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Redox regulating system and its application for neonatal chronic lung disease in mice

Research Project

Project/Area Number 20591311
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Embryonic/Neonatal medicine
Research InstitutionResearch Institute, Osaka Medical Center for Maternal and Child Health

Principal Investigator

YANAGIHARA Itaru  Research Institute, Osaka Medical Center for Maternal and Child Health (60314415)

Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords新生児慢性肺疾患 / レドックス / ウレアプラズマ / 早産
Research Abstract

Ureaplasma spp. is detected in the urogenital tract, including the vagina, cervix, chorioamnion, and placenta. Their colonization is associated with histologic chorioamnionitis (CAM). In this study, pathologic examinations of 151 placentas delivered at <32 wk of gestation were performed. Among 151 placentas, 42% (63/151) were culture positive for Ureaplasma spp. Colonization by Ureaplasma spp. was an independent risk factor for CAM (OR, 11.27 ; 95% CI, 5.09 -24.98).

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (62 results)

All 2011 2010 2009 2008 Other

All Journal Article (24 results) (of which Peer Reviewed: 18 results) Presentation (33 results) Remarks (3 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Silica and titanium dioxide nanoparticles cause pregnancy complications in mice.2011

    • Author(s)
      Yamashita K, Yanagihara I, Tsutsumi Y, et al.
    • Journal Title

      Nat Nanotechnol. 6(5)

      Pages: 321-8

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Silica and titanium dioxide nanoparticles cause pregnancy complications in mice.2011

    • Author(s)
      Yamashita K, et al.
    • Journal Title

      Nat Nanotechnol.

      Volume: 6(5) Pages: 321-8

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of TCR Vγ2 gene rearrangement by the helix-loop-helix protein, E2A.2011

    • Author(s)
      Nozaki M, et al.
    • Journal Title

      Int Immunol.

      Volume: 23(5) Pages: 297-305

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relationship between heat-induced fibrillogenicity and hemolytic activity of thermostable direct hemolysin and a related hemolysin of Vibrio parahaemolyticus.2011

    • Author(s)
      Ohnishi K, et al.
    • Journal Title

      FEMS Microbiol Lett.

      Volume: 318(1) Pages: 10-17

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Polymorphisms in the annexin A5 gene promoter in Japanese women with recurrent pregnancy loss.2011

    • Author(s)
      Miyamura H, et al.
    • Journal Title

      Mol Hum Reprod.

      Volume: (In press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structure and functional characterization of Vibrio parahaemolyticus thermostable direct hemolysin.2010

    • Author(s)
      Yanagihara I, Nakahira K, Honda T, et al.
    • Journal Title

      J Biol Chem. 285(21)

      Pages: 16267-74

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Placental features of chorioamnionitis colonized with Ureaplasma species in preterm delivery.2010

    • Author(s)
      Namba F, Hasegawa T, Yanagihara I, et al.
    • Journal Title

      Pediatr Res. 67(2)

      Pages: 166-72

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Birth length is a predictor of adiponectin levels in Japanese young children.2010

    • Author(s)
      Nishihara M, Yanagihara I, Waguri M, et al.
    • Journal Title

      J Pediatr Endocrinol Metab. 23

      Pages: 913-920

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Birth length is a predictor of adiponectin levels in Japanese young children.2010

    • Author(s)
      Nishihara M, et al.
    • Journal Title

      J Pediatr Endocrinol Metab.

      Volume: 23(9) Pages: 913-920

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cytoskeleton-modulating effectors of enteropathogenic and enterohemorrhagic Escherichia coli : a case for EspB as an intrinsically less-ordered effector.2010

    • Author(s)
      Hamada D, et al.
    • Journal Title

      FEBS J.

      Volume: 277(11) Pages: 2409-2415

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structure and functional characterization of Vibrio parahaemolyticus thermostable direct hemolysin.2010

    • Author(s)
      Yanagihara I, et al.
    • Journal Title

      J Biol Chem.

