The specificity of liver lymphocytes in childhood and its relationship to liver diseases
| Project/Area Number |
20591272
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Niigata University |
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Principal Investigator |
KAWAMURA Toshihiko Niigata University, 医歯学系, 准教授 (70301182)
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| Co-Investigator(Kenkyū-buntansha) |
KAWAMURA Hiroki 新潟大学, 医歯学系, 講師 (20333495)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 小児 / 肝臓 / リンパ球 / 肝臓病 / 免疫学 / 自己抗体 / NKT細胞 / B細胞 / 自己免疫疾患 |
|---|
| Research Abstract |
Autoantibody-producing B220^<low> B-1 cells were abundantly found in the liver of neonatal mice. These B-1 cells were found to produce autoantibodies upon NKT cell activation. We also found that CD94/NKG2A inhibits NKT cell activation in hepatic injury, and that higher proportions of NKT cells express NKG2A in young mice than in adult mice.
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Report
(4 results)
Research Products
(24 results)
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[Journal Article] NKG2A inhibits invariant NKT cell activation in hepatic injury.2009
Author(s)
Kawamura T, Takeda K, Kaneda H, Matsumoto H, Hayakawa Y, Raulet DH, Ikarashi Y, Kronenberg M, Yagita H, Kinoshita K, Abo T, Okumura K, Smyth MJ.
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Journal Title
J Immunol 182
Pages: 250-258
Related Report
Peer Reviewed
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