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Regulation mechanism in keratinocyte growth and differentiation by p53 homologue p51/p63 and Maf

Research Project

Project/Area Number 20591314
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Dermatology
Research InstitutionTohoku University

Principal Investigator

OKUYAMA Ryuhei  Tohoku University, 医学部, 教授 (80292332)

Co-Investigator(Renkei-kenkyūsha) IKAWA Shuntaro  東北大学, 加齢医学研究所, 准教授 (50241576)
OGAWA EISAKU  信州大学, 医学部, 助授 (20451586)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords表皮細胞 / p51 / p63 / シグナル伝達 / デスモプラキン / 乾癬 / p51/p63 / Desmoplakin / Perp / Bach
Research Abstract

p51/p63, a homologue of p53 tumor suppressor, is well known to play a role in oncogenesis. Simultaneously, p51/p63 promotes development of cellular characters specific for squamous cells, such as keratinocytes. Contrast to p51/p63, TGFβ suppresses these cellular characters as squamous cells, which leads to induction of cellular functions specific for mesenchymal cells. We focused on desmoplakin, calcium-dependent homophilic adhesion molecule, because the desmoplakin is a unique molecule in squamous cells. We found that desmoplakin expression is increased by p51/p63 whereas it is decreased by TGFβ.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (75 results)

All 2011 2010 2009 2008 Other

All Journal Article (43 results) (of which Peer Reviewed: 26 results) Presentation (21 results) Book (11 results)

  • [Journal Article] Dual odidase 1(DUOX1) induced by Th2 cytokines promotes STAT6 phosphoylation via oxidative inactivation of PTP1B in human epidermal keratinocytes.2011

    • Author(s)
      Hirakawa S, Saito R, Ohara H, Okuyama R, Aiba S.
    • Journal Title

      J Immunol 186

      Pages: 4672-4770

    • Related Report
      2010 Final Research Report
  • [Journal Article] Epidermal FABP (FABP5) regulates keratinocyte differentiation via 13(S)-HODE-mediated activation of the NF-kB signaling pathway.2011

    • Author(s)
      Ogawa E, Owada Y, Ikawa S, Adachi Y, Egawa T, Nemoto K, Suzuki K, Hishinuma T, Kawashima H, Kondo H, Muto M, Aiba S, Okuyama R.
    • Journal Title

      J Invest Dermatol 131

      Pages: 604-612

    • Related Report
      2010 Final Research Report
  • [Journal Article] Mutation analysis of the SHOC2 gene in Noonan-like syndrome and in hematologic malignancies.2010

    • Author(s)
      Komatsuzaki S, Aoki Y, Niihori T, Okamoto N, Hennekam RCM, Hopman S, Ohashi H, Mizuno S, Watanabe Y, Kamasaki H, Kondo I, Moriyama N, Kurosawa K, Kawame H, Okuyama R, Imaizumi M, Rikiishi T, Tsuchiya S, Kure S, Matsubara Y.
    • Journal Title

      J Hum Genet 55

      Pages: 801-809

    • Related Report
      2010 Final Research Report
  • [Journal Article] Dermoscopic features of non-pigmented eccrine poromas in association with their histopathological features.2010

    • Author(s)
      Minagawa A, Koga H, Takahashi M, Sano K, Okuyama R.
    • Journal Title

      Br J Dermatol 163

      Pages: 1264-1268

    • Related Report
      2010 Final Research Report
  • [Journal Article] Bach1-dependent and -independent regulation of heme oxygenase-1 in keratinocytes.2010

    • Author(s)
      Okada S, Muto A, Ogawa E, Nakanome A, Katoh Y, Ikawa S, Aiba S, Igarashi K, Okuyama R.
    • Journal Title

      J Biol Chem 285

      Pages: 23581-23589

    • Related Report
      2010 Final Research Report
  • [Journal Article] Influence of p53 deficiency on the apoptotic response, DNA damage removal and mutagenesis in UVB-exposed mouse skin.2010

    • Author(s)
      Ikehata H, Okuyama R, Ogawa E, Nakamura S, Usami A, Mori T, Tnanaka K, Aiba S, Ono T.
    • Journal Title

