Skin regeneration -Signal transduction in hair follicles-

• Project/Area Number: 20591345
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Dermatology
• Research Institution: Osaka University
• Principal Investigator: ITAMI Satoshi Osaka University, 大学院・医学系研究科, 寄附講座教授 (30136791)
• Co-Investigator(Kenkyū-buntansha): INUI Shigeki 大阪大学, 大学院・医学系研究科, 寄附講座准教授 (30324750)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 毛包 / 幹細胞 / LRIG1 / 再生 / ARA55 / hic-5 / ケロイド / 線維芽細胞 / TGF-β-Smad / ARA55/hic-5 / 男性ホルモン

Research Abstract

Lrig1 expressing keratinocytes localize the hair follicle junctional zone. Loss of Lrig1 causes a selective increase in β-catenin-induced ectopic hair follicle formation in the interfollicular epidermis. Lrig1 expressing keratinocytes constitutively shed LRIG1 ectodomains in vitro by ADAM17, and the ectodomains regulate cell proliferation and EGF signaling in a paracrine manner.
ARA55/hic-5 was strongly expressed in keloid tissues and fibroblasts. ARA55/hic-5 overexpression stimulated the collagen production through TGF-β-Smad pathway.

Research Products

• [Journal Article] Paracrine regulation of growth factor signaling by shed leucine-rich repeats and immunoglobulin-like domains 1. (2011)
  • Author(s): Yi W, Holmlund C, Nilsson J, Inui S, Lei T, Itami S, Henriksson R, Hedman H.
  • Journal Title: Exp Cell Res. 317 Pages: 504-512
• [Journal Article] Paracrine regulation of growth factor signaling by shed leucine-rich repeats and immunoglobulin-like domains 1 (2011)
  • Author(s): Yi W, Holmlund C, Nilsson J, Inui S, Lei T, Itami S, Henriksson R, Hedman H
  • Journal Title: Exp Cell Res. Volume: 317 Pages: 504-512
  • Peer Reviewed
• [Journal Article] In vitro and in vivo evidence of pathogenic roles of Hic-5/ARA55 in keloids through Smad pathway and profibrotic transcription. (2010)
  • Author(s): Inui S, Shono F, Noguchi F, Nakajima T, Hosokawa K, Itami S.
  • Journal Title: J Dermatol Sci. 58 Pages: 152-154
  • NAID: 10027400939
• [Journal Article] 毛髪の医学 (2010)
  • Author(s): 板見智
  • Journal Title: 1.毛の細胞生物学、日皮協ジャーナル 32巻、2号 Pages: 24-31
• [Journal Article] In vitro and in vivo evidence of pathogenic roles of Hic-5/ARA55 in keloids through Smad pathway and profibrotic transcription. (2010)
  • Author(s): Inui S, Shono F, Noguchi F, Nakajima T, Hosokawa K, Itami S.
  • Journal Title: J Dermatol Sci. Volume: 58 Pages: 152-154
  • NAID: 10027400939
  • Peer Reviewed
• [Journal Article] Lrig1 expression defines a distinct multipotent stem cell population in mammalian epidermis. (2009)
  • Author(s): Jensen KB, Collins CA, Nascimento E, Tan DW, Frye M, Itami S, Watt FM.
  • Journal Title: Cell Stem Cell. 4 Pages: 427-439
• [Journal Article] Keratinocyte growth inhibition through the modification of Wnt signaling by androgen in balding dermal papilla cells. (2009)
  • Author(s): Kitagawa T, Matsuda KI, Inui S, Takenaka H, Katoh N, Itami S, Kishimoto S, Kawata M.
  • Journal Title: J Clin Endocrinol Metab. 94 Pages: 1288-1294
• [Journal Article] 男性型脱毛症の病態と治療 (2009)
  • Author(s): 板見智
  • Journal Title: 日本皮膚科学会雑誌 119巻 Pages: 2966-2968
  • NAID: 10028278606
• [Journal Article] Induction of gene encoding FABP4 in Pten-null keratinocytes. (2009)
  • Author(s): Tsuda M, Inoue-Narita T, Suzuki A, Itami S, Blumenberg M, Manabe M.
  • Journal Title: FEBS Lett. 583 Pages: 1319-1322
• [Journal Article] Progranulin, a secreted tumorigenesis and dementia-related factor, regulates mouse hair growth. (2009)
  • Author(s): Kato M, Hasunuma N, Nakayama R, Takeda J, Itami S, Tair M, Manabe M, Osada S.
  • Journal Title: J Dermatol Sci. 53 Pages: 234-236
  • NAID: 10025332926
• [Journal Article] Keratinocyte growth inhibition through the modification of Wnt signaling by androgen in balding dermal papilla cells (2009)
  • Author(s): Kitagawa T, Matsuda KI, Inui S, Takenaka H, Katoh N, Itami S, Kishimoto S, Kawata M.
  • Journal Title: J Clin Endocrinol Metab. 94 Pages: 1288-1294
  • Peer Reviewed
• [Journal Article] Progranulin, a secreted tumorigenesis and dementia-related factor, regulates mouse hair growth (2009)
