Computational leukemic stem cell models in systems biology for predicting relapse and development of risk-stratified chemotherapy
| Project/Area Number |
20591248
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Pediatrics
|
|---|
| Research Institution | Kanazawa Medical University |
|---|
Principal Investigator |
SAIKAWA Yutaka Kanazawa Medical University, 医学部, 教授 (60283107)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
KOMATSUZAKI Toshihiko 金沢大学, 機械工学系, 准教授 (80293372)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
|
|---|
| Keywords | システム生物学 / 白血病幹細胞 / コンピューターシミュレーション / セルラオートマトン / セルオートマトン / 血液病学 |
|---|
| Research Abstract |
We constructed the 3-dimmensional computer simulation system for investigation of cellular dynamics in normal granulopoiesis. Granulocytic cell dynamics under the simulation of chemotherapy and G-CSF rescue fitted well to the cell behavior under clinical situations. A model of acute myelogenous leukemia was simulated by means of introducing leukemic stem cell systems.
|
Report
(4 results)
Research Products
(14 results)
