Human CD34+ cell-transplanted NOG mouse model for HIV transmission via skin or mucosa
| Project/Area Number |
20591340
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | University of Yamanashi |
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Principal Investigator |
KAWAMURA Tatsuyoshi University of Yamanashi, 医学部附属病院, 講師 (70262657)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | HIV / 動物モデル / 樹状細胞 / CCR5阻害薬 / NOGマウス / Langerhans cell / NOG mouse / 性行為HIV感染 |
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| Research Abstract |
We could detect human splenic dendritic cells in the Human CD34+ cell-transplanted NOG mouse. Furthermore, we could detect human dermal DCs and/or Langerhans cells in the murine skin, during the wound repairing. These findings clearly indicated that the Human CD34+ cell-transplanted NOG mouse are useful model for HIV transmission via skin or mucosa.
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Report
(4 results)
Research Products
(23 results)
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[Journal Article] Novel and recurrent nonsense mutation of the SLC39A4 gene in Japanese patients with acrodermatitis enteropathica2009
Author(s)
Nakano H, Nakamura Y, Kawamura T, Shibagaki N, Matsue H, Aizu T, Rokunohe D, Akasaka E, Kimura K, Nishizawa A, Umegaki N, Mitsuhashi Y, Shimada S, Sawamura D
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Journal Title
Br J Dermatol. 161(1)
Pages: 184-186
Related Report
Peer Reviewed
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