New evaluation for severity of Kawasaki disease using HMGB1 values.

• Project/Area Number: 20591281
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Pediatrics
• Research Institution: Kagoshima University
• Principal Investigator: NOMURA Yuichi Kagoshima University, 医歯学総合研究科, 准教授 (90237884)
• Co-Investigator(Kenkyū-buntansha): NISHI Junichiro 鹿児島大学, 医学部・歯学部附属病院, 講師 (40295241) ; HASHIGUCHI Teruto 鹿児島大学, 医歯学総合研究科, 准教授 (70250917)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 川崎病 / 重症度 / 冠動脈後遺症 / 免疫グロブリン治療 / 不応例 / Gunmaスコア / HMGB1 / 重症度評価 / 免疫グロブリン大量療法 / 免疫グロブリン療法不応 / 治療抵抗例

Research Abstract

We examined the efficacy of high mobility group box 1 (HMGB1) value for evaluating the severity of KD. Methods : Serum HMGB1 values were compared between the responders (143 patients) to initial intravenous immunoglobulin (IVIG) and nonresponders (23 patients). Results : Compared with responders, non-responders showed significantly elevated HMGB1 values. ROC analysis revealed an optimal cut-off value for HMGB1 for nonresponders. The sensitivity with high HMGB1 was 43% and accuracy 73%. When predicted non-responder is defined as a patient with Gunma score of 5 or over or high HMGB1 value, the sensitivity was 74% and accuracy 63%. Conclusion : Combinational use of HMGB1 value and Gunma score is useful for determine the severity of KD as the prediction for nonresponder of IVIG.

Research Products

• [Journal Article] 喘息性気管支炎の治療で用いたステロイドが川崎病主要症状をマスクした川崎病不全型の1例 (2011)
  • Author(s): 益田君教、野村裕一、摺木伸隆、上野健太郎、江口太助、鮫島幸二、河野嘉文
  • Journal Title: 児臨 Volume: (in press)
  • Peer Reviewed
• [Journal Article] Patient with autoimmune neutropenia developed Kawasaki syndrome after treatment with G-CSF. (2011)
  • Author(s): Kentaro, Ueno, Yuichi Nomura, Michiko Arata, Shinsuke Maruyama, Takayuki Tanabe, Taisuke Eguchi, Yoshifumi Kawano.
  • Journal Title: Pediatr Int Volume: (in press)
  • Peer Reviewed
• [Journal Article] Elevated value of a drug-induced lymphocyte stimulation test for immunoglobulin is one of the immunological abnormalities of Kawasaki disease. (2010)
  • Author(s): Yuichi Nomura, Kiminori Masuda, Taisuke Eguchi, Yasuko Morita, Kentaro Ueno, Yoshifumi Kawano
  • Journal Title: Int Arch Allergy Immunol. 153 Pages: 102-106
  • Peer Reviewed
• [Journal Article] A severe form of Kawasaki disease presenting with only fever and cervical lymphadenopathy at admission (2010)
  • Author(s): Yuichi Nomura, Michiko Arata, Chihaya Koriyama, Kiminori Masuda, Yasuko Morita, Daisuke Hazeki, Kentaro Ueno, Taisuke Eguchi, Yoshifumi Kawano
  • Journal Title: J Pediatr 156 Pages: 786-791
  • Peer Reviewed
• [Journal Article] Platelet vascular endothelial growth factor is a useful predictor for prognosis in Kawasaki syndrome. (2010)
  • Author(s): Kentaro Ueno, Yuichi Nomura, Kiminori Masuda, Yasuko Morita, Daisuke Hazeki, Taisuke Eguchi, Teruto Hashiguchi, Ikuro Maruyama, Yoshifumi Kawano
  • Journal Title: British J Haematol 148(2) Pages: 285-292
  • Peer Reviewed
• [Journal Article] A severe form of Kawasaki disease presenting with only fever and cervical lymphadenopathy at admission. (2010)
  • Author(s): Yuichi Nomura, Michiko Arata, Chihaya Koriyama, Kiminori Masuda, Yasuko Morita, Daisuke Hazeki, Kentaro Ueno, Taisuke Eguchi, Yoshifumi Kawano.
