| Project/Area Number |
20591293
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | National Research Institute for Child Health and Development |
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Principal Investigator |
TSUNAWAKI Shohko National Research Institute for Child Health and Development, 研究所・母児感染研究部, 室長 (00211384)
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|---|
| Co-Investigator(Kenkyū-buntansha) |
守屋 美恵 独立行政法人国立成育医療研究センター, 母児感染研究部, 共同研究員 (60470001)
塩田 清二 昭和大学, 医学部, 教授 (80102375)
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| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 好中球 / 志賀毒素 / スフィンゴ糖脂質 / 溶血性尿毒症 / ラクトシルセラミド / スフィゴ糖脂質 / 細菌 / 溶血尿毒素 / 溶血尿毒症 |
|---|
| Research Abstract |
Enterohemorrhagic Escherichia coli (EHEC), a major pathogen of pediatric hemorrhagic colitis, cause hemolytic uremic syndrome (HUS) and encephalopathy. Shiga toxins (Stx1 and Stx2) produced by EHEC damage target cells which highly express Gb3, but the transport mechanism of Stxs from the intestinal tract to the target cells is unclear. In this study, we demonstrate that Stxs bind to LacCer in neutrophils and accumulate in the nucleus bypassing lysosomes and Golgi bodies. In view of neutrophil accumulation in glomeruli of patients with HUS, they should transport Stxs to target cells from the intestinal tract.
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