The role of the bias in Th-subset 1/2/17 on pathogenesis of atopic dermatitis.
| Project/Area Number |
20591335
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | University of Tsukuba |
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Principal Investigator |
OTSUKA Fujio University of Tsukuba, 大学院・人間総合科学研究科, 教授 (10092157)
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| Co-Investigator(Kenkyū-buntansha) |
KAWACHI Yasuhiro 筑波大学, 大学院・人間総合科学研究科, 准教授 (00272196)
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| Co-Investigator(Renkei-kenkyūsha) |
FUJISAWA Yasuhiro 筑波大学, 大学院・人間総合科学研究科, 講師 (70550193)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | アトピー性皮膚炎 / Th細胞 / ヘルパーT細胞 / Th17 / 接触皮膚炎 / Th1 / Th2 / 皮膚炎 |
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| Research Abstract |
Recent studies demonstrated that both impaired skin barrier function and allergic immunonogical property are important aspects of the pathogenesis of atopic dermatitis and contact dermatitis. However, the role of Th17 cells in the pathogenesis of contact dermatitis is not clear. In this study, we investigated the role of Th17 cells in allergic contact dermatitis. The hematopoietic stem cells which constitutively overexpress ROR・t were transplanted to irradiated mice and artificial allergic dermatitis was induced to the mice. The dermatitis in the transplanted mice was suppressed compared to the control mice. These findings indicate that constitutive overexpression of ROR ・t results in the increase of Th17 cells, but suppressed allergy due to the increase of Treg cells.
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Report
(4 results)
Research Products
(23 results)
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[Journal Article] Attenuation of UVB-Induced Sunburn Reaction and Oxidative DNA Damage with No Alterations in UVB-induced Skin Carcinogenesis in Nrf2 Gene-Deficient Mice.2008
Author(s)
Kawachi Y, Xu X, Taguchi S, Sakurai H, Fujisawa Y, Nakamura Y, Ishii Y, Furuta J, Takahashi T, Itoh K, Yamamoto M, Yamazaki F, Otsuka F
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Journal Title
J Invest Dermatol 128
Pages: 1773-1779
Related Report
Peer Reviewed
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