Research of the role of tenascin C in coronary development

• Project/Area Number: 20591310
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Embryonic/Neonatal medicine
• Research Institution: Tokyo Women's Medical University
• Principal Investigator: TOMITA Sachiko Tokyo Women's Medical University, 医学部, 助教 (40231451)
• Co-Investigator(Kenkyū-buntansha): YOSHIDA Kyoko 三重大学, 医学研究科, 准教授 (00242967)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 冠動脈 / 形態形成 / テネイシンC / 発生 / 血管形成 / 発達 / テネイシン

Research Abstract

Cells destined to form the coronary vasculature which supply oxygen and nutrients to the heart are thought to originate in the proepicardium. We examined an extracellular glycoprotein tenascin C in formation of the coronary stem and epithelial mesenchymal transformation of proepicardium-derived cells. Expression of tenascin C was seen in developing coronary stems and coronary smooth muscle cells. It is suggested that tenascin C facilitates the differentiation of proepicardium-derived cells into myofibroblast/smooth muscle cells, however, not induce the invasion/migration of the cells in vitro system.

Research Products

• [Journal Article] Effects of transforming growth factor-b3 and matrix metalloproteinase-3 on the pathogenesis of chronic mitral valvular disease in dogs (2011)
  • Author(s): Obayashi K, Miyagawa-Tomita S, Matsumoto H, Koyama H, Nakanishi T,Hirose H
  • Journal Title: Am J Vet Res 72 Pages: 194-202
  • Peer Reviewed
• [Journal Article] Tenascin C induces epithelial-mesenchymal transition-like change accompanied by SRC activation and focal adhesion kinase phosphorylation in human breast cancer cells (2011)
  • Author(s): Nagaharu K, Zhang X, Yoshida T, Katoh, D, Hanamura, N, Kozuka Y, Ogawa T, Shiraishi T, Imanaka-Yoshida K
  • Journal Title: Am J Pathol 178 Pages: 754-63
  • Peer Reviewed
• [Journal Article] Developmental defects of coronary vasculature in rat embryos administered bis-diamine (2011)
  • Author(s): Hanato T, Nakagawa M, Okamoto N, Nishijima S, Fujino H, Shimada M, Takeuchi Y, Imanaka-Yoshida K
  • Journal Title: Birth Defects Res B Dev Reprod Toxicol 92 Pages: 10-6
  • Peer Reviewed
• [Journal Article] 心筋炎 (2011)
  • Author(s): 今中恭子
  • Journal Title: 病理と臨床 29 Pages: 126-131
• [Journal Article] Effects of transforming growth factor-beta3 and matrix metalloproteinase-3 on the pathogenesis of chronic mitral valvular disease in dogs. (2011)
  • Author(s): Obayashi K, Miyagawa-Tomita S, Matsumoto H, Koyama H, Nakanishi T, Hirose H.
  • Journal Title: American Journal of Veterinary Research Volume: 72 Pages: 194-202
  • Peer Reviewed
• [Journal Article] Tenascin C induces epithelial-mesenchymal transition-like change accompanied by SRC activation and focal adhesion kinase phosphorylation in human breast cancer cells. (2011)
  • Author(s): Nagaharu K, Zhang X, Yoshida T, Katoh D, Hanamura N, Kozuka Y, Ogawa T, Shiraishi T, Imanaka-Yoshida, K.
  • Journal Title: Am J Pathol Volume: 178 Pages: 754-763
  • Peer Reviewed
• [Journal Article] Developmental defects of coronary vasculature in rat embryos administered bis-diamine. (2011)
  • Author(s): Hanato T, Nakagawa M, Okamoto N, Nishijima S, Fujino H, Shimada M, Takeuchi Y, Imanaka-Yoshida K.
