Exploring New Anti-Cytokine Therapy for Kawasaki Disease
| Project/Area Number |
20591289
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Nippon Medical School |
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Principal Investigator |
FUKAZAWA Ryuji Nippon Medical School, 医学部, 准教授 (80277566)
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| Co-Investigator(Kenkyū-buntansha) |
小川 俊一 日本医科大学, 医学部, 教授 (50194436)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 小児循環器学 / 川崎病 / サイトカイン / 血小板 / 遺伝子プロファイリング / 抗サイトカイン療法 / Innate Immunity / 補体 / 抗サイトカイン治療 |
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| Research Abstract |
We tried to reveal cytokines action on very early stage of Kawasaki Disease (KD) by analyzing gene profiling in thrombocyte of Kawasaki disease patients. On very early stage of KD, the genes involving innate immunity and complement activation, such as Interleukin-1, Interleukin-18 and C1q, were significantly expressed. However, we could not detect complement activation in the serum of KD patients on admission. Analysis of Single Nucleotide Polymorphism about the genes involving innate immunity is on-going.
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Report
(4 results)
Research Products
(17 results)