      Volume: 285(21) Pages: 16267-16274

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transcriptional regulation of the human establishment of cohesion 1 homolog 2 gene.2010

    • Author(s)
      Nishihara M, et al.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 393(1) Pages: 111-117

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Placental features of chorioamnionitis colonized with Ureaplasma species in preterm delivery.2010

    • Author(s)
      Namba F, Hasegawa T, et al.
    • Journal Title

      Pediatr Res.

      Volume: 67(2) Pages: 166-172

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Placental features of chorioamnionitis colonized with Ureaplasma species in preterm delivery.2010

    • Author(s)
      Namba F, Hasegawa T, Nakayama M, Hamanaka T, Yamashita T, Nakahira K, Kimoto A, Nozaki M, Nishihara M, Mimura K, Yamada M, Kitajima H, Suehara N, Yanagihara I.
    • Journal Title

      Pediatr Res. 67(2)

      Pages: 166-72

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transcriptional regulation of the human establishment of cohesion 1 homolog 2 gene.2010

    • Author(s)
      Nishihara M, Yamada M, Nozaki M, Nakahira K, Yanagihara I.
    • Journal Title

      Biochem Biophys Res Commun. 393(1)

      Pages: 111-7

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structure and functional characterization of Vibrio parahaemolyticus thermostable direct hemolysin(TDH).2010

    • Author(s)
      Yanagihara I, Nakahira K, Yamane T, Kaieda S, Mayanagi K, Hamada D, Fukui T, Ohnishi K, Kajiyama S, Shimizu T, Sato M, Ikegami T, Ikeguchi M, Honda T, Hashimoto H.
    • Journal Title

      J Biol Chem. Mar 24(In press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 胎内感染と流早産・新生児合併症2008

    • Author(s)
      柳原格、下屋浩一郎
    • Journal Title

      日本周産期・新生児医学会雑誌 44(4)

      Pages: 1032-3

    • Related Report
      2010 Final Research Report
  • [Journal Article] 妊婦及び早産児からのウレアプラズマ属細菌の分離培養2008

    • Author(s)
      柳原格
    • Journal Title

      日本産婦人科感染症研究会会誌 24

      Pages: 41-5

    • Related Report
      2010 Final Research Report
  • [Journal Article] Molecular basis of actin reorganization promoted by binding of enterohaemorrhagic Escherichia coli EspB to alpha-catenin2008

    • Author(s)
      Hamaguchi M, Hamada D, Suzuki KN, Sakata I, Yanagihara I.
    • Journal Title

      FEBS J 275

      Pages: 6260-6267

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of an amyloidogenic sequence attached to yellow fluorescent protein. Proteins2008

    • Author(s)
      Hamada D, Tsumoto K, Sawara M, Tanaka N, Nakahira K, Shiraki K. Yanagihara I.
    • Journal Title

      Proteins 72

      Pages: 811-821

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 子宮内感染/炎症と抗アネキシンA2 IgM抗体2008

    • Author(s)
      難波文彦, ほか
    • Journal Title

      小児科 49

      Pages: 989-994

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 妊婦及び早産児からのウレアプラズマ属細菌の分離培養2008

    • Author(s)
      柳原格
    • Journal Title

      日本産婦人科感染症研究会 24

      Pages: 41-45

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 「胎内感染と流早産・新生児合併症」座長のまとめ2008

    • Author(s)
      柳原格、下屋浩一郎
    • Journal Title

      日本周産期・新生児医学会会誌 44

      Pages: 1032-1033

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 当センターにおける超早産児からのウレアプラズマ属細菌の検出頻度とその臨床背景2008

    • Author(s)
      白石淳, ほか
    • Journal Title

      近畿新生児研究会 17

      Pages: 31-35

    • Related Report
      2008 Annual Research Report
  • [Presentation] 腸管出血性大腸菌の産するEspBのα-カテニン結合をかいしたアクチン再構成の分子機構2010

