• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Investigation of pathologic factors of chronic active EB virus infection using microarray and human tissue model

Research Project

Project/Area Number 20591276
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Pediatrics
Research InstitutionNagoya University

Principal Investigator

ITO Yoshinori  Nagoya University, 医学部附属病院, 講師 (20373491)

Co-Investigator(Renkei-kenkyūsha) KIMURA Hiroshi  名古屋大学, 大学院・医学研究科, 准教授 (30303621)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
KeywordsEBウイルス / ヒト組織モデル / 感染モデル / 扁桃組織 / 慢性活動性EBウイルス感染症 / マイクロアレイ
Research Abstract

To establish a model system for the study of Epstein-Barr virus (EBV) infection, we tested the ability of B95-8 virus and recombinant EBV expressing enhanced green fluorescent protein (EGFP-EBV) to replicate in human lymphoid tissue. Human tonsil tissues that had been surgically removed during routine tonsillectomy were sectioned into small blocks and placed on top of collagen sponge gels in culture medium at the air-interface, then a cell-free viral suspension was directly applied to the top of each tissue block. Increasing levels of EBV DNA in culture medium were observed after 12-15 days through 24 days post-infection in tissue models infected with B95-8 and EGFP-EBV. Expression levels of eight EBV-associated genes in cells collected from culture medium were increased during culture. Additionally, flow cytometry analyses revealed that most EGFP^+ cells were CD3^- CD56^- CD19^+ HLA-DR^+, and represented both nalve (IgD^+) and memory (CD27^+) B cells. Moreover, EBV replication in this model was suppressed by acyclovir treatment in a dose-dependent manner. These data suggest that this model has potential for use in the pathological analysis of local tissues at the time of primary infection, as well as for screening novel antiviral agents.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (113 results)

All 2011 2010 2009 2008

All Journal Article (43 results) (of which Peer Reviewed: 41 results) Presentation (69 results) Book (1 results)

  • [Journal Article] Serum concentrations of complement anaphylatoxins and proinflammatory mediators in patients with 2009 H1N1 influenza.2011

    • Author(s)
      Kimura H, Ito Y, et al
    • Journal Title

      Microbiol Immunol in press.

    • NAID

      10031121459

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effectiveness and safety of inactivated influenza vaccination in pediatric liver transplant recipients over three influenza seasons2011

    • Author(s)
      Ito Y, Kimura H
    • Journal Title

      Pediatr Transplant 15(1)

      Pages: 112-116

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Immunologic and Virologic Analyses in Pediatric Liver Transplant Recipients with Chronic High Epstein-Barr Viral Loads.2010

    • Author(s)
      Ito Y, Kimura H, et al
    • Journal Title

      J Infect Dis 202(3)

      Pages: 461-469

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of the levels of human herpesvirus 6 (HHV-6) DNA and cytokines in the cerebrospinal fluid and serum of children with HHV-6 encephalopathy.2010

    • Author(s)
      Ito Y, Kimura H, et al
    • Journal Title

      J Med Virol 82(8)

      Pages: 1410-1415

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Multicenter Evaluation of Prototype Real-time PCR Assays for EBV and CMV DNA in Whole Blood Samples from Transplant Recipients.2010

    • Author(s)
      Ito Y, Kimura H
    • Journal Title

      Microbiol Immunol 54(9)

      Pages: 516-522

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] インフルエンザ脳症ガイドライン(改訂版)(解説)2010

    • Author(s)
      伊藤嘉規, 他31名
    • Journal Title

      小児感染免疫 21

      Pages: 421-466

    • Related Report
      2010 Final Research Report
  • [Journal Article] Quantitative Analysis of Epstein-Barr Virus (EBV)-Related Gene Expression in Patients with Chronic Active EBV Infection.2010

    • Author(s)
      Iwata S, Wada K, Tobita S, Gotoh K, Ito Y, et al.
    • Journal Title

      J Gen Virol

      Volume: 91(1) Pages: 42-50

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Multiplex Real-time PCR Assay for Quantifying BK Polyo mavirus, JC Polyomavirus, and Adenovirus DNA Simultaneously.2010

    • Author(s)
      Funahashi Y, Iwata S, Ito Y, et al.
    • Journal Title

      J Clin Microbiol

      Volume: 48(3) Pages: 825-830

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Immunologic and Virologic Analyses in Pediatric Liver Transplant Recipients with Chronic High Epstein-Barr ViralLoads.2010

    • Author(s)
      Gotoh K, Ito Y, et al.
    • Journal Title

      J Infect Dis

      Volume: 202(3) Pages: 461-469

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of the levelS of human herpesvirus 6(HHV-6) DNA and cytokines in the cerebrospinal fluid and serum of children with HHV-6 encephalopathy.2010

    • Author(s)
      Kawabe S, Ito Y, et al.
    • Journal Title

      J Med Virol

      Volume: 82(8) Pages: 1410-1415

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Multicenter Evaluation of Prototype Real-time PCR Assaysfor EBV and CMV DNA in Whole Blood Samples from Transplant Recipients.2010

