| Project/Area Number |
20591317
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|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Dermatology
|
|---|
| Research Institution | University of Yamanashi |
|---|
Principal Investigator |
HARADA Kazutoshi University of Yamanashi, 医学部附属病院, 講師 (20324197)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
|---|
| Keywords | 皮膚悪性腫瘍 / 慢性炎症 / 遺伝子変異 / AID(activation induced deaminase) / 皮膚腫瘍 / 発癌 / シグナル伝達 |
|---|
| Research Abstract |
AID, a DNA mutagenic enzyme, was expressed in inflammatory skin disorders, including lichen planus, lichen sclerosis et atrophicus and DLE. The AID was not expressed in human keratinocyte cell line, however, addition of TNF-a, a inflammatory cytokine, induced the ectopic expression of AID in this cell line. These data suggested that sustained inflammation in skin yielded the ectopic expression of AID in keratinocytes. As a result of aberrant expression of AID, the enzyme induces DNA mutation and skin carcinogenesis.
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