| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Research Abstract |
Jun kinase (Jnk) is an important kinase that is involved in T cell activation, proliferation and IL-2 production. We have found that Jnk activation by anti-CD3 plus anti-CD28 stimulation is enhanced in activated T cells compared to resting T cells. Although MEKK2 is important in Jnk activation, phosphorylated MKK4 in activated T cells, which is not found in resting T cells seems to be involved in enhanced Jnk activation. Jnk activation in activated T cells is not inhibited enough by calcineurin inhibitor, and this may explain some part of therapy-resistant GVHD.
|