  • Journal Title: J Pediatr. Volume: 156 Pages: 786-791
  • Peer Reviewed
• [Journal Article] Elevated value of a drug-induced lymphocyte stimulation test for immunoglobulin is one of the immunological abnormalities of Kawasaki disease. (2010)
  • Author(s): Yuichi Nomura, Kiminori Masuda, Taisuke Eguchi, Yasuko Morita, Kentaro Ueno, Yoshifumi Kawano.
  • Journal Title: Int Arch Allergy Immunol. Volume: 153 Pages: 102-106
  • Peer Reviewed
• [Journal Article] Platelet vascular endothelial growth factor is a useful predictor for prognosis in Kawasaki syndrome (2010)
  • Author(s): Kentaro Ueno, Yuichi Nomura, Kiminori Masuda, Yasuko Morita, Daisuke Hazeki, Taisuke Eguchi, Teruto Hashiguchi, Ikuro Maruyama, Yoshifumi Kawano
  • Journal Title: British J Haematol. 148 Pages: 285-292
  • Peer Reviewed
• [Journal Article] Multicenter and retrospective case study of warfarin and aspirin combination therapy in patients with giant coronary aneurysms caused by Kawasaki disease. (2009)
  • Author(s): Suda K, Kudo Y, Higaki T, Nomura Y, Miura M, Matsumura M, Ayusawa M, Ogawa S, Matsuishi T
  • Journal Title: Circ J. 73(7) Pages: 1319-1323
  • NAID: 10025932851
  • Peer Reviewed
• [Journal Article] An elevated value of high mobility group box 1 is a potential marker for poor response to high-dose of intravenous immunoglobulin treatment in patients with Kawasaki syndrome. (2009)
  • Author(s): Taisuke Eguchi, Yuichi Nomura, Teruto Hashiguchi, Kiminori Masuda, Michiko Arata, Daisuke Hazeki, Kentaro Ueno, Junichiro Nishi, Yoshifumi Kawano, Ikuro Maruyama
  • Journal Title: Pedatr Infect Dis J. 28(4) Pages: 39-341
  • Peer Reviewed
• [Journal Article] An elevated value of high mobility group box 1 is a potential marker for poor response to high-dose of intravenous immunoglobulin treatment in patients with Kawasaki syndrome (2009)
  • Author(s): Taisuke Eguchi, Yuichi Nomura, Teruto Hashiguchi, Kiminori Masuda, Michiko Arata, Daisuke Hazeki, Kentaro Ueno, Junichiro Nishi, Yoshifumi Kawano, Ikuro Maruyama.
  • Journal Title: Pedatr Infect Dis J. 28 Pages: 339-341
  • Peer Reviewed
• [Journal Article] Multicenter and retrospective case study of warfarin and aspirin combination therapy in patients with giant coronary aneurysms caused by Kawasaki disease (2009)
  • Author(s): Suda K, Kudo Y, Higaki T, Nomura Y, Miura M, Matsumura M, Ayusawa M, Ogawa S, Matsuishi T.
