Computational leukemic stem cell models in systems biology for predicting relapse and development of risk-stratified chemotherapy

• Project/Area Number: 20591248
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Pediatrics
• Research Institution: Kanazawa Medical University
• Principal Investigator: SAIKAWA Yutaka Kanazawa Medical University, 医学部, 教授 (60283107)
• Co-Investigator(Kenkyū-buntansha): KOMATSUZAKI Toshihiko 金沢大学, 機械工学系, 准教授 (80293372)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2008: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
• Keywords: システム生物学 / 白血病幹細胞 / コンピューターシミュレーション / セルラオートマトン / セルオートマトン / 血液病学

Research Abstract

We constructed the 3-dimmensional computer simulation system for investigation of cellular dynamics in normal granulopoiesis. Granulocytic cell dynamics under the simulation of chemotherapy and G-CSF rescue fitted well to the cell behavior under clinical situations. A model of acute myelogenous leukemia was simulated by means of introducing leukemic stem cell systems.

Research Products

• [Journal Article] 骨髄系造血のコンピューターシミュレーション (2010)
  • Author(s): 犀川太
  • Journal Title: 金沢大学十全医学会雑誌 第119巻 Pages: 120-121
  • NAID: 10027786977
  • Peer Reviewed
• [Journal Article] Dense methylation of types 1 and 2 regulatory regions of the CD10 gene promoter in infant acute lymphoblastic leukemia with MLL/AF4 fusion gene (2010)
  • Author(s): Ikawa Y., Saikawa Y.
  • Journal Title: J Pediatr Hematol Oncol 32 Pages: 4-10
  • NAID: 120001939296
  • Peer Reviewed
• [Journal Article] Minimal residual disease-based augmented therapy in childhood acute lymphoblastic leukemia (2010)
  • Author(s): Yamaji K., Saikawa Y.
  • Journal Title: Pediatric Blood and Cancer 55 Pages: 1287-1295
  • Peer Reviewed
• [Journal Article] 骨髄系造血のコンピューターシミュレーション (2010)
  • Author(s): 犀川太
  • Journal Title: 金沢大学十全医学会雑誌 Volume: 119 Pages: 120-121
  • NAID: 10027786977
• [Journal Article] Dense methylation of types 1 and 2 regulatory regions of the CD10 gene promoter in infant acute lymphoblastic leukemia with MLL/AF4 fusion gene (2010)
  • Author(s): Yasuhiro Ikawa
  • Journal Title: Journal of Pediatric Hematology Oncology Volume: 1 Pages: 4-10
  • Peer Reviewed
• [Journal Article] Minimal residual disease-based augmented therapy in childhood acute lymphoblastic leukemia (2010)
  • Author(s): Kazutaka Yamaji
  • Journal Title: Pediatric Blood and Cancer Volume: 55 Pages: 1287-1295
  • Peer Reviewed
• [Journal Article] Dense methylation of types 1 and 2 regulatory regions of the CD10 gene promoter in infant acute lymphoblastic leukemia with MLL/AF4 fusion gene (2010)
  • Author(s): Yasuhiro Ikawa
  • Journal Title: Journal of Pediatric Hematology Oncology 1 Pages: 4-10
  • Peer Reviewed
• [Journal Article] Conputational Hematology in systems biology (2008)
  • Author(s): Horisawa T., Komatsuzaki T., Saikawa Y.
  • Journal Title: Cellular automata LNCS5191 Pages: 486-493
  • Peer Reviewed
• [Journal Article] Computational Hematology in Systems Biology (2008)
  • Author(s): T. Horisawa
  • Journal Title: Cellular Automata LNCS 5191 Pages: 486-493
  • Peer Reviewed
• [Presentation] Dense methylation patterns of CD10-negative infant acute lymphoblastic leukemia with MLL gene arrangements (2009)
  • Author(s): Saikawa Y
  • Organizer: 100^<th> annual meeting of American Association of Cancer Research
  • Place of Presentation: Denver, USA
• [Presentation] Dense methylation patterns of CD10-negative infant acute lymphoblastic leukemia with MLL gene rearrangements (2009)
  • Author(s): Yasuhiro Ikawa
  • Organizer: 100^<th> annual meeting 2009 of American Association of Cancer Research
  • Place of Presentation: Denver, USA
• [Presentation] Computational Hematology in Systems Biology (2008)
  • Author(s): Saikawa Y
  • Organizer: 8th International Conference on Cellular Automata for Research and Industry
  • Place of Presentation: Yohohama, Japan
• [Remarks] ホームページ等
  • URL: http://www.ped-kanazawa-med.jp/study_introduction/blood_tumorl.html
• [Remarks]
  • URL: http://www.ped-kanazawa-med.jp/study_introduction/blood_tumorl.html