Regulation of Langerhans cell function by fibroblasts

• Project/Area Number: 20591336
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Dermatology
• Research Institution: The University of Tokyo
• Principal Investigator: TADA Yayoi The University of Tokyo, 医学部附属病院, 講師 (00334409)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 樹状細胞 / 線維芽細胞

Research Abstract

Molecules which are released from dead cells and activate immune systems are called danger signals. We found that one of such danger signals, monosodium urate crystal, induces Langerhans cell migration to the lymph node and augment contact hypersensitivity.

Research Products

• [Journal Article] Identification of a novel marker for dendritic cell maturation, mouse transmembrane protein 123. (2010)
  • Author(s): Takekoshi T, Tada Y, Watanabe T, Sugaya M, Hoashi T, Komine M, Kawashima T, Shimizu T, Hau CS, Asahina A, Yokomizo T, Sato S, Tamaki K
  • Journal Title: J Biol Chem. 285 Pages: 31876-84
• [Journal Article] Possible roles of IL-27 in the pathogenesis of psoriasis. (2010)
  • Author(s): Shibata S, Tada Y, Kanda N, Nashiro K, Kamata M, Karakawa M, Miyagaki T, Kai H, Saeki H, Shirakata Y, Watanabe S, Tamaki K, Sato S
  • Journal Title: J Invest Dermatol. 130 Pages: 1034-9
• [Journal Article] Vaccination with TAT-antigen fusion protein induces protective, CD8(+) T cell-mediated immunity against Leishmania major. (2010)
  • Author(s): Kronenberg K, Brosch S, Butsch F, Tada Y, Shibagaki N, Udey MC, von Stebut E
  • Journal Title: J Invest Dermatol. 130 Pages: 2602-10
• [Journal Article] Serum TARC/CCI17 levels are increased in dermatomyositis associated with interstitial lung disease. (2010)
  • Author(s): Kawashima T, Tada Y, et al.
  • Journal Title: Journal of Dermatological Science Volume: 160巻 Pages: 52-54
  • Peer Reviewed
• [Journal Article] Identification of a novel marker for dendritic cell maturation, mouse transmembrane protein 123. (2010)
  • Author(s): Takekoshi T, Tada Y, et al.
  • Journal Title: journal of biological chemistry Volume: 285巻 Pages: 31876-31884
  • Peer Reviewed
• [Journal Article] Atypical cutaneous sarcoidosis with diffuse, indurated erythema. (2009)
  • Author(s): Tada Y, Kanda N, Ohnishi T, Watanabe S
  • Journal Title: Eur J Dermatol. 19 Pages: 639-639
• [Journal Article] Novel effects of diosgenin on skin aging. (2009)
  • Author(s): Tada Y, Kanda N, Haratake A, Tobiishi M, Uchiwa H, Watanabe S
  • Journal Title: Steroids 74 Pages: 504-511
• [Journal Article] Prolactin enhances basal and IL-17-induced CCL20 production by human keratinocytes. (2009)
  • Author(s): Kanda N, Shibata S, Tada Y, Nashiro K, Tamaki K, Watanabe S
  • Journal Title: Eur J Immunol. 39 Pages: 996-1006
• [Journal Article] Novel effects of diosgenin on skin aging (2009)
  • Author(s): Tada Y, et al.
  • Journal Title: Steroids 74 Pages: 504-511
  • Peer Reviewed
• [Journal Article] Atypical cutaneous sarcoidosis with diffuse, indurated erythema (2009)
  • Author(s): Tada Y, et al.
  • Journal Title: European Journal of Dermatology 19 Pages: 639-639
  • Peer Reviewed
• [Journal Article] Generalized morphea positive for anticentromere antibody. (2008)
  • Author(s): Ohmatsu H, Tada Y et al.
  • Journal Title: Eur J Dermatol 18 Pages: 718-719
  • Peer Reviewed
• [Journal Article] Serum 5-S-cysteinyldopa levels in patients with psoriasis undergoing narrowband ultaviolet B phototherapy (2008)
  • Author(s): Kikuchi k, tada Y et al.
  • Journal Title: Clin Exp Dermatol 33 Pages: 750-753
  • Peer Reviewed
• [Journal Article] Serunm levels of souluble CD26 in patients with scleroderma. (2008)
  • Author(s): Tamaki Z, Tada Y et al.
  • Journal Title: J Dermatol Sci 52 Pages: 67-69
  • Peer Reviewed
• [Presentation] IL-1受容体拮抗薬とP2Y6拮抗薬の乾癬治療としての可能性について (2009)
  • Author(s): 多田弥生
  • Organizer: 第24回日本乾癬学会
  • Place of Presentation: 東海大学校友会館(東京都)
  • Year and Date: 2009-09-04
• [Presentation] Mouse epidermal keratinocytes express Sema4D/CD100 and its receptor CD72 is expressed on Langerhans cells. (2008)
  • Author(s): Shimizu T, Tada Y et al.
  • Organizer: International Investigatve Dermatology 2008
  • Place of Presentation: 京都
• [Remarks] ホームページ等