    • Author(s)
      Ito Y, et al.
    • Journal Title

      Microbiol Immunol

      Volume: 54(9) Pages: 516-522

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effectiveness and safety of inactivated influenza vaccination in pediatric liver transplant recipients over three influenza seasons.2010

    • Author(s)
      Gotoh K, Ito Y, et al.
    • Journal Title

      Pediatr Transplant

      Volume: 15(1) Pages: 112-116

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Kinetics of Epstein-Barr Virus Load and Virus-Specific CD8+ T Cells in Acute Infectious Mononucleosis.2010

    • Author(s)
      Hoshino Y, Nishikawa K, Ito Y, et al.
    • Journal Title

      J Clin Virol

      Volume: 50(3) Pages: 244-246

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Acute cerebellar ataxia associated with primary Epstein-Barr virus infection.2010

    • Author(s)
      Harai T, Kanegane H, Ito Ya, Ito Yo, et al.
    • Journal Title

      Pediatr Int

      Volume: in press

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bortezomib induces apoptosis in T lymphoma cells and natural killer lymphoma cells independent of Epstein-Barrvirus infection.2010

    • Author(s)
      Iwata S, Yano S, Ito Y, et al.
    • Journal Title

      Int J Cancer

      Volume: in press

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Serum concentrations of complement anaphylatoxins and proinflammatory mediators in p atients with 2009 H1N1 influenza.2010

    • Author(s)
      Ohta R, Torii Y, Imai M, Kimura H, Okada N, Ito Y.
    • Journal Title

      Microbiol Immunol

      Volume: in press

    • NAID

      10031121459

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Late-Onset Sensorineural Hearing Loss Due to Asymptomatic Congenital Cytomegalovirus Infection Retrospectively Diagnosed by Polymerase Chain Reaction Using Preserved Umbilical Cord.2010

    • Author(s)
      Ikeno M, Okumura A, Ito Y, et al.
    • Journal Title

      Clin Pediatr

      Volume: in press

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] インフルエンザ脳症ガイドライン(改訂版)(解説)2010

    • Author(s)
      森島恒雄、岡部信彦、中村祐輔、河岡義裕、山口清次、水口雅、市山高志、長谷川秀樹、奥村彰久、伊藤嘉規, 他
    • Journal Title

      小児感染免疫

      Volume: 21 Pages: 421-466

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Acute cerebellar ataxia associated with primary Epstein-Barr virus infection.2010

    • Author(s)
      Harai T, Ito Y, et al.
    • Journal Title

      Pediatr Int (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Multiplex Real-time PCR Assay for Quantifying BK Polyomavirus, JC Polyomavirus, and Adenovirus DNA Simultaneously.2010

    • Author(s)
      Funahashi Y, Ito Y, et al.
    • Journal Title

      J Clin Microbiol (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Immunologic and Virologic Analyses in Pediatric Liver Transplant Recipients with Chronic High Epstein-Barr Viral Loads.2010

    • Author(s)
      Gotoh K, Ito Y, et al.
    • Journal Title

      J Infect Dis (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cytomegalovirus and Epstein-Barr virus coinfection in three toddlers with prolonged illnesses.2009

    • Author(s)
      Ito Y, Kimura H, et al
    • Journal Title

      J Med Virol 81(8)

      Pages: 1399-1402

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of Epstein-Barr virus (EBV)-infected lymphocyte subtypes by flow cytometric in situ hybridization in EBV-associated lymphoproliferative diseases.2009

    • Author(s)
      Kimura H, Ito Y, et al
    • Journal Title

      J Infect Dis 200(7)

      Pages: 1078-1087

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Serum and cerebrospinal fluid levels of cytokines in acute encephalopathy associated with human herpesvirus-6 infection.2009

    • Author(s)
      Ito Y, et al
    • Journal Title

      Brain Dev-Jpn 31(10)

      Pages: 731-738

    • NAID

      10026412963

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Multiplex real-time PCR for the simultaneous detection of herpes simplex virus, human herpesvirus 6, and human herpesvirus 72009

    • Author(s)
      Wada K, Ito Y, et al.
    • Journal Title

      Microbiol Immunol 53

      Pages: 22-29

    • NAID

      10026403953

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Acute retinal necrosis caused by herpes simplex virus type 2 in a 3-year-old Japanese boy2009

    • Author(s)
      Tanaka-Kitajima N, Ito Y, et al.
    • Journal Title

      Eur J Pediatr 168

      Pages: 1125-1125

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cytomegalovirus and Epstein-Barr virus coinfection in three toddlers with prolonged illnesses.2009

    • Author(s)
      Ito Y, et al.
    • Journal Title

      J Med Virol 81

      Pages: 1399-1402

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of Epstein-Barr virus(EBV)-infected lymphocyte subtypes by flow cytometric in situ hybridization in EBV-associated lymphopro liferative diseases.2009

    • Author(s)
      Kimura H, Ito Y, et al.
    • Journal Title

      J Infect Dis 200

      Pages: 1078-1087

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Serum and cerebrospinal fluid levels of cytokines in acute encephalopathy associated with human herpesvirus-6 infection.2009