      Mutagenesis 25

      Pages: 397-405

    • Related Report
      2010 Final Research Report
  • [Journal Article] Genetic analysis of hierarchical regulation of Gata1 and NF-E2 p45 gene expression in megakaryopoiesis.2010

    • Author(s)
      Takayama M, Fujita R, Suzuki M, Okuyama R, Aiba S, Motohashi H, Yamamoto M.
    • Journal Title

      Mol Cell Biol 30

      Pages: 2668-2680

    • Related Report
      2010 Final Research Report
  • [Journal Article] Gene expression profiling defines the role of a danger signal ATP-exposed keratinocytes in skin inflammation.2010

    • Author(s)
      Ohara H, Saito R, Hirakawa S, Shimada M, Mano N, Hishinuma T, Okuyama R, Aiba S.
    • Journal Title

      J Dermatol Sci 58

      Pages: 143-151

    • Related Report
      2010 Final Research Report
  • [Journal Article] Paraneoplastic pemphigus associated with malignant gastrointestinal stromal tumor.2010

    • Author(s)
      Masu T, Okuyama R, Tsunoda T, Hashimoto T, Aiba S.
    • Journal Title

      Acta Derm Venereol

      Volume: 90 Pages: 89-90

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Infantile erosive pustular dermatosis of the scalp associated with Klippel-Feil syndrome.2010

    • Author(s)
      Shimada R, Masu T, Hanamizu H, Aiba S, Okuyama R.
    • Journal Title

      Acta Derm Venereol

      Volume: 90 Pages: 200-201

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gene expression profiling defines the role of a danger signal ATP-exposed keratinocytes in skin inflammation.2010

    • Author(s)
      Ohara H, Saito R, Hirakawa S, Shimada M, Mano N, Hishinuma T, Okuyama R, Aiba S.
    • Journal Title

      J Dermatol Sci

      Volume: 58 Pages: 143-151

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Influence of p53 deficiency on the apoptotic response, DNA damage removal and mutagenesis in UVB-exposed mouse skin.2010

    • Author(s)
      Ikehata H, Okuyama R, Ogawa E, Nakamura S, Usami A, Mori T, Tnanaka K, Aiba S, Ono T.
    • Journal Title

      Mutagenesis

      Volume: 25 Pages: 397-405

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genetic analysis of hierarchical regulation of Gata1 and NF-E2 p45 gene expression in megakaryopoiesis.2010

    • Author(s)
      Takayama M, Fujita R, Suzuki M, Okuyama R, Aiba S, Motohashi H, Yamamoto M.
    • Journal Title

      Mol Cell Biol

      Volume: 30 Pages: 2668-2680

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bach1-dependent and-independent regulation of heme oxygenase 1 in keratinocytes.2010

    • Author(s)
      Okada S, Muto A, Ogawa E, Nakanome A, Katoh Y, Ikawa S, Aiba S, Igarashi K, Okuyama R.
    • Journal Title

      J Biol Chem

      Volume: 285 Pages: 23581-23589

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impetigo with tense bulla on the dorsal hand.2010

    • Author(s)
      Masu T, Suetake S, Alba S, Okuyama R.
    • Journal Title

      J Dermatol

      Volume: 37 Pages: 683-684

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The exudate of pressure ulcers contains a substantial amount of vascular endothelial growth factor.2010

    • Author(s)
      Takayama M, Kuramoto Y, Okuyama R, Yamasaki K, Aiba S.
    • Journal Title

      Tohoku J Exp Med

      Volume: 221 Pages: 315-319

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dermoscopic features of non-pigmented eccrine poromas in association with their histopathological features.2010

    • Author(s)
      Minagawa A, Koga H, Takahashi M, Sano K, Okuyama R.
    • Journal Title

      Br J Dermatol

      Volume: 163 Pages: 1264-1268

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mutation analysis of the SHOC2 gene in Noonan-like syndrome and in hematologic malignancies.2010

    • Author(s)
      Komatsuzaki S, Aoki Y, Niihori T, Okamoto N, Hennekam RCM, Hopman S, Ohashi H, Mizuno S, Watanabe Y, Kamasaki H, Kondo I, Moriyama N, Kurosawa K, Kawame H, Okuyama R, Imaizumi M, Rikiishi T, Tsuchiya S, Kure S, Matsubara Y.
    • Journal Title

