Regulation of Mash1 transcription and cell growth by genes identified in gene expression analysis of cancer

• Project/Area Number: 20591268
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Pediatrics
• Research Institution: Chiba Cancer Center (Research Institute)
• Principal Investigator: ISOGAI Eriko Chiba Cancer Center (Research Institute), 臨床ゲノムセンター・がんゲノム研究室, 上席研究員 (40300917)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 神経芽腫 / 神経発生 / neuroblastoma / neuronal development

Research Abstract

Mash1 is transiently and permanently expressed in normal developmental process and in neuroblastoma, respectively. In this study, it was suggested that LIM-only protein, LMO3 and bHLH protein, HEN2, that are highly expressed in unfavorable neuroblastoma, cooperate for promoting Mash1 transcription and development of neuroblastoma through interfering with the function of HES1, a negative regulator of Mash1 transcription.

Research Products

• [Journal Article] Oncogenic LMO3 collaborates with HEN2 to enhance neuroblastoma cell growth through transactivation of Mash1 (2011)
  • Author(s): Eriko Isogai, Miki Ohira, Toshinori Ozaki, Shigeyuki Oba, Yohko Nakamura, Akira Nakagawara
  • Journal Title: PLoS ONE vol.6
  • Peer Reviewed
• [Journal Article] Oncogenic LMO3 collaborates with HEN2 to enhance neuroblastoma cell growth through transactivation of Mash1 (2011)
  • Author(s): Eriko Isogai
  • Journal Title: PLoS ONE Volume: 6
  • Peer Reviewed
• [Presentation] Constitutive Hen2 expression promotes proliferation and interferes with differentiation in neural crest cells (2010)
  • Author(s): 磯貝恵理子
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪、大阪国際会議場
  • Year and Date: 2010-09-22
• [Presentation] Constitutive Hen2 expression promotes proliferation and interferes with differentiation in neural crest cells (2010)
  • Author(s): 磯貝恵理子
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪国際会議場(大阪)
  • Year and Date: 2010-09-22
• [Presentation] Constitutive Hen2 Expression in Neural Crest Cells Could Be a Trigger of Neuroblastoma Development (2010)
  • Author(s): 磯貝恵理子
  • Organizer: Advanced in Neuroblastoma Research 2010
  • Place of Presentation: Sweden Stockholm、Stockholm City Conference Centre
  • Year and Date: 2010-06-23
• [Presentation] Constitutive Hen2 Expression in Neural Crest Cells Could Be a Trigger ofNeuroblastoma Development (2010)
  • Author(s): 磯貝恵理子
  • Organizer: Advanced in Neuroblastoma Research 2010
  • Place of Presentation: Stockholm City Conference Centre (Sweden)
  • Year and Date: 2010-06-23
• [Presentation] In vitro and in vivo analyses of genes derived from neuroblastoma and involved in transcriptional regulation of Mash1 (2009)
  • Author(s): 磯貝恵理子
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: 横浜、パシフィコ横浜
  • Year and Date: 2009-10-01
• [Presentation] In vitro and in vivo analyses of genes derived from neuroblastoma and involved in transcriptional regulation of Mash1 (2009)
  • Author(s): 磯貝恵理子
  • Organizer: 第68回日本癌学会
  • Place of Presentation: 横浜、パシフィコ横浜
  • Year and Date: 2009-10-01
• [Presentation] 神経芽腫由来遺伝子による、Mash1の転写制御 (2008)
  • Author(s): 磯貝恵理子
  • Organizer: 第24回日本小児がん学会
  • Place of Presentation: 千葉、幕張メッセ国際会議場
  • Year and Date: 2008-11-15
• [Presentation] 神経芽腫由来遺伝子による、Mash1の転写制御 (2008)
  • Author(s): 磯貝恵理子
  • Organizer: 日本小児がん学会
  • Place of Presentation: 千葉
  • Year and Date: 2008-11-15
• [Presentation] Transcriptional regulation of Mash1 by genes derived from neuroblastoma (2008)
  • Author(s): 磯貝恵理子
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋、名古屋国際会議場
  • Year and Date: 2008-10-29
• [Presentation] Transcriptional regulation of Mash1 by genes derived from neuroblastoma (2008)
  • Author(s): 磯貝恵理子
  • Organizer: 日本癌学会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-10-29