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Regenerative medical therapy using bone marrow derived cells

Research Project

Project/Area Number 20591332
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Dermatology
Research InstitutionHokkaido University

Principal Investigator

ABE Riichiro  Hokkaido University, 大学院・医学研究科, 准教授 (60344511)

Co-Investigator(Kenkyū-buntansha) SHIMIZU Hiroshi  北海道大学, 大学院・医学研究科, 教授 (00146672)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2008: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Keywords皮膚炎症 / 再生学 / 皮膚生理学 / 皮膚性理学
Research Abstract

Recent studies have suggested that bone marrow cells transdifferentiate to a variety of cellular lineages including skin. Investments for regenerative medicine have been used respective model mouse as a preclinical step. In our study, we conducted basic research to achieve radical cure for epidermolysis bullosa to which there is no effective therapy.
First as a basic research step, we demonstrated the existence of the factors secreted from keratinocytes that induces transdifferentiation from bone marrow derived cells into keratinocyte. Next as a preclinical step, bone marrow transplantation from normal mouse to type XVII collagen knock out mouse, one of the epidermolysis bullosa model mouse, induced production of the defect protein (XVII type collagen) and improvement of clinical manifestation of the mouse. So we suggested that the bone marrow transplantation from normal mouse to model mouse can be one of the effective therapies for epidermolysis bullosa..

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (19 results)

All 2010 2009 2008 Other

All Journal Article (11 results) (of which Peer Reviewed: 11 results) Presentation (3 results) Remarks (5 results)

  • [Journal Article] Bone marrow transplantation restores epidermal basement membrane protein expression and rescues epidermolysis bullosa model mice.2010

    • Author(s)
      Fujita Y, Abe R, Inokuma D, Sasaki M, Hoshina D, Natsuga K, Nishie W, McMillan JR, Nakamura H, Shimizu T, Akiyama M, Sawamura D, Shimizu H.
    • Journal Title

      Proc Natl Acad Sci USA 107

      Pages: 14345-50

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prevalent LIPH founder mutations lead to loss of P2Y5 activation ability of PA-PLA1alpha in autosomal recessive hypotrichosis.2010

    • Author(s)
      Shinkuma S, Akiyama M, Inoue A, Aoki J, Natsuga K, Nomura T, Arita K, Abe R, Ito K, Nakamura H, Ujiie H, Shibaki A, Suga H, Tsunemi Y, Nishie W, Shimizu H.
    • Journal Title

      Hum Mutat 31

      Pages: 602-10

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Bone marrow transplantation restores epidermal basement membrane protein expression and rescues epidermolysis bullosa model mice.2010

    • Author(s)
      Fujita Y
    • Journal Title

      Proc Natl Acad Sci USA

      Volume: 107 Pages: 14345-14350

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Topical application of dehydroxymethylepoxyquinomicin improves allergic inflammation via NF-kappaB inhibition.2010

    • Author(s)
      Hamasaka A
    • Journal Title

      Ann Intern Med

      Volume: 126 Pages: 400-403

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Topical application of anti-angiogenic peptides based on pigment epithelium-derived factor can improve psoriasis2010

    • Author(s)
      Abe R
    • Journal Title

      J Dermatol Sci 57

      Pages: 183-191

    • NAID

      10027399968

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Collagen XVII participates in keratinocyte adhesion to collagen IV, and in p38MAPK-dependent migration and cell signaling.2009

    • Author(s)
      Qiao H, Shibaki A, Long HA, Wang G, Li Q, Nishie W, Abe R, Akiyama M, Shimizu H, McMillan JR.
    • Journal Title

      J Invest Dermatol 129

      Pages: 2288-95

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Granulysin as a marker for early diagnosis of Stevens-Johnson syndrome and toxic epidermal necrolysis2009

    • Author(s)
      Abe R
    • Journal Title

      Ann Intern Med 151

      Pages: 514-515

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bone marrow-derived cells are not the origin of the cancer stem cells in ultraviolet-induced skin cancer2009

    • Author(s)
      Ando S
    • Journal Title

      Am J Pathol 74

      Pages: 595-601

    • Related Report
      2009 Annual Research Report 2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mesenchymal stem cells are recruited into wounded skin and contribute to wound repair by transdifferentiation into multiple skin cell type.2008

    • Author(s)
      Sasaki M, Abe R, Fujita Y, Ando S, Inokuma D, Shimizu H.
    • Journal Title

      J Immunol 180

      Pages: 2581-7

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] A novel DNA vaccine-targeting macrophage migration inhibitory factor improves the survival of mice with sensis2008

    • Author(s)
      Tohyama S
    • Journal Title

      Gene Therapy 15

      Pages: 1513-22

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Elevated soluble Fas ligand in Stevens-Johnson syndrome and toxic epidermal necrolysis preceding skin detachment2008

    • Author(s)
      Murata J
    • Journal Title

      J Allergy Clin Immunol 122

      Pages: 992-1000

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] 骨髄細胞を用いた表皮水疱症治療2010

    • Author(s)
      阿部理一郎
    • Organizer
      第109回日本皮膚科学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2010-04-17
    • Related Report
      2010 Final Research Report
  • [Presentation] 骨髄幹細胞を用いた再生医療2009

    • Author(s)
      阿部理一郎
    • Organizer
      第39回日本皮膚アレルギー・接触皮膚炎学会総会学術大会
    • Place of Presentation
      京都
    • Year and Date
      2009-11-07
    • Related Report
      2009 Annual Research Report
  • [Presentation] Topical application of anti-angiogenic peptides based on pigment epitheli um-derived factor can improve psoriasis2008

    • Author(s)
      Abe R
    • Organizer
      The 5th International Investigative Dermatology 2008
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2008-05-17
    • Related Report
      2008 Annual Research Report
  • [Remarks] ホームページ等

    • Related Report
      2010 Final Research Report
  • [Remarks] 北海道大学医学部皮膚科ホームページ

    • URL

      http://www.derm-hokudai.jp/jp/

    • Related Report
      2010 Final Research Report
  • [Remarks]

    • URL

      http://www.derm-hokudai.jp/

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.derm-hokudai.jp/

    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.derm-hokudai.jp/

    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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