    • Author(s)
      Ichiyama T, Ito Y, et al.
    • Journal Title

      Brain Dev 31

      Pages: 731-738

    • NAID

      10026412963

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Quantitative Analysis of Epstein-Barr Virus(EBV)-Related Gene Expression in Patients with Chronic Active EBV Infection2009

    • Author(s)
      Iwata S, Ito Y, et al.
    • Journal Title

      J Gen Virol 91

      Pages: 42-50

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article]2009

    • Author(s)
      伊藤嘉規
    • Journal Title

      単純ヘルペスウイルス感染症. 小児科臨床ピクシス11抗菌薬・抗ウイルス薬の使い方(中山書店)

      Pages: 152-157

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Multiplex real-time PCR for the simultaneous detection of herpessimplex virus, human herpesvirus 6, and human herpesvirus 72009

    • Author(s)
      Wada K, Ito Y, et al.
    • Journal Title

      Microbiology and Immunology 53

      Pages: 22-29

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Oligonucleotide Microarray Analysis of Gene Expression Profiles followed by a Real-time RT-PCR Assay in Chronic Active Epstein-Barr Virus Infection2008

    • Author(s)
      Ito Y, Kimura H
    • Journal Title

      J Infect Dis 197(5)

      Pages: 663-666

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clinical and virologic characteristics of 15 patients with chronic active Epstein-Barr virus infection treated with hematopoietic stem cell transplantation2008

    • Author(s)
      Ito Y, Kimura H, et al
    • Journal Title

      Clin Infect Dis 46(10)

      Pages: 1525-1534

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Epstein-Barr virus (EBV) nuclear antigen 1-specific CD4+ T cells directly kill EBV-carrying NK and T cells2008

    • Author(s)
      Ito Y, et al
    • Journal Title

      Cancer Sci 99(8)

      Pages: 1633-1642

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Measuring Epstein-Barr virus (EBV) load : the significance and application for each EBV-associated disease2008

    • Author(s)
      Kimura H, Ito Y, et al
    • Journal Title

      Rev Med Virol 18(3)

      Pages: 305-319

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Simultaneous monitoring by real-time PCR of Epstein-Barr virus, human cytomegalovirus, and human herpesvirus 6 in juvenile and adult liver transplant recipients2008

    • Author(s)
      Ito Y, Kimura H, et al
    • Journal Title

      Transplant Proceedings 40(10)

      Pages: 3578-3582

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] One-Step multiplex real-time PCR assay to analyze the latency patterns of Epstein-Barr virus infection.2008

    • Author(s)
      Kubota N, Ito Y, et al.
    • Journal Title

      Journal of Virological Methods 147

      Pages: 26-36

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Oligonucleotide Microarray Analysis of Gene Expression Profiles followed by a Real-time RT-PCR Assay in Chronic Active Epstein-Barr Virus Infection.2008

    • Author(s)
      Ito Y, et al.
    • Journal Title

      Journal of Infectious Diseases 197

      Pages: 663-666

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical and virologic characteristics of 15 patients with chronic active Epstein-Barr virus infection treated with hematopoietic stem cell transplantation.2008

    • Author(s)
      Gotoh K, Y Ito, et al.
    • Journal Title

      Clinical Infectious Diseases 46

      Pages: 1525-1534

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Epstein-Barr virus (EBV)nuclear antigen 1-specific CD4+ T cells directly kill EBV-carrying NK and T cells.2008

    • Author(s)
      Demachi-Okamura A, Ito Y, et al.
    • Journal Title

      Cancer Science 99

      Pages: 1633-1642

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Measuring Epstein-Barr virus (EBV)load : the significance and application for each EBV-associated disease.2008

    • Author(s)
      Kimura H, Ito Y, et al.
    • Journal Title

      Reviews in Medical Virology 18

      Pages: 305-319

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Simultaneous monitoring by real-time PCR of Epstein-Barr virus, human cytomegalovirus, and human herpesvirus 6 in juvenile and adult liver transplant recipients2008

    • Author(s)
      Ono Y, Ito Y, et al.
    • Journal Title

      Transplantation Proceedings 40

      Pages: 3578-3582

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] Increased levels of cytokines and high-mobility group box 1 are associated with the development of severe pneumonia, but not acute encephalopathy, in 2009 H1N1 influenza-infected children2010

    • Author(s)
      伊藤嘉規, et al
    • Organizer
      Cell Symposia Influenza : Translating basic insights
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2010-12-02
    • Related Report
      2010 Final Research Report
  • [Presentation] B型肝炎ウイルスキャリアとなった小児19例における感染要因の検討2010

    • Author(s)
      伊藤嘉規, 他
    • Organizer
      第42回日本小児感染症学会総会学術集会
    • Place of Presentation
      仙台
    • Year and Date
      2010-11-27
    • Related Report
      2010 Final Research Report
  • [Presentation] ヒトリンパ組織を用いたEpstein-Barr Virus感染モデルの確立とその応用2010

