研究センター 幹細胞プロセシング分野

    • URL

      http://stemcell-u.tokyo.org/scp/

    • Related Report
      2010 Final Research Report
  • [Remarks] 東京大学医科学研究所 幹細胞治療研究モンター 幹細胞プロセシング分野

    • URL

      http://stemcell-u-tokyo.org/scp/

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://stemcell-u-tokyo.org/scp/

    • Related Report
      2009 Annual Research Report
  • [Remarks] A-IBMN Rearch(by Asian-Pacific International Molecular Biology Network)Highlights:"Turning stem cells into Blood", on 17 December 2008.

    • URL

      http://www.natureasia.com/A-IMBN/article.php?id=168

    • Related Report
      2008 Annual Research Report
  • [Patent(Industrial Property Rights)] Method for producing eosinophils from pluripotent stem cells2010

    • Inventor(s)
      辻浩一郎、馬峰、斎藤博久、松本健治、中畑龍俊
    • Industrial Property Rights Holder
      京都大学
    • Filing Date
      2010-12-03
    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] ヒト由来の多能性幹細胞を分化させる方法2010

    • Inventor(s)
      辻浩一郎、海老原康博
    • Industrial Property Rights Holder
      東京大学
    • Industrial Property Number
      2010-222583
    • Filing Date
      2010-09-30
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Patent(Industrial Property Rights)] Method for producing mast cells from pluripotent stem cells2010

    • Inventor(s)
      辻浩一郎、馬峰、中畑龍俊
    • Industrial Property Rights Holder
      京都大学
    • Filing Date
      2010-09-08
    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] Method for producing mast cells from pluripotent stem cells2010

    • Inventor(s)
      辻浩一郎、馬峰、中畑龍俊
    • Industrial Property Rights Holder
      京都大学
    • Filing Date
      2010-09-08
    • Related Report
      2010 Annual Research Report
  • [Patent(Industrial Property Rights)] Method for producing eosinophils from pluripotent stem cells2010

    • Inventor(s)
      辻浩一郎、馬峰、斎藤博久、松本健治、中畑龍俊
    • Industrial Property Rights Holder
      京都大学
    • Filing Date
      2010-12-03
    • Related Report
      2010 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 多能性幹細胞からの肥満細胞の製造方法2009

    • Inventor(s)
      辻浩一郎、馬峰、中畑龍俊
    • Industrial Property Rights Holder
      京都大学
    • Filing Date
      2009-09-08
    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] 多能性幹細胞からの肥満細胞の製造方法2009

    • Inventor(s)
      辻浩一郎, 馬峰, 中畑龍俊
    • Industrial Property Rights Holder
      国立大学法人 京都大学
    • Filing Date
      2009-09-08
    • Related Report
      2009 Annual Research Report
    • Overseas

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Published: 2008-04-01   Modified: 2016-04-21  

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