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Chronic Active Epstein-Barr Virus Infection and its Pathogenetic Roles

Research Project

Project/Area Number 20591292
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Pediatrics
Research InstitutionHokkaido Institute of Public Health

Principal Investigator

OKANO Motohiko  Hokkaido Institute of Public Health, 感染症センター, センター長 (50261300)

Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywords慢性活動性EBウイルス感染症 / リンパ増殖性疾患 / リンパ腫 / 診断 / 治療 / 病態
Research Abstract

The pathogenetic roles for chronic active Epstein-Barr virus infection (CAEBV) were studied mainly by virological, immunological and pathological approaches. An extreme activation of EBV and heterogeneous immunodeficiency were demonstrated. Major target cells of EBV were shown to be either T or NK cells. Furthermore, sensitivities of infected cells to various therapeutic agents were variable. These results appeared to be beneficial to further recognizing the disease.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (41 results)

All 2011 2010 2009 2008 Other

All Journal Article (33 results) (of which Peer Reviewed: 33 results) Presentation (6 results) Book (2 results)

  • [Journal Article] Features of chronic active Epstein-Barr virus infection and related human diseases.2011

    • Author(s)
      Okano M
    • Journal Title

      Open Hematology Journal 5

      Pages: 1-3

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] インドからのD4型麻疹ウイルス輸入症例-札幌市2011

    • Author(s)
      菊地正幸
    • Journal Title

      病原微生物検出情報

      Volume: 32 Pages: 44-45

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Features of chronic active Epstein-Barr virus infection and related human diseases2011

    • Author(s)
      Okano M
    • Journal Title

      Open Hematology Journal

      Volume: 5 Pages: 1-3

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 慢性に経過するEpstein-Barrウイルス関連疾患2010

    • Author(s)
      岡野素彦
    • Journal Title

      臨床とウイルス 38

      Pages: 213-223

    • NAID

      10026902435

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 1歳未満の乳児における麻疹抗体保有状況について2010

    • Author(s)
      長野秀樹
    • Journal Title

      北海道公衆衛生学雑誌

      Volume: 23 Pages: 132-135

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 慢性に経過するEpstein-Barrウイルス関連疾患2010

    • Author(s)
      岡野素彦
    • Journal Title

      臨床とウイルス

      Volume: 38 Pages: 213-223

    • NAID

      10026902435

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A case of paralytic poliomyelitis associated with poliovirus vaccine strains in Hokkaido, Japan2010

    • Author(s)
      Miyoshi M
    • Journal Title

      Japanese Journal of Infectious Diseases

      Volume: 63 Pages: 216-217

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 中国からのH1型麻疹ウイルス輸入症例-札幌市2010

    • Author(s)
      菊地正幸
    • Journal Title

      病原微生物検出情報

      Volume: 31 Pages: 203-203

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 北海道におけるパンデミック(HIN1)2009インフルエンザの発生状況について-定点医療機関からの報告を中心に-2010

    • Author(s)
      横山裕之
    • Journal Title

      北海道立衛生研究所報

      Volume: 60 Pages: 53-56

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 北海道におけるパンデミック(HIN1)2009インフルエンザについて-2009/10シーズン-2010

    • Author(s)
      駒込理佳
    • Journal Title

      北海道立衛生研究所報

      Volume: 60 Pages: 57-60

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 2009年度の北海道における麻疹PA抗体保有状況2010

    • Author(s)
      長野秀樹
    • Journal Title

      北海道立衛生研究所報

      Volume: 60 Pages: 79-80

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Different genotypic sapoviruses detected in two simultaneous outbreaks of gastroenteritis among school children in the same district in Hokkaido, Japan2010

    • Author(s)
      Miyoshi M
    • Journal Title

      Japanese Journal of Infectious Diseases 63

      Pages: 75-78

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Afive-year old boy with unicentric Castleman's disease affecting the mesentery : utility of serum IL-6 level and 18F-FDG PET for diagnosis.2009

    • Author(s)
      Toita N, Kawamura N, Hatano N, Takezaki S, Ohkura Y, Yamada M, Okano M, Okada T, Sasaki F, Kubota KC, Itoh T, Ariga T
    • Journal Title

      Journal of Pediatric Hematology and Oncology. 31

      Pages: 693-695

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Epstein-Barr virus infection and its pathogenetic roles for human diseases.2009

    • Author(s)
      Okano M
    • Journal Title

      Current Pediatric Reviews 5

      Pages: 192-197

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 麻疹の現況と問題点-北海道における麻疹発生状況とその分析から-2009

    • Author(s)
      地主勝
    • Journal Title

      小児科 50

      Pages: 495-500

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 北海道におけるC型肝炎ウイルス検査について2009

    • Author(s)
      長野秀樹
    • Journal Title

      北海道公衆衛生学会雑誌 22

      Pages: 122-124

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Epidemiological and molecular studies of measles at different clusters in Hokkaido district, Japan, 20072009

    • Author(s)
      長野秀樹
    • Journal Title

      Japanese Journal of Infectious Diseases 62

      Pages: 209-211

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pandemic(H1N1)2009インフルエンザから学ぶこと2009

    • Author(s)
      岡野素彦
    • Journal Title

      北海道立衛生研究所報 59

      Pages: 1-5

    • NAID

      120006794464

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 北海道における新型インフルエンザA(H1N1)の発生状況について-4月~7月-2009