  • Journal Title: Birth Defects Res B Dev Reprod Toxicol Volume: 92 Pages: 10-16
  • Peer Reviewed
• [Journal Article] 心筋炎 (2011)
  • Author(s): 今中恭子
  • Journal Title: 病理と臨床 Volume: 29 Pages: 126-131
• [Journal Article] Role of mesodermal FGF8 and FGF10 overlaps in the development of the arterial pole of the heart and pharyngeal arch arteries (2010)
  • Author(s): Watanabe Y, Miyagawa-Tomita S, Vincent SD, Kelly RG, Moon AM, Buckingham ME
  • Journal Title: Circ Res 106 Pages: 495-503
  • Peer Reviewed
• [Journal Article] Endothelin receptor Type A expression defines a distinct cardiac subdomain within the heart field and later implicated in chamber myocardium formation (2010)
  • Author(s): Asai R, Kurihara Y, Fujisawa K, Sato T, Kawamura Y, Kokubo H, Tonami K, Nishiyama K, Uchijima Y, Miyagawa-Tomita S, Kurihara H
  • Journal Title: Development 137 Pages: 3823-3833
  • Peer Reviewed
• [Journal Article] Tenascin-C enhances crosstalk signaling of integrin alphavbeta3/PDGFR-beta complex by SRC recruitment promoting PDGF-induced proliferation and migration in smooth muscle cells (2010)
  • Author(s): Ishigaki T, Imanaka-Yoshida K, Shimojo N, Matsushima S, Taki W, Yoshida T
  • Journal Title: J Cell Physiol 28(Epub head of prints)
  • Peer Reviewed
• [Journal Article] Dynamic expression of tenascin-C after myocardial ischemia and reperfusion : assessment by 125I-anti-tenascin-C antibody imaging (2010)
  • Author(s): Taki J, Inaki A, Wakabayashi H, Imanaka-Yoshida K, Ogawa K, Hiroe M, Shiba K, Yoshida T, Kinuya S
  • Journal Title: J Nucl Med 51 Pages: 1116-22
  • Peer Reviewed
• [Journal Article] テネイシンCの役割 (2010)
  • Author(s): 今中恭子
  • Journal Title: 総合臨床 59 Pages: 1725-1728
• [Journal Article] Tenascin-C may aggravate left ventricular remodeling and function after myocardial infarction in mice (2010)
  • Author(s): Nishioka T, Onishi K, Shimojo N, Nagano Y, Matsusaka H, Ikeuchi M, Ide T, Tsutsui H, Hiroe M, Yoshida T, Imanaka-Yoshida K
  • Journal Title: Am J Physiol Heart Circ Physiol 298
  • Peer Reviewed
• [Journal Article] Role of mesodermal FGF8 and FGF10 overlaps in the development of the arterial pole of the heart and pharyngeal arch arteries. (2010)
  • Author(s): Watanabe Y, Miyagawa-Tomita S, Vincent SD, Kelly RG, Moon AM, Buckingham ME.
  • Journal Title: Circulation Research Volume: 106 Pages: 495-503
  • Peer Reviewed
• [Journal Article] Endothelin receptor Type A expression defines a distinct cardiac sub-domain within the heart field and later implicated in chamber myocardium formation. (2010)
  • Author(s): Asai R, Kurihara Y, Fujisawa K Sato T, Kawamura Y, Kokubo H, Tonami K, Nishiyama K, Uchijima Y, Miyagawa-Tomita S, Kurihara H.
  • Journal Title: Development Volume: 137 Pages: 3823-3833
  • Peer Reviewed
• [Journal Article] Tenascin-C enhances crosstalk signaling of integrin alphavbeta3/PDGFR-beta complex by SRC recruitment promoting PDGF-induced proliferation and migration in smooth muscle cells. (2010)
  • Author(s): Ishigaki, T, Imanaka-Yoshida K, Shimojo N, Matsushima S, Taki W, Yoshida T.
  • Journal Title: J Cell Physiol. Volume: 28(Epub ahead of prints)
  • Peer Reviewed
• [Journal Article] Dynamic expression of tenascin-C after myocardial ischemia and reperfusion : assessment by 125I-anti-tenascin-C antibody imaging. (2010)
  • Author(s): Taki J, Inaki A, Wakabayashi H, Imanaka-Yoshida K, Ogawa K, Hiroe M, Shiba K, Yoshida T, Kinuya S.
