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Impact of glucocorticoid exposure for fetus in fetal development and neonatal disease

Research Project

Project/Area Number 20591295
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Embryonic/Neonatal medicine
Research InstitutionAsahikawa Medical College

Principal Investigator

NAGAYA Ken  Asahikawa Medical College, 医学部, 講師 (80396382)

Co-Investigator(Kenkyū-buntansha) FUJIEDA Kenji  旭川医科大学, 医学部, 教授 (60173407)
MAKITA Yoshio  旭川医科大学, 医学部, 教授 (20271778)
HAYASHI Tokitugi  旭川医科大学, 医学部, 講師 (40322911)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywordsグルココルチコイド / 医療・福祉 / ゲノム / 子宮内発育不全 / 副腎機能 / グルコルチコイド / 胎児 / 新生児 / 11β-hydroxysteroid dehydrogenase type2 / 11β-hdroxsteroid dehdroenase type2
Research Abstract

The urinary steroid of 61 preemies was measured by using LC-MS/MS. In current study, the index of placental 11ss-hydroxysteroid dehydrogenase type2 (11ssHSD2) substituted for urinary (THF+allo-THF)/THE within 48 hours of life. The infants with low activity of 11ssHSD2 had severer illness than those with high or middle activity of 11ssHSD2. It was suggested that the infants with low placental 11ssHSD2 activity were insufficient for adrenal maturity because they were dependent on their mothers in adrenal function.
Moreover, we were examined the impact of intrauterine infection (IUI) for neonatal adrenal function in 30 preemies with less than 30 weeks of gestational age. The adrenal fetal zone product (DHEA) for 1 and 2 weeks of life was high in infants with IUI, and the metabolites of cortisol were not difference regardless of IUI. It was suggested that IUI did not lead regression of adrenal fetal zone of neonates but the activity of hypothalamic-pituitary-adrenal axis was increased in infants with IUI.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (1 results)

All 2009

All Journal Article (1 results)

  • [Journal Article] 胎児・新生児期の副腎機能2009

    • Author(s)
      長屋建、藤枝憲二
    • Journal Title

      日本未熟児新生児学会誌 21

      Pages: 33-38

    • NAID

      10025626201

    • Related Report
      2010 Final Research Report 2009 Annual Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

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