Study on the mechanism of autoimmunity and malignancy developed in primary immunodeficiency

• Project/Area Number: 20591245
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Pediatrics
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: MORIO Tomohiro Tokyo Medical and Dental University, 大学院・医歯学総合研究科, 准教授 (30239628)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 先天性免疫不全症 / 自己免疫疾患 / 悪性腫瘍 / DNA損傷修復 / 毛細血管拡張小脳失調症 / Mre11 / V(D)J再構成 / 免疫グロブリンクラススイッチ / ATM / リンパ系悪性腫瘍 / 分類不能型免疫不全症 / Mrel1欠損症 / DNA損傷修復応答 / ゲノム不安定性 / T細胞サブセット / Anergy / B細胞新生能 / T細胞新生能 / Good症候群 / DNA損傷修復異常

Research Abstract

We studied on the mechanism of autoimmunity and malignancy frequently observed in patients with primary immunodeficiency (PID). Patients with impaired DNA damage response such as ataxia telangiectasia (AT) and Mre11 deficiency showed chromosomal abnormality caused by defect in DNA damage processing. AT patients showed defective T-cell development as well. T-cell anergy was not properly executed in lymphocytes from ICOS deficiency showing autoimmunity. Skewed TCR V repertoire usage was observed in ～50% of CVID patients. These findings suggest the presence of various mechanism underling autoimmune disorder and malignancy in PID patients.

Research Products

• [Journal Article] Analysis of mutations andrecombination activity inRAG-deficient patient. (2011)
  • Author(s): Asai E., Wada T., Sakakibara Y., Toga A., Toma T., Shimizu T., Imai K., Nonoyama S., Morio T., Kamachi Y., Ohara O., Yachie A.
  • Journal Title: Clin.Immunol 138 Pages: 172-177
• [Journal Article] AutoimmuneLymphoproliferative Syndrome Like Disease With Somatic KRAS Mutation. (2011)
  • Author(s): Takagi M, Shinoda K, Piao J, MitsuikiN, Takagi M, Matsuda K, Muramatsu H,Doisaki S, Nagasawa M, Morio T.,Kasahara Y, Koike K, Kojima S, Takao A,Mizutani S.
  • Journal Title: Blood 117 Pages: 2887-2890
• [Journal Article] 【内科疾患の診断基準病型分類・重症度】免疫・その他先天性免疫不全症候群 (2011)
  • Author(s): 森尾友宏
  • Journal Title: 内科 105 Pages: 1296-1300
• [Journal Article] Analysis of mutations and recombination activity in RAG-deficient patient. (2011)
  • Author(s): Asai E.Wada T.Sakakibara Y.Toga A.Toma T.Shimizu T.Imai K.Nonoyama S.Morio T.Kamachi Y.Ohara O.Yachie A.
  • Journal Title: Clin.Immunol Volume: 138 Pages: 172-177
  • NAID: 120002772030
  • Peer Reviewed
• [Journal Article] Mizutani S.Autoimmune Lymphoproliferative Syndrome Like Disease With Somatic KRAS Mutation. (2011)
  • Author(s): Takagi M.Shinoda K.Piao J.Mitsuiki N.Takagi M.Matsuda K.Muramatsu H.Doisaki S.Nagasawa M.Morio T.Kasahara Y.Koike K.Kojima S.Takao A.
  • Journal Title: Blood Volume: 117 Pages: 2887-2890
  • Peer Reviewed
• [Journal Article] 免疫・その他:先天性免疫不全症候群 (2011)
  • Author(s): 森尾友宏
  • Journal Title: 内科(特集号【内科疾患の診断基準病型分類・重症度】) Volume: 105 Pages: 1296-1300
• [Journal Article] Qualitative and quantitativedifferences in the intensity of Fas-mediated intracellular signals determine life and death in T cells. (2010)
  • Author(s): Shin MJ, Shim JH, Lee JY, Chae WJ, LeeHK, Morio T., Park JH, Chang EJ, Lee SK.
  • Journal Title: Int J.Hematol. 92 Pages: 262-270
• [Journal Article] Prominent eosinophilia but less eosinophil activation in a patientwith Omenn syndrome. (2010)
  • Author(s): Seki M., Kimura H., Mori A., Shimada A., Yamada Y., Maruyama K., Hayashi Y., Agematsu K., Morio T., Yachie A., Kato M.
  • Journal Title: Pediatr.Int. 52
• [Journal Article] Successful cord blood transplantation for a CHARGE syndrome with CHD7 mutation showing DiGeorge sequence including hypoparathyroidism. (2010)
  • Author(s): Inoue H., Takada H., Kusuda T., Goto T., Ochiai M., Kinjo T., Muneuchi J., TakahataY., Takahashi N., Morio T., Kosaki K., Hara T.
  • Journal Title: Eur.J.Paedirtr. 169 Pages: 839-844
• [Journal Article] IkB regulates TH17 development by cooperating with ROR nuclear receptors. (2010)
  • Author(s): Okamoto K, Iwai Y, Ohhora M, YamamotoM, Morio T., Aoki K, Ohya K, Jetten AM,Akira S, Muta T, Takayanagi H.
  • Journal Title: Nature. 464 Pages: 1381-1385
• [Journal Article] X-linked thrombocytopenia (XLT) due to WAS mutations: Clinicalcharacteristics, long-term outcome,and treatment options. (2010)
  • Author(s): Albert MH, Bittner TC, Nonoyama S,Notarangelo LD, Burns S, Imai K, Espanol T, Fasth A, Pellier I, StraussG, Morio T., Gathmann B, Noordzij JG,Fillat C, Hoenig M, Nathrath M, MeindlA, Pagel P, Wintergerst U, Fischer A,Thrasher AJ, Belohradsky BH, Ochs HD.
  • Journal Title: Blood. 115 Pages: 3231-3238
• [Journal Article] Autopsystudy of cerebellar degeneration insiblings with ataxia-telangiectasia-like disorder. (2010)
  • Author(s): Oba D., Hayashi M., Minamitani M., HamanoS., Uchisaka N., Kikuchi A., Kishimoto H., Takagi M., Morio T., Mizutani S.