  • Journal Title: J Nucl Med Volume: 51 Pages: 1116-1122
  • Peer Reviewed
• [Journal Article] テネイシンCの役割 (2010)
  • Author(s): 今中恭子
  • Journal Title: 総合臨床 Volume: 59 Pages: 1725-1728
• [Journal Article] Role of mesodermal FGF8 and FGF10 overlaps in the development of the arterial pole of the heart and pharyngeal arch arteries. (2010)
  • Author(s): Watanabe Y, Miyagawa-Tomita S, Vincent SD, Kelly RG, Moon AM, Buckingham ME
  • Journal Title: Circulation Research 106 Pages: 495-503
  • Peer Reviewed
• [Journal Article] Tenascin-C may aggravate left ventricular remodeling and function after myocardial infarction in mice. (2010)
  • Author(s): Nishioka T, Onishi K, Shimojo N, Nagano Y, Matsusaka H, Ikeuchi M, Ide T, Tsutsui H, Hiroe M, Yoshida T, Imanaka-Yoshida K.
  • Journal Title: Am J Physiol Heart Circ Physiol 298
  • Peer Reviewed
• [Journal Article] 冠血管の発生 (2009)
  • Author(s): 宮川-富田幸子、今中恭子
  • Journal Title: 細胞 14 Pages: 6-9
• [Journal Article] (2009)
  • Author(s): Shirai M, Imanaka-Yoshida K, Schneider MD, Schwartz RJ, Morisaki T
  • Journal Title: Proc Natl Acad Sci USA 106 Pages: 18604-18609
  • Peer Reviewed
• [Journal Article] 冠血管の発生 (2009)
  • Author(s): 宮川-富田幸子, ら
  • Journal Title: 細胞 14 Pages: 6-9
• [Journal Article] T-box 2, a mediator of Bmp-Smad signaling, induced hyaluronan synthase 2 and Tgfbeta2 expression and endocardial cushion formation. (2009)
  • Author(s): Shirai M, Imanaka-Yoshida K, Schneider MD, Schwartz RJ, Morisaki T.
  • Journal Title: Proc Natl Acad Sci U S A 106 Pages: 18604-9
  • Peer Reviewed
• [Journal Article] An FGF autocrine loop initiated in second heart field mesoderm regulates morphogenesis at the arterial pole of the heart (2008)
  • Author(s): Eon Joo Park, Watanabe Y, Smyth G, Miyagawa-Tomita S, Meyers E, Klingensmith J, Camenisch T, Buckingham M, Moon AM
  • Journal Title: Development 135 Pages: 3599-3610
  • Peer Reviewed
• [Journal Article] 心外膜原基由来細胞を制御するテネイシンCの検討 (2008)
  • Author(s): 宮川-富田幸子、杉村洋子、中西敏雄、今中-吉田恭子
  • Journal Title: 日本小児循環器学会誌 24 Pages: 20-28
  • Peer Reviewed
• [Journal Article] An FGF autocrine loop initiated in second heart field mesoderm regulates morphogenesis at the arterial pole of the heart (2008)
  • Author(s): Eon Joo Park, et al.
  • Journal Title: Development 135 Pages: 3599-3610
  • Peer Reviewed
• [Journal Article] 心外膜原基由来細胞を制御するテネイシンCの検討 (2008)
  • Author(s): 宮川-富田 幸子ら.
  • Journal Title: 日本小児循環器学会雑誌 24 Pages: 20-28
  • Peer Reviewed
• [Journal Article] Matricelular proteins-New molecular targets to prevent heart failure
  • Author(s): Okamoto H, Imanaka-Yoshida K
  • Journal Title: Cardiovasc.Ther. (in press)
  • Peer Reviewed
• [Journal Article] Tenascin C may regulate the recruitment of smooth muscle cells during coronary artery development
  • Author(s): Ando K, Takahashi M, Yamagishi T, Miyagawa-Tomita S, Imanaka-Yoshida K, Yoshida T, Nakajima Y
  • Journal Title: Differentiation (in press)
  • Peer Reviewed
• [Journal Article] Matricellular proteins-New molecular targets to prevent heart failure.