    • Author(s)
      後藤研誠、伊藤嘉規, 他
    • Organizer
      第58回日本ウイルス学会学術集会
    • Place of Presentation
      徳島
    • Year and Date
      2010-11-07
    • Related Report
      2010 Final Research Report
  • [Presentation] 特異な経過によりキャリア化したgenotype AeによるB型肝炎ウイルス母子感染例2010

    • Author(s)
      鈴木道雄、伊藤嘉規, 他
    • Organizer
      第14回東海小児感染症研究会
    • Place of Presentation
      名古屋キャッスルプラザ
    • Year and Date
      2010-10-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] インフルエンザの治療戦略2010

    • Author(s)
      伊藤嘉規
    • Organizer
      愛知県インフルエンザセミナー
    • Place of Presentation
      名古屋
    • Year and Date
      2010-09-25
    • Related Report
      2010 Final Research Report
  • [Presentation] インフルエンザの治療戦略2010

    • Author(s)
      伊藤嘉規
    • Organizer
      愛知県インフルエンザセミナー
    • Place of Presentation
      名古屋安保ホール
    • Year and Date
      2010-09-25
    • Related Report
      2010 Annual Research Report
  • [Presentation] Flow cytometric in situ hybridization法を用いたEBV感染症の非侵襲的診断2010

    • Author(s)
      河邉慎司、伊藤嘉規, 他
    • Organizer
      第113回日本小児科学会学術集会
    • Place of Presentation
      盛岡
    • Year and Date
      2010-04-23
    • Related Report
      2010 Final Research Report
  • [Presentation] Flow cytometric in situ hybridization法を用いたEBV感染症の非侵襲的診断2010

    • Author(s)
      河邉慎司、伊藤嘉規, 他
    • Organizer
      第113回日本小児科学会学術集会
    • Place of Presentation
      盛岡盛岡市民文化ホール
    • Related Report
      2010 Annual Research Report
  • [Presentation] 小児生体肝移植例における季節性インフルエンザワクチンの有用性2010

    • Author(s)
      後藤研誠、伊藤嘉規, 他
    • Organizer
      第113回日本小児科学会学術集会
    • Place of Presentation
      盛岡盛岡市民文化ホール
    • Related Report
      2010 Annual Research Report
  • [Presentation] Flow cytometric in situ hybridization法による非侵襲感染細胞定量/同定法のEBV関連疾患への臨床応用2010

    • Author(s)
      河邉慎司、伊藤嘉規, 他
    • Organizer
      第25回ヘルペスウイルス研究会
    • Place of Presentation
      浜松商工会議所福利研修センター
    • Related Report
      2010 Annual Research Report
  • [Presentation] EBV関連T/NKリンパ腫株に対するHDAC阻害剤の効果と作用機序2010

    • Author(s)
      岩田誠子、斎藤高志、牛島洋子、伊藤嘉規, 他
    • Organizer
      第25回ヘルペスウイルス研究会
    • Place of Presentation
      浜松商工会議所福利研修センター
    • Related Report
      2010 Annual Research Report
  • [Presentation] EBV関連T/NKリンパ腫におけるバルプロ酸の効果と作用機序2010

    • Author(s)
      岩田誠子、牛島洋子、伊藤嘉規, 他
    • Organizer
      第58回日本ウイルス学会学術集会
    • Place of Presentation
      徳島あわぎんホール
    • Related Report
      2010 Annual Research Report
  • [Presentation] 重症肺炎・急性脳症を合併した新型インフルエンザ小児例における炎症性メディエーターの検討2010

    • Author(s)
      鳥居ゆか、伊藤嘉規, 他
    • Organizer
      第58回日本ウイルス学会学術集会
    • Place of Presentation
      徳島あわぎんホール
    • Related Report
      2010 Annual Research Report
  • [Presentation] Flow cytometric in situ hybridization法によるウイルス感染細胞同定/定量法のEBV関連T/NKリンパ増殖性疾患へに臨床応用2010

    • Author(s)
      河邉慎司、伊藤嘉規, 他
    • Organizer
      第58回日本ウイルス学会学術集会
    • Place of Presentation
      徳島あわぎんホール
    • Related Report
      2010 Annual Research Report
  • [Presentation] ヒトリンパ組織を用いたEpstein-Barr Virus感染モデルの確立とその応用2010

    • Author(s)
      後藤研誠、伊藤嘉規, 他
    • Organizer
      第58回日本ウイルス学会学術集会
    • Place of Presentation
      徳島あわぎんホール
    • Related Report
      2010 Annual Research Report
  • [Presentation] 重症肺炎・急性脳症を合併した新型インフルエンザ小児例における炎症性メディエーターの検討2010

    • Author(s)
      鳥居ゆか、伊藤嘉規, 他
    • Organizer
      第42回日本小児感染症学会総会学術集会
    • Place of Presentation
      仙台仙台国際センター
    • Related Report
      2010 Annual Research Report
  • [Presentation] FISH法によるウィルス感染細胞同定/定量法の慢性活動性EBウイルス感染症への臨床応用2010