  • Journal Title: Acta Neuropathol. 119 Pages: 513-520
• [Journal Article] Qualitative and quantitative differences in the intensity of Fas-mediated intracellular signals determine life and death in T cells. (2010)
  • Author(s): Shin MJ.Shim JH.Lee JY.Chae WJ.Lee HK.Morio T.Park JH.Chang EJ.Lee SK.
  • Journal Title: Int J.Hematol. Volume: 92 Pages: 262-270
  • NAID: 10026712140
  • Peer Reviewed
• [Journal Article] Prominent eosinophilia but less eosinophil activation in a patient with Omenn syndrome. (2010)
  • Author(s): Seki M.Kimura H.Mori A.Shimada A.Yamada Y.Maruyama K.Hayashi Y.Agematsu K.Morio T.Yachie A.Kato M.
  • Journal Title: Pediatr.Int. Volume: 52
  • Peer Reviewed
• [Journal Article] Successful cord blood transplantation for a CHARGE syndrome with CHD7 mutation showing DiGeorge sequence including hypoparathyroidism. (2010)
  • Author(s): Inoue H.Takada H.Kusuda T.Goto T.Ochiai M.Kinjo T.Muneuchi J.Takahata Y.Takahashi N.Morio T.Kosaki K.Hara T.
  • Journal Title: Eur.J.Paedirtr. Volume: 169 Pages: 839-844
  • Peer Reviewed
• [Journal Article] IkB regulates TH 17 development by cooperating with ROR nuclear receptors. (2010)
  • Author(s): Okamoto K.Iwai Y.Ohhora M.Yamamoto M.Morio T.Aoki K.Ohya K.Jetten AM.Akira S.Muta T.Takayanagi H.
  • Journal Title: Na ture. Volume: 464 Pages: 1381-1385
  • Peer Reviewed
• [Journal Article] X-linked thrombocytopenia(XLT)due to WAS mutations : Clinical characteristics, long-term outcome, and treatment options. (2010)
  • Author(s): Albert MH.Bittner TC.Nonoyama S.Notarangelo LD.Burns S.Imai K.Espanol T.Fasth A.Pellier I.Strauss G.Morio T.Gathmann B.Noordzij JG.Fillat C.Hoenig M.Nathrath M.Meindl A.Pagel P.Wintergerst U.Fischer A.Thrasher AJ.Belohradsky BH.Ochs HD
  • Journal Title: Blooa. Volume: 115 Pages: 3231-3238
  • Peer Reviewed
• [Journal Article] Autopsy study of cerebellar degeneration in siblings with ataxia-telangiectasia-like disorder. (2010)
  • Author(s): Oba D.Hayashi M.Minamitani M.Hamano S.Uchisaka N.Kikuchi A.Kishimoto H.Takagi M.Morio T.Mizutani S.
  • Journal Title: Acta Neuropathol. Volume: 119 Pages: 513-520
  • Peer Reviewed
• [Journal Article] Autopsy study of cerebellar degeneration in siblings with ataxia-telangiectasia-like disorder. (2010)
  • Author(s): Oba D., Hayashi M., Minamitani M., Hamano S., Uchisaka N., Kikuchi A., Kishimoto H., 高木正稔, 森尾友宏, 水谷修紀
  • Journal Title: Acta Neuropathol. 119巻 Pages: 513-20
  • Peer Reviewed
• [Journal Article] Fatal degeneration of specialized cardiac muscle associated with chronic activeEpstein-Barr virus infection. (2009)
  • Author(s): Hasegawa D., Kaji M., Takeda H., KawasakiK., Takahashi H., Ochiai H., Morio T., Omori Y., Yokozaki H., Kosaka Y.
  • Journal Title: PediatrInt. 51 Pages: 846-848
• [Journal Article] Immunologically silent cancer clone transmission from mother to offspring. (2009)
  • Author(s): Isoda T., Ford A., Tomizawa D., van DelftF., De Castro DG., Mitsuiki N., Score J., Taki T., Takagi M., Morio T., Saji H., Greaves M., Mizutani S.
  • Journal Title: Proc.Natl.Acad.Sci.USA. 106 Pages: 178821788-178821785
• [Journal Article] Phenotypic Variations between Affected Siblings with Ataxia-Telangiectasia: Ataxia-Telangiectasia in Japan. (2009)
  • Author(s): Morio T., Takahashi N., Watanabe F., HondaF., Sato M., Takagi M., Imadome KI., Miyawaki T., Delia D., Nakamura K., GattiRA., Mizutani S.
  • Journal Title: Int.J.Hematol. 90 Pages: 455-462
  • NAID: 10026109392
• [Journal Article] Two brothers with ataxia-telangiectasia-like disorder with lung adenocarcinoma. (2009)
  • Author(s): Uchisaka N., Takahashi N., Sato M., Kikuchi A., Mochizuki S., Imai K., Nonoyama S., Ohara O., Watanabe F., Mizutani S., Hanada R., Morio T.
  • Journal Title: J.Pediatr. 155 Pages: 435-438
• [Journal Article] Bilateral anterior granulomatous keratouveitis with sunset glow fundus in a patient with autoiommune polyglandular syndrome. (2009)
  • Author(s): Futagami Y., Sugita S., Fujimaki T., Yokoyama T., Morio T., Mochizuki M.
  • Journal Title: Ocul Immunol Inflamm. 17 Pages: 88-90
• [Journal Article] Impaired CD4 and CD8 effector function and decreased memory T-cell populations in ICOS deficient patients. (2009)
  • Author(s): Takahashi N., Matsukoto K., Saito H., Nanki T., Miyasaka N., Kobata T., Azuma M., Lee S-K., Mizutani S., Morio T.