  • Author(s): Okamoto H, Imanaka-Yoshida K
  • Journal Title: Cardiovasc.Ther Volume: (in press)
  • Peer Reviewed
• [Journal Article] Tenascin C may regulate the recruitment of smooth muscle cells during coronary artery development
  • Author(s): Ando K, Takahashi M, Yamagishi T, Miyagawa-Tomita S, Imanaka-Yoshida K, Yoshida T, Nakajima Y.
  • Journal Title: Differentiation Volume: (in press)
  • Peer Reviewed
• [Presentation] 心臓形態形成・改変における細胞外マトリックスの役割-心臓を創り直す手がかり (2010)
  • Author(s): 今中恭子
  • Organizer: 心臓血管発生研究会、特別シンポジウム
  • Place of Presentation: 千葉
  • Year and Date: 2010-07-10
• [Presentation] 心臓形態形成・改変における細胞外マトリックスの役割-心臓を創り直す手がかり (2010)
  • Author(s): 今中恭子
  • Organizer: 心臓血管発生研究会
  • Place of Presentation: 千葉
  • Year and Date: 2010-07-10
• [Presentation] Tenascin-C may regulate recruitment of mural cells during coronary arterial development (2010)
  • Author(s): Imanaka-Yoshida K, Ando K, Yamagishi T, Yoshida T, Nakajima Y, Miyagawa-Tomita S
  • Organizer: Weinstein Cardiovascular Development Conference
  • Place of Presentation: Amsterdam, The Netherlands
• [Presentation] Tenascin C as a Target for Regulation of Cardiac Remodeling. Keystone Symposia (2010)
  • Author(s): 今中-吉田恭子
  • Organizer: Cardiovascular Development and Repair
  • Place of Presentation: Keystone, Colorado, USA
• [Presentation] Tenascin C may regulate recruitment of mural cells during coronary arterial development (2010)
  • Author(s): Imanaka-Yoshida K, Ando K, Yamagishi T, Yoshida T, Nakajima Y, Miyagawa-Tomita S.
  • Organizer: Weinstein Cardiovascular Development Conference
  • Place of Presentation: Amsterdam, Netherlands
• [Presentation] TGF-beta3 and MMP3 contribute to pathogenesis of myxomatous mitral valve in canine. (2010)
  • Author(s): Obayashi K, Miyagawa-Tomita S, Matsumoto H, Koyama H, Nakanishi T, Hirose H.
  • Organizer: Weinstein Cardiovascular Development Conference
  • Place of Presentation: Amsterdam, Netherlands
• [Presentation] Endothelin type-A receptor expression defines a distinct subdomain with in the crescent-forming heart field contributing to chamber myocardium. (2010)
  • Author(s): Asai R, Kurihara Y, Sato T, Kawamura Y, Kokubo H, Tonami K, Uchijima Y, Saga Y, Miyagawa-Tomita S, Kurihara H.
  • Organizer: Weinstein Cardiovascular Development Conference
  • Place of Presentation: Amsterdam, Netherlands
• [Presentation] The transcriptional repressor prdm1/blimp1 is required within the second heart field for the morphogenesis of the distal outflow tract. (2010)
  • Author(s): Vincent SD, Miyagawa-Tomita S, Buckingham M
  • Organizer: Weinstein Cardiovascular Development Conference
  • Place of Presentation: Amsterdam, Netherlands
• [Presentation] Hesr2 disrupted mice develop aortic valve disease with advancing age. (2010)
  • Author(s): Kokubo H, Miyagawa-Tomita S, Nakashima Y, Nakanishi T.
  • Organizer: 3^<rd> Congress of Asia-Pacific Cardiac Society
  • Place of Presentation: Chiba
• [Presentation] 成獣Hesr2ノックアウトマウスの心機能解析 (2010)
  • Author(s): 中罵八隅、宮川-富田幸子、富松宏文、中西敏雄、小久保博樹
  • Organizer: 第46回日本小児循環器学会
  • Place of Presentation: 千葉
• [Presentation] Endothelin type-A receptor expression defines a distinct subpopulation within the first heart field contributing to chamber myocardium (2010)
  • Author(s): 浅井理恵子、栗原由紀子、藤澤興、佐藤崇裕、河村悠美子、小久保博樹、磯波一夫、西山功一、内島泰信、宮川-富田幸子、栗原裕基
  • Organizer: 第33回日本分子生物学会
  • Place of Presentation: 神戸
• [Presentation] Tenascin C as a Target for Regulation of Cardiac Remodeling (2010)
  • Author(s): Imanaka-Yoshida, K.