    • Author(s)
      河邉慎司、伊藤嘉規, 他
    • Organizer
      第42回日本小児感染症学会総会学術集会
    • Place of Presentation
      仙台仙台国際センター
    • Related Report
      2010 Annual Research Report
  • [Presentation] メソトレキセートを含む多剤併用療法を行った関節型若年性特発性関節炎患者におけるEBウイルスの再活性化の検討2010

    • Author(s)
      川田潤一、岩田直美、伊藤嘉規
    • Organizer
      第42回日本小児感染症学会総会学術集会
    • Place of Presentation
      仙台仙台国際センター
    • Related Report
      2010 Annual Research Report
  • [Presentation] 移植後小児例における新型インフルエンザワクチンの有効性・安全性に関する検討2010

    • Author(s)
      鳥居ゆか、伊藤嘉規, 他
    • Organizer
      第42回日本小児感染症学会総会学術集会
    • Place of Presentation
      仙台仙台国際センター
    • Related Report
      2010 Annual Research Report
  • [Presentation] B型肝炎ウイルスキャリアとなった小児19例における感染要因の検討2010

    • Author(s)
      伊藤嘉規, 他
    • Organizer
      第42回日本小児感染症学会総会学術集会
    • Place of Presentation
      仙台仙台国際センター
    • Related Report
      2010 Annual Research Report
  • [Presentation] 生体肝移植後小児への新型インフルエンザワクチンの接種経験2010

    • Author(s)
      鳥居ゆか、伊藤嘉規, 他
    • Organizer
      第14回日本ワクチン学会学術集会
    • Place of Presentation
      東京九段会館
    • Related Report
      2010 Annual Research Report
  • [Presentation] Immunologic and Virologic Analyses in Pediatric Liver Transp lant Recipients with Chronic High Epstein-Barr Viral Loads.2010

    • Author(s)
      Gotoh K, Ito Y, et al.
    • Organizer
      14th Biennial Conference of the International Association for Research on Epstein-Barr Virus and Associated Diseases.
    • Place of Presentation
      University of Birmingham(英国)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Noninvasive identification of EBV infected lymphocyte subtypes in EBV associated T/NK lymphoproliferative diseases2010

    • Author(s)
      Kimura H, Ito Y, et al.
    • Organizer
      14th Biennial Conference of the International Association for Research on Epstein-Barr Virus and Associated Diseases.
    • Place of Presentation
      University of Birmingham(英国)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Bortezomib Induces Apoptosis in T Lymphoma Cells and Natural Killer Lymphoma Cells Independent of Epstein-Barr Virus Infection.2010

    • Author(s)
      Kawada J, Iwata S, Yano S, Ushijima Y, Gotoh K, Ito Y, et al.
    • Organizer
      14th Biennial Conference of the International Association for Research on Epstein-Barr Virus and Associated Diseases.
    • Place of Presentation
      University of Birmingham(英国)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Acute encephalopathy with biphasic seizures and late reduced diffusionassociated with Epstein-Barr virus.2010

    • Author(s)
      Hara S, Nosaka N, Kimura H, Ito Y.
    • Organizer
      14th Biennial Conference of the International Association for Research on Epstein-Barr Virus and Associated Diseases.
    • Place of Presentation
      University of Birmingham(英国)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Pretreatment EBV DNA Copy Number Is Predictive for Response to SMILE Chemotherapy for Newly-Diagnosed Stage IV, Relapsed. or Refractory Extranodal NK/T Cell Lymphoma, Nasal Type Results of NKTSG Phase Study.2010

    • Author(s)
      Suzuki R, Kimura H, Ito Y, et al.
    • Organizer
      52nd American Society of Hematology Annual Meeting and Exposition.
    • Place of Presentation
      Orange County ConventionCenter(Orland,米国)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Increased levels of cytokines and high-mobility group box lare associated with the development of severe pneumonia, but not acute encephalopathy, in 2009 H1N1 influenza-infectedchildren.2010

    • Author(s)
      Y.Ito, et al.
    • Organizer
      Cell Symposia Influenza : Translating basic insight
    • Place of Presentation
      Washington Marriott Hotel (Washington DC,米国)
    • Related Report
      2010 Annual Research Report
  • [Presentation] 肝移植後小児例におけるインフルエンザワクチンの有効性・安全性に関する検討2009

    • Author(s)
      後藤研誠、伊藤嘉規, 他
    • Organizer
      第41回日本小児感染症学会総会・学術集会
    • Place of Presentation
      福井
    • Year and Date
      2009-11-14
    • Related Report
      2010 Final Research Report
  • [Presentation] 肝移植後小児例におけるインフルエンザワクチンの有効性・安全性に関する検討2009

    • Author(s)
      後藤研誠、伊藤嘉規, 他
    • Organizer
      第41回日本小児感染症学会総会・学術集会
    • Place of Presentation
      福井市(福井県)
    • Year and Date
      2009-11-14
    • Related Report
      2009 Annual Research Report
  • [Presentation] Drug-induced hypersensitivity syndrome(DIHS)様の経過にサイトメガロウイルス再活性化を伴った1例2009