  • Journal Title: Circ J. 73 Pages: 1319-1323
  • NAID: 10025932851
  • Peer Reviewed
• [Journal Article] A Patient with Selective IgA Deficiency complicated by Kawasaki Syndrome. (2008)
  • Author(s): Takuro Nishikawa, Yuichi Nomura, Yukiharu Kono, Yoshifumi Kawano
  • Journal Title: Pediatr Int. 50 Pages: 816-818
  • Peer Reviewed
• [Journal Article] 免疫グロブリン大量療法後に著しい血小板減少を来した川崎病の1例 (2008)
  • Author(s): 西川拓朗, 熊本崇, 島子敦史, 野村裕一, 河野嘉文, 川上清
  • Journal Title: 児臨 61 Pages: 985-989
  • Peer Reviewed
• [Journal Article] Early diagnosis of Kawasaki disease in patients with cervical lymphadenopathy. (2008)
  • Author(s): Sadamitsu Yanagi, Yuichi Nomura, Kiminori Masuda, Chihaya Koriyama, Koji Sameshima, Taisuke Eguchi, Mari Imamura, Michiko Arata, Yoshifumi Kawano
  • Journal Title: Pediatr Int. 50 Pages: 179-183
  • NAID: 10021947374
  • Peer Reviewed
• [Journal Article] 川崎病との鑑別を要した日本紅斑熱の1例 (2008)
  • Author(s): 宮園明典、野村裕一、益田君教、鮫島幸二、河野嘉文
  • Journal Title: 児臨 61 Pages: 801-803
  • Peer Reviewed
• [Journal Article] A patient with Kawasaki syndrome and 21-hydroxylase deficiency. (2008)
  • Author(s): Daisuke Hazeki, Yuichi Nomura, Michiyo Mizota, Keiko Yotsumoto, Yukiko Nonaka, Takayuki Tanabe, Yoshifumi Kawano
  • Journal Title: Pediatr Int. 50 Pages: 119-120
  • Peer Reviewed
• [Journal Article] A patient with Kawasaki syndrome and 21-hydroxylase deficiency. (2008)
  • Author(s): Daisuke Hazeki, Yuichi Nomura, et. al
  • Journal Title: Pediatr Int 50 Pages: 119-120
  • Peer Reviewed
• [Journal Article] 川崎病との鑑別を要した日本紅斑熱の1例. (2008)
  • Author(s): 宮園明典, 野村裕一, 他
  • Journal Title: 小児科臨床 61 Pages: 801-803
  • Peer Reviewed
• [Journal Article] Early diagnosis of Kawasaki disease in patients with cervical lymphadenopathy. (2008)
  • Author(s): Sadamitsu Yanagi, Yuichi Nomura, et al.
  • Journal Title: Pediatr Int 50 Pages: 179-183
  • NAID: 10021947374
  • Peer Reviewed
• [Journal Article] 免疫グロブリン大量療法後に著しい血小板減少を来した川崎病の1例. (2008)
  • Author(s): 西川拓朗, 熊本崇, 島子敦史, 野村裕一, 他
  • Journal Title: 小児科臨床 61 Pages: 985-989
  • Peer Reviewed
• [Journal Article] A Patient with Selective IgA Deficiency complicated by Kawasaki Syndrome. (2008)
  • Author(s): Takuro Nishikawa, Yuichi Nomura, et al.
  • Journal Title: Pediatr Int 50 Pages: 179-183
  • Peer Reviewed
• [Journal Article] 喘息性気管支炎の治療で用いたステロイドが川崎病主要症状をマスクした川崎病不全型の1例
  • Author(s): 益田君教、野村裕一、摺木伸隆、上野健太郎、江口太助、鮫島幸二、河野嘉文
  • Journal Title: 児臨 in press
  • Peer Reviewed
• [Journal Article] Patient with autoimmune neutropenia developed Kawasaki syndrome after treatment with G-CSF.
  • Author(s): Kentaro Ueno, Yuichi Nomura, Michiko Arata, Shinsuke Maruyama, Takayuki Tanabe, Taisuke Eguchi, Yoshifumi Kawano
  • Journal Title: Pediatr Int (in press)
• [Presentation] 学校心臓検診における川崎病患児スクリーニング (2010)
  • Author(s): 野村裕一
  • Organizer: 平成22年度九州学校検診協議会
  • Place of Presentation: 鹿児島市
  • Year and Date: 2010-08-08
• [Presentation] Novel Autoantibody-induced severe neutropenia in a patient with Kawasaki syndrome. (2010)
  • Author(s): Ueno K, Nomura Y, Masamoto I, Masuda K, Morita Y, Eguchi T, Okamoto Y, Kawano Y.