  • Organizer: Keystone Symposia : Cardiovascular Development and Repair
  • Place of Presentation: Keystone, Colorado,アメリカ合衆国
• [Presentation] Endothelin type-A receptor expression defines a distinct subdomain within the first heart field contributing to chamber myocardium (2009)
  • Author(s): 浅井理恵子, 栗原由起子,佐藤宗裕,河村美子,小久保博樹,相賀裕美子,宮川-富田幸子, 栗原裕基
  • Organizer: 第32回日本分子生物学会
  • Place of Presentation: 神奈川
• [Presentation] Tenascin C regulates recruitment of smooth muscle cells during coronary arterial development (2009)
  • Author(s): Ando K, Yamagishi T, Miyagawa-Tomita S, Imanaka-Yoshida K, Yoshida T, Nakajima Y
  • Organizer: 49^<th> Ann Meeting of the American Society for Cell Biology(2012)(B391)
  • Place of Presentation: カリフォルニア、米国
• [Presentation] テネイシンCによる心臓血管新生の制御 (2009)
  • Author(s): 今中-吉田恭子,原万里,浪方美幸,レオンバルディビィアサライサベル,堰本晃代,吉田利通,宮川-富田幸子
  • Organizer: 第13回Molecular Cardiovascular Conference
  • Place of Presentation: 小樽
• [Presentation] Margaret Buckingham心臓円錐動脈幹と鰓弓動脈の発生における中胚葉性fgf8とfgf10の機能解析 (2009)
  • Author(s): 渡辺祐介, 宮川-富田幸子, Robert Kelly, Anne Moon
  • Organizer: 第8回心臓血管発生研究会
  • Place of Presentation: 福島
• [Presentation] 僧帽弁閉鎖不全症発症におけるTGFβ3およびMMP3の役割 (2009)
  • Author(s): 大林浩二,宮川-富田幸子,松本浩毅、小山秀一、廣瀬昶
  • Organizer: 日本臨床獣医学会(22)
  • Place of Presentation: 埼玉
• [Presentation] Endothelin typeA-receptor expression defines a distinct subpopulation within the first heart field contributing to chamber myocardium (2009)
  • Author(s): Asai R, Kurihara Y, Sato T,Kawamura Y,Kokubo H, Miyagawa-Tomita S
  • Organizer: 42^<nd> Ann Meet Jpn Soc Dev Biol
  • Place of Presentation: Nigata
• [Presentation] The transcriptional repressor prdm1/blimp1 is required within the second heart field for the morphogenesis of the distal outflow tract (2009)
  • Author(s): Vincent SD, Miyagawa-Tomita S, Buckingham M
  • Organizer: Weinstein Cardiovascular Developmental Conference
  • Place of Presentation: California, USA
• [Presentation] TGF-β3 and MMP3 contribute to pathogenesis of myxomatous mitral valve in canine (2009)
  • Author(s): Obayashi K, Miyagawa-Tomita S, Matsumoto H, Koyama H, Nakanishi T, Hirose H
  • Organizer: Weinstein Cardiovascular Developmental Conference, 148
  • Place of Presentation: California, USA
• [Presentation] Endothelin type-A receptor expression defines a distinct subdomain within the crescent-forming heart field contributing to chamber myocardium (2009)
  • Author(s): Asai R, Kurihara Y, Sato T, Kawamura Y, Kokubo H, Tonami K, Uchijima Y, Saga Y, Miyagawa-Tomita S, Kurihara H
  • Organizer: Weinstein Cardiovascular Developmental Conference
  • Place of Presentation: California, USA
• [Presentation] Tenascin-C expression and neural crest are associated with formation of the coronary orifice (2009)
  • Author(s): Miyagawa-Tomita S, Sugimura H, Tomimatsu H, Yoshida T, Nakanishi T, Imanaka-Yoshida K
  • Organizer: Weinstein Cardiovascular Developmental Conference
  • Place of Presentation: California, USA
• [Presentation] 僧帽弁閉鎖不全症発症におけるTGFbetaの役割 (2009)
  • Author(s): 大林浩二、宮川-富田幸子、松本浩毅、小山秀一、廣瀬昶
  • Organizer: 第147回日本獣医学会
  • Place of Presentation: 栃木
• [Presentation] 僧帽弁閉鎖不全症発症におけるTGFβの役割 (2009)
  • Author(s): 大林浩二、宮川-富田幸子, ら
  • Organizer: 第147回日本獣医学会
  • Place of Presentation: 栃木
• [Presentation] Tenascin-C expression and neural crest are associated with formation of the coronary orifice. (2009)
  • Author(s): Miyagawa-Tomita S, et al.