    • Author(s)
      羽根田泰宏、伊藤嘉規, 他
    • Organizer
      第41回日本小児感染症学会総会・学術集会
    • Place of Presentation
      福井(福井県)
    • Year and Date
      2009-11-14
    • Related Report
      2009 Annual Research Report
  • [Presentation] Multiplex Real-time PCR法によるBK virus・JC virus・Adenovirus同時同定システムの確立2009

    • Author(s)
      伊藤嘉規, 他
    • Organizer
      第57回日本ウイルス学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2009-10-25
    • Related Report
      2010 Final Research Report
  • [Presentation] FISH法を用いたEBV関連リンパ増殖性疾患の非侵襲診断および病態解析2009

    • Author(s)
      木村宏、伊藤嘉規, 他
    • Organizer
      第57回日本ウイルス学会学術集会
    • Place of Presentation
      東京都
    • Year and Date
      2009-10-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] HHV-6脳症における髄液・血清中のウイルスDNA・サイトカインの局在2009

    • Author(s)
      河邉慎司、伊藤嘉規, 他
    • Organizer
      第57回日本ウイルス学会学術集会
    • Place of Presentation
      東京都
    • Year and Date
      2009-10-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] Bortezomibに誘導されるEBV関連T/NKリンパ腫におけるapoptosisの検討2009

    • Author(s)
      岩田誠子、伊藤嘉規, 他
    • Organizer
      第57回日本ウイルス学会学術集会
    • Place of Presentation
      東京都
    • Year and Date
      2009-10-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] Multiplex Real-time PCR法によるBK virus・JC virus・Adenovirus同時同定システムの確立2009

    • Author(s)
      伊藤嘉規, 他
    • Organizer
      第57回日本ウイルス学会学術集会
    • Place of Presentation
      東京都
    • Year and Date
      2009-10-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] Restricted EBV gene expression in pediatric liver transplant recipients with chronic high Epstein-Barr viral losds.2009

    • Author(s)
      Gotoh K, Ito Y, et al.
    • Organizer
      14th International Conference on Immunobiology and Prophylaxis of Human Herpesvirus infections
    • Place of Presentation
      Kobe
    • Year and Date
      2009-10-06
    • Related Report
      2010 Final Research Report
  • [Presentation] Localization of viral DNA and cytokines in children with human herpesvirus 6 encephalopathy.2009

    • Author(s)
      Kawabe S, Ito Y, et al.
    • Organizer
      14th International Conference on Immunobiology and Prophylaxis of Human Herpesvirus infections
    • Place of Presentation
      Kobe, Japan
    • Year and Date
      2009-10-06
    • Related Report
      2009 Annual Research Report
  • [Presentation] Restricted EBV gene expression in pediatric liver transplant recipients with chronic high Epstein-Barr viral losds2009

    • Author(s)
      Gotoh K, Ito Y, et al.
    • Organizer
      14th International Conference on Immunobiology and Prophylaxis of Human Herpesvirus infections
    • Place of Presentation
      Kobe, Japan
    • Year and Date
      2009-10-06
    • Related Report
      2009 Annual Research Report
  • [Presentation] Identification of EBV-infected lymphocyte subtypes by a novel FISH assay in EBV-associated T/NK lymphoproliferative diseases.2009

    • Author(s)
      Kimura H, Ito Y, et al.
    • Organizer
      14th International Conference on Immunobiology and Prophylaxis of Human Herpesvirus infections
    • Place of Presentation
      Kobe, Japan
    • Year and Date
      2009-10-06
    • Related Report
      2009 Annual Research Report
  • [Presentation] 全血検体を使用したEBV、CMVおよびHHV-6同時定量システムの移植後感染症診断への応用2009

    • Author(s)
      伊藤嘉規
    • Organizer
      第13回多摩ウイルス感染症研究会
    • Place of Presentation
      東京
    • Year and Date
      2009-09-19
    • Related Report
      2010 Final Research Report
  • [Presentation] 全血検体を使用したEBV、CMVおよびHHV-6同時定量システムの移植後感染症診断への応用2009

    • Author(s)
      伊藤嘉規, 他
    • Organizer
      第13回多摩ウイルス感染症研究会
    • Place of Presentation
      東京都
    • Year and Date
      2009-09-19
    • Related Report
      2009 Annual Research Report
  • [Presentation] Immunologic and virologic analyses in pediatric liver transplant recipients with chronically high Epstein-Barr virus loads.2009

    • Author(s)
      Gotoh K, Ito Y, et al.
    • Organizer
      The 34th International Herpesvirus Workshop
    • Place of Presentation
      Ithaca, U.S.A.
    • Year and Date
      2009-07-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] Identification of Epstein-Barr virus(EBV)-infected lymphocyte subtypes by flow cytometric in situ hybridization in EBV-associated lymphopro liferative diseases.2009

    • Author(s)
      Kimura H, Ito Y, et al.
    • Organizer
      The 34th International Herpesvirus Workshop
    • Place of Presentation
      Ithaca, U.S.A.
    • Year and Date
      2009-07-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] FISH法によるEBV感染細胞同定法の確立と慢性活動性EBV感染症診断への応用2009