  • Journal Title: J.Immunol. 182 Pages: 5515-5527
• [Journal Article] Rapid diagnosis of ataxia-telangiectasia by flow cytometric monitoring of DNA damage-dependent ATM phosphorylation. (2009)
  • Author(s): Honda M., Takagi M., Chessa L., Morio T., Mizuatni S.
  • Journal Title: Leukemia. 23 Pages: 409-414
• [Journal Article] 免疫低下に伴うMAC感染症に合併した呼吸器クリプトスポリジウム症の1例 (2009)
  • Author(s): 所正治, HusseinAmjad I.A., 田中身和, 山口智博, 森尾友宏, 佐藤隆介, 水谷修紀
  • Journal Title: Clinical Parasitology 19 Pages: 55-58
• [Journal Article] V(D)J 再構成および免疫グロブリンクラススイッチにおけるATM の役割 (2009)
  • Author(s): 森尾友宏
  • Journal Title: 臨床免疫・アレルギー科 51 Pages: 154-161
  • NAID: 40016500612
• [Journal Article] ウイルス感染の排除機構と免疫記憶 (2009)
  • Author(s): 森尾友宏
  • Journal Title: 小児内科 41 Pages: 970-975
• [Journal Article] Ex vivo-expanded donor CD4+ lymphocyte infusion againstrelapsing neuroblastoma : a transient graft-versus-tumoreffect. (2009)
  • Author(s): Yoshida H., Kusuki S., Hayashi Y., Ohta H., 森尾友宏, Ozono K.
  • Journal Title: Pediatric Blood & Cancer. 52巻 Pages: 895-7
  • Peer Reviewed
• [Journal Article] Chemokine receptor expression and functional effects of chemokines on B cells : implication in the pathogenesis of rheumatoid arthritis. (2009)
  • Author(s): Nanki T., Takada K., Komano Y., 森尾友宏, Kanegane H., Nakajima A., Lipsky PE., Miyasaka N.
  • Journal Title: Arthritis Res Ther. 11巻
  • Peer Reviewed
• [Journal Article] Immunologically silent cancer clone transmission from mother to offspring. (2009)
  • Author(s): 磯田健志, Ford A., Tomizawa D., van Delft F., De Castro DG., Mitsuiki N., Score J., Taki T., 高木正稔, 森尾友宏, Saji H., Greaves M., 水谷修紀
  • Journal Title: Proc.Natl.Acad.Sci.USA. 106巻 Pages: 17882-5
  • Peer Reviewed
• [Journal Article] Ex vivo expanded cord blood CD4 T lymphocytes exhibit a distinct expression profile of cytokine-related genes from those of peripheral blood origin. (2009)
  • Author(s): Miyagawa Y., Kiyokawa N., Ochiai N., Imadome K-I., Horiuchi Y., Onda K., Yajima M., Nakamura H., Katagiri YU., Okita H., 森尾友宏, 清水則夫, Fujimoto J., Fujiwara S.
  • Journal Title: Immunology. 128巻 Pages: 405-19
  • Peer Reviewed
• [Journal Article] Identification of severe combined immunodeficiency by T-cell receptor excision circles quantification using neonatal guthrie cards. (2009)
  • Author(s): Morinishi Y., Imai K., Nakagawa N., Sato H., Horiuchi K., Ohtsuka Y., Kaneda Y., Taga T., Hisakawa H., Miyaji R., Endo M., Oh-Ishi T., Kamachi Y., Akahane K., Kobayashi C., Tsuchida M., 森尾友宏, Sasahara Y., Kumaki S., Ishigaki K., Yoshida M., Urabe T., Kobayashi N., Okimoto Y., Reichenbach J., Hashii Y., Tsuji Y., Kogawa K., Yamaguchi S., Kanegane H., Miyawaki T., Yamada M., Ariga T., Nonoyama S.
  • Journal Title: J.Pediatr. 155巻 Pages: 829-33
  • Peer Reviewed
• [Journal Article] Phenotypic Variations between Affected Siblings with Ataxia-Telangiectasia : Ataxia-Telangiectasia in Japan. (2009)
  • Author(s): 森尾友宏, Takahashi N., Watanabe F., Honda F., Sato M., 高木正稔, Imadome KI., Miyawaki T., Delia D., Nakamura K., Gatti RA., 水谷修紀
  • Journal Title: Int.J.Hematol. 90巻 Pages: 455-62
  • NAID: 10026109392
  • Peer Reviewed
• [Journal Article] A significant association of viral loads with corneal endothelial cell damage in cytomegalovirus anterior uveitis. (2009)
  • Author(s): Miyanaga M., 杉田直, 清水則夫, 森尾友宏, Miyata K., Mochizuki M.
  • Journal Title: Br J Ophthalmol.[Epub ahead of print]
  • Peer Reviewed
• [Journal Article] Two brothers with ataxia-telangiectasia-like disorder with lung adenocarcinoma. (2009)
  • Author(s): Uchisaka N., Takahashi N., Sato M., Kikuchi A., Mochizuki S., Imai K., Nonoyama S., Ohara O., Watanabe F., 水谷修紀, Hanada R., 森尾友宏
  • Journal Title: J.Pediatr. 155巻 Pages: 435-438
  • Peer Reviewed
• [Journal Article] Bilateral anterior granulomatous keratouveitis with sunset glow fundus in a patient with autoimmune polyglandular syndrome. (2009)
  • Author(s): Futagami Y., 杉田直, Fujimaki T., Yokoyama T., 森尾友宏, Mochizuki M.
