Participation of plakin family proteons in differentiation of keratinocytes : Fundamental study to new cancer therapy

• Project/Area Number: 20591331
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Dermatology
• Research Institution: Kurume University
• Principal Investigator: KARASHIMA Tadashi Kurume University, 医学部, 講師 (70211175)
• Co-Investigator(Kenkyū-buntansha): HASHIMOTO Takashi 久留米大学, 医学部, 教授 (20129597)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 角化細胞 / プラキン・ファミリー / 細胞分化 / 細胞骨格

Research Abstract

A basic research had done based on the idea of leading cancer cells to the differentiation for the development of new treatment to various skin cancers and treating cancer. Plakin family protein which of the expressed in epidermal cells had the function of inhibition the proliferation of the cancer cells, and the result of suggesting the possibility of differentiating cancer cells was obtained.

Research Products

• [Journal Article] From anti-p200 pemphigoid to anti-laminin gamma1 pemphigoid. (2010)
  • Author(s): Dainichi T, Koga H, Tsuji T, Ishii N, Ohyama B, Ueda A, Natsuaki Y, Karashima T, Nakama T, Yasumoto S, Zillikens D, Hashimoto T
  • Journal Title: J Dermatol 37 Pages: 231-238
• [Journal Article] Epidermolysis bullosa acquisita : What's new? (2010)
  • Author(s): Ishii N. Hamada T, Dainichi T, Karashima T, Nakama T, Yasumoto S, Zillikens D, Hashimoto T
  • Journal Title: J Dermatol 37 Pages: 220-230
  • NAID: 10027066051
• [Journal Article] From anti-p200 pemphigoid to anti-laminin gammal pemphigoid. (2010)
  • Author(s): Dainichi T, Karashima T, et al.
  • Journal Title: J Dermatol Volume: 37 Pages: 231-238
  • Peer Reviewed
• [Journal Article] Epidermolysis bullosa acquisita : what's new? (2010)
  • Author(s): Ishii N, Karashima T, et al.
  • Journal Title: J Dermatol Volume: 37 Pages: 220-230
  • NAID: 10027066051
  • Peer Reviewed
• [Journal Article] Anti-laminin gamma-1 pemphigoid. (2009)
  • Author(s): Dainichi T, Kurono S, Ohyama B, Ishii N, Sanzen N, Hayashi M, Shimono C, Taniguchi Y, Koga H, Karashima T, Yasumoto S, Zillikens Z, Sekiguchi K, Hashimoto T
  • Journal Title: Proc Natl Acad Sci USA. 106(8) Pages: 2800-2805
• [Journal Article] hypomelanosis of Ito (2009)
  • Author(s): 橋川恵子、寺原慶子、辛島正志、安元慎一郎、橋本隆
  • Journal Title: 皮膚病診療 Vol.31、No.2 Pages: 175-178
  • Peer Reviewed
• [Journal Article] Anti-laminin gamma-1 pemphigoid (2009)
  • Author(s): Dainichi T, Karashima T, et al.
  • Journal Title: Proc Natl Acad Sci USA 106 106 Pages: 2800-2805
  • Peer Reviewed
• [Journal Article] hypomelanosis of Ito (2009)
  • Author(s): 橋川恵子, 寺原慶子, 辛島正志, 安元慎一郎, 橋本隆
  • Journal Title: 皮膚病診療 31 Pages: 175-178
  • Peer Reviewed
• [Presentation] Anti-epiplakin autoantibodies in paraneoplastic pemphigus. (2010)
  • Author(s): Natsuaki Y, Koga H, Fukuda S, Ishii N, Dainichi T, Hamada T, Karashima T, Ishikawa T, Yasumoto S, Goto M, Fujiwara S, Hashimoto T
  • Organizer: The 70th annual Society for Investigative Dermatology meeting
  • Place of Presentation: Atlanta, USA
• [Presentation] Anti-epiplakin autoantibodies in paraneoplastic pemphigus. (2010)
  • Author(s): Natsuaki Y, Karashima T, et al.
  • Organizer: The 70^<th> annual Society for Investigative Dermatology meeting
  • Place of Presentation: Atlanta, USA
• [Presentation] 抗ラミニンγ類天疱瘡の自己抗体の病原性の検討 (2009)
  • Author(s): 古賀浩嗣、石井文人、濱田尚宏、大日輝記、辛島正志、安元慎一郎、橋本隆
  • Organizer: 第13回九州基礎皮膚科研究会
  • Place of Presentation: 福岡市
  • Year and Date: 2009-12-12
• [Presentation] development of mouse animal model for anti-laminin gamma-1 pemphigoid. (2009)
  • Author(s): Koga H, Ishii N, Dainichi T, Hamada T, Karashima T, Yasumoto S, Hashimoto T
  • Organizer: The 34th Annual meeting of the Japanese Society for Investigative Dermatology
  • Place of Presentation: Fukuoka
• [Presentation] 当科で検討した抗BP180型粘膜類天疱瘡症例のまとめ (2009)
  • Author(s): 大島明奈、古賀浩嗣、福田俊平、大山文悟、石井文人、濱田尚宏、辛島正志、安元慎一郎、橋本隆
  • Organizer: 第31回水疱症研究会
  • Place of Presentation: 松山市
• [Presentation] Development of mouse animal model for anti-laminin gamma-1 pemphigoid (2009)
  • Author(s): 古賀浩嗣, 辛島正志, et al.
  • Organizer: The 34th Annual Meeting of the Japanese Society for Investigative Dermatology
  • Place of Presentation: 福岡市