    • Author(s)
      河邉慎司、伊藤嘉規, 他
    • Organizer
      第50回日本臨床ウイルス学会
    • Place of Presentation
      高知市(高知県)
    • Year and Date
      2009-06-13
    • Related Report
      2009 Annual Research Report
  • [Presentation] Comparison of the cerebrospinal fluid levels and serum concentrations of human herpesvirus 6 (HHV-6) DNA and cytokines in children with HHV-6 encephalopathy.2009

    • Author(s)
      伊藤嘉規, et al.
    • Organizer
      12th International CMV/BetaHerpesvirus Workshop
    • Place of Presentation
      Boston
    • Year and Date
      2009-05-10
    • Related Report
      2010 Final Research Report
  • [Presentation] リアルタイムPCR法によるEBV・CMV定量法の標準アプリケーション開発に向けた多施設共同試験2009

    • Author(s)
      伊藤嘉規, 他
    • Organizer
      第83回日本感染症学会総会
    • Place of Presentation
      名古屋市(愛知県)
    • Year and Date
      2009-05-10
    • Related Report
      2009 Annual Research Report
  • [Presentation] Comparison of the cerebrospinal fluid levels and serum concentrations of human herpesvirus 6(HHV-6)DNA and cytokines in children with HHV-6 encephalopathy.2009

    • Author(s)
      Ito Y, et al.
    • Organizer
      12th International CMV/BetaHerpesvirus Workshop
    • Place of Presentation
      Boston, U.S.A.
    • Year and Date
      2009-05-10
    • Related Report
      2009 Annual Research Report
  • [Presentation] リアルタイムPCR法によるEBV・CMV定量法の標準アプリケーション開発に向けた多施設共同試験2009

    • Author(s)
      伊藤嘉規, 他
    • Organizer
      第83回日本感染症学会総会
    • Place of Presentation
      東京
    • Year and Date
      2009-04-23
    • Related Report
      2010 Final Research Report
  • [Presentation] FISH法によるEBV感染細胞同定の確立とEBV感染症解析への応用2009

    • Author(s)
      木村宏、伊藤嘉規, 他
    • Organizer
      第112回日本小児科学会学術集会
    • Place of Presentation
      奈良
    • Year and Date
      2009-04-17
    • Related Report
      2010 Final Research Report
  • [Presentation] FISH法によるEBV感染細胞同定の確立とEBV感染症解析への応用2009

    • Author(s)
      木村宏、伊藤嘉規, 他
    • Organizer
      第112回日本小児科学会学術集会
    • Place of Presentation
      奈良市(奈良県)
    • Year and Date
      2009-04-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] 無症候性高EBウイルス血症が長期間持続する生体肝移植後小児例の臨床的・基礎的検討2009

    • Author(s)
      後藤研誠、伊藤嘉規, 他
    • Organizer
      第112回日本小児科学会学術集会
    • Place of Presentation
      奈良市(奈良県)
    • Year and Date
      2009-04-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] 後天性CMV感染症の経過中にEBV感染を起こした超低出生体重児の1例2009

    • Author(s)
      細野治樹、伊藤嘉規, 他
    • Organizer
      第112回日本小児科学会学術集会
    • Place of Presentation
      奈良市(奈良県)
    • Year and Date
      2009-04-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] 後遺症を残したHHV-6関連脳症2症例の臨床経過および病態についての検討2008

    • Author(s)
      祖父江文子, 伊藤嘉規, 他
    • Organizer
      第40回日本小児感染症学会
    • Place of Presentation
      名古屋市(愛知県)
    • Year and Date
      2008-11-16
    • Related Report
      2008 Annual Research Report
  • [Presentation] 07-08シーズンのノロウイルス胃腸炎入院例の臨床像(ロタウイルス胃腸炎との比較)2008

    • Author(s)
      荒井直子, 伊藤嘉規, 他
    • Organizer
      第40回日本小児感染症学会
    • Place of Presentation
      名古屋市(愛知県)
    • Year and Date
      2008-11-16
    • Related Report
      2008 Annual Research Report
  • [Presentation] 病初期に脳梁膨大部病変を認めだけいれん群発型HHV-6脳症の一例2008

    • Author(s)
      中原宏, 伊藤嘉規, 他
    • Organizer
      第40回日本小児感染症学会
    • Place of Presentation
      名古屋市(愛知県)
    • Year and Date
      2008-11-16
    • Related Report
      2008 Annual Research Report
  • [Presentation] CPTH遺伝子変異が認められたHHV-6脳症の一例2008

    • Author(s)
      安井正宏, 伊藤嘉規, 他
    • Organizer
      第40回日本小児感染症学会
    • Place of Presentation
      名古屋市(愛知県)
    • Year and Date
      2008-11-16
    • Related Report
      2008 Annual Research Report
  • [Presentation] 後遺症を残したHHV-6関連脳症2症例の臨床経過および病態についての検討、後遺症を残したHHV-6関連脳症2症例の臨床経過および病態についての検討2008

    • Author(s)
      祖父江文子、伊藤嘉規, 他
    • Organizer
      第40回日本小児感染症学会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-11-15
    • Related Report
      2010 Final Research Report
  • [Presentation] Flow cytometry/in situ hybridization法を用いたEBV感染リンパ球の新規定量・同定法の確立と臨床応用2008

