Involvement of dendritic cells in pathophysiology of the acute phase of Kawasaki disease
Project/Area Number |
20591291
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Pediatrics
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Research Institution | Kurume University |
Principal Investigator |
SUDA Kenji Kurume University, 医学部, 准教授 (10399173)
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Co-Investigator(Kenkyū-buntansha) |
TAKAHASHI Tomoyuki 久留米大学, 医学部, 准教授 (20332687)
YASUKAWA Hideo 久留米大学, 医学部, 講師 (60289361)
IEMURA Motofumi 久留米大学, 医学部, 助教 (30399175)
MUTA Hiromi 久留米大学, 医学部, 助教 (40343694)
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Project Period (FY) |
2008 – 2010
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Project Status |
Completed (Fiscal Year 2010)
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Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | 川崎病 / 樹状細胞 / サイトカイン / ケモカイン / 医療・福祉 / 病因 |
Research Abstract |
The number of circulating myeloid dendritic cells (DC) significantly decreased in Kawasaki disease (KD) at presentation than in controls. In KD, the number of myeloid and plasmacytoid DC significantly correlated with disease severity represented by serum albumin and interleukin-6. This decreased number of mDC quickly normalized after immunoglobulin treatment.
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Report
(4 results)
Research Products
(104 results)
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[Journal Article] Long-term prognosis of patients with Kawasaki disease complicated by giant coronary aneurysms : a single- institution experience.2011
Author(s)
Suda K, Iemura M, Nishiono H, Teramachi Y, Koteda Y, Kishim oto S, Kudo Y, Itoh S, Ishii H, Ueno T, Tashiro T, Nobuyoshi M, Kato H, Matsuishi T.
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Journal Title
Circulation 123(17)
Pages: 1836-42
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Peer Reviewed
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[Journal Article]2009
Author(s)
須田憲治
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Journal Title
巨大冠動脈瘤 : 自然歴. 小児科ピクシス9 川崎病のすべて(中山書店)
Pages: 137-8
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[Presentation] Involvement of myeloid dendritic cell in the pathogenesis of acute phase of Kawasaki disease.2010
Author(s)
Suda K, Kishimoto S , Takahashi T, Okamura H, Yasukawa H, Nishino H, Teramachi Y, Itoh S , Yokoyama T, Iemura M, Imaizumi T, Matsuishi T.
Organizer
The 74^<th> annual scientific meeting of the Japanese Circulation Society.
Place of Presentation
Kyoto, Japan
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[Presentation] Involvement of myeloid dendritic cell in the pathogenesis of acutephase of Kawasaki Disease2010
Author(s)
Suda K, Kishimoto S, Takahashi T, Okamura H, Yasukawa T, Nishino H, Teramachi Y, Yokoyama T, Iemura M, Imaizumi T, Matsuishi T
Organizer
第74回日本循環器学会
Place of Presentation
京都
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[Presentation] Transient hypercoagulable state and neurological symptom after transcatheter occlusion of atrial septal defect using Amplatzer septal occluder2009
Author(s)
Suda K, Kudo Y, Itoh S, Tananari Y, Nishino H, Ishii H, Imeura M, Maeno Y, Yasunaga H, Matsuishi T.
Organizer
Annual meeting of European Society of Cardiology 2009
Place of Presentation
Barcelona, Spain
Related Report
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[Presentation] Long-term prognosis of Kawasaki syndrome with giant coronary aneurysms : A muruti-center study2009
Author(s)
Suda K, Iemura M, Miura M, Ogawa S, Ayusawa M, Higaki T, Nomura Y, Matsumura M, Matsuishi T.
Organizer
American Heart Association 2009
Place of Presentation
Orlando, FL, USA
Related Report
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[Presentation] 成人動脈管開存に対するコイル塞栓術2009
Author(s)
須田憲治, 寺町陽三, 岸本慎太郎, 伊藤晋一, 籠手田雄介, 西野裕, 家村素史, 赤木禎治, 棚成嘉文, 工藤嘉公, 松石豊次郎
Organizer
第45回日本小児循環器学会
Place of Presentation
神戸
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[Presentation] Change of antibody titers against measles in patients with Kawasaki Disease treated with intravenous gamma globulin.2008
Author(s)
Ishii H, Suda K, Kishimoto S, Koteda Y, Iemura M, Kudo Y, Itoh S, Nishino H, Teramachi Y, Matsuishi T.
Organizer
9th International Kawasaki Disease Symposium
Place of Presentation
Taipei, Taiwan
Related Report
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[Presentation] Transient subclinical ventricular dysfunction after intravenous gamma globulin infusion in patients with Kawasaki Disease.2008
Author(s)
Suda K, Kishimoto S, Koteda Y, Kudo Y, Itoh S, Ishii H, Nishino H, Teramachi Y, Iemura M, Matsuishi T.
Organizer
9th International Kawasaki Disease Symposium
Place of Presentation
Taipei, Taiwan
Related Report
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[Presentation] Impaired micro-vascular hyperaemic response by laser doppler monitoring in patients with coronary artery aneurysms due to Kawasaki Disease.2008
Author(s)
Iemura M, Sugimura T, Kishimoto S, Koteda Y, Ishii H, Kudo Y, Itoh S, Nishino H, Teramachi Y, Suda K, Matsuishi T.
Organizer
9th International Kawasaki Disease Symposium
Place of Presentation
Taipei, Taiwan
Related Report
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[Presentation] 川崎病急性期のBNP2008
Author(s)
岸本慎太郎,須田憲治,籠手田雄介,工藤嘉公,伊藤晋一,石井治佳,西野裕,寺町陽三,家村素史,吉本裕良,松石豊次郎
Organizer
第44回日本小児循環器学会
Place of Presentation
郡山
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