  • Author(s): Kato M, Hasunuma N, Nakayama R, Takeda J, Itami S, Taira M, Manabe M, Osada S.
  • Journal Title: J Dermatol Sci. 36 Pages: 82-85
  • NAID: 10025332926
  • Peer Reviewed
• [Journal Article] Lrig1 expression defines a distinct multipotent stem cell population in mammalian epidermis (2009)
  • Author(s): Jensen KB, Collins CA, Nascimento E, Tan DW, Frye M, Itami S, Watt FM.
  • Journal Title: Cell Stem Cell. 4 Pages: 427-439
  • Peer Reviewed
• [Journal Article] 毛髪の再生 (2008)
  • Author(s): 板見智
  • Journal Title: 日本臨床 66巻 Pages: 892-896
• [Journal Article] 毛周期と幹細胞 (2008)
  • Author(s): 板見智
  • Journal Title: 遺伝子医学MOOK別冊、進みつづける細胞移植治療の実際 下巻 Pages: 50-53
• [Presentation] Molecular mechanism of TGF-β1 promoter activation by androgen in balding dermal papilla cells. (2010)
  • Author(s): Inui S, Nakao T, Nakajima T, Itami S.
  • Organizer: 6^<th> World Congress of Hair Research.
  • Place of Presentation: Cairns, Australia
  • Year and Date: 2010-06-16
• [Presentation] PPAR binding protein is involved in signaling for quiescence of hair follicle stem cells. (2010)
  • Author(s): Nakajima T, Inui S, Fushimi T, Noguchi F, Itami S.
  • Organizer: 6^<th> World Congress of Hair Research.
  • Place of Presentation: Cairns, Australia
  • Year and Date: 2010-06-16
• [Presentation] Molecular mechanism of TGF-β1 promoter activation by androgen in balding dermal papilla cells. (2010)
  • Author(s): Shigeki Inui, Toshifumi Nakao, Takeshi Nakajima, Satoshi Itami
  • Organizer: 6^<th> World Congress of Hair Research
  • Place of Presentation: Cairns, Australia
• [Presentation] Leptin is a paracrine regulator of hair cycle. (2009)
  • Author(s): Inui S
  • Organizer: JSID-Asia-Oceanis-Forum, Hakata
  • Place of Presentation: Japan
  • Year and Date: 2009-12-06
• [Presentation] Leptin is a paracrine regulator of hair cycle (2009)
  • Author(s): Shigeki Inui
  • Organizer: JSID-Asia-Oceanis-Forum
  • Place of Presentation: Hakata, Japan
  • Year and Date: 2009-12-06
• [Presentation] 毛髪再生はどこまで可能か、再生医療とアンチエイジング (2009)
  • Author(s): 板見智
  • Organizer: 第9回抗加齢医療学会総会
  • Place of Presentation: 東京
  • Year and Date: 2009-05-29
• [Presentation] Leptin is a paracrine regulator of hair cycle. (2008)
  • Author(s): Sumikawa Y, Inui S, Itami S.
  • Organizer: International Investigative Dermatology.
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2008-05-17
• [Presentation] Leptin is a paracrine regulator of hair cycle (2008)
  • Author(s): Sumikawa Y
  • Organizer: International Investigative Dermatology
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2008-05-17
• [Book] 男性型脱毛症、ガイドライン外来診療2011(泉孝英編)(東京) (2011)
  • Author(s): 板見智
  • Publisher: 日経メディカル開発
• [Book] Hair diseases (Alopecia Areata and Androgenetic Alopecia) in Therapy of Skin Diseases(Krieg T, Bickers DR)(Miyachi Y (eds))(Berlin, Heidelberg) (2010)
  • Author(s): Itami S, Inui S.
  • Publisher: Springer . Verlag
• [Book] 脱毛症診療ガイドライン(円形脱毛症について)、What's New in皮膚科学(宮地良樹編)(東京) (2010)
  • Author(s): 板見智
  • Publisher: メディカルレビュー社
• [Book] Hair diseases (Alopecia Areata and Androgenetic Alopecia) in Therapy of Skin Diseases. (2010)
  • Author(s): Satoshi Itami, Shigeki Inui
  • Total Pages: 766
  • Publisher: Springer-Verlag GmbH, Germany
• [Book] Hair diseases (Alopecia Areata and Androgenetic Alopecia) in Therapy of Skin Diseases (2010)
  • Author(s): Satoshi Itami, Shigeki Inui
  • Total Pages: 766
  • Publisher: Springer-Verlag GmbH, Germany
• [Book] 男性型脱毛症(AGA)、皮膚疾患診療実践ガイド(宮地良樹、古川福実編)(東京) (2009)
  • Author(s): 板見智
  • Publisher: 文光堂
• [Book] 2.正常皮膚の正常値.毛包系、Advanced Cosmetic Dermatology3、スキンケアを科学する(今山修平、宮地良樹、松永佳世子、宇津木龍一編)(東京) (2008)
  • Author(s): 板見智
  • Publisher: 南江堂
• [Remarks] 日本皮膚科学会脱毛症診療ガイドライン作成委員
• [Remarks] 坪井良治、板見智、乾重樹、 植木理恵、勝岡憲生、倉田荘太郎、幸野健、齊藤典充、真鍋求、山崎正視、男性型脱毛症診療ガイドライン(2010年版)、日皮会誌:120(5),977-986,2010.
• [Remarks] 荒瀬誠二、坪井良治、山崎正視、板見智、乾重樹、勝岡憲生、齊藤典充、真鍋求、伊藤雅章、橋本剛、刈谷直之、成澤寛、秋山真志、植木理恵、伊藤泰介、中村元信、幸野健、円形脱毛症診療ガイドライン2010、日皮会誌:120(9),1841-1859,2010.
• [Remarks] 一般向け図書
• [Remarks] 板見智:専門医が語る毛髪科学最前線、集英社新書、集英社、東京、1-173、2009.
• [Remarks] 報道機関向け情報
• [Remarks] 円形脱毛症、ステロイド注射は推奨?学会が治療法評価、朝日新聞、8月21日、2010
• [Remarks] 前立腺癌、薄毛と関連?、読売新聞、2月21