      J Hum Genet

      Volume: 55 Pages: 801-809

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] メラノサイト特異的タンパク陰性の原発不明悪性黒色腫の1例2010

    • Author(s)
      木庭幸子、芦田敦子、高沢裕子、大橋敦子、後藤康文、礒部研一、奥山隆平
    • Journal Title

      Skin cancer

      Volume: 25 Pages: 353-357

    • NAID

      10030441671

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 若年発症の落葉状天庖瘡の2例2010

    • Author(s)
      江川貞恵、大谷朋之、菊地克子、奥山隆平、相場節也
    • Journal Title

      臨床皮膚科

      Volume: 64 Pages: 646-649

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 定期的にダーモスコピーで観察している足底の小型先天性色素細胞母斑の1例2010

    • Author(s)
      皆川茜、古賀弘志、高田実、奥山隆平
    • Journal Title

      小児皮膚科学会誌

      Volume: 29 Pages: 51-54

    • NAID

      10026418515

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 乾癬の表皮細胞では何が起きているのか?2010

    • Author(s)
      奥山隆平
    • Journal Title

      日本皮膚科学会誌

      Volume: 120 Pages: 2706-2708

    • NAID

      10027732806

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 乾癬:免疫細胞や表皮細胞では何が起っているのか?2010

    • Author(s)
      奥山隆平
    • Journal Title

      皮膚科の臨床

      Volume: 52 Pages: 1379-1384

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Functional expression of heme-oxygenase-1 in human differentiated epidermis and its regulation by cytokines.2009

    • Author(s)
      Numata I, Okuyama R, Memezawa A, Ito Y, Takeda K, Furuyama K, Shibahara S, Aiba S.
    • Journal Title

      J Invest Dermatol 129

      Pages: 2954-2603

    • Related Report
      2010 Final Research Report
  • [Journal Article] Cutaneous accumulation of abnormal polyglutamine proteins of patients with dentatorubral-pallidoluysian atrophy.2009

    • Author(s)
      Ohta M, Okuyama R, Ogawa E, Kisu K, Sato H, Aoki M, Aiba S.
    • Journal Title

      Eur J Neurol 16

      Pages: 1246-1249

    • Related Report
      2010 Final Research Report
  • [Journal Article] Ectopic expression of the p53 homologue p63 is linked to squamous metaplasia in extramammary Paget's disease with invasive adenocarcinoma.2009

    • Author(s)
      Okuyama R, Ogawa E, Egawa T, Nagoshi H, Tagami H, Ikawa S, Aiba S.
    • Journal Title

      Histopahology 54

      Pages: 378-381

    • Related Report
      2010 Final Research Report
  • [Journal Article] Functional expression of heme-oxygenase-1 in human differentiated epidermis and its regulation by cytokines.2009

    • Author(s)
      Numata I, et al.
    • Journal Title

      J Invest Dermatol

      Volume: 129 Pages: 2954-2603

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cutaneous accumulation of abnormal polyglutamine proteins of patients with dentatorubral-pallidoluysian atrophy.2009

    • Author(s)
      Ohta M, et al.
    • Journal Title

      Eur J Neurol

      Volume: 16 Pages: 1246-1249

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] TGF-beta1 dampens the susceptibility of dendritic cells to environmental stimulation, leading to the requirement for danger signals for activation.2009

    • Author(s)
      Ohtani T, et al.
    • Journal Title

      Immunology

      Volume: 126 Pages: 485-499

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Increased hyaluronan production and decreased E-cadherin expression by cytokine-stimulated keratinocytes lead to spongiosis formation.2009

    • Author(s)
      Ohtani T, et al.
    • Journal Title

      J Invest Dermatol

      Volume: 129 Pages: 1412-1420

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ectopic expression of the p53 homologue p63 is linked to squamous metaplasia in extramammary Paget's disease with invasive adenocarcinoma.2009

    • Author(s)
      Okuyama R, et al.
    • Journal Title

      Histopahology

      Volume: 54 Pages: 378-381

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] p63-induced onset of keratinocyte differentiation via the c-Jun-N terminal kinase pathway is counteracted by keratinocyte growth factor.2008

