Analysis of T cell co-stimulatory molecules in secondary hemophagocytic syndrome.

• Project/Area Number: 20591260
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Pediatrics
• Research Institution: Wakayama Medical University
• Principal Investigator: KOUNAMI Shinji Wakayama Medical University, 医学部, 講師 (50316098)
• Co-Investigator(Kenkyū-buntansha): YOSHIYAMA Megumi 和歌山県立医科大学, 医学部, 助教 (00433368)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 小児血液学 / 血球貧食症候群 / T細胞抑制性補助シグナル / 遺伝子多型 / 二次性血球貪食症候群 / CTLA-4 / BTLA / PD-1

Research Abstract

Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening conditions characterized by uncontrolled activation of T-cells and macrophages. The precise mechanism leading to the development of immune response dysregulation resulting in hypercytokinemia has not been well evaluated. We speculated and analyzed that T cell costimulatory molecules might be involved in the abnormal immune reactions in acquired HLH. Our results suggest that CTLA-4 polymorphism might play a role in the development of acquired HLH.

Research Products

• [Journal Article] Cytotoxic T-Lymphocyte-associated antigen 4 gene polymorphisms in Japanese children with infection-associated hemophagocytic lymphohistiocytosis. (2010)
  • Author(s): Megumi Yoshiyama, Shinji Kounami, Keiko Nakayama, Takahiro Okutani, Noriyuki Aoyagi, Norishige Yoshikawa
  • Journal Title: Acta Haematol 123 Pages: 186-190
  • Peer Reviewed
• [Journal Article] CTLA-4 gene polymorphisms in Japanese children with infection-associated hemophagocytic lymphohistiocytosis. (2010)
  • Author(s): Yoshiyama M, Kounami S, et al
  • Journal Title: Acta Haematologica Volume: 123 Pages: 186-190
  • Peer Reviewed
• [Journal Article] 血小板減少性紫斑病が診断契機となったcommonvariable immunodeficiencyの6歳男児例 (2009)
  • Author(s): 神波信次、中山京子、芳山恵、吉川徳茂、岩橋誠司、末永智浩
  • Journal Title: 小児内科 41(6) Pages: 951-954
  • Peer Reviewed
• [Journal Article] 血小板減少性紫斑病が診断契機となった common variable immuno-deficiency の6歳男児例 (2009)
  • Author(s): 神波信次, 中山京子, 芳山恵, 末永智浩, 岩橋誠司, 吉川徳茂
  • Journal Title: 小児内科 41(6) Pages: 951-954
• [Journal Article] Clinical assessment of Mycoplasma pneumoniae-associated hemophagocytic lymphohistiocytosis. (2008)
  • Author(s): Megumi Yoshiyama, Shinji Kounami, Keiko Nakayama, Noriyuki Aoyagi, Norishige Yoshikawa
  • Journal Title: Ped Int 50 Pages: 432-435
  • NAID: 10025344099
  • Peer Reviewed
• [Journal Article] 急性リンパ性白血病維持療法中に発症したPneumocystis pneumoniaeの3症例 (2008)
  • Author(s): 神波信次, 中山京子, 芳山恵, 吉川徳茂
  • Journal Title: 日本小児血液学会誌 22(5/6) Pages: 360-365
  • Peer Reviewed
• [Journal Article] 急性リンパ性白血病維持療法中のPneumocystis pneumoniaの3症例 (2008)
  • Author(s): 神波信次, 中山京子, 芳山恵, 他
  • Journal Title: 日本小児血液学会誌 22 Pages: 360-365
  • NAID: 10029309930
• [Journal Article] Clinical assessment of Mycoplasma pneumoniae-associated hemo phagocytic lymphohistiocytosis (2008)
  • Author(s): Yoshiyama M, Kounami S, Nakayama K, 他
  • Journal Title: Pediatrics International 50 Pages: 432-435
  • NAID: 10025344099
  • Peer Reviewed
• [Presentation] CTLA-4遺伝子多型は小児感染症関連血球貪食症候群に関与する (2009)
  • Author(s): 芳山恵, 神波信次, 中山京子, 吉川徳茂
  • Organizer: 日本血液学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2009-11-24
• [Presentation] 再燃を繰り返す脳室炎にリネゾリド内服が有効であった1男児例 (2009)
  • Author(s): 濱武継, 南弘一, 中山京子, 神波信次, 樋口隆造, 吉川徳茂
  • Organizer: 第41回日本小児感染症学会総会
  • Place of Presentation: 福井市
  • Year and Date: 2009-11-14
• [Presentation] Paclitaxelが有効であった肺静脈原発平滑筋肉腫の1例 (2008)
  • Author(s): 神波信次, 中山京子, 芳山恵, 他
  • Organizer: 第24回日本小児がん学会総会
  • Place of Presentation: 千葉
• [Presentation] 腸腰筋原発と考えられたanaplastic large cell lymphomaの1例 (2008)
  • Author(s): 村田祥吾, 神波信次, 中山京子, 芳山恵, 他
  • Organizer: 第24回日本小児がん学会総会
  • Place of Presentation: 千葉