Molecular mechanisms of regulatory B cells in immuno-dermatological diseases
Project/Area Number |
20591339
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Dermatology
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Research Institution | Kanazawa University |
Principal Investigator |
FUJIMOTO Manabu Kanazawa University, 医学系, 准教授 (90272591)
|
Project Period (FY) |
2008 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | B細胞 / 免疫 / 皮膚疾患 / 皮膚免疫 / 自己免疫疾患 |
Research Abstract |
Peritoneal B-la cells have been shown to suppress the later phase of contact hypersensitivity reaction. The cell surface expression phenotype of splenic marginal zone regulatory B cells has been clarified. Moreover, the role of regulatory B cells in murine model of systemic lupus erythematosus has been demonstrated.
|
Report
(4 results)
Research Products
(22 results)
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[Journal Article] CD22 expression mediates the regulatory functions of peritoneal B-1a cells during the remission phase of contact hypersensitivity reactions.2010
Author(s)
Nakashima H, Hamaguchi Y, Watanabe R, Ishiura N, Kuwano Y, Okochi H, Takahashi Y, Tamaki K, Sato S, Tedder TF, Fujimoto M.
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Journal Title
J Immunol 184
Pages: 4637-4645
Related Report
Peer Reviewed
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[Journal Article] Differential phosphorylation of functional tyrosines in CD19 modulates B lymphocyte activation.2010
Author(s)
Ishiura N, Nakashima H, Watanabe R, Kuwano Y, Adachi T, Takahashi Y, Tsubata T, Okochi H, Tamaki K, Tedder TF, Fujimoto M.
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Journal Title
Eur J Immunol 40
Pages: 1192-1204
Related Report
Peer Reviewed
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[Journal Article] CD19, a response regulator of B lymphocytes, regulates wound healing through hyaluronan-induced TLR4 signaling.2009
Author(s)
Iwata Y, Yoshizaki A, Komura K, Shimizu K, Ogawa F, Hara T, Muroi E, Bae S, Takenaka M, Yukami T, Hasegawa M, Fujimoto M, Tomita Y, Tedder TF, Sato S.
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Journal Title
Am J Pathol. 175
Pages: 649-660
Related Report
Peer Reviewed
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[Journal Article] Establishment of experimental eosinophilic vasculitis by IgE-mediated cutaneous reverse passive Arthus reaction.2009
Author(s)
Ishii T, Fujita T, Matsushita T, Yanaba K, Hasegawa M, Nakashima H, Ogawa F, Shimizu K, Takehara K, Tedder TF, Sato S, Fujimoto M.
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Journal Title
Am J Pathol. 174
Pages: 2225-2233
Related Report
Peer Reviewed
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[Journal Article] P-selectin glycoprotein ligand-1 contributes to wound healing predominantly as a P-selectin ligand and partly as an E-selectin ligand.2009
Author(s)
Tomita H, Iwata Y, Ogawa F, Komura K, Shimizu K, Yoshizaki A, Hara T, Muroi E, Yanaba K, Bae S, Takenaka M, Hasegawa M, Fujimoto M, Sato S.
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Journal Title
J Invest Dermatol 129
Pages: 2059-2067
NAID
Related Report
Peer Reviewed
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[Journal Article] CD19 regulates skin and lung fibrosis via Toll-like receptor signaling in a model of bleomycin-induced scleroderma.2008
Author(s)
Yoshizaki A, Iwata Y, Komura K, Ogawa F, Hara T, Muroi E, Takenaka M, Shimizu K, Hasegawa M, Fujimoto M, Tedder TF, Sato S.
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Journal Title
Am J Pathol 172
Pages: 1650-1663
Related Report
Peer Reviewed
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[Journal Article] Blockade of CD40-CD40 ligand interactions attenuates skin fibrosis and autoimmunity in the tight-skin mouse.2008
Author(s)
Komura K, Fujimoto M, Yanaba K, Matsushita T, Matsushita Y, Horikawa M, Ogawa F, Shimizu K, Hasegawa M, Takehara K, Sato S.
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Journal Title
Ann Rheum Dis 67
Pages: 867-872
Related Report
Peer Reviewed
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[Journal Article] Blockade of CD40-CD40 ligand interactions attenuates skin fibrosis and autoimmunity in the tight-skin mouse2008
Author(s)
Komura K, Fujimoto M, Yanaba K, Matsushita T, Matsushita Y, Horikawa M, Ogawa F, Shimizu K, Hasegawa M, Takehara K, Sato S
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Journal Title
Ann Rheum Dis 67
Pages: 867-72
Related Report
Peer Reviewed