  • Journal Title: Ocul Immunol Inflamm. 17巻 Pages: 88-90
  • Peer Reviewed
• [Journal Article] Impaired CD4 and CD8 effector function and decreased memory T-cell populations in ICOS deficient patients. (2009)
  • Author(s): Takahashi N., Matsukoto K., Saito H., Nanki T., Miyasaka N., Kobata T., Azuma M., Lee S-K., 水谷修紀, 森尾友宏
  • Journal Title: J.Immunol. 182巻 Pages: 5515-5527
  • Peer Reviewed
• [Journal Article] Rapid diagnosis of ataxia-telangiectasia by flow cytometric monitoring of DNA damage-dependent ATM phosphorylation. (2009)
  • Author(s): Honda M., 高木正稔, Chessa L., 森尾友宏, 水谷修紀
  • Journal Title: Leukemia. 23巻 Pages: 409-414
  • Peer Reviewed
• [Journal Article] 眼部帯状庖疹の涙液中の水痘・帯状庖疹ウイルスDNA量 (2009)
  • Author(s): 山本紗也香、杉田直、森尾友宏、清水則夫、望月學
  • Journal Title: 臨床眼科 63巻 Pages: 707-710
  • Peer Reviewed
• [Journal Article] 化学療法抵抗性を示したWilms腫瘍に対する薬物動態解析にもとづくトポテカン(ノギテカン)の投与経験 (2009)
  • Author(s): 青木由貴、高木正稔、前田佳真、新井洋美、高橋真弓、柴田聡子、磯田健志、満生紀子、長澤正之、森尾友宏、安原眞人、水谷修紀
  • Journal Title: 小児がん 46巻 Pages: 337-342
  • NAID: 110007359137
  • Peer Reviewed
• [Journal Article] 化学療法抵抗性を示したWilms腫瘍、favorable histology、ステージIVの1例 (2009)
  • Author(s): 高木正稔、青木由貴、磯田健志、佐藤隆介、満生紀子、梶原道子、長澤正之、森尾友宏、李慶徳、山高篤行、森川信行、黒田達夫、水谷修紀
  • Journal Title: 小児がん 46巻 Pages: 387-392
  • NAID: 110007359111
  • Peer Reviewed
• [Journal Article] 【見直してみよう!麻疹・風疹・水痘・ムンプス】ウイルス感染の排除機構と免疫記憶 (2009)
  • Author(s): 森尾友宏
  • Journal Title: 小児内科 41巻 Pages: 970-975
• [Journal Article] V(D)J再構成および免疫グロブリンクラススイッチにおけるATMの役割 (2009)
  • Author(s): 森尾友宏
  • Journal Title: 臨床免疫・アレルギー科 51巻 Pages: 154-161
  • NAID: 40016500612
• [Journal Article] (2009)
  • Author(s): 森尾友宏
  • Journal Title: 新版臨床免疫学第二版、免疫不全症(講談社) Pages: 168-175
• [Journal Article] (2009)
  • Author(s): 森尾友宏
  • Journal Title: 専門医をめざす!小児科試験問題集(中山書店) Pages: 127-146
• [Journal Article] (2009)
  • Author(s): 森尾友宏
  • Journal Title: 病気が見えるvol 6免疫・膠原病・感染症 免疫(MEDIC MEDIA) Pages: 1-31
• [Journal Article] Rapid diagnosis of ataxia-telangiectasia by flow cytometric monitoringof DNA damage-dependent ATM phosphorylation. (2009)
  • Author(s): Honda M, Takagi M, Chessa L, Morio T, Mizuatni s.
  • Journal Title: Leukemia. 23 Pages: 409-14
  • Peer Reviewed
• [Journal Article] Vesical varices and telangiectasias in a patient with ataxia telangiectasia. (2008)
  • Author(s): Suzuki K., Tsugawa K., Oki E., Morio T., Ito E., Tanaka H.
  • Journal Title: Ped.Nephrol. 23 Pages: 1005-1008
• [Journal Article] Ataxia telangiectasiaの臨床的特徴全国調査から明らかになったこと (2008)
  • Author(s): 森尾友宏
  • Journal Title: 小児科臨床 61 Pages: 1805-1810
• [Journal Article] 【原発性免疫不全症候群】Ataxia telangiectasia (2008)
  • Author(s): 森尾友宏
  • Journal Title: アレルギー・免疫 15 Pages: 1370-1377
• [Journal Article] Quantitative PCR for the detection of genomic DNA of Epstein-Barr virus in ocular fluids of patients with uveitis. (2008)
  • Author(s): Yamamoto s. Sugita s. Sugamoto Y. Shimizu N. Morio T. Mochizuki M.
  • Journal Title: Jpn. J. Ophthalmol 52(6) Pages: 463-7
  • NAID: 10025148880
  • Peer Reviewed
• [Journal Article] Association of varicella-zoster virus (VZV)load in the aqueous humorwith clinical manifestations of anterior uveitis in herpes zoster ophthalmicus and zoster sine herpete. (2008)
  • Author(s): Kido s, Sugita s, Horie s, Miyanaga M, Miyata K, Shimizu N, Morio T, Mochizuki M.
  • Journal Title: Br J Ophthalmol 92(4) Pages: 505-8
  • Peer Reviewed
• [Journal Article] Vesical varices and telangiectasias in a patient with ataxia telangiectasia. 23 : 1005-1008, 2008. (2008)
  • Author(s): Suzuki K, Tsugawa K, Oki E, Morio T, Ito E, Tanaka H.
  • Journal Title: Ped. Nephrol. 23 Pages: 1005-1008
  • Peer Reviewed
• [Journal Article] Ku, Artemis, and Ataxia-Telangiectasia-Mutated: Signaling Networks in DNA Damage. (2008)
  • Author(s): Morio T, Kim H.
  • Journal Title: Int J Biochem Cell Biol. 40 Pages: 598-603
  • Peer Reviewed
• [Journal Article] Tyrosine kinases Btk and Tec regulate osteoclast differentiation by linkingRANK and ITAM signals. (2008)
  • Author(s): Shinohara M, Koga T, OkamotoK, Sakaguchi s, Arai K, YasudaH, Takai T, Kodama T, Morio T, Geha RS, Kitamura D, KurosakiT, Ellmeier w, Takayanagi H.
  • Journal Title: Cell 132 Pages: 794-806
  • Peer Reviewed
• [Journal Article] Common variable immunodeficiency. (2008)
  • Author(s): Takahashi N. Morio T.