  • Organizer: Weinstein Cardiovascular Developmental Conference
  • Place of Presentation: カリフォルニア、米国
• [Presentation] Endothelin type-A receptor expression defines a distinct subdomain within the crescent-forming heart field contributing to chamber myocardium (2009)
  • Author(s): Asai R, et al.
  • Organizer: Weinstein Cardiovascular Developmental Conference
  • Place of Presentation: カリフォルニア、米国
• [Presentation] The transcriptional repressor prdml/blimpl is required within the second heart field for the morphogenesis of the dlstal outflow tract (2009)
  • Author(s): Vincent SD, Miyagawa-Tomita S, et al.
  • Organizer: Weinstein Cardiovascular Developmental Conference
  • Place of Presentation: カリフォルニア、米国
• [Presentation] Endothelin typeA-receptor expression defines a distinct subpopulation within the first heart field contributing to chamber myocardium. (2009)
  • Author(s): Asai R, et al.
  • Organizer: 42^<nd> Ann Meet Jpn Soc Dev Biol
  • Place of Presentation: 新潟
• [Presentation] 僧帽弁閉鎖不全症発症におけるTGFβ3およびMMP3の役割 (2009)
  • Author(s): 大林浩二、宮川-富田幸子, ら
  • Organizer: 日本臨床獣医学会
  • Place of Presentation: 埼玉
• [Presentation] 僧帽弁粘液腫様変性におけるTGFβの役割 (2009)
  • Author(s): 大林浩二、宮川-富田幸子, ら
  • Organizer: 第45回日本小児循環器学会
  • Place of Presentation: 神戸
• [Presentation] 心臓円錐動脈幹と鰓弓動脈の発生における中胚葉性fgf8とfgf10の機能解析 (2009)
  • Author(s): 渡辺祐介、宮川-富田幸子, ら
  • Organizer: 第8回心臓血管発生研究会
  • Place of Presentation: 福島
• [Presentation] Tenascin C regulates recruitment of smooth muscle cells during coronary arterial development. (2009)
  • Author(s): Ando K, et al.
  • Organizer: 49^<th> Ann Meeting of the American Society for Cell Biology
  • Place of Presentation: カリフォルニア、米国
• [Presentation] Endothelin type-A receptor expression defines a distinct subdomain within the first heart field contributing to chamber myocardium. (2009)
  • Author(s): 浅井理恵子, ら
  • Organizer: 第32回日本分子生物学会
  • Place of Presentation: 神奈川
• [Presentation] 鶏胚の心臓流出路におけるアポトーシスの検討 (2008)
  • Author(s): 吉岡朋子、宮川-富田幸子
  • Organizer: 第1回Tokyo Heart Development Club
  • Place of Presentation: 東京女子医科大学、東京
  • Year and Date: 2008-04-18
• [Presentation] Hesr2 knockout mice show calcification in the aortic valve (2008)
  • Author(s): Kokubo H, Miyagawa-Tomita S, Nakashima Y, Nakanishi T, Saga Y
  • Organizer: 31^<st> Mol Biol Soc Japan and 81^<st> Jpn Biochem Soc Meeting(2T22-1)(2P-1160)
  • Place of Presentation: Kobe, Japan
• [Presentation] Relationship the cardiac conduction system and endthelinA receptor-LacZ/EGFP expression cells in early cardiac development (2008)
  • Author(s): Asai R, Sato M, Kawamura Y, Miyagawa-Tomita S, Kurihara Y, Kurihara H