    • Author(s)
      浜口満英、浜田大三、鈴木香代、坂田育弘、柳原格
    • Organizer
      第56回日本生化学会近畿支部例会
    • Place of Presentation
      大阪
    • Year and Date
      2010-07-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] ウレアプラズマ感染早産胎盤における絨毛膜羊膜炎の病理像2010

    • Author(s)
      柳原格, 他
    • Organizer
      近畿腸管微生物研究会
    • Place of Presentation
      大阪
    • Year and Date
      2010-06-05
    • Related Report
      2010 Annual Research Report
  • [Presentation] LPS誘導性早産モデルマウスに対するチオレドキシンの有効性2010

    • Author(s)
      柳原格
    • Organizer
      京都大学ウイルス研究所ミニシンポジウムレドックス生命医科学の展望(ATL Allergy TRX)
    • Place of Presentation
      京都、招待講演
    • Year and Date
      2010-03-15
    • Related Report
      2010 Final Research Report
  • [Presentation] LPS誘導性早産モデルマウスに対するチオレドキシンの有効性2010

    • Author(s)
      柳原格
    • Organizer
      京都大学ウイルス研究所ミニシンポジウムレドックス生命医科学の展望:ATL Allergy TRX
    • Place of Presentation
      京都
    • Year and Date
      2010-03-15
    • Related Report
      2009 Annual Research Report
  • [Presentation] The pathological findings and molecular mechanisms of Ureaplasma spp. infection in preterm delivery2010

    • Author(s)
      柳原格
    • Organizer
      7^<th> European Society for Infectious Diseases in Obstetrics and Gynaecology (ESIDOG)
    • Place of Presentation
      Trieste, Italy, Invited
    • Related Report
      2010 Final Research Report
  • [Presentation] ウレアプラズマ感染-流早産そして次世代への影響-2010

    • Author(s)
      柳原格
    • Organizer
      第37回日本マイコプラズマ学会
    • Place of Presentation
      東京、シンポジスト
    • Related Report
      2010 Final Research Report
  • [Presentation] 腸炎ビブリオの産生するthermostable direct hemolysin(TDH)の構造学的解析2010

    • Author(s)
      柳原格, 他
    • Organizer
      第57回トキシンシンポジウム
    • Place of Presentation
      大津
    • Related Report
      2010 Annual Research Report
  • [Presentation] ウレアプラズマ感染-流早産そして次世代への影響-2010

    • Author(s)
      柳原格
    • Organizer
      第37回日本マイコプラズマ学会
    • Place of Presentation
      東京
    • Related Report
      2010 Annual Research Report
  • [Presentation] 妊娠マウスを用いたUreaplasma parvum由来multiple banded antigen(MBA)による胎内炎症惹起機構の解明2010

    • Author(s)
      内田薫, 他
    • Organizer
      第37回日本マイコプラズマ学会
    • Place of Presentation
      東京
    • Related Report
      2010 Annual Research Report
  • [Presentation] 妊娠マウスを用いたUreaplasma parvumによる胎内炎症惹起機構の解明を目指して2010

    • Author(s)
      内田薫, 他
    • Organizer
      第46回日本周産期・新生児医学会総会
    • Place of Presentation
      神戸
    • Related Report
      2010 Annual Research Report
  • [Presentation] 当センターの原因不明不育症患者における1st trimester流産検体の病理学的所見の分類2010

    • Author(s)
      味村和也, 他
    • Organizer
      第46回日本周産期・新生児医学会総会
    • Place of Presentation
      神戸
    • Related Report
      2010 Annual Research Report
  • [Presentation] 胎児消化管におけるサーファクタント蛋白質AとDの局在と産生に関する検討2010

    • Author(s)
      奥山宏臣, 他
    • Organizer
      第46回日本周産期・新生児医学会総会
    • Place of Presentation
      神戸
    • Related Report
      2010 Annual Research Report
  • [Presentation] Lipopolysaccharide(LPS)誘発早産モデルマウスにおけるチオレドキシン(TRX)の早産抑制効果2010