  • Organizer: The 3rd Congress of Asia-Pacific Pediatric Cardiac Society
  • Place of Presentation: Urayasu, Japan
• [Presentation] Kawasaki disease patients with six principal symptoms have a high risk for requiring additional IVIG. (2010)
  • Author(s): Nomura Y, Arata M, Masuda K, Suruki N, Ueno K, Yoshikawa H, Eguchi T, Kawano Y.
  • Organizer: The 3rd Congress of Asia-Pacific Pediatric Cardiac Society
  • Place of Presentation: Urayasu, Japan
• [Presentation] An elevated value of a drug-induced lymphocyte stimulation test for immunoglobulin is one of the immunological abnormalities of Kawasaki disease. (2010)
  • Author(s): Nomura Y, Masuda K, Eguchi T, Morita Y, Arata M, Ueno K, Kawano Y.
  • Organizer: The 44 th association of Europian pediatric cardiology
  • Place of Presentation: Innsbruck, Austria
• [Presentation] 血清プロカルシトニン値の川崎病重症度評価における有用性の検討 (2010)
  • Author(s): 益田君教, 摺木伸隆, 荒田道子, 柳元孝介, 上野健太郎, 吉川英樹, 江口太助, 野村裕一, 河野嘉文.
  • Organizer: 第113回日本小児科学会学術集会
  • Place of Presentation: 岩手
• [Presentation] 顆粒球コロニー刺激因子を投与後に川崎病と診断された自己免疫性好中球減少症の1例 (2010)
  • Author(s): 上野健太郎, 荒田道子, 丸山慎介, 江口太助, 田邊貴幸, 野村裕一, 河野嘉文
  • Organizer: 第113回日本小児科学会学術集会
  • Place of Presentation: 岩手
• [Presentation] 体重25kg以上の川崎病患児の検討 (2010)
  • Author(s): 柳元孝介, 荒田道子, 櫨木大祐, 上野健太郎, 江口太助, 島子敦史, 益田君教, 野村裕一, 河野嘉文
  • Organizer: 第46回日本小児循環器学会総会
  • Place of Presentation: 浦安市
• [Presentation] 6か月未満発症の川崎病にはTSST-1が関与する (2010)
  • Author(s): 野村裕一
  • Organizer: 第46回日本小児循環器学会総会
  • Place of Presentation: 浦安市
• [Presentation] 免疫グロブリン大量療法を行わなかった川崎病患児の検討 (2010)
  • Author(s): 益田君教、野村裕一、森田康子、江口太助.
  • Organizer: 第30回日本川崎病学会・学術集会
  • Place of Presentation: 京都
• [Presentation] An elevated value of a drug-induced lymphocyte stimulation test for immunoglobulin is one of the immunological abnormalities of Kawasakidisease (2010)
  • Author(s): Nomura Y, Masuda K, Eguchi T, Morita Y, Arata M, Ueno K, Kawano Y
  • Organizer: 第44回ヨーロッパ小児心臓病学会
  • Place of Presentation: Innsbruck (Austria)
• [Presentation] Kawasaki disease patients with six principal symptoms have a high risk for requiring additional IVIG (2010)
  • Author(s): Nomura Y, Arata M, Masuda K, Suruki N, Ueno K, Yoshikawa H, Eguchi T, Kawano Y
  • Organizer: The 3rd Congress of Asia-Pacific Pediatric Cardiac Society
  • Place of Presentation: Urayasu, Japan
• [Presentation] 川崎病の免疫グロブリン大量療法不応への主要症状の関与 (2009)
  • Author(s): 益田君教, 摺木伸隆, 荒田道子, 上野健太郎, 江口太助, 野村裕一
  • Organizer: 第29回日本川崎病学会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-10-16
• [Presentation] 川崎病重症度評価における血小板血管内皮細胞増殖因子の有用性 (2009)
