The development of novel immune gene therapy for chronic viral infections.

• Project/Area Number: 20591279
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Pediatrics
• Research Institution: Ehime University
• Principal Investigator: TAUCHI Hisamichi Ehime University, 大学院・医学系研究科, 准教授 (30314959)
• Co-Investigator(Kenkyū-buntansha): ISHII Eiichi 愛媛大学, 大学院・医学系研究科, 教授 (20176126) ; YAMAKAWA Masaki 愛媛大学, 大学院・医学系研究科, 教授 (60127917)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 難治性感染症 / 免疫遺伝子治療 / EBウイルス / 細胞障害活性T細胞 / T細胞クローン / 細胞傷害活性 / 遺伝子治療 / 小児難治性感染症 / ウイルス特異的CTL

Research Abstract

Development of new treatments for children with intractable infections such as chronic active EB virus infection and virus-associated hemophagocytic syndrome have been demanded. We establishmed EB virus specific human CD4, CD8 T lymphocyte. We confirmed the EB virus specific CD4, CD8 T lymphocyte have cytotoxicity for LCL cell line.

Research Products

• [Journal Article] Outcome of pediatric patients with Langerhans cell histiocytosis treated with 2 chlorodeoxyadenosine : a nationwide survey in Japan. (2010)
  • Author(s): Imamura T, Sato T, Tauchi H, 他8名
  • Journal Title: Int J Hematol. 91 Pages: 646-651
  • NAID: 10026402057
  • Peer Reviewed
• [Journal Article] Subtypes of familial hemophagocytic lymphohistiocytosis in Japan based on genetic and functional analyses of cytotoxic T lymphocytes. (2010)
  • Author(s): Nagai K, Yamamoto K, Fujiwara H, An J, Ochi T, Suemori K, Yasumi T, Tauchi H, Koh K, Sato M, Morimoto A, Heike T, Ishii E, Yasukawa M.
  • Journal Title: PLoS ONE Volume: 30
  • Peer Reviewed
• [Journal Article] Outcome of pediatric patients with Langerhans cell histiocytosis treated with 2 chlorodeoxyadenosine : a nationwide survey in Japan. (2010)
  • Author(s): Imamura T, Sato T, Shiota Y, Kanegane H, Kudo K, Nakagawa S, Nakadate H, Tauchi H, Kamizono J, Morimoto A.
  • Journal Title: Int J Hematol. Volume: 91 Pages: 646-651
  • NAID: 10026402057
  • Peer Reviewed
• [Journal Article] Human herpesvirus 6 infection impairs Toll-like receptor signaling. (2010)
  • Author(s): Murakami Y, Tanimoto K, Fujiwara H, An J, Suemori K, Ochi T, Hasegawa H, Yasukawa M.
  • Journal Title: Virol J Volume: 91
  • Peer Reviewed
• [Journal Article] The key role of cell factor/KIT signaling in the proliferation of blast cells from Down syndrome-related leukemia. (2009)
  • Author(s): Toki T, Kanezaki R, Tauchi H, 他8名
  • Journal Title: Leukemia. 23 Pages: 95-103
  • Peer Reviewed
• [Journal Article] Children's toxicology from bench to bed - Drug-induced Renal Injury (2) : Nephrotoxiciy induced by cisplatin and ifosfamide in children. (2009)
  • Author(s): Fujieda M, Matsunaga A, Tauchi H, 他4名
  • Journal Title: J.Toxicol.Sci. 34 Pages: 251-257
  • Peer Reviewed
• [Journal Article] Reconstruction using a frozen bone method for osteosarcoma of the talus. A case report and review of the literature. (2009)
  • Author(s): Sakayama K, Kidani T, Tauchi H, 他6人
  • Journal Title: Anticancer Res. 29 Pages: 4093-4098
  • Peer Reviewed
• [Journal Article] The key role of cell factor/KIT signaling in the proliferation of blast cells from Down syndrome-related leukemia (2009)
  • Author(s): Toki T, Kanezaki R, Adachi S, Fujino H, Xu G, Sato T, Suzuki K, Tauchi H, Endo M, Ito E
  • Journal Title: Leukemia 23 Pages: 95-103
  • Peer Reviewed
• [Journal Article] Children's toxicology from bench to bed-Drug induced Renal Injury(2): Nephrotoxiciy induced by cisplatin and ifosfamide in children (2009)
  • Author(s): Mikiya Fujieda, Akira Matsunaga, Atsushi Hayashi, Hisamichi Tauchi, Kohsuke Chayama, Takashi Sekine
  • Journal Title: J.Toxicol.Sci. 34 Pages: 251-257
  • Peer Reviewed
• [Journal Article] Reconstruction using a frozen bone method for osteosarcoma of the talus. A case report and review of the literature (2009)
  • Author(s): Sakayama K, Kidani T, Sugawara Y, Tauchi H, Fujibuchi T, Tanji N, Yamamoto H, Tsuchiya H