    • Author(s)
      野崎昌俊, 他
    • Organizer
      第46回日本周産期・新生児医学会総会
    • Place of Presentation
      神戸
    • Related Report
      2010 Annual Research Report
  • [Presentation] bHLH転写因子E2AによるVγ2遺伝子再構成の制御機構2010

    • Author(s)
      野崎昌俊, 他
    • Organizer
      第20回Kyoto T cell Conference
    • Place of Presentation
      オーラル
    • Related Report
      2010 Annual Research Report
  • [Presentation] アネキシンA5遺伝子多型と習慣流産の関連2010

    • Author(s)
      宮村浩徳, 他
    • Organizer
      第55回日本人類遺伝学会総会
    • Place of Presentation
      大宮
    • Related Report
      2010 Annual Research Report
  • [Presentation] Structural study of thermostable direct hemolysin from Vibrio parahaemolyticus2010

    • Author(s)
      Hiroshi Hashimoto, et al.
    • Organizer
      日本生物物理学会総会
    • Place of Presentation
      仙台
    • Related Report
      2010 Annual Research Report
  • [Presentation] Regulation of Vγ2 gene rearrangement by the helix-loop-helix protein, E2A2010

    • Author(s)
      Masatoshi Nozaki, et al.
    • Organizer
      14^<th> International Congress of Immunology
    • Place of Presentation
      神戸
    • Related Report
      2010 Annual Research Report
  • [Presentation] The pathological findings and molecular mechanisms of Ureaplasma spp.infection in preterm delivery2010

    • Author(s)
      Itaru Yanagihara
    • Organizer
      7^<th> European Society for Infectious Diseases in Obstetrics and Gynaecology (ESIDOG)
    • Place of Presentation
      Trieste, Italy
    • Related Report
      2010 Annual Research Report
  • [Presentation] The mRNA expression of fatty acid amide hydrolase in human whole blood may correlate with recovery in patients with sepsis2010

    • Author(s)
      Mitsuhide Hamaguchi, et al.
    • Organizer
      第38回日本救急医学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2010 Annual Research Report
  • [Presentation] 習慣流産におけるアネキシンA5遺伝子多型の検討2010

    • Author(s)
      太田小百合, 他
    • Organizer
      第33回日本分子生物学会年会、第83回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Related Report
      2010 Annual Research Report
  • [Presentation] 大阪府立母子保健総合医療センターにおける感染性早産制御に向けた試み2010

    • Author(s)
      柳原格、難波文彦、北島博之、中山雅弘、藤村正哲
    • Organizer
      第112回日本小児科学会
    • Place of Presentation
      奈良
    • Related Report
      2009 Annual Research Report
  • [Presentation] Thioredoxin-1 prevents LPS-induced preterm delivery in mouse model.(5165.2)2010

    • Author(s)
      Namba Fumihiko, Mikiko Kobayashi-Miura, Junji Yodoi, Itaru Yanagihara
    • Organizer
      Pediatric Academic Societies Annual Meeting 2009
    • Place of Presentation
      Baltimore, USA
    • Related Report
      2009 Annual Research Report
  • [Presentation] ウレアプラズマ属による組織学的絨毛膜羊膜炎-特徴的胎盤病理像とその詳細-2010

    • Author(s)
      野崎昌俊、難波文彦、中山雅弘、白石淳、濱中拓郎、西原正泰、北島博之、末原則幸、柳原格
    • Organizer
      第45回日本周産期・新生児医学会学術集会
    • Place of Presentation
      名古屋
    • Related Report
      2009 Annual Research Report
  • [Presentation] Roberts症候群モデルメダカの作製と表現型の解2010

    • Author(s)
      森田明広、長谷川妙子、中平久美子、谷口善仁、武田俊一、近藤寿人、豊田敦、榊佳之、島田敦子、武田洋幸、柳原格
    • Organizer
      日本動物学会第80回大会
    • Place of Presentation
      静岡
    • Related Report
      2009 Annual Research Report
  • [Presentation] Analysis of tetrameric structure of TDH2010