  • Journal Title: Jpn. J. Clin. Immunol. 31 Pages: 9-16
  • NAID: 10021242183
  • Peer Reviewed
• [Journal Article] Use of multiplex PCR and real-time PCR to detect human herpes virus genome in ocular fluids of patients with uveitis. (2008)
  • Author(s): Sugita S, Shimizu N, Watanabe K, Mizukami M, Morio T, Su gamoto Y, Mochizuki M.
  • Journal Title: Br J Ophthalmol. 92 Pages: 928-932
  • Peer Reviewed
• [Journal Article] Successful treatment of chronic granulomatous disease with fludarabine-based reduced-intensity conditioning and unrelated bone marrow transplantation. (2008)
  • Author(s): Hasegawa D, Fukushima M, Hosokawa Y, Takeda H, KawasakiK, Mizukami T, Nunoi H, Ochiai H, Morio T, Kosaka Y.
  • Journal Title: Int J Hematol. 87 Pages: 88-90
  • NAID: 10021255278
  • Peer Reviewed
• [Presentation] 細胞移植・細胞治療に関する国・学会の指針と基盤整備 (2011)
  • Author(s): 森尾友宏
  • Organizer: 第33回日本造血細胞移植学会総会
  • Place of Presentation: 愛媛
  • Year and Date: 2011-03-10
• [Presentation] 造血細胞移植後の体系的免疫能評価法 (2011)
  • Author(s): 森尾友宏
  • Organizer: 第33回日本造血細胞移植学会総会
  • Place of Presentation: 愛媛
  • Year and Date: 2011-03-09
• [Presentation] 免疫細胞操作とその治療応用:現状と今後の展開 (2010)
  • Author(s): 森尾友宏
  • Organizer: 第13回中国地区小児免疫薬物療法研究会
  • Place of Presentation: 広島
  • Year and Date: 2010-03-13
• [Presentation] EBウイルス関連T/NKリンパ増殖性疾患モデルマウスの政策と病態発現解析 (2010)
  • Author(s): 今留謙一、矢島美彩子、川野布由子、中川温子、新井文子、市川紗弓、森尾友宏、大賀正一、大石勉、清水則夫、山本直樹、藤原成悦
  • Organizer: 第20回EBウイルス感染症研究会
  • Place of Presentation: 東京
  • Year and Date: 2010-03-06
• [Presentation] 先天性免疫不全症:診断と治療ABC (2010)
  • Author(s): 森尾友宏
  • Organizer: 兵庫県PIDセミナー
  • Place of Presentation: 兵庫
  • Year and Date: 2010-03-05
• [Presentation] 分類不能型免疫不全症の全国調査と亜群同定 (2010)
  • Author(s): 森尾友宏
  • Organizer: 第3回日本免疫不全症研究会
  • Place of Presentation: 東京
  • Year and Date: 2010-01-30
• [Presentation] 分類不能型免疫不全症診断の全国調査と亜群同定 (2010)
  • Author(s): 森尾友宏、今井耕輔、小原収、金兼弘和、竹森利忠、田中敏郎、松本功、原寿郎
  • Organizer: 第3回日本免疫不全症研究会
  • Place of Presentation: 東京
  • Year and Date: 2010-01-30
• [Presentation] Btk Controls ROS Production and Apoptosis in Human Neutrophils.XIVth meeting of the European Society for Immunodeficiencies.Isutanbul (2010)
  • Author(s): Morio T
  • Organizer: Republic of Turkey
• [Presentation] Impaired CD4 and CD8 Effector Function and Decreased MemoryT-cell Populations in ICOS-deficient Patients. (2010)
  • Author(s): Morio T, Terada N, Nanki T, Miyasaka N, Kobata T, Matsumoto K, Azuma M, Mizutani S
  • Organizer: 14th International Congressof Immunology 2010
  • Place of Presentation: Kobe, Japan
• [Presentation] IκBζ is required for the transcriptional program in Th17 development. (2010)
  • Author(s): Okamoto K, Iwai Y, Oh-hora M, Yamamoto M, Morio T, Jetten AM, Akira S, Muta T, Takayanag H.
  • Organizer: 14th International Congress of Immunology 2010
  • Place of Presentation: Kobe,Japan
• [Presentation] Functional analysis of Fas-mediated activation signaling pathways in Tcells. (2010)
  • Author(s): Shin M J, Shim J, Lee J, Chae W, Lee H, Morio T, Park J H, Chang E, Lee S.
  • Organizer: 14th International Congress of Immunology 2010
  • Place of Presentation: Kobe, Japan
• [Presentation] Btk controls ROS production and apoptosis in human neutrophil. (2010)
  • Author(s): Honda F, Ikeda Y, Takahashi1 N, Lee S, Mizutani S, Morio T
  • Organizer: 14th International Congress of Immunology 2010
  • Place of Presentation: Kobe, Japan
• [Presentation] 日本における先天性免疫不全症に対する臍帯血移植成績 (2010)
  • Author(s): 森尾友宏、富澤大輔、梶原道子、水谷修紀、熱田由子、加藤剛二、原寿郎、加藤俊一
  • Organizer: 第113回日本小児科学会学術集会
  • Place of Presentation: 岩手
• [Presentation] Common variable immunodeficiency (CVID): Molecular basis of immune dysfunction. (2010)
  • Author(s): 森尾友宏
  • Organizer: The 2nd Symposium for PID in Asia
  • Place of Presentation: Chiba
• [Presentation] Btk Controls ROS Production and Apoptosis in Human Neutrophils. (2010)
  • Author(s): Morio T.
  • Organizer: XIVth meeting of the European Society for Immunodeficiencies.
  • Place of Presentation: Isutanbul, Republic of Turkey
• [Presentation] Impaired CD4 and CD8 Effector Function and Decreased Memory T-cell Populations in ICOS-deficient Patients. (2010)
  • Author(s): Morio T.Terada N.Nanki T.Miyasaka N.Kobata T.Matsumoto K.Azuma M.Mizutani S.