    • Author(s)
      Okuyama R, Ogawa E, Egawa T, Nagoshi H, Obinata M, Tagami H, Ikawa S, Aiba S.
    • Journal Title

      J Biol Chem 283

      Pages: 34241-34249

    • Related Report
      2010 Final Research Report
  • [Journal Article] Impaired hair placode formation with reduced expression of hair follicle-related genes in mice lacking Lgr4.2008

    • Author(s)
      Mohrii Y, Kato S, Umezawa A, Okuyama R, Nishimori K.
    • Journal Title

      Dev Dyn 237

      Pages: 2235-3342

    • Related Report
      2010 Final Research Report
  • [Journal Article] p63 constitutes a useful histochemical marker for Pagetoid Bowen's disease to be differentiated from extramammary Paget's disease.2008

    • Author(s)
      Memezawa A, Okuyama R, Tagami H, Aiba S.
    • Journal Title

      Acta Derm Venereol 88

      Pages: 619-620

    • Related Report
      2010 Final Research Report
  • [Journal Article] Profiles of FOXP3 regulatory T-cells (Tregs) in dermatitis, psoriasis vulgaris and mycosis fungoides.2008

    • Author(s)
      Fujimura T, Okuyama R, Ito Y, Aiba S.
    • Journal Title

      British J Dermatol 158

      Pages: 1256-1263

    • Related Report
      2010 Final Research Report
  • [Journal Article] p51/p63 inhibits ultraviolet B-induced apoptosis via Akt activation.2008

    • Author(s)
      Okuyama R, Ogawa E, Ikawa S, Nagoshi H, Egawa T, Kurihara A, Yabuki M, Tagami H, Obinata M, Aiba S.
    • Journal Title

      Oncogene 27

      Pages: 848-856

    • Related Report
      2010 Final Research Report
  • [Journal Article] Notch signaling : its role played in the epidermal homeostasis and in the pathogenesis of the skin diseases.2008

    • Author(s)
      Okuyama R, Tagami H, Aiba S.
    • Journal Title

      J Dermatol Science 49

      Pages: 187-194

    • Related Report
      2010 Final Research Report
  • [Journal Article] p51/p63 inhibits ultraviolet B-induced apoptosis via Akt activation2008

    • Author(s)
      Okuyama R, et.al.
    • Journal Title

      Oncogene 27

      Pages: 848-856

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] p63/p51-induced onset of keratinocyte differentiation via the c-Jun N-terminal kinase pathway is counteracted by keratinocyte growth factor2008

    • Author(s)
      Okuyama R, et.al.
    • Journal Title

      Journal of Biological Chemistry 283

      Pages: 34241-34249

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Notch signaling : its role played in the epidermal homeostasis and in the pathogensis of the skin diseases2008

    • Author(s)
      Okuyama R, et.al.
    • Journal Title

      Journal of Dermatological Science 49

      Pages: 187-194

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Profiles of Foxp3+ regulatory T cells in eczematous dermatitis, psoriasis vulgaris and mycosis fungoides2008

    • Author(s)
      Fujumura T, et.al.
    • Journal Title

      British Journal of Dermatology 158

      Pages: 1256-1263

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impaired hair placode formation with reduced expression of hair follicle-related genes in mice lacking Lgr42008

    • Author(s)
      Mohri Y, et.al.
    • Journal Title

      Developmental Dynamics 237

      Pages: 2235-2242

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] P63 constitutes a useful histochemical marker for differentiation of pagetoid Bowen's disease from extramammary Paget's disease2008

    • Author(s)
      Memezawa A, et.al.
    • Journal Title

      Acta Dermato-Venereologica 88

      Pages: 619-620

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] 皮膚科の診療と基礎研究の発展的な融合を目指して2011

    • Author(s)
      奥山隆平
    • Organizer
      日本皮膚科学会東北6県合同地方会
    • Place of Presentation
      仙台
    • Year and Date
      2011-02-04
    • Related Report
      2010 Final Research Report
  • [Presentation] p63 functions : Its role in keratinocyte regulation and cross-talk with Notch2011