  • Organizer: 31^<st> Mol Biol Soc Japan and 81^<st> Jpn Biochem Soc Meeting(2P-0992)
  • Place of Presentation: Kobe, Japan
• [Presentation] Function of Histon H3-K9 methylase, G9 and GLP in cardiac development (2008)
  • Author(s): Inagawa K, Kojima M, Nakajima K, Miyagawa-Tomita S, Tachibana M, Managai Y, Takeuchi T
  • Organizer: 31^<st> Mol Biol Soc Japan and 81^<st> Jpn Biochem Soc Meeting(4P-0841)
  • Place of Presentation: Kobe, Japan
• [Presentation] 心臓形態形成におけるテネイシンCの役割 (2008)
  • Author(s): 原万里、浪方美幸、ポンセデレオンバルディビアサライサベル、堰本晃代、吉田利通、宮川-富田幸子、今中-吉田恭子
  • Organizer: 第30回心筋生検研究会(p-30)
  • Place of Presentation: 三重
• [Presentation] Hesr2欠損マウスは石灰化大動脈弁を示す (2008)
  • Author(s): 小久保博樹、宮川-富田幸子、中嶌八隅、中西敏雄、相賀裕美子
  • Organizer: 第30回心筋生検研究会(p-11)
  • Place of Presentation: 三重
• [Presentation] 鳥類モデルを用いた冠動脈血管新生の解析 (2008)
  • Author(s): 宮川-富田幸子、杉村洋子、富松宏文、中西敏雄
  • Organizer: 第30回心筋生検研究会(シンポジウム5)
  • Place of Presentation: 三重
• [Presentation] Role of Fgf8 and Fgf10 during second heart field and pharyngeal arch artery development (2008)
  • Author(s): Watanabe Y, Miyagawa-Tomita S, Park EJ, Kelly R, Moon A, Buckingham M
  • Organizer: Frontiers in Developmental Biology
  • Place of Presentation: Giens, France
• [Presentation] Relationship the cardiac conduction sytem and endthelin A receptor-LacZ/EGFP expression cells in early cardiac development (2008)
  • Author(s): Asai R, Sato M, Kawamura Y, Miyagawa-Tomita S, Kurihara Y, Kurihara H
  • Organizer: Frontiers in Developmental Biology
  • Place of Presentation: Giens, France
• [Presentation] hesr2ノックアウトマウスに認められる大動脈弁石灰化 (2008)
  • Author(s): 小久保博樹、宮川-富田幸子、中嶌八隅、中西敏雄、相賀裕美子
  • Organizer: 第7回心臓血管発生研究会、12
  • Place of Presentation: 福島
• [Presentation] TGF-betaの僧帽弁編成における役割 (2008)
  • Author(s): 大林浩二、宮川-富田幸子
  • Organizer: 第7回心臓血管発生研究会、11
  • Place of Presentation: 福島
• [Presentation] 心臓形態形成におけるテネイシンCの役割 (2008)
  • Author(s): 原万里、波方美幸、Ponse de Leon BSI, 堰本晃代、吉田利通、宮川-富田幸子、今中-吉田恭子
  • Organizer: 第7回心臓血管発生研究会、10
  • Place of Presentation: 福島
• [Presentation] 心臓発生初期におけるendthelinA受容体-LacZ/EGFP発現細胞と刺激伝導系の関連 (2008)
  • Author(s): 浅井理恵子、佐藤崇裕、河村悠美子、宮川-富田幸子、栗原由紀子、栗原裕基
  • Organizer: 第7回心臓血管発生研究会、5
  • Place of Presentation: 福島
• [Presentation] ワークショップ、心臓刺激伝導系の発生-最近のトピックス- (2008)
  • Author(s): 宮川-富田幸子
  • Organizer: 第7回心臓血管発生研究会
  • Place of Presentation: 福島
• [Presentation] Hesr2 disrupted mice develop dysfunction of the semilunar valve with age (2008)
  • Author(s): Kokubo H, Miyagawa-Tomita S, Saga Y
  • Organizer: 44^<th> Ann Meeting Jpn Soc Ped, I-D-19
  • Place of Presentation: Fukushima, Japan
• [Presentation] 冠動脈開口部形成には心臓神経堤細胞が関与する (2008)
  • Author(s): 宮川-富田幸子