  • Organizer: 14th International Congress of Immunology 2010
  • Place of Presentation: Kobe, Japan
• [Presentation] IKBζis required for the transcriptional program in Th17 development. (2010)
  • Author(s): Okamoto K.Iwai Y.Oh-hora M.Yamamoto M.Morio T.Jetten AM.Akira S.Muta T.Takayanag H.
  • Organizer: 14th International Congress of Immunology 2010
  • Place of Presentation: Kobe, Japan
• [Presentation] Functional analysis of Fas-mediated activation signaling pathways in T cells. (2010)
  • Author(s): Shin M J.Shim J.Lee J.Chae W.Lee H.Morio T.Park J H.Chang E.Lee S.
  • Organizer: 14th International Congress of Immunology 2010
  • Place of Presentation: Kobe, Japan
• [Presentation] Btk controls production and apoptosis in human neutrophil. (2010)
  • Author(s): Honda F.Ikeda Y.Takahashil N.Lee S.Mizutani S.Morio T.s RO
  • Organizer: 14th International Congress of Immunology 2010
  • Place of Presentation: Kobe, Japan
• [Presentation] 日本における先天性免疫不全症に対する謄帯血移植成績 (2010)
  • Author(s): 森尾友宏、富澤大輔、梶原道子、水谷修紀、熱田由子、加藤剛二、原寿郎、加藤俊一
  • Organizer: 第113回日本小児科学会学術集会
  • Place of Presentation: 岩手
• [Presentation] Common variable immunodeficiency(CVID) : Molecular basis of immunedysfunction (2010)
  • Author(s): 森尾友宏
  • Organizer: The 2nd Symposium for PID in Asia.
  • Place of Presentation: Chiba in Japan.
• [Presentation] Infusion of Ex-vivo Expanded Donor T-Lymphocytes for Intractable Infections and Leukemia. (2010)
  • Author(s): 森尾友宏
  • Organizer: 第32回日本造血細胞移植学会シンポジウム
  • Place of Presentation: 浜松
• [Presentation] 悪性リンパ腫を合併したWiskott-Aldrich症候群患者に対する骨髄非破壊的前処置による骨髄移植の経験 (2010)
  • Author(s): 力石健、笹原洋二、星能元、森尾友宏、土屋滋
  • Organizer: 第32回日本造血細胞移植学会総会
  • Place of Presentation: 浜松
• [Presentation] 当科で施行した造血幹細胞移植患者における網羅的PCR法による経時的ウイルス (2010)
  • Author(s): 満生紀子、遠藤明史、青木由貴、小野敏明、高木正稔、梶原道子、長澤正之、峯岸志津子、落合央、清水則夫、森尾友宏、水谷修紀
  • Organizer: 第32回日本造血細胞移植学会総会
  • Place of Presentation: 浜松
• [Presentation] ヘルペス属ウイルス感染に対する免疫応答の基礎と臨床 (2009)
  • Author(s): 森尾友宏
  • Organizer: 第12回茨城県小児感染症研究会
  • Place of Presentation: 茨城
  • Year and Date: 2009-11-17
• [Presentation] 免疫不全症に対する造血細胞移植 (2009)
  • Author(s): 森尾友宏
  • Organizer: 第2回石川県小児科State of the Art Meeting
  • Place of Presentation: 金沢
  • Year and Date: 2009-10-10
• [Presentation] RISTによる非血縁臍帯血移植を施行したSCID3例 (2009)
  • Author(s): 満生紀子、大川哲平、高橋考治、遠藤明史、青木由貴、小野敏明、落合央、峯岸志津子、高木正稔、梶原道子、長澤正之、森尾友宏、水谷修紀
  • Organizer: 小児H-SCT研究会
  • Place of Presentation: 東京
  • Year and Date: 2009-10-09
• [Presentation] カクテル療法と骨髄移植により寛解したWiskott-Aldrich症候群に伴う紫斑病性腎炎の1例 (2009)
  • Author(s): 田中絵里子、森尾友宏、水谷修紀
  • Organizer: 第44回日本小児腎臓病学会総会
  • Place of Presentation: 東京
  • Year and Date: 2009-06-27
• [Presentation] 造血細胞移植後合併症に対する免疫細胞療法の現状と展望 (2009)
  • Author(s): 森尾友宏
  • Organizer: 第90回沖縄臨床血液研究会
  • Place of Presentation: 沖縄
  • Year and Date: 2009-05-15
• [Presentation] ICOS欠損症におけるT 細胞機能異常 (2009)
  • Author(s): 森尾友宏
  • Organizer: 第2回日本免疫不全症研究会
  • Place of Presentation: 東京
  • Year and Date: 2009-01-31
• [Presentation] ICOS欠損症におけるT細胞機能異常 (2009)
  • Author(s): 森尾友宏, 高橋尚美, 水谷修紀
  • Organizer: 第2日本免疫不全症研究会
  • Place of Presentation: 東京
  • Year and Date: 2009-01-30
• [Presentation] ROS-induced DNA damage response. (2009)
  • Author(s): 森尾友宏
  • Organizer: The 66th KSBMB Annual Meeting2009
  • Place of Presentation: COEX, Korea
• [Presentation] Btkによる好中球活性酸素産生及びアポトーシスの制御 (2009)
  • Author(s): 本田冨美子、水谷修紀、Sang-Kyou Lee、森尾友宏
  • Organizer: 第39回日本免疫学会総会・学術集会
  • Place of Presentation: 大阪
• [Presentation] Basic to Clinical:Artemis/Cernnunos/Lig4 deficiency (2009)
  • Author(s): 森尾友宏、水谷修紀
  • Organizer: 第51回日本小児血液学会
  • Place of Presentation: 千葉
• [Presentation] Btkによる好中球活性酸素産生及びアポトーシスの制御 (2009)
  • Author(s): 本田冨美子、水谷修紀、Sang-Kyou Lee、森尾友宏
  • Organizer: 第37回日本臨床免疫学会総会
  • Place of Presentation: 東京
• [Presentation] 当科における同種造血幹細胞移植(1995-2007年)の検討 (2009)
  • Author(s): 長澤正之、小野敏明、遠藤明史、青木由貴、磯田健志、富澤大輔、高木正稔、梶原道子、森尾友宏、水谷修紀
  • Organizer: 第112回日本小児科学会学術総会
  • Place of Presentation: 奈良
• [Presentation] ROS induced DNA damage response. Symposium : "ROS and NO". (2009)
  • Author(s): 森尾友宏
  • Organizer: The 46^<th> Meeting of Korean Society of Biochemistry and Molecular Biology.