    • Author(s)
      中野道晴
    • Journal Title

      北海道立衛生研究所報 59

      Pages: 21-25

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 北海道における麻疹-発生状況と感染症流行予測調査-2009

    • Author(s)
      長野秀樹
    • Journal Title

      北海道立衛生研究所報 59

      Pages: 75-77

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Early diagnosis for polyarthritis of juvenile idiopathic arthritis using systemic gallium scintigraphy2009

    • Author(s)
      Yamazaki S
    • Journal Title

      Pediatric International 51

      Pages: 587-590

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A 5-year-old boy with unicentric Castleman disease affecting the mesentery : utility of serum IL-6 level and ^<18>F-FDG PET for diagnosis2009

    • Author(s)
      Toita N
    • Journal Title

      Journal of Pediatric Hematology/Oncology 31

      Pages: 693-695

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Epstein-Barr virus and its pathogenetic roles for human diseases2009

    • Author(s)
      岡野素彦
    • Journal Title

      Current Pediatric Reviews 5

      Pages: 1-6

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 麻疹検査診断体制ならびに検査診断法について2009

    • Author(s)
      駒瀬勝啓
    • Journal Title

      病原微生物検出情報 30

      Pages: 45-47

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 2007年度の北海道における麻疹発生状況2008

    • Author(s)
      地主勝
    • Journal Title

      病原微生物検出情報 29

      Pages: 128-129

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ポリオワクチン接種後に発症した小児急性弛緩性麻痺の1例2008

    • Author(s)
      三好正浩
    • Journal Title

      病原微生物検出情報 29

      Pages: 200-201

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 北海道における麻疹報告の動向について-2007年の定点および非定点医療機関からの報告について-2008

    • Author(s)
      横山裕之
    • Journal Title

      北海道立衛生研究所報 58

      Pages: 27-30

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 2008年の北海道における麻疹報告の動向2008

    • Author(s)
      中野道晴
    • Journal Title

      北海道立衛生研究所報 58

      Pages: 31-34

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 北海道におけるインフルエンザの流行について-2004/05〜2007/08シーズン-2008

    • Author(s)
      長野秀樹
    • Journal Title

      北海道立衛生研究所報 58

      Pages: 59-64

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 北海道立保健所のHIV検査相談システムに導入された即日検査の効果について2008

    • Author(s)
      長野秀樹
    • Journal Title

      北海道立衛生研究所報 58

      Pages: 65-68

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 2007年度の北海道における麻疹PA抗体保有調査2008

    • Author(s)
      地主勝
    • Journal Title

      北海道立衛生研究所報 58

      Pages: 69-71

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ノロウイルス検査キットの有用性の検討2008

    • Author(s)
      石田勢津子
    • Journal Title

      北海道立衛生研究所報 58

      Pages: 73-75

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 北海道におけるC型肝炎ウイルス検査について2008

    • Author(s)
      長野秀樹
    • Journal Title

      北海道公衆衛生学雑誌 2

      Pages: 122-124

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] 麻疹発生状況と流行予測調査(2008)2009

    • Author(s)
      長野秀樹
    • Organizer
      第61回北海道公衆衛生学会
    • Place of Presentation
      札幌
    • Year and Date
      2009-11-12
    • Related Report
      2009 Annual Research Report
  • [Presentation] 2色蛍光標識 Taqman RT-PCRによるノロウイルスの遺伝子群別同時検出法2008

    • Author(s)
      石田勢津子
    • Organizer
      第31回日本分子生物学会
    • Place of Presentation
      神戸市・神戸ポートアイランド
    • Year and Date
      2008-12-09
    • Related Report
      2008 Annual Research Report
  • [Presentation] 北海道における麻しんの発生動向-2007年の定点及び非定点医療機関報告の比較2008

    • Author(s)
      横山裕之
    • Organizer
      第60回北海道公衆衛生学会
    • Place of Presentation
      札幌市・北海道大学学術交流会館
    • Year and Date
      2008-11-14
    • Related Report
      2008 Annual Research Report
  • [Presentation] 2007年の北海道における麻疹発生状況について2008

    • Author(s)
      地主勝
    • Organizer
      第60回北海道公衆衛生学会
    • Place of Presentation
      札幌市・北海道大学学術交流会館
    • Year and Date
      2008-11-14
    • Related Report
      2008 Annual Research Report
  • [Presentation] 2008年の北海道における麻しん発生動向-全数報告と旧定点医療機関報告の比較-2008

    • Author(s)
      中野道晴
    • Organizer
      第60回北海道公衆衛生学会
    • Place of Presentation
      札幌市・北海道大学学術交流会館
    • Year and Date
      2008-11-14
    • Related Report
      2008 Annual Research Report
  • [Presentation] HIV感染-北海道の現状と課題-2008

    • Author(s)
      長野秀樹
    • Organizer
      第60回北海道公衆衛生学会
    • Place of Presentation
      札幌市・北海道大学学術交流会館
    • Year and Date
      2008-11-13
    • Related Report
      2008 Annual Research Report
  • [Book] 「第14回ヘルペス感染症フォーラム」、慢性活動性EBウイルス感染症の病態と長期予後2008

    • Author(s)
      大賀正一
    • Total Pages
      131
    • Publisher
      マッキャン・ヘルスケア
    • Related Report
      2008 Annual Research Report
  • [Book] 小児感染症学改訂第2版(岡部信彦編)(EBウイルス感染症)

    • Author(s)
      岡野素彦
    • Publisher
      診断と治療社(印刷中)
    • Related Report
      2010 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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