  • Organizer: シンポジウム"心臓血管発生:先天性心疾患予防へ向けて"第44回日本小児循環器学会
  • Place of Presentation: 福島
• [Presentation] Fgf autocrine loop initiated in second heart field mesoderm regulates morphogenesis at the arterial pole of the heart (2008)
  • Author(s): Park EJ, Watanabe Y, Smyth G, Miyagawa-Tomita S, Meyers EN, Klingensmith J, Camenisch T, Buckingham M, Moon AM
  • Organizer: Weinstein Cardiovascular Development Conference, 9
  • Place of Presentation: Houston, Texas, USA
• [Presentation] Role of Fgf8 and Fgf10 during second heart field and pharyngeal arch artery development (2008)
  • Author(s): Watanabe Y, Miyagawa-Tomita S, Park EJ, Kelly R, Moon A, Buckingham M
  • Organizer: Weinstein Cardiovascular Development Conference, 180
  • Place of Presentation: Houston, Texas, USA
• [Presentation] Tenascin-C may play a significant role in maturation of coronary arteries in mouse (2008)
  • Author(s): Imanaka-Yoshida K, Hara M, Namikata M, Yoshida T, Schwartz RJ, Miyagawa-Tomita S
  • Organizer: Weinstein Cardiovascular Development Conference,97
  • Place of Presentation: Houston, Texas, USA
• [Presentation] Neural crest and proepicardial cells contribute to formation of the coronary orifice with Tenascin-C (2008)
  • Author(s): Miyagawa-Tomita S, Sugimura H, Nakanishi Toshio, Imanaka-Yoshida K
  • Organizer: Weinstein Cardiovascular Development Conference,148
  • Place of Presentation: Houston, Texas, USA
• [Presentation] Role of Fgf signaling during anterior heart field and pharyngeal arch artery development (2008)
  • Author(s): Watanabe Y, Miyagawa-Tomita S, Robert GK, Moon A, Buckingham M
  • Organizer: HeartRepair 2^<nd> Annual Meeting
  • Place of Presentation: Madrid, Spain
• [Presentation] 冠動脈開口部形成には心臓神経堤細胞が関与する (2008)
  • Author(s): 宮川-富田 幸子ら
  • Organizer: 日本小児循環器学会
  • Place of Presentation: 福島
• [Presentation] 鳥類モデルを用いた冠動脈血管新生の解析 (2008)
  • Author(s): 宮川-富田 幸子ら
  • Organizer: 第30回心筋生検研究会
  • Place of Presentation: 三重
• [Book] Annual Review循環器(山口徹他編集)(心臓発生と心筋分化誘導のマスター因子) (2011)
  • Author(s): 竹内純、宮川-富田幸子、笹岡陽介、小柴和子
  • Total Pages: 365
  • Publisher: 中外医学社
• [Book] Annual Review循環器(山口徹他編集)(細胞外マトリックス調節因子) (2011)
  • Author(s): 今中恭子
  • Total Pages: 365
  • Publisher: 中外医学社
• [Book] Annual Review循環器(山口徹、高本真一、小室一成、佐地勉編) (2011)
  • Author(s): 竹内純、宮川-富田幸子、笹岡陽介、小柴和子
  • Publisher: 中外医学社(心臓発生と心筋分化誘導のマスター因子(分担))
• [Book] Annual Review循環器(山口徹、高本真一、小室一成、佐地勉編) (2011)
  • Author(s): 今中恭子
  • Publisher: 中外医学社(細胞外マトリックス調節因子(分担))
• [Book] Dogs and Cats 犬と猫の診療指針(Clinical Veterinary Advisor クリニカルベテリナリーアドバイザー) (2010)
  • Author(s): Etienne Cote監修、長谷川篤彦監訳
  • Total Pages: 1851
  • Publisher: Mosby (Elsevier) interzoo発行 Mosby Elsevier Inc.