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Cerebral oxygenation and hemodynamics in premature infant using near-infrared time-resolved spectroscopy

Research Project

Project/Area Number 20591299
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Embryonic/Neonatal medicine
Research InstitutionKagawa University

Principal Investigator

ISOBE Kenichi  香川大学, 医学部, 准教授 (00159815)

Co-Investigator(Kenkyū-buntansha) KUSAKA Takashi  香川大学, 医学部附属病院, 講師 (50274288)
KAWADA Kou  国立病院機構京都医療センター, 小児科, 医長 (40284369)
OKUBO Kensuke  おおくぼ小児科, 院長 (80335851)
KUBOI Tohru  東京都立小児総合医療センター, 総合周産期母子医療センター新生児科, 医員 (00437683)
NAKAMURA Shinji  香川大学, 医学部附属病院, 病院助教 (30437686)
KOYANO Kousuke  香川大学, 医学部附属病院, 病院助教 (20437685)
HISHIDA Tomoko  香川大学, 教育学部, 教授 (00243759)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords貧血 / 脳内酸素化状態 / 脳血液量 / 近赤外線分光法 / 時間分解分光装置 / 新生児未熟児 / 新生仔豚 / 新生児 / 未熟児 / 脳循環
Research Abstract

Anemia of prematurity is a common disease, particularly in very low birth weight infants, and transfusion is an important treatment. However, there is no clear evidence for the currently widely used transfusion criteria using the blood hemoglobin level (Hb) and hematocrit value (Ht). Thus, preparation of new transfusion criteria using an index other than the Hb and Ht has been attempted. We measured the cerebral Hb concentration, Hb oxygen saturation (ScO_2) and cerebral blood volume (CBV) in anemic animal model and infants with anemia of prematurity using time-resolved near-infrared spectroscopy (TRS). In animal study, we demonstrated that TRS method could be used to monitor the cerebral oxygenation and hemodynamics in the anemic neonates at the bedside. Thus, fifteen measurements were performed in 10 premature infants. CBV significantly decreased and ScO_2 significantly increased after transfusion. Measurement of CBV and ScO_2 is useful to investigate the necessity of transfusion.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (10 results)

All 2012 2011 2010 2008

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (7 results)

  • [Journal Article] Extrauterine environment influences spontaneous low-frequency oscillations in the preterm brain2012

    • Author(s)
      Kato I, Kusaka T, Nishida T, Koyano K, Nakamura S, Nakamura M, Konishi Y, Kunikata J, Jinnai W, Yasuda S, Okada H, Itoh S, Isobe K
    • Journal Title

      Brain Dev

      Volume: (in press)

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hemodynamic changes in the breast and frontal cortex of mother during breastfeeding2011

    • Author(s)
      Tanimoto K, Kusaka T, Nishida T, Ogawa K, Kato I, Ijichi S, Mikami J, Sobue I, Isobe K, Itoh S
    • Journal Title

      Pediatr Res

      Volume: 70 Pages: 400-405

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Functional lateralization of sensorimotor cortex in infants measured using multichannel near-infrared spectroscopy2011

    • Author(s)
      Kusaka T, Isobe K, Miki T, Ueno M, Koyano K, Nakamura S, Nishida T, Itoh S
    • Journal Title

      Pediatr Res

      Volume: 69 Pages: 430-435

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Presentation] 未熟児貧血における輸血療法時の脳血液量、脳内ヘモグロビン酸素飽和度の変化について2011

    • Author(s)
      小谷野耕佑、磯部健一他
    • Organizer
      第56回日本未熟児新生児学会
    • Place of Presentation
      東京
    • Year and Date
      2011-11-15
    • Related Report
      2010 Final Research Report
  • [Presentation] Cerebral blood volume in anemic piglets using near-infrared time-resolved spectroscopy2011

    • Author(s)
      Kosuke Koyano, Kenichi Isobe et al.
    • Organizer
      BRAIN' 11 & BRAINPET' 11
    • Place of Presentation
      Barcelona, Spain
    • Year and Date
      2011-05-27
    • Related Report
      2010 Final Research Report
  • [Presentation] The impact of blood transfusion on cerebral hemodynamics and oxygenation in anemic premature infants2011

    • Author(s)
      Kosuke Koyano, Kenichi Isobe et al.
    • Organizer
      BRAIN' 11 & BRAINPET' 11
    • Place of Presentation
      Barcelona, Spain
    • Year and Date
      2011-05-27
    • Related Report
      2010 Final Research Report
  • [Presentation] Changes in cerebral blood volume of piglets with acute anemia induced by partial blood exchange transfusion2010

    • Author(s)
      Kosuke Koyano, Kenichi Isobe et al.
    • Organizer
      The 6th Congress of Asian Society for Pediatric Research
    • Place of Presentation
      Taipei, Taiwan
    • Year and Date
      2010-04-16
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] Changes in cerebral blood volume of piglets with acute anemia induced by partial blood exchange transfusion2010

    • Author(s)
      Kenichi Isobe
    • Organizer
      The 6th Congress of Asian Society for Pediatric Research
    • Place of Presentation
      Taipei International Convention Center, Taiwan
    • Year and Date
      2010-04-16
    • Related Report
      2009 Annual Research Report
  • [Presentation] Effects of hemodilution on cerebral optical properties and hemodynamics in newborn piglets using near-infrared time-resolved spectroscopy2008

    • Author(s)
      Kenichi Isobe, et al.
    • Organizer
      ISOTT2008
    • Place of Presentation
      Sapporo, Japan
    • Year and Date
      2008-08-06
    • Related Report
      2010 Final Research Report
  • [Presentation] Effects of hemodilution on cerebral optical properties and hemodynamics in newborn piglets using near-infrared time-resolved spectroscopy2008

    • Author(s)
      Kenichi Isobe, et al.
    • Organizer
      ISOTT2008
    • Place of Presentation
      札幌
    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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