  • Journal Title: Anticancer Res. 29 Pages: 4093-4098
  • Peer Reviewed
• [Journal Article] (2009)
  • Author(s): 田内久道
  • Journal Title: 小児科領域の服薬指導Q&A(医薬ジャーナル社) Pages: 18-33
• [Journal Article] Clinical features and outcome of MLL gene rearranged acute lymphoblastic leukemia in infants with additional chromosomal abnormalities other than 11q23 translocation. (2008)
  • Author(s): Tauchi H, Tomizawa D, Ishii E.
  • Journal Title: Leuk Res. 32 Pages: 1523-1529
  • Peer Reviewed
• [Journal Article] A complete remission of sclerosing rhabdomyosarcoma with multiple lung and bone metastases treated with multi-agent chemotherapy and peripheral blood stem cell transplantation (PBSCT) : a case report. (2008)
  • Author(s): Sakayama K, Tauchi H, Sugawara Y.
  • Journal Title: Anticancer Res. 28 Pages: 2361-2367
  • Peer Reviewed
• [Journal Article] Clinical features and outcome of MLL generearranged acute lymphoblastic leukemia in infants with additional chromosomal abnormalities other than 11q23 translocation. (2008)
  • Author(s): Tauchi H, Tomizawa D, Eguchi M, Eguchi-Ishimae M, Koh K, Hirayama M, Miyamura N, Kinukawa N, Hayashi Y, Horibe K, Ishii E
  • Journal Title: Leukemia Research 32 Pages: 1523-1529
  • Peer Reviewed
• [Journal Article] Acomplete remission of sclerosing rhabdomyosarcoma with multiple lung and bone metastasestreated with multi-agent chemotherapy and peripheral blood stem cell transplantation (PBSCT) : a case report. (2008)
  • Author(s): Sakayama K, Tauchi H, Sugawara Y, Kidani T, Tokuda K, Miyazaki T, Watanabe Y, Yamamoto H
  • Journal Title: Anticancer Research 28 Pages: 2361-2367
  • Peer Reviewed
• [Journal Article] Subtypes of familial hemophagocytic lymphohistiocytosis in Japan based on genetic and functional analyses of cytotoxic T lymphocytes.
  • Author(s): Nagai K, Ishii E, Tauchi H, 他9名
  • Journal Title: PLOS ONE 2010 (in press)
  • Peer Reviewed
• [Presentation] 臨床実習証を用いた医学部学生に対する感染制御教育とその成果 (2010)
  • Author(s): 田内久道、中野夏代、長谷川均、高田清式、村上雄一、安川正貴
  • Organizer: 第80回日本感染症学会西日本地方会
  • Place of Presentation: 松山市
  • Year and Date: 2010-11-20
• [Presentation] 日本における家族性血球貪食性リンパ組織球症の実態とその多様性 (2009)
  • Author(s): 永井功造, 越智俊元, 末盛浩一朗, 藤原弘, 本田美里, 田内久道, 森本哲, 大賀正一, 石井榮一, 安川正貴
  • Organizer: 第71回日本血液学会学術集会
  • Place of Presentation: 京都
  • Year and Date: 2009-10-25
• [Presentation] Clinical features and outcome of MLL gene rearranged acute lymphoblastic leukemia in infants with additional chromosomal abnormalities other than 11q23 translocation. (2009)
  • Author(s): 田内久道
  • Organizer: 第12回乳児白血病講演会
  • Place of Presentation: 東京
  • Year and Date: 2009-04-11
• [Presentation] Clinical features and outcome of MLL gene rearranged acute lymphoblastic leukemia in infants with additional chromosomal abnormalities other than 11q23 translocation (2009)
  • Author(s): Tauchi H
  • Organizer: 第12回乳児白血病講演会
  • Place of Presentation: 東京
  • Year and Date: 2009-04-11
• [Presentation] 11q23転座以外の付加的染色体異常を認めたMLL遺伝子再構成陽性の乳児急性リンパ性白血病の臨床的特徴及び予後 (2008)
  • Author(s): 田内久道、江口真理子、石前峰斉、石井榮一、富澤大輔、康勝好、平山雅浩、宮村能子、絹川直子、林泰秀、堀部敬三
  • Organizer: 第70回日本血液学会総会
  • Place of Presentation: 京都
  • Year and Date: 2008-10-11
• [Presentation] ダウン症関連白血病細胞の増殖におけるStem cell factor/KITシグナリング (2008)
  • Author(s): 土岐力、金崎里香、足立壮一、徐剛、佐藤知彦、鈴木かほり、田内久道、遠藤幹也、伊藤悦朗
  • Organizer: 第70回日本血液学会総会
  • Place of Presentation: 京都
  • Year and Date: 2008-10-11
• [Presentation] Can the screening examinations at the age of 12 years forecast the following late effect of childhood cancer survivors? (2008)
  • Author(s): Honda M, Ishida Y, Ooto Y, Tauchi H, Tokuda K, Ishii E
  • Organizer: 10^<th> Intemational Conference on Long-Term Complications of Treatment of Chidren and Adolescents for Cancer
  • Place of Presentation: Canada
• [Book] これから出会う物語 (2010)
  • Author(s): 市川光太郎, 他
  • Publisher: 中山書店
• [Book] これから出会う物語 (2010)
  • Author(s): 田内久道
  • Publisher: 中山書店
• [Book] 小児科領域の服薬指導Q&A (2009)
  • Author(s): 荒木博陽, 他
  • Publisher: 医薬ジャーナル社