| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Research Abstract |
Laminin-5 (LN332) is a heterotrimeric basement membrane-specific glycoprotein composed of α3, β3, and γ2 subunits and involves in biological activities such as keratinocyte differentiation, proliferation, as well as a maintenance of stable basement membrane structure. Studies of in vivo wound tissue suggest that LN332 plays a role in facilitating cell migration during wound healing. In this study, we demonstrated that a synthetic peptide, PEP75, which contains the syndecan-binding sequence of the laminin α3LG4 module, induces keratinocyte migration in in vitro, ex vivo, and in vivo. To activate integrin function through syndecans by this synthetic peptide could be a novel therapeutic approach for chronic cutaneous wound.
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