Elucidation of mechanism of drug eruption due to epidermal growth factor receptor tyrosine kinase inhibitors
| Project/Area Number |
20591319
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | Nagoya University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MURO Yoshinao 名古屋大学, 大学院・医学系研究科, 准教授 (80270990)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 上皮成長因子受容体チロシンキナーゼ阻害薬 / 薬疹 / CCL2 / CCL5 / IL-1 / IL-1R2 / 発症メカニズム / EGFR受容体阻害薬 / ざそう様薬疹 / ケラチノサイト / 発症機序 / 小胞体ストレス応答 |
|---|
| Research Abstract |
Epidermal growth factor receptor tyrosine kinase(EGFR-TK) is a transducer of mitogenic signals, and is involved in the pathogenesis and progression of a number of cancers, including non-small cell lung cancer(NSCLC). Gefitinib is an EGFR-TK inhibitor that is clinically used to treat NSCLC ; however, this drug frequently causes adverse effects, including skin eruptions. The mechanism underlying these skin reactions is elusive, although it is assumed that they are caused by the inhibition of EGFR-TK signaling in epidermal and adnexal cells. In this study, we demonstrate that IL-1-mediated signaling is activated to induce the high expression of CCL2 and CCL5 via reduction of IL-1R2 in the skin lesions caused by gefitinib.
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Report
(4 results)
Research Products
(46 results)
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[Journal Article] Overexpression of LEDGF/DFS70 induces IL-6 via p38 activation in HaCaT cells which is similar to that seen in the psoriatic condition2010
Author(s)
Takeichi T, Sugiura K, Muro Y, Matsumoto K, Ogawa Y, Futamura K, Kaminuma O, Hashimoto N, Shimoyama Y, Saito H, Tomita Y.
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Journal Title
J Invest Dermatol
Volume: 130
Pages: 2760-2767
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Peer Reviewed
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[Journal Article] Evaluation of cetirizine hydrochloride-based therapeutic strategy for chronic urticaria2008
Author(s)
Sugiura K, Hirai S, Suzuki T, Usuda T, KondoT, Azumi T, Masaki S, Yokoi T, Nitta Y, Kamiya S, Ando K, Mori T, Tomita Y
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Journal Title
Nagoya J Med Sci.
Volume: 70(3-4)
Pages: 97-106
NAID
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Peer Reviewed
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[Presentation] Examination of Gene Expression Profiles in Hair Root Tissue Provides Useful Local Information2009
Author(s)
Yagami A, Matsumoto K, Futamura K, Matsuda A, Orihara K, Hashimoto N, Kojima R, Morita H, Sugiura K, Muro Y, Tomita Y, Matsunaga K, Saito H
Organizer
American Academy of Allergy Asthma & Immunology
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