Analyses of suppressive effect of Raf kinase inhibitor protein on cutaneous squamous cell carcinoma progression, and consideration for therapeutic use.

• Project/Area Number: 20591313
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Dermatology
• Research Institution: Hirosaki University
• Principal Investigator: ROKUNOHE Daiki Hirosaki University, 医学部・附属病院, 助手 (50436036)
• Co-Investigator(Kenkyū-buntansha): NAKANO Hajime 弘前大学, 大学院・医学研究科, 准教授 (90281922) ; MATSUZAKI Yasushi 弘前大学, 医学部附属病院, 講師 (50322946)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 皮膚腫瘍 / シグナル伝達 / 細胞増殖 / 分化 / 転移 / 癌 / 分子生物学 / MAPキナーゼ / RNAi

Research Abstract

In well-and moderately-differentiated SCCs, RKIP was broadly and strongly stained in the tumor nests, and RKIP staining was stronger in the keratinizing tumor cells. On the other hand, RKIP staining was only weak or negative in poorly-differentiated SCCs. These results suggest that RKIP is associated with differentiation of cutaneous SCC and assessing RKIP expression may yield important information to the prognosis of the cutaneous SCC patients.

Research Products

• [Journal Article] Raf kinase inhibitor protein expression correlates with differentiation but not with ERK phosphorylation in cutaneous squamous cell carcinoma. (2010)
  • Author(s): Rokunohe D, Nakano H, Akasaka E, Kimura K, Takiyoshi N, Nakajima K, Aizu T, Kaneko T, Matsuzaki Y, Tsuchida S, Sawamura D
  • Journal Title: J Dermatol Sci. 60 Pages: 199-201
  • NAID: 10027841189
  • Peer Reviewed
• [Journal Article] Raf kinase inhibitor protein expression correlates with differe ntiation but not with ERK phosphorylation in cutaneous squamous cell carcinoma. (2010)
  • Author(s): Rokunohe D, Nakano H, et al.
  • Journal Title: Journal of Dermatological Science Volume: 60 Pages: 199-201
  • Peer Reviewed
• [Presentation] Raf kinase inhibitor protein expression correlate with differentiation without affecting the MAPK pathway activity in cutaneous SCC. (2009)
  • Author(s): 六戸大樹
  • Organizer: The 34^<th> annual meeting of the Japanese Society for Investigative Dermatology.
  • Place of Presentation: Fukuoka
• [Presentation] 古典的MAPキナーゼ抑制タンパクRKIPの皮膚有棘細胞癌における役割 (2009)
  • Author(s): 六戸大樹
  • Organizer: 第25回日本皮膚悪性腫瘍学会学術大会
  • Place of Presentation: 岡山市
• [Presentation] Raf kinase inhibitor protein expression correlate with differentiation without affecting the MAPK pathway activity in cutaneous SCC (2009)
  • Author(s): 六戸大樹
  • Organizer: The 34th Annual Meeting of the Japanese Society for Investigative Dermatology
  • Place of Presentation: 福岡市
• [Presentation] 古典的MAPキナーゼ抑制タンパクRKIPの皮膚有棘細胞癌における役割 (2009)
  • Author(s): 六戸大樹
  • Organizer: 第25回 日本皮膚悪性腫瘍学会学術大会
  • Place of Presentation: 岡山市
• [Presentation] 古典的MAPキナーゼ抑制タンパクRKIPの皮膚有棘細胞癌における役割 (2008)
  • Author(s): 六戸大樹
  • Organizer: 第15回分子皮膚科学フォーラム
  • Place of Presentation: 京都
  • Year and Date: 2008-11-15