| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Research Abstract |
We studied how mutations in the XPD gene result in different skin cancer susceptibilities in patients with xeroderma pigmentosum (XP) or trichothiodystrophy (TTD). XP-D and TTD cells were both deficient in the repair of UV-induced DNA damage because of helicase activity defects of TFIIH. Since TFIIH also acts as a coactivator, TTD-specific decrease in TFIIH content possibly results in transcriptional defects, which might be implication for the lack of increased incidence of skin cancers in TTD patients.
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