Chronic Active Epstein-Barr Virus Infection and its Pathogenetic Roles
| Project/Area Number |
20591292
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Hokkaido Institute of Public Health |
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Principal Investigator |
OKANO Motohiko Hokkaido Institute of Public Health, 感染症センター, センター長 (50261300)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | 慢性活動性EBウイルス感染症 / リンパ増殖性疾患 / リンパ腫 / 診断 / 治療 / 病態 |
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| Research Abstract |
The pathogenetic roles for chronic active Epstein-Barr virus infection (CAEBV) were studied mainly by virological, immunological and pathological approaches. An extreme activation of EBV and heterogeneous immunodeficiency were demonstrated. Major target cells of EBV were shown to be either T or NK cells. Furthermore, sensitivities of infected cells to various therapeutic agents were variable. These results appeared to be beneficial to further recognizing the disease.
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Report
(4 results)
Research Products
(41 results)
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[Journal Article] Afive-year old boy with unicentric Castleman's disease affecting the mesentery : utility of serum IL-6 level and 18F-FDG PET for diagnosis.2009
Author(s)
Toita N, Kawamura N, Hatano N, Takezaki S, Ohkura Y, Yamada M, Okano M, Okada T, Sasaki F, Kubota KC, Itoh T, Ariga T
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Journal Title
Journal of Pediatric Hematology and Oncology. 31
Pages: 693-695
Related Report
Peer Reviewed
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