Analysis of T cell co-stimulatory molecules in secondary hemophagocytic syndrome.
| Project/Area Number |
20591260
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
KOUNAMI Shinji Wakayama Medical University, 医学部, 講師 (50316098)
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| Co-Investigator(Kenkyū-buntansha) |
YOSHIYAMA Megumi 和歌山県立医科大学, 医学部, 助教 (00433368)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 小児血液学 / 血球貧食症候群 / T細胞抑制性補助シグナル / 遺伝子多型 / 二次性血球貪食症候群 / CTLA-4 / BTLA / PD-1 |
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| Research Abstract |
Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening conditions characterized by uncontrolled activation of T-cells and macrophages. The precise mechanism leading to the development of immune response dysregulation resulting in hypercytokinemia has not been well evaluated. We speculated and analyzed that T cell costimulatory molecules might be involved in the abnormal immune reactions in acquired HLH. Our results suggest that CTLA-4 polymorphism might play a role in the development of acquired HLH.
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Report
(4 results)
Research Products
(12 results)
