The specificity of liver lymphocytes in childhood and its relationship to liver diseases

• Project/Area Number: 20591272
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Pediatrics
• Research Institution: Niigata University
• Principal Investigator: KAWAMURA Toshihiko Niigata University, 医歯学系, 准教授 (70301182)
• Co-Investigator(Kenkyū-buntansha): KAWAMURA Hiroki 新潟大学, 医歯学系, 講師 (20333495)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 小児 / 肝臓 / リンパ球 / 肝臓病 / 免疫学 / 自己抗体 / NKT細胞 / B細胞 / 自己免疫疾患

Research Abstract

Autoantibody-producing B220^<low> B-1 cells were abundantly found in the liver of neonatal mice. These B-1 cells were found to produce autoantibodies upon NKT cell activation. We also found that CD94/NKG2A inhibits NKT cell activation in hepatic injury, and that higher proportions of NKT cells express NKG2A in young mice than in adult mice.

Research Products

• [Journal Article] Coincidence of autoantibody production with the activation of natural killer T cells in a-galactosylceramide-mediated hepatic injury. (2011)
  • Author(s): Matsumoto H, Kawamura T, Kobayashi T, Kanda Y, Kawamura H, Abo T.
  • Journal Title: Immunology 133 Pages: 21-28
  • Peer Reviewed
• [Journal Article] Coincidence of autoantibody production with the activation of natural killer T cells in a-galactosylceramide-mediated hepatic injury (2011)
  • Author(s): 松本浩晃, 他5名
  • Journal Title: Immunology Volume: 133 Pages: 21-28
  • Peer Reviewed
• [Journal Article] "Senobi" stretch ameliorates asthma symptoms by restoring autonomic nervous system balance. (2010)
  • Author(s): Sato K, Kawamura T, Abo T.
  • Journal Title: J Investig Med 58 Pages: 968-970
  • Peer Reviewed
• [Journal Article] The "Senobi" breathing exercise is recommended as first line treatment for obesity. (2010)
  • Author(s): Sato K, Kawamura T, Yamagiwa S.
  • Journal Title: Biomed Res 31 Pages: 259-262
  • NAID: 130004470758
  • Peer Reviewed
• [Journal Article] Identification and characterization of autoantibody-producing B220low B-1 cells appearing in malarial infection. (2010)
  • Author(s): Kanda Y, Kawamura H, Matsumoto H, Kobayashi T, Kawamura T, Abo T.
  • Journal Title: Cell Immunol 263 Pages: 49-54
  • Peer Reviewed
• [Journal Article] Co-appearance of autoantibody-producing B220low B cells with NKT cells in the course of hepatic injury. (2010)
  • Author(s): Fujii Y, Kawamura H, Kawamura T, Kanda Y, Matsumoto H, Kobayashi T, Yamamoto T, Aoyama T, Abo T.
  • Journal Title: Cell Immunol 26 Pages: 105-112
  • Peer Reviewed
• [Journal Article] Senobi stretch ameliorates asthma symptoms by restoring autonomic nervous system balance (2010)
  • Author(s): 佐藤万成、川村俊彦、安保徹
  • Journal Title: Journal of Investigative Medicine Volume: 58 Pages: 968-970
  • Peer Reviewed
• [Journal Article] The "Senobi" breathing exercise is recommended as first line treatment for obesity (2010)
  • Author(s): 佐藤万成、川村俊彦、山際訓
