The development of novel immune gene therapy for chronic viral infections.
| Project/Area Number |
20591279
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Ehime University |
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Principal Investigator |
TAUCHI Hisamichi Ehime University, 大学院・医学系研究科, 准教授 (30314959)
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| Co-Investigator(Kenkyū-buntansha) |
ISHII Eiichi 愛媛大学, 大学院・医学系研究科, 教授 (20176126)
YAMAKAWA Masaki 愛媛大学, 大学院・医学系研究科, 教授 (60127917)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 難治性感染症 / 免疫遺伝子治療 / EBウイルス / 細胞障害活性T細胞 / T細胞クローン / 細胞傷害活性 / 遺伝子治療 / 小児難治性感染症 / ウイルス特異的CTL |
|---|
| Research Abstract |
Development of new treatments for children with intractable infections such as chronic active EB virus infection and virus-associated hemophagocytic syndrome have been demanded. We establishmed EB virus specific human CD4, CD8 T lymphocyte. We confirmed the EB virus specific CD4, CD8 T lymphocyte have cytotoxicity for LCL cell line.
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Report
(4 results)
Research Products
(26 results)
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[Journal Article] Subtypes of familial hemophagocytic lymphohistiocytosis in Japan based on genetic and functional analyses of cytotoxic T lymphocytes.2010
Author(s)
Nagai K, Yamamoto K, Fujiwara H, An J, Ochi T, Suemori K, Yasumi T, Tauchi H, Koh K, Sato M, Morimoto A, Heike T, Ishii E, Yasukawa M.
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Clinical features and outcome of MLL generearranged acute lymphoblastic leukemia in infants with additional chromosomal abnormalities other than 11q23 translocation.2008
Author(s)
Tauchi H, Tomizawa D, Eguchi M, Eguchi-Ishimae M, Koh K, Hirayama M, Miyamura N, Kinukawa N, Hayashi Y, Horibe K, Ishii E
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Journal Title
Leukemia Research 32
Pages: 1523-1529
Related Report
Peer Reviewed
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