| Project/Area Number |
20591306
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Embryonic/Neonatal medicine
|
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| Research Institution | Juntendo University |
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Principal Investigator |
OKUMURA Akihisa Juntendo University, 医学部, 准教授 (60303624)
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| Co-Investigator(Kenkyū-buntansha) |
HAYAKAWA Masahiro 名古屋大学, 医学部附属病院, 講師 (40343206)
YAMAMOTO Toshiyuki 東京女子医科大学, 付置研究所, 准教授 (20252851)
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| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 新生児脳障害 / 胎児発育不全 / RNA発現 / 脂肪酸組成 / トロンボキサンA2 / ドコサヘキサエン酸 / 脳室周囲白質軟化症 / RNA発現解析 / 臍帯血 / リボゾーム蛋白 / エリスロポエチン / アンギオテンシン変換酵素 / P-セレクチン / 8-イソプロスタン |
|---|
| Research Abstract |
There were no significant differences in the cord blood levels of Tau protein, S-100B, 8OHdG, or MMP-9 between the preterm infants with and without periventricular leukomalacia. We examined the difference in mRNA expression in umbilical cord blood according to the presence or absence of periventricular leukomalacia. Five of the 15 up-regulated genes are coding ribosomal proteins, and another encodes a translation elongation factor. This may indicate an activation of lymphocytes during the fetal period. We examined the difference in mRNA expression in the cerebrum between fetal growth retardation model rats and control ones. Seventy-three genes were up-regulated in fetal growth retardation model rats, and 55 were down-regulated. We evaluated the effect of maternal docosahexaenoic acid-enriched diet on the brain of fetal growth retardation model rats. The percentage of docosahexaenoic acid was higher in the docosahexaenoic acid-enriched group than in the control group.
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