    • Author(s)
      奥山隆平
    • Organizer
      鳥取大学染色体工学研究センターセミナー
    • Place of Presentation
      米子
    • Year and Date
      2011-01-20
    • Related Report
      2010 Final Research Report
  • [Presentation] 乾癬:病態の解析から治療法の開発へ2010

    • Author(s)
      奥山隆平
    • Organizer
      日本皮膚科学会青森地方会
    • Place of Presentation
      盛岡
    • Year and Date
      2010-09-26
    • Related Report
      2010 Final Research Report
  • [Presentation] 乾癬:病態の解析から治療法の開発へ2010

    • Author(s)
      奥山隆平
    • Organizer
      日本皮膚科学会青森地方会
    • Place of Presentation
      青森
    • Year and Date
      2010-09-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] 乾癬:病態の解析から治療法の開発へ2010

    • Author(s)
      奥山隆平
    • Organizer
      日本皮膚科学会岩手地方会
    • Place of Presentation
      盛岡
    • Year and Date
      2010-09-25
    • Related Report
      2010 Annual Research Report
  • [Presentation] 乾癬の表皮細胞では何が起きているのか2010

    • Author(s)
      奥山隆平
    • Organizer
      日本皮膚科学会総会教育講演
    • Place of Presentation
      大阪
    • Year and Date
      2010-04-17
    • Related Report
      2010 Final Research Report
  • [Presentation] 乾癬の表皮細胞では何が起きているのか?2010

    • Author(s)
      奥山隆平
    • Organizer
      日本皮膚科学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2010-04-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] Mutations of KIT and BRAF in circulating tumor cells isolated from peripheral blood of melanoma patients. Melanoma 2010 congress.2010

    • Author(s)
      Sakaizawa K, Goto Y, Takata M, Okuyama R
    • Organizer
      Sydney
    • Place of Presentation
      Australia
    • Related Report
      2010 Final Research Report
  • [Presentation] Antigen specific immune response against WT1 in melanoma patients.2010

    • Author(s)
      Kiniwa Y, Takazawa Y, Okuyama R
    • Organizer
      Melanoma 2010 congress.
    • Place of Presentation
      Sydney, Australia
    • Related Report
      2010 Final Research Report
  • [Presentation] Activation of toll-like receptor 4 on human melanoma cells induced cell proliferation and migration.2010

    • Author(s)
      Goto Y, Kiniwa Y, Sakaizawa K, Uchiyama A, Koga H, Takata M, Okuyama R
    • Organizer
      Melanoma 2010 congress.
    • Place of Presentation
      Sydney, Australia
    • Related Report
      2010 Final Research Report
  • [Presentation] FABP7 expression in association with melanoma progression : Utility asaprognostic marker.2010

    • Author(s)
      Goto Y, Okuyama R.
    • Organizer
      日本研究皮膚科学会
    • Place of Presentation
      和歌山
    • Related Report
      2010 Annual Research Report
  • [Presentation] Mutataion of KIT and BRAF in circulating tumor cells isolated from peripheral blood of melanoma patients.2010

    • Author(s)
      Sakaizawa K, Goto Y, Takata M, Okuyama R.
    • Organizer
      日本研究皮膚科学会
    • Place of Presentation
      和歌山
    • Related Report
      2010 Annual Research Report
  • [Presentation] Decreased adhesion ability in the mouse keratinocyte lacking fatty acid binding protein 5(FABP5)gene.2010

    • Author(s)
      Nemoto K, Adachi Y, Okuvama R, Owada Y, Muto M.
    • Organizer
      日本研究皮膚科学会
    • Place of Presentation
      和歌山
    • Related Report
      2010 Annual Research Report
  • [Presentation] 相場節也 UVB照射マウス皮膚表皮にみられる「変異誘発抑制」応答の機構解明2009

    • Author(s)
      池畑広伸、小野哲也、奥山隆平
    • Organizer
      日本放射線影響学会
    • Place of Presentation
      広島
    • Year and Date
      2009-11-12
    • Related Report
      2010 Final Research Report
  • [Presentation] 教育講演 関節症性乾癬:いかに診断し治療を進めるか2009

    • Author(s)
      奥山隆平
    • Organizer
      日本皮膚科学会総会
    • Place of Presentation
      福岡
    • Year and Date
      2009-02-25
    • Related Report
      2010 Final Research Report
  • [Presentation] Notch2 down-regulation in wound healing is contributed to acceleration of cell motility.2009