  • Author(s): 上野健太郎, 野村裕一, 益田君教, 橋口照人, 森田康子, 櫨木大祐, 江口太助, 河野嘉文
  • Organizer: 第45回日本小児循環器学会
  • Place of Presentation: 大阪
• [Presentation] 免疫グロブリン大量療法不応の Gunma スコアと high mobility group box 1値を用いた予測の有用性 (2009)
  • Author(s): 野村裕一, 上野健太郎, 益田君教, 森田康子, 櫨木大祐, 江口太助, 河野嘉文
  • Organizer: 第45回日本小児循環器学会
  • Place of Presentation: 大阪
• [Presentation] 重症川崎病患者に対する免疫グロブリン・プレドニゾロン初期併用療法の有用性を検討するRAISE Study-研究デザインと進捗状況- (2009)
  • Author(s): 小林徹, 佐地勉, 薗部友良, 森川昭廣, 濱岡建城, 原寿郎, 小川俊一, 市田蕗子, 阿部淳, 野村裕一, 三浦大, 井上佳也, 荒川浩一
  • Organizer: 第29回日本川崎病学会
  • Place of Presentation: 名古屋
• [Presentation] 喘息発作に対するステロイド投与が川崎病主要症状をマスクした川崎病不全型の1例 (2009)
  • Author(s): 益田君教, 摺木伸隆, 上野健太郎, 江口太助, 野村裕一
  • Organizer: 第29回日本川崎病学会
  • Place of Presentation: 名古屋
• [Presentation] A peak of M/Z 4215 is a potential new marker for poor-response of immunoglobulim treatment in patients with Kawasaki syndrome. (2008)
  • Author(s): Nomura Y, Masuda K, Hazaki D, Ueno K, Eguchi T, Nishi J, Kawano Y.
  • Organizer: The Second Asia-Pacific Congress of Pediatric Cardiology and Cardiac Surgery
  • Place of Presentation: Jeju, Korea
• [Presentation] Presenting only fever and lymphadenopathy at admission is an independent risk for an additional IVIG in Kawasaki syndrome. (2008)
  • Author(s): Arata M, Nomura Y, Masuda K, Eguchi T, Kawano Y.
  • Organizer: 9th International Kawasaki Disease Symposium.
  • Place of Presentation: Taipei, Taiwan
• [Presentation] An elevated value of high mobility group box 1 is a potential marker for poor responder to IVIG in patients with Kawasaki syndrome. (2008)
  • Author(s): Eguchi T, Nomura Y, Hashiguchi T, Masuda K, Arata M, Hazeki D,Ueno K, Maruyama I, Kawano Y.
  • Organizer: 9th International Kawasaki Disease Symposium.
  • Place of Presentation: Taipei, Taiwan
• [Presentation] 川崎病患児おける免疫グロブリン大量療法抵抗性の新たなマーカー検索. (2008)
  • Author(s): 野村裕一, 益田君教, 他
  • Organizer: 第44回日本小児循環器学会
  • Place of Presentation: 福島
• [Presentation] 川崎病における免疫グロブリン製剤に対するリンパ球幼若化試験の検討. (2008)
  • Author(s): 益田君教, 森田康子, 摺木伸隆, 藤山りか, 山元公恵, 鮫島幸二, 江口太助, 野村裕一.
  • Organizer: 第28回日本川崎病研究会
  • Place of Presentation: 札幌
• [Presentation] 川崎病により末梢に重篤な冠動脈後遺症をきたした右単一冠動脈の1例. (2008)
  • Author(s): 江口太助, 野村裕一, 他
  • Organizer: 第28回日本川崎病研究会
  • Place of Presentation: 札幌
• [Presentation] 川崎病回復期における好中球減少症発症機序の検討. (2008)
  • Author(s): 上野健太郎, 野村裕一, 他
  • Organizer: 第28回日本川崎病研究会
  • Place of Presentation: 札幌
• [Book] 中山書店(東京) (2009)
  • Author(s): 野村裕一
  • Publisher: 川崎病のすべて(ブドウ球菌説)
• [Book] 川崎病のすべて、ブドウ球菌説 (2009)
  • Author(s): 野村裕一, 石井正浩監修
  • Total Pages: 2
  • Publisher: 中山書店、東京