  • Place of Presentation: Seoul.Korea.
• [Presentation] Basic to Clinical : Artemis/Cernnunos/Lig4 deficiency (2009)
  • Author(s): 森尾友宏、水谷修紀
  • Organizer: 第51回日本小児血液学会
  • Place of Presentation: 東京
• [Presentation] JMMLに対し臍帯血移植を施行し10年経過後混合キメリズムの状態でSLEを発症した1例 (2009)
  • Author(s): 青木由貴、満生紀子、遠藤明史、小野敏明、高木正稔、梶原道子、長澤正之、森尾友宏、水谷修紀、今留謙一
  • Organizer: 第51回日本小児血液学会
  • Place of Presentation: 東京
• [Presentation] Low grade MDSの骨髄所見を示した先天性角化不全症TINF2変異の一例 (2009)
  • Author(s): 磯田健志、遠藤明史、満生紀子、小野敏明、青木由貴、富澤大輔、高木正稔、長澤正之、森尾友宏、西尾信博、濱麻人、在家祐司、真部淳、伊藤雅文、小島勢二、水谷修紀
  • Organizer: 第51回日本小児血液学会
  • Place of Presentation: 東京
• [Presentation] 急性白血病に対する非血縁者感骨髄移植10年後に食道がんを合併した1例 (2009)
  • Author(s): 梶原道子、遠藤明史、満生紀子、小野敏明、高木正稔、長澤正之、森尾友宏、水谷修紀
  • Organizer: 第51回日本小児血液学会
  • Place of Presentation: 東京
• [Presentation] MDSで発症し毛細血管拡張を欠くAtaxia Telangiectasiaの女児 (2009)
  • Author(s): 鬼頭敏幸、高木正稔、熊田知浩、才田聡、藤井達哉、森尾友宏、水谷修紀、鶴澤正仁
  • Organizer: 第51回日本小児血液学会
  • Place of Presentation: 東京
• [Presentation] 当科における原発性免疫不全症に対する乙随非破壊的前処置による移植の検討 (2009)
  • Author(s): 満生紀子、遠藤明史、小野敏明、高木正稔、長澤正之、森尾友宏、水谷修紀
  • Organizer: 第51回日本小児血液学会
  • Place of Presentation: 東京
• [Presentation] RISTにて臍帯血移植後、TMA、血球貪食症候群を発症し死亡したX連鎖重症複合型免疫不全症の1例 (2009)
  • Author(s): 遠藤明史、満生紀子、小野敏明、高木正稔、長澤正之、森尾友宏、水谷修紀
  • Organizer: 第51回日本小児血液学会
  • Place of Presentation: 東京
• [Presentation] 急性白血病治療中にカリシウイルス腸炎を発症した3例の遷延性ウイルス排泄の検討 (2009)
  • Author(s): 小野敏明、遠藤明史、満生紀子、高木正稔、長澤正之、片山未来、渡邊健、落合央、大山敦、峯岸志津子、清水則夫、森尾友宏、水谷修紀
  • Organizer: 第51回日本小児血液学会
  • Place of Presentation: 東京
• [Presentation] Ex vivo expansion of CD4 T-cells from cryopreserved cord blood andits application in adaptive immunotherapy post cord blood transplant. (2008)
  • Author(s): Morio T.
  • Organizer: 第35回日本低温医学会総会
  • Place of Presentation: 東京
  • Year and Date: 2008-11-21
• [Presentation] 造血幹細胞移植後の細胞治療の現状と展望 (2008)
  • Author(s): 森尾友宏
  • Organizer: 第3回新潟細胞再生療法フォーラム
  • Place of Presentation: 新潟
  • Year and Date: 2008-10-24
• [Presentation] 造血幹細胞移植後ウイルス感染症に対する活性化CD4DLI療法 (2008)
  • Author(s): 森尾友宏, 梶原道子, 清水則夫, 伊藤仁也, 藤原成悦, 大隅一興, 関根暉彬
  • Organizer: 第56回日本輸血・細胞治療学会
  • Place of Presentation: 福岡
  • Year and Date: 2008-04-26
• [Presentation] Ataxia telangiectasia (2008)
  • Author(s): 森尾友宏
  • Organizer: Involement of ATM in immunodeficiency and leukemogenesis Symposium on Recent Advances in Cell Function and Defense Mechanisim
  • Place of Presentation: Yonsei Univeristy, Seoul,Korea
  • Year and Date: 2008-04-18
• [Presentation] Immunodefiencies with impaired DNA damage response. (2008)
  • Author(s): 森尾友宏
  • Organizer: Recent Advances in DNA Damage Response
  • Place of Presentation: Yonsei Univeristy, Seoul, Korea
  • Year and Date: 2008-04-18
• [Presentation] Ataxia telangiectasia : Involement of ATM in immunodeficiency and Ieukemogenesis. (2008)
  • Author(s): Morio T.
  • Organizer: Symposium on Recent Advances in Cell Functionand Defense Mechanisim
  • Place of Presentation: Seoul
  • Year and Date: 2008-04-18
• [Presentation] Immunodefiencies with impaired DNA damage response. (2008)
  • Author(s): Morio T.
