Molecular mechanisms of regulatory B cells in immuno-dermatological diseases

• Project/Area Number: 20591339
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Dermatology
• Research Institution: Kanazawa University
• Principal Investigator: FUJIMOTO Manabu Kanazawa University, 医学系, 准教授 (90272591)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: B細胞 / 免疫 / 皮膚疾患 / 皮膚免疫 / 自己免疫疾患

Research Abstract

Peritoneal B-la cells have been shown to suppress the later phase of contact hypersensitivity reaction. The cell surface expression phenotype of splenic marginal zone regulatory B cells has been clarified. Moreover, the role of regulatory B cells in murine model of systemic lupus erythematosus has been demonstrated.

Research Products

• [Journal Article] CD22 expression mediates the regulatory functions of peritoneal B-1a cells during the remission phase of contact hypersensitivity reactions. (2010)
  • Author(s): Nakashima H, Hamaguchi Y, Watanabe R, Ishiura N, Kuwano Y, Okochi H, Takahashi Y, Tamaki K, Sato S, Tedder TF, Fujimoto M.
  • Journal Title: J Immunol 184 Pages: 4637-4645
  • Peer Reviewed
• [Journal Article] Regulatory B cells (B10 cells) have a suppressive role in murine lupus : CD19 and B10 cell deficiency exacerbates systemic autoimmunity. (2010)
  • Author(s): Watanabe R, Ishiura N, Nakashima H, Kuwano Y, Okochi H, Tamaki K, Sato S, Tedder TF, Fujimoto M.
  • Journal Title: J Immunol 184 Pages: 4801-4809
  • Peer Reviewed
• [Journal Article] Protective and pathogenic roles for B cells during systemic autoimmunity in NZB/W F1 mice. (2010)
  • Author(s): Haas KM, Watanabe R, Matsushita T, Nakashima H, Ishiura N, Okochi H, Fujimoto M, Tedder TF.
  • Journal Title: J Immunol. 184 Pages: 4789-4800
  • Peer Reviewed
• [Journal Article] Differential phosphorylation of functional tyrosines in CD19 modulates B lymphocyte activation. (2010)
  • Author(s): Ishiura N, Nakashima H, Watanabe R, Kuwano Y, Adachi T, Takahashi Y, Tsubata T, Okochi H, Tamaki K, Tedder TF, Fujimoto M.
  • Journal Title: Eur J Immunol 40 Pages: 1192-1204
  • Peer Reviewed
• [Journal Article] Autoantibody-mediated regulation of B cell responses by functional anti-CD22 autoantibodies in patients with systemic sclerosis. (2010)
  • Author(s): Odaka M, Hasegawa M, Hamaguchi Y, Ishiura N, Kumada S, Matsushita T, Komura K, Sato S, Takehara K, Fujimoto M.
  • Journal Title: Clin Exp Immunol. 159 Pages: 176-184
  • Peer Reviewed
• [Journal Article] Inducible costimulator ligand (ICOSL) regulates bleomycin-induced lung and skin fibrosis independent of ICOS-ICOSL pathway. (2010)
  • Author(s): Tanaka C, Fujimoto M, Hamaguchi Y, Sato S, Takehara K, Hasegawa M.
  • Journal Title: Arthritis Rheum 62 Pages: 1723-1732
  • NAID: 10029469768
  • Peer Reviewed
• [Journal Article] CD22 expression mediates the regulatory functions of peritoneal B-1a cells Buring the remission phase of contact hypersensitivity reactions. (2010)
  • Author(s): Nakashma H, et al.
  • Journal Title: The Journal of Immunology Volume: 185 Pages: 4637-4645
  • Peer Reviewed
• [Journal Article] Regulatory B cells (B10 cells) have a suppressive role in murine lupus : CD19 and B10 cell deficiency exacerbates systemic sutoimmunity. (2010)
  • Author(s): Watanabe R, et al.
  • Journal Title: The Journal of Immunology Volume: 185 Pages: 4801-4809
  • Peer Reviewed
• [Journal Article] Protective and pathogenic roles for B cells during systemic autoimmunity in NZB/W F1 mice. (2010)
  • Author(s): Haas KM, et al.
  • Journal Title: The Journal of Immunology Volume: 185 Pages: 4789-4800
  • Peer Reviewed
• [Journal Article] Regulatory B cells (B10 cells) have a suppressive role in murine lupus : CD19 and B10 cell deficiency exacerbates systemic autoimmunity (2010)
  • Author(s): Watanabe R, Ishiura N, Nakashima H, Kuwano Y, Okochi H, Tamaki K, Sato S, Tedder TF, Fujimoto M.
  • Journal Title: Journal of Immunology (印刷中)
  • Peer Reviewed
• [Journal Article] RhoH plays critical roles in FcεRI-dependent signal transduction in mast cells. (2009)
  • Author(s): Oda H, Fujimoto M, Patrick MS, Chida D, Sato Y, Azuma Y, Aoki H, Abe T, Suzuki H, Shirai M.
  • Journal Title: J Immunol. 182 Pages: 957-962
  • Peer Reviewed
• [Journal Article] CD19, a response regulator of B lymphocytes, regulates wound healing through hyaluronan-induced TLR4 signaling. (2009)
  • Author(s): Iwata Y, Yoshizaki A, Komura K, Shimizu K, Ogawa F, Hara T, Muroi E, Bae S, Takenaka M, Yukami T, Hasegawa M, Fujimoto M, Tomita Y, Tedder TF, Sato S.
  • Journal Title: Am J Pathol. 175 Pages: 649-660
  • Peer Reviewed
• [Journal Article] Establishment of experimental eosinophilic vasculitis by IgE-mediated cutaneous reverse passive Arthus reaction. (2009)
  • Author(s): Ishii T, Fujita T, Matsushita T, Yanaba K, Hasegawa M, Nakashima H, Ogawa F, Shimizu K, Takehara K, Tedder TF, Sato S, Fujimoto M.
  • Journal Title: Am J Pathol. 174 Pages: 2225-2233
  • Peer Reviewed
• [Journal Article] A novel inhibitor of Smad-dependent transcriptional activation suppresses tissue fibrosis in mice models of systemic sclerosis. (2009)
  • Author(s): Hasegawa M, Matsushita Y, Horikawa M, Higashi K, Tomigahara Y, Kaneko H, Shirasaki F, Fujimoto M, Takehara K, Sato S.
  • Journal Title: Arthritis Rheum 60 Pages: 3465-3475
  • Peer Reviewed
• [Journal Article] P-selectin glycoprotein ligand-1 contributes to wound healing predominantly as a P-selectin ligand and partly as an E-selectin ligand. (2009)
  • Author(s): Tomita H, Iwata Y, Ogawa F, Komura K, Shimizu K, Yoshizaki A, Hara T, Muroi E, Yanaba K, Bae S, Takenaka M, Hasegawa M, Fujimoto M, Sato S.
  • Journal Title: J Invest Dermatol 129 Pages: 2059-2067
  • NAID: 120006984034
  • Peer Reviewed
• [Journal Article] CD19 regulates skin and lung fibrosis via Toll-like receptor signaling in a model of bleomycin-induced scleroderma. (2008)
  • Author(s): Yoshizaki A, Iwata Y, Komura K, Ogawa F, Hara T, Muroi E, Takenaka M, Shimizu K, Hasegawa M, Fujimoto M, Tedder TF, Sato S.
  • Journal Title: Am J Pathol 172 Pages: 1650-1663
  • Peer Reviewed
• [Journal Article] Regulatory B cells inhibit EAE initiation while other B cells promote disease progression. (2008)
  • Author(s): Matsushita T, Yanaba K, Bouaziz J-D, Fujimoto M, Tedder TF.
  • Journal Title: J Clin Invest 118 Pages: 3420-3430
  • Peer Reviewed
• [Journal Article] A regulatory B cell subset with a unique CD1d^<high>CD5^+ phenotype controls T cell-dependent inflammatory responses. (2008)
  • Author(s): Yanaba K, Bouaziz J-D, Hass KM, Poe JC, Fujimoto M, Tedder TF.
  • Journal Title: Immunity 28 Pages: 639-650
  • Peer Reviewed
• [Journal Article] Blockade of CD40-CD40 ligand interactions attenuates skin fibrosis and autoimmunity in the tight-skin mouse. (2008)
  • Author(s): Komura K, Fujimoto M, Yanaba K, Matsushita T, Matsushita Y, Horikawa M, Ogawa F, Shimizu K, Hasegawa M, Takehara K, Sato S.
  • Journal Title: Ann Rheum Dis 67 Pages: 867-872
  • Peer Reviewed
• [Journal Article] Regulatory B cells inhibit EAE initiation while other B cells promote disease progression (2008)
  • Author(s): Matsushita T, Yanaba K, Bouaziz J D, Fuiimoto M, Tedder TF
  • Journal Title: J Clin Invest 118 Pages: 3420-30
  • Peer Reviewed
• [Journal Article] A regulatory B cell subset with a unique CD1dhighCD5+ phenotype controls T cell-dependent inflammatory responses (2008)
  • Author(s): Yanaba K, Bouaziz J-D, Hass KM, Poe JC, Fujimoto M, Tedder TF
  • Journal Title: Immunity 28 Pages: 639-650
  • Peer Reviewed
• [Journal Article] Blockade of CD40-CD40 ligand interactions attenuates skin fibrosis and autoimmunity in the tight-skin mouse (2008)
  • Author(s): Komura K, Fujimoto M, Yanaba K, Matsushita T, Matsushita Y, Horikawa M, Ogawa F, Shimizu K, Hasegawa M, Takehara K, Sato S
  • Journal Title: Ann Rheum Dis 67 Pages: 867-72
  • Peer Reviewed