| Project/Area Number |
20591275
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Kanazawa University |
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Principal Investigator |
KOIZUMI Shoichi Kanazawa University, 子どものこころの発達研究センター, 特任教授 (50019973)
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| Co-Investigator(Renkei-kenkyūsha) |
YACHIE Akihiro 金沢大学, 医学系, 教授 (40210281)
WADA Tatzou 金沢大学, 医学系, 講師 (30313646)
NISHIMURA Ryousei 金沢大学, 医学系, 講師 (50324116)
SUGIMOTO Naotoshi 金沢大学, 医学系, 准教授 (80272954)
OHTA Kunio 金沢大学, 医学系, 准教授 (00303280)
NIIDA Yo 金沢大学, 子どものこころの発達研究センター, 特任准教授 (40293344)
SAIKAWA Yutaka 金沢大学, 医学系, 教授 (60283107)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | ヘムオキシゲナーゼ / 炎症 / 血管炎 / 内皮細胞 / ヘモグロビン / 骨髄移植 / 乳児白血病 / GVHD / 腎尿細管 |
|---|
| Research Abstract |
Heme oxygenase-1(HO-1) is the rate-limiting enzyme that adds an oxygen molecule to the porphyrin ring of heme, thereby catalyzing to biliverdin, free iron (finally to bilirubin and ferritin, respectively) and carbon monoxide. In 1999, the first case of human HO-1 deficiency was reported by Yachie et al. at our Department of Pediatrics, Kanazawa University Hospital The male patient suffered from generalized severe inflammation since the age of 2, and died at 6 years of age. Quite recently the 2nd case was discovered and reported. Aggressive clinical and patho-physiological studies about these two cases and some experimental investigations have shown detailed clinical findings of HO-1 deficiency and revealed that the HO-1 enzyme is crucial for development and growth of human beings on hematopoiesis, immunological system and the defense mechanism against inflammation and oxidative stresses.
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