| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
|---|
| Research Abstract |
We examined the efficacy of high mobility group box 1 (HMGB1) value for evaluating the severity of KD. Methods : Serum HMGB1 values were compared between the responders (143 patients) to initial intravenous immunoglobulin (IVIG) and nonresponders (23 patients). Results : Compared with responders, non-responders showed significantly elevated HMGB1 values. ROC analysis revealed an optimal cut-off value for HMGB1 for nonresponders. The sensitivity with high HMGB1 was 43% and accuracy 73%. When predicted non-responder is defined as a patient with Gunma score of 5 or over or high HMGB1 value, the sensitivity was 74% and accuracy 63%. Conclusion : Combinational use of HMGB1 value and Gunma score is useful for determine the severity of KD as the prediction for nonresponder of IVIG.
|
