Role of macrophage migration inhibitory factor in the epidermis and analysis of physiological mechanism
Project/Area Number |
20591315
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Dermatology
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Research Institution | University of Toyama |
Principal Investigator |
ASANO Yukie (2009-2010) University of Toyama, 大学病院, 助教 (40420327)
渡辺 宏数 (2008) University of Toyama, 大学病院, 助教 (20399950)
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Co-Investigator(Kenkyū-buntansha) |
NORISUGI Osamu 富山大学, 大学病院, 助教 (90419333)
浅野 幸恵 富山大学, 大学病院, 助教 (40420327)
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Project Period (FY) |
2008 – 2010
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Project Status |
Completed (Fiscal Year 2010)
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Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
Keywords | MIF / サイトカイン / ケモカイン / 表皮細胞 / 増殖 / 分化 / 炎症 / 紫外線 / マクロファージ / 細胞増殖 / 炎症性サイトカイン / フィラグリン |
Research Abstract |
We examined the role of Macrophage migration inhibitory factor (MIF) in the proliferation and differentiation of theepidermis. The expression of cytokeratin 14 increased in normal human epidermal kerationocytes (NHEKs) or HaCaT cells after the addition of recombinant MIF. On the other hand, we observed decrease expression of of filaggrin and transglutaminase 1 in NHEKs and HaCaT cells after the addition of recombinant MIF. The cell growth increased by the addition of MIF and decreased after the transfection of MIF siRNA. Furthermore, it was suggested that MIF might promote the proliferation and suppress the differentiation of epidermis via Rho-GTPase, PI3K and ERK1/2.
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Report
(4 results)
Research Products
(36 results)
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[Journal Article] Interleukin-1β and macrophage migration inhibitory factor (MIF) in dermal fibroblasts mediate UVA induced matrix etalloproteinase-1 expression.2008
Author(s)
Honda A, Abe R, Makino T, Norisugi O, Fujita Y, Watanabe H, Nishihira J, Yamagishi S, Iwakura Y, Shimizu H, Shimizu T
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Journal Title
J Dermatol Sci. 49
Pages: 63-72
Related Report
Peer Reviewed
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[Journal Article] Macrophage migration inhibitory factor ameliorates UV-induced photokeratitis in mice.2008
Author(s)
Kitaichi N, Shimizu T, Yoshida K, Honda A, Yoshihisa Y, Kase S, Ohgami K, Norisugi O, Makino T, Nishihira J, Yamagishi S, Ohno S.
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Journal Title
Exp Eye Res. 86
Pages: 929-936
Related Report
Peer Reviewed
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[Journal Article] 紫外線角膜炎に対するマクロファージ遊走阻止因子の効果2008
Author(s)
北市伸義, 清水忠道, 吉田和彦, 本田歩, 吉久陽子, 加瀬諭, 大神一浩, 乗杉理, 牧野輝彦, 西平順, 山岸昌一, 大野重昭
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Journal Title
日本眼科学会雑誌 112(11)
Pages: 1017-1017
Related Report
Peer Reviewed
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