The elucidation of the stimulus responses which carry out selection of the centromere autoantigens from macromolecule complexes
| Project/Area Number |
20591320
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | Nagoya University |
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Principal Investigator |
MURO Yoshinao 名古屋大学, 大学院・医学系研究科, 准教授 (80270990)
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| Co-Investigator(Kenkyū-buntansha) |
SUGIURA Kazumitsu 名古屋大学, 医学系研究科, 准教授 (70335032)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 皮膚病理学 / 強皮症 / 抗セントロメア抗体 / 自己抗原 / 自己抗体 / セントロメア |
|---|
| Research Abstract |
This study aimed to clarify the stimulus responses which carry out selection of centromere autoantigens from maculomolecular complexes including more than forty proteins. We examined immunoreactivities of nine different kinds of centromere proteins, which are different from three major centromere autoantigens, against sera from many patients and confirmed that a few of them reacted with a few patients'sera. At present, we have not identified any factors which might differentiate major centromere autoantigens from minor autoantigens that rarely react to autoantibodies.
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Report
(4 results)
Research Products
(60 results)
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[Journal Article]2010
Author(s)
室慶直
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Journal Title
脂漏性皮膚炎・ふけ症 今日の治療指針 2010年版(医学書院)
Pages: 953-953
Related Report
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[Journal Article]2009
Author(s)
室慶直
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Journal Title
抗核抗体検査の使用法と解釈法 知っておきたい皮膚病の常識・非常識(全日本病院出版会)
Pages: 18-24
Related Report
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[Journal Article]2009
Author(s)
室慶直、星野慶、高間弘道
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Journal Title
顔面紅斑 手と顔から見つける膠原病(秀潤社)
Pages: 1052-1053
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