  • Journal Title: Biomedical Research Volume: 31 Pages: 259-262
  • NAID: 130004470758
  • Peer Reviewed
• [Journal Article] Co-appearance of autoantibody-producing B220^<low> B cells with NKT cells in the course of hepatic injury (2010)
  • Author(s): 藤井祐紀、川村宏樹, 川村俊彦, 他6名
  • Journal Title: Cellular Immunology 260 Pages: 105-112
  • Peer Reviewed
• [Journal Article] Identification and characterization of autoantibody-producing B220^<low> B cells appearing in malarial infection (2010)
  • Author(s): 神田泰洋、川村宏樹、松本浩晃, 他3名
  • Journal Title: Cellular Immunology (印刷中)
  • Peer Reviewed
• [Journal Article] NKG2A inhibits invariant NKT cell activation in hepatic injury. (2009)
  • Author(s): Kawamura T, Takeda K, Kaneda H, Matsumoto H, Hayakawa Y, Raulet DH, Ikarashi Y, Kronenberg M, Yagita H, Kinoshita K, Abo T, Okumura K, Smyth MJ.
  • Journal Title: J Immunol 182 Pages: 250-258
  • Peer Reviewed
• [Journal Article] NKG2A inhibits invariant NKT cell activation in hepatic injury (2009)
  • Author(s): 川村俊彦, 竹田和由, 金田容秀, 他10名
  • Journal Title: Journal of Immunology 182 Pages: 250-258
  • Peer Reviewed
• [Journal Article] Appearance of B220low autoantibody-producin B-1 cells at neonatal and older stages in mice. (2008)
  • Author(s): Tachikawa S, Kawamura T, Kawamura H, Kanda Y, Fujii Y, Matsumoto H, Abo T.
  • Journal Title: Clin Exp Immunol 153 Pages: 448-455
  • Peer Reviewed
• [Journal Article] Appearance of B220^<low> autoantibody-producing B-1 ce11s at neonatal and older stages in mice (2008)
  • Author(s): 太刀川彩保子, 川村俊彦, 川村弘樹, 他4名
  • Journal Title: Clinical and Experimental Immunology 153 Pages: 488-455
  • Peer Reviewed
• [Presentation] IFN-αによる肝NK細胞の活性化. (2009)
  • Author(s): 神田泰洋、川村宏樹、川村俊彦、安保徹.
  • Organizer: 第39回日本免疫学会総会・学術集会.
  • Place of Presentation: 大阪
  • Year and Date: 2009-12-03
• [Presentation] IFN-αによる肝NK細胞の活性化 (2009)
  • Author(s): 神田泰洋、川村宏樹、川村俊彦, 他1名
  • Organizer: 第39回日本免疫学会総会・学授受集会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2009-12-03
• [Presentation] 正常マウスでのNKT細胞活性化による自己抗体産生. (2008)
  • Author(s): 松本浩晃、川村俊彦、川村宏樹、安保徹.
  • Organizer: 第38回日本免疫学会総会・学術集会.
  • Place of Presentation: 京都
  • Year and Date: 2008-12-01
• [Presentation] 正常マウスでのNKT細胞活性化による自己抗体産生 (2008)
  • Author(s): 松本浩晃, 川村俊彦, 川村宏樹, 他2名
  • Organizer: 第38回日本免疫学会総会・学授受集会
  • Place of Presentation: 京都
  • Year and Date: 2008-12-01
• [Book] NK細胞の機能(病態のしくみがわかる免疫学). (2010)
  • Author(s): 川村俊彦.
  • Publisher: 医学書院.
• [Book] 皮膚(病態のしくみがわかる免疫学) (2010)
  • Author(s): 川村俊彦.
  • Publisher: 医学書院.
• [Book] 神経疾患:重症筋無力症、多発性硬化症(病態のしくみがわかる免疫学). (2010)
  • Author(s): 川村俊彦.
  • Publisher: 医学書院.
• [Book] 妊娠(病態のしくみがわかる免疫学). (2010)
  • Author(s): 川村俊彦.
  • Publisher: 医学書院.
• [Book] 健康の維持:自然免疫および獲得免疫による健康管理(リッピンコットシリーズ イラストレイテッド免疫学). (2009)
  • Author(s): 川村俊彦、安保徹.
  • Publisher: 丸善出版.
• [Book] リッピンコットシリーズ イラストレイテッド免疫学(翻訳)第13章健康の維持 : 自然免疫および獲得免疫による健康管理 (2009)
  • Author(s): 川村俊彦, 安保徹
  • Total Pages: 352
  • Publisher: 丸善出版社