  • Organizer: Recent Advances in DNA Damage Response
  • Place of Presentation: Seoul
  • Year and Date: 2008-04-18
• [Presentation] Stability of Artemis protein is regulated by Hsp72. (2008)
  • Author(s): Watanabe F, Morio T, Ogigami N, Kiyono T,Domenico Delia, Mizutani S
  • Organizer: Ataxia telangiectasia workshop 2008
  • Place of Presentation: Otsu, Shiga
• [Presentation] Generation of DNA double-stranded breaks in stalled DNA replication forks:anessential stepinitiated by Artemis toward a second wave of DNA damage response and ATM activation. (2008)
  • Author(s): Unno J, Takagi M, Watanabe F, Sato M, Takahashi N, Morio T, Teraoka H, Mizutani S
  • Organizer: Ataxia telangiectasia workshop 2008
  • Place of Presentation: Otsu, Shiga
• [Presentation] Ataxia-Telangiectasia in Japan:Phenotypic variations in affected siblings with Ataxia-Telangiectasia. (2008)
  • Author(s): Morio T, Watanabe F, Takahashi N, Sato M, Sato R, Takagi M, Imadome K, Miyawaki T, Domenico Delia, Nakamura K, Richard Gatti, Mizutani S
  • Organizer: Ataxia telangiectasia workshop 2008
  • Place of Presentation: Otsu,Shiga
• [Presentation] Identification of Novel Mutation in Japanese Patients with Ataxia Telangiectasia;Absence of Founder Mutations. (2008)
  • Author(s): Nakamura K, Morio T, Mizutani S, Richard A Gatti.
  • Organizer: Ataxia telangiectasia workshop 2008
  • Place of Presentation: Otsu,Shiga
• [Presentation] Regulation of Artemis/ATM-related DNA damage response network. (2008)
  • Author(s): Mizutani S, Unno J, Watanabe F, Takagi M, Morio T, Teraoka H, Domenico D.
  • Organizer: Ataxia telangiectasia workshop 2008
  • Place of Presentation: Otsu,Shiga
• [Presentation] Mre11遺伝子変異を認めAtaxia telangiectasia like disorderと診断した肺腺癌の小児兄弟例 (2008)
  • Author(s): 内坂直樹、菊地陽、望月慎史、外山大輔、山西未穂、荒川ゆうき、花田良二、高橋尚美、渡邊文晶、佐藤正樹、森尾友宏、水谷修紀
  • Organizer: 第50回日本小児血液学会総会・第24回日本小児がん学会学術集会
  • Place of Presentation: 千葉
• [Presentation] フローサイトメトリーを用いたDNA損傷の定量化と毛細血管拡張性小脳失調症診断方法の確立 (2008)
  • Author(s): 本田真由子、高木正稔、森尾友宏、水谷修紀
  • Organizer: 第50回日本小児血液学会総会・第24 回日本小児がん学会学術集会
  • Place of Presentation: 千葉
• [Presentation] 造血細胞移植後ex vivo 増幅CD4T 細胞輸注療法 (2008)
  • Author(s): 森尾友宏
  • Organizer: 第70回日本血液学会総会
  • Place of Presentation: 京都
• [Presentation] 造血細胞移植後ex vivo 増幅CD4T細胞輸注療法 (2008)
  • Author(s): 森尾友宏
  • Organizer: 第70回日本血液学会総会
  • Place of Presentation: 京都
• [Presentation] Ataxia-Telangiectasia in Japan : Phenotypic variations in affectedsiblings with Ataxia-Telangiectasia. (2008)
  • Author(s): Morio T, Watanabe F, TakahashiN, Sato M, Sato R, Takagi M, Imadome K, Miyawaki T, Domenico Delia, Nakamura K, Richard Gatti, Mizutani s.
  • Organizer: Ataxia telangiectasia workshop 2008
  • Place of Presentation: Otsu, Shiga
• [Presentation] Identification of Novel Mutation in Japanese Patients with Ataxia Telangiectasia ; Absence of Founder Mutations. (2008)
  • Author(s): Nakamura K, Morio T, Mizutani s, Richard A Gatti.
  • Organizer: Ataxia telangiectasia workshop 2008.
  • Place of Presentation: Otsu, Shiga
• [Presentation] Regulation of Artemis/ATM-related DNA damage response network. (2008)
  • Author(s): Mizutani s, Unno J, Watanabe F, Takagi M, Morio T, Teraoka H, Domenico D.
  • Organizer: Ataxia telangiectasia workshop 2008.
  • Place of Presentation: Otsu, Shiga
• [Book] 免疫不全症(新版臨床免疫学第二版) (2009)
  • Author(s): 森尾友宏(分担執筆)
  • Publisher: 講談社
• [Book] 免疫(病気が見えるvol 6 免疫・膠原病・感染症) (2009)
  • Author(s): 森尾友宏(分担監修)
• [Book] 先天性免疫不全症(ハリソン内科学第3版)(原著第17版) (2009)
  • Author(s): 森尾友宏(分担訳者)
• [Book] ハリソン内科学第3版(原著第17版)先天性免疫不全症 (2009)
  • Author(s): 森尾友宏
  • Publisher: メディカル・サイエンス・インターナショナル
• [Book] 遺伝病に対して何ができるだろうか?(症例でわかる新しい臨床遺伝学)第14章 (2008)
  • Author(s): 森尾友宏(分担訳者)
  • Publisher: メディカル・サイエンス・インターナショナル
• [Book] 小児科臨床61(9) (2008)
  • Author(s): 森尾友宏
  • Publisher: Ataxia telangiectasiaの臨床的特徴 全国調査から明らかになったこと
• [Book] アレルギー・免疫15(10) (2008)
  • Author(s): 森尾友宏
  • Publisher: 【原発性免疫不全症候群】Ataxia telangiectasia
• [Remarks] ホームページ等
• [Patent(Industrial Property Rights)] 滑膜由来間葉幹細胞(MSCs)の軟骨・半月板再生への応用 (2009)
  • Inventor(s): 宗田大、森尾友宏、清水則夫、黒岩保幸
  • Industrial Property Rights Holder: 東京区科歯科大学(株)タイネット
  • Industrial Property Number: 2009-525260
  • Filing Date: 2009-02-02