    • Author(s)
      Itaru Yanagihara, Kumiko Nakahira, Hiroshi Hashimoto, Kiyouhisa Ohnishi, Akihiro Morita, Takeshi Honda
    • Organizer
      44^<th> US-Japan Cooperative Medical Science Program, Cholera and Other Bacterial Enteric Infections
    • Place of Presentation
      San Diego, CA, USA
    • Related Report
      2009 Annual Research Report
  • [Presentation] 腸炎ビブリオの産生するTDHの構造学的解析2010

    • Author(s)
      柳原格、中平久美子、大西紀陽久、本田武司
    • Organizer
      第83回日本細菌学会総会
    • Place of Presentation
      横浜
    • Related Report
      2009 Annual Research Report
  • [Presentation] 大阪府立母子保健総合医療センターにおける感染性早産制御に向けた試み2009

    • Author(s)
      柳原格、難波文彦、北島博之、中山雅弘、藤村正哲
    • Organizer
      第112回日本小児科学会
    • Place of Presentation
      奈良、オーラル
    • Related Report
      2010 Final Research Report
  • [Presentation] Analysis of tetrameric structure of TDH2009

    • Author(s)
      Yanagihara I, Honda T, et al.
    • Organizer
      44^<th> US-Japan Cooperative Medical Science Program.
    • Place of Presentation
      San Diego, CA, USA, Invited
    • Related Report
      2010 Final Research Report
  • [Presentation] Pathway group meeting2008

    • Author(s)
      Yanagihara I
    • Organizer
      WHO Preterm Birth International Collaboretive
    • Place of Presentation
      Geneva, Switzerland
    • Year and Date
      2008-04-21
    • Related Report
      2008 Annual Research Report
  • [Presentation] WHO Preterm Birth International Collaborative Meeting.2008

    • Author(s)
      柳原格
    • Organizer
      Pathway Group
    • Place of Presentation
      Geneva, Switzerland, Invited
    • Related Report
      2010 Final Research Report
  • [Presentation] Anti-annexin A2 IgM antibody in preterm infants : Its association with chorioamnionitis2008

    • Author(s)
      Namba F, et al
    • Organizer
      Pediatric Academic Societies Annual Meeting
    • Place of Presentation
      Hawaii, USA
    • Related Report
      2008 Annual Research Report
  • [Presentation] Placental Features of Chorioamnionitis Colonized With Ureaplasma Species in Preterm Delivery2008

    • Author(s)
      Namba F, et al
    • Organizer
      15^<th> Congress of Federation of Asia and Oceania Perinatal Societies
    • Place of Presentation
      Nagoya
    • Related Report
      2008 Annual Research Report
  • [Presentation] Analysis of Tetrameric Structure of TDH2008

    • Author(s)
      Yanagihara I, et al
    • Organizer
      US-Japan cooperative Medical Science Program
    • Place of Presentation
      Fukuoka
    • Related Report
      2008 Annual Research Report
  • [Remarks] ホームページ

    • URL

      http://www.med.osaka-u.ac.jp/pub/inst-mch/IM/mysite2/index.html

    • Related Report
      2010 Final Research Report
  • [Remarks]

    • URL

      http://www.med.osaka-u.ac.jp/pub/inst-mch/IM/mysite2/index.html

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.med.osaka-u.ac.jp/pub/inst-mch/IM/mysite2/index.html

    • Related Report
      2009 Annual Research Report
  • [Patent(Industrial Property Rights)] 母体投与用薬剤2008

    • Inventor(s)
      淀井淳司、三浦美樹子、柳原格、難波文彦、中平久美子
    • Industrial Property Rights Holder
      レドックスバイオサイエンス社、淀井淳司、三浦美樹子、柳原格、難波文彦、中平久美子
    • Filing Date
      2008-10-07
    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] 母体投与用薬剤2008

    • Inventor(s)
      淀井淳司, 三浦美樹子, 柳原格, 難波文彦, 中平久美子
    • Industrial Property Rights Holder
      レドックス・バイオサイエンス社(出願人)
    • Industrial Property Number
      2008-261081
    • Filing Date
      2008-10-07
    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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