    • Author(s)
      Okuyama R, Saito R, Ogawa E, Ikawa S, Aiba S.
    • Organizer
      日本研究皮膚科学会
    • Place of Presentation
      福岡
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] p63 prevents growth arrest via sonic hedgehog induction.2009

    • Author(s)
      Ogawa E, Okuyama R, Okada S, Ikawa S, Aiba S.
    • Organizer
      日本研究皮膚科学会
    • Place of Presentation
      福岡
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] LGR4 deletion induces eye open at birth phenotype with reduced keratinocyte motility.2008

    • Author(s)
      Okuyama R, Mohri Y, Kato S, Ogawa E, Matsuo T, Umezawa A, Nishimori K, Aiba S.
    • Organizer
      International Investigative Dermatology 2008
    • Place of Presentation
      Kyoto, Japan
    • Related Report
      2010 Final Research Report
  • [Presentation] Profiles of Foxp3+ regulatory T-cells (Tregs) in Bowen's disease and squamous cell carcinoma.2008

    • Author(s)
      Fujimura T, Okuyama R, Hidaka T, Ito Y, Aiba S.
    • Organizer
      International Investigative Dermatology 2008
    • Place of Presentation
      Kyoto, Japan
    • Related Report
      2010 Final Research Report
  • [Presentation] LGR4 deletion induces eye open at birth phenotype with reduced keratinocyte motility2008

    • Author(s)
      Okuyama R, et.al.
    • Organizer
      International Investigative Dermatology
    • Place of Presentation
      Kyoto
    • Related Report
      2008 Annual Research Report
  • [Presentation] Profiles of Foxp3+ regulatory T-cells(Treg) in Bowen's disease and squamous cell carcinoma2008

    • Author(s)
      Fujimura T, et.al.
    • Organizer
      International Investigative Dermatology
    • Place of Presentation
      Kyoto
    • Related Report
      2008 Annual Research Report
  • [Book] 疾患モデル活用ハンドブック2011

    • Author(s)
      秋山徹、奥山隆平
    • Related Report
      2010 Final Research Report
  • [Book] 病気と薬パーフェクトBOOK(紅皮症)2011

    • Author(s)
      木庭幸子、奥山隆平
    • Related Report
      2010 Final Research Report
  • [Book] 病気と薬パーフェクトBOOK(光線過敏症)2011

    • Author(s)
      木庭幸子、奥山隆平
    • Related Report
      2010 Final Research Report
  • [Book] 今日の治療指針(脂漏性皮膚炎・ふけ症)2011

    • Total Pages
      1020
    • Related Report
      2010 Final Research Report
  • [Book] 今日の治療指針(鶏眼・胼胝)2010

    • Total Pages
      991
    • Related Report
      2010 Final Research Report
  • [Book] 秋山徹、奥山隆平河府和義編:完全版マウス・ラット疾患モデル活用ハンドブック皮膚疾患2010

    • Author(s)
      木庭幸子、奥山隆平
    • Total Pages
      6
    • Publisher
      羊土社
    • Related Report
      2010 Annual Research Report
  • [Book] 山口徹、北原光夫、福井次矢編:今日の治療指針鶏眼・胼胝2010

    • Author(s)
      奥山隆平
    • Total Pages
      1
    • Publisher
      医学書院
    • Related Report
      2010 Annual Research Report
  • [Book] 今日の治療指針(酒〓皮膚炎 口囲皮膚炎)2009

    • Total Pages
      906
    • Related Report
      2010 Final Research Report
  • [Book] 今日の治療指針(凍瘡)2008

    • Total Pages
      880
    • Related Report
      2010 Final Research Report
  • [Book] 水疱性類天疱瘡、膿瘡、発赤、面皰、痒疹

    • Author(s)
      奥山隆平
    • Publisher
      南山堂医学大事典(in press)
    • Related Report
      2010 Final Research Report
  • [Book] 皮膚科臨床インサイト(乾癬と妊娠)

    • Author(s)
      奥山隆平
    • Publisher
      in press
    • Related Report
      2010 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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