    • Author(s)
      木村宏, 伊藤嘉規, 他
    • Organizer
      第56回日本ウイルス学会
    • Place of Presentation
      岡山市(岡山県)
    • Year and Date
      2008-10-28
    • Related Report
      2008 Annual Research Report
  • [Presentation] 臓器・造血器幹細胞移植後の臨床検体を用いた比較検討によるEBVおよびCMV定量法の標準化に向けた多施設共同試験2008

    • Author(s)
      伊藤嘉規, 木村宏
    • Organizer
      第56回日本ウイルス学会
    • Place of Presentation
      岡山市(岡山県)
    • Year and Date
      2008-10-27
    • Related Report
      2008 Annual Research Report
  • [Presentation] 無症候性高EBウイルス血症が長期間持続する生体肝移植後小児例についての検討2008

    • Author(s)
      後藤研誠, 伊藤嘉規, 他
    • Organizer
      第56回日本ウイルス学会
    • Place of Presentation
      岡山市(岡山県)
    • Year and Date
      2008-10-27
    • Related Report
      2008 Annual Research Report
  • [Presentation] 臓器・造血器幹細胞移植後の臨床検体を用いた比較検討によるEBVおよびCMV定量法の標準化に向けた多施設共同試験2008

    • Author(s)
      伊藤嘉規、木村宏
    • Organizer
      第56回日本ウイルス学会
    • Place of Presentation
      岡山
    • Year and Date
      2008-10-26
    • Related Report
      2010 Final Research Report
  • [Presentation] One-step multiplex real-time RT-PCR法を用いたCAEBVにおけるEBV関連遺伝子発現の解析2008

    • Author(s)
      岩田誠子, 伊藤嘉規, 他
    • Organizer
      第56回日本ウイルス学会
    • Place of Presentation
      岡山市(岡山県)
    • Year and Date
      2008-10-26
    • Related Report
      2008 Annual Research Report
  • [Presentation] Multiplex real-time PCR for the simultaneous detection of herpes simplex virus, human herpesvirus 6, and human herpesvirus 72008

    • Author(s)
      Yoshinori Ito, et al.
    • Organizer
      33rd International Herpesvirus Workshop
    • Place of Presentation
      Estoril, Portugal
    • Year and Date
      2008-07-28
    • Related Report
      2008 Annual Research Report
  • [Presentation] Clinical and virologic characteristics of 15 patients with chronic active Epstein-Barr virus infection treated with hematopoietic stem cell transplantation2008

    • Author(s)
      Gotoh K, Y Ito, et al
    • Organizer
      33rd International Herpesvirus Workshop
    • Place of Presentation
      Estoril, Portugal
    • Year and Date
      2008-07-28
    • Related Report
      2008 Annual Research Report
  • [Presentation] Multiplex real-time PCR for the simultaneous detection of herpes simplex virus, human herpesvirus 6, and human herpesvirus 7.2008

    • Author(s)
      伊藤嘉規, et al.
    • Organizer
      33rd International Herpesvirus Workshop
    • Place of Presentation
      Estoril
    • Year and Date
      2008-07-27
    • Related Report
      2010 Final Research Report
  • [Presentation] 重度肝障害およびDICを合併した重症水痘男児例の検討2008

    • Author(s)
      後藤研誠, 伊藤嘉規, 他
    • Organizer
      第49回日本臨床ウイルス学会
    • Place of Presentation
      犬山市(愛知県)
    • Year and Date
      2008-06-15
    • Related Report
      2008 Annual Research Report
  • [Presentation] 脳炎・脳症迅速診断のためのHSV-1、HHV-6およびHHV-7同時定量システムの確立と髄液・血清中のウイルス量の比較2008

    • Author(s)
      河邊慎司, 伊藤嘉規, 他
    • Organizer
      第49回日本臨床ウイルス学会
    • Place of Presentation
      犬山市(愛知県)
    • Year and Date
      2008-06-15
    • Related Report
      2008 Annual Research Report
  • [Presentation] 単純ヘルペスウイルス2型による急性網膜壊死(acute retinal necrosis : ARN)の小児例2008

    • Author(s)
      北島直子, 伊藤嘉規, 他
    • Organizer
      第49回日本臨床ウイルス学会
    • Place of Presentation
      犬山市(愛知県)
    • Year and Date
      2008-06-15
    • Related Report
      2008 Annual Research Report
  • [Presentation] 慢性活動性EBウイルス感染症においてマイクロアレイ解析で発現増強を認めた遺伝子2008

    • Author(s)
      伊藤嘉規, 他
    • Organizer
      第111回日本小児科学会
    • Place of Presentation
      東京
    • Year and Date
      2008-04-25
    • Related Report
      2010 Final Research Report
  • [Book] 単純ヘルペスウイルス感染症:小児科ピクシス11抗菌薬・抗ウイルス薬の使い方2009

    • Author(s)
      伊藤嘉規
    • Publisher
      中山書店
    • Related Report
      2010 Final Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi