Human CD34+ cell-transplanted NOG mouse model for HIV transmission via skin or mucosa

• Project/Area Number: 20591340
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Dermatology
• Research Institution: University of Yamanashi
• Principal Investigator: KAWAMURA Tatsuyoshi University of Yamanashi, 医学部附属病院, 講師 (70262657)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2008: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
• Keywords: HIV / 動物モデル / 樹状細胞 / CCR5阻害薬 / NOGマウス / Langerhans cell / NOG mouse / 性行為HIV感染

Research Abstract

We could detect human splenic dendritic cells in the Human CD34+ cell-transplanted NOG mouse. Furthermore, we could detect human dermal DCs and/or Langerhans cells in the murine skin, during the wound repairing. These findings clearly indicated that the Human CD34+ cell-transplanted NOG mouse are useful model for HIV transmission via skin or mucosa.

Research Products

• [Journal Article] Marked response to imatinib mesylate in metastatic acral lentiginous melanoma on the thumb. (2011)
  • Author(s): Yamaguchi M, et al.
  • Journal Title: Clin Exp Dermatol. Volume: 36 Pages: 174-177
  • Peer Reviewed
• [Journal Article] A case of lymphoepithelioma-like carcinoma of the skin associated with EpsteineBarr virus infection. (2010)
  • Author(s): Aoki R, Mitsui H, Harada K, Kawamura T, Shibagaki N, Tsukamoto K, Murata S, Shimada S
  • Journal Title: J AM ACAD DERMATOL. 62(4) Pages: 681-684
  • Peer Reviewed
• [Journal Article] A case of lymphoepithelioma-like carcinoma of the skin associated with Epstein-Barr virus infection. (2010)
  • Author(s): Aoki R, et al.
  • Journal Title: J Am Acad Dermatol Volume: 62 Pages: 681-684
  • Peer Reviewed
• [Journal Article] Psoriasiform eruption associated with alopecia areata during infliximab therapy. (2009)
  • Author(s): Nakagomi D, Harada K, Yagasaki A, Kawamura T, Shibagaki N, Shimada S
  • Journal Title: Clin Exp Dermatol. 34(8) Pages: 923-924
  • Peer Reviewed
• [Journal Article] Agminated acquired melanocytic naevus modified by vitiligo vulgaris arising in the elderly (2009)
  • Author(s): Nakamura Y, Kambe N, Deguchi N, Kawamura T, Shibagaki N, Matsue H, Shimada S
  • Journal Title: Clin Exp Dermatol. 34(7)
  • Peer Reviewed
• [Journal Article] Novel and recurrent nonsense mutation of the SLC39A4 gene in Japanese patients with acrodermatitis enteropathica (2009)
  • Author(s): Nakano H, Nakamura Y, Kawamura T, Shibagaki N, Matsue H, Aizu T, Rokunohe D, Akasaka E, Kimura K, Nishizawa A, Umegaki N, Mitsuhashi Y, Shimada S, Sawamura D
  • Journal Title: Br J Dermatol. 161(1) Pages: 184-186
  • Peer Reviewed
• [Journal Article] Gram-positive bacteria enhance HIV-1 susceptibility in Langerhans cells, but not in dendritic cells, via Toll-like receptor activation (2009)
  • Author(s): Ogawa Y, Kawamura T, Kimura T, Ito M, Blauvelt A, Shimada S
  • Journal Title: Blood. 21;113(21) Pages: 5157-5166
  • Peer Reviewed
• [Journal Article] A clinical study of Henoch-Schonlein Purpura associated with malignancy. (2009)
  • Author(s): Mitsui H, Shibagaki N, Kawamura T, Matsue H, Shimada S
  • Journal Title: J Eur Acad Dermatol Venereol. 23(4) Pages: 394-401
  • Peer Reviewed
• [Journal Article] Improving chemotherapeutic drug penetration in melanoma by imatinib mesylate. (2008)
  • Author(s): Ogawa Y, Kawamura T, Furuhashi M, Tsukamoto K, Shimada S
  • Journal Title: J Dermatol Sci. 51(3) Pages: 190-199
  • NAID: 10024298463
• [Presentation] HIVの生体内侵入メカニズム,シンポジウム2 (2010)
  • Author(s): 川村龍吉
  • Organizer: IIIV研究の新しい展開,第58回日本ウイルス学会
  • Place of Presentation: 徳島市
  • Year and Date: 2010-11-07
• [Presentation] Strategies to prevent sexual transmission of HIV. (2010)
  • Author(s): 川村龍吉
  • Organizer: The 11th KUMAMOTO AIDS Seminar / Global COE Joint International Symposium.
  • Place of Presentation: Kumamoto, Japan.
  • Year and Date: 2010-10-07
• [Presentation] CCR5阻害剤内服による性行為HIV感染予防の試み,エイズ予防財団主催 (2010)
  • Author(s): 川村龍吉
  • Organizer: 第12回白馬シンポジウムin徳島-最先端のエイズ研究を徹底討論する-
  • Place of Presentation: 徳島市
  • Year and Date: 2010-05-16
• [Presentation] HIV感染症の現状と治療指針 (2010)
  • Author(s): 川村龍吉
  • Organizer: 第109回日本皮膚科学会総会
  • Place of Presentation: 大阪市(教育講演)
  • Year and Date: 2010-04-18
• [Presentation] Galderma Award Lecture. (2009)
  • Author(s): 川村龍吉
  • Organizer: The 34th Annual Meetings of the Japanese Society for Investigative Dermatology
  • Place of Presentation: Fukuoka, Japan.
  • Year and Date: 2009-12-10
• [Presentation] 自然免疫、獲得免疫および自己免疫におけるランゲルハンス細胞の役割 (2009)
  • Author(s): 川村龍吉
  • Organizer: 第16回皮膚科リサーチセミナー
  • Place of Presentation: 名古屋市
  • Year and Date: 2009-11-17
• [Presentation] Mechanisms responsible for the enhanced HIV transmission by HSV2. Satellite symposium. (2009)
  • Author(s): 川村龍吉
  • Organizer: The 10th KUMAMOTO AIDS Seminar / Global COE Joint International Symposium
  • Place of Presentation: Kumamoto, Japan.
  • Year and Date: 2009-09-29
• [Presentation] Mechanisms responsible for the enhanced HIV transmission by STDs. (2009)
  • Author(s): Kawamura T., Ogawa Y, Shimada S.
  • Organizer: The 10th KUMAMOTO AIDS Seminar / Global COE Joint International Symposium.
  • Place of Presentation: Kumamoto, Japan.
  • Year and Date: 2009-09-28
• [Presentation] Mechanism for 1IIV invasion via skin or mucosa. (2009)
  • Author(s): 川村龍吉
  • Organizer: The 4th joint Meeting of Japanese Dermatological Association and Australasian College of Dermatologists.
  • Place of Presentation: Sapporo, Japan
  • Year and Date: 2009-07-10
• [Presentation] 性行為HIV感染におけるHIVの生体内侵入メカニズム (2009)
  • Author(s): 川村龍吉
  • Organizer: 第18回北海道性感染症研究会
  • Place of Presentation: 札幌市
  • Year and Date: 2009-06-19
• [Presentation] 性行為HIV感染におけるHIVの生体内侵入メカニズム (2009)
  • Author(s): 川村龍吉
  • Organizer: 第18回北海道性感染症研究会
  • Place of Presentation: 札幌プリンスホテル(札幌)
  • Year and Date: 2009-06-19
• [Presentation] STDによるHIV感染促進メカニズム,エイズ予防財団主催 (2008)
  • Author(s): 川村龍吉
  • Organizer: 第11回白馬シンポジウムin長崎-エイズ研究最前線-
  • Place of Presentation: 長崎市
  • Year and Date: 2008-12-06
• [Presentation] AIDSとSTD (2008)
  • Author(s): 川村龍吉
  • Organizer: 第44回山梨大学医師会講座
  • Place of Presentation: 甲府市
  • Year and Date: 2008-11-07
• [Presentation] HIVの生体内侵入メカニズム (2008)
  • Author(s): 川村龍吉
  • Organizer: 第6回Kumamoto Dermatological Academy
  • Place of Presentation: 熊本市
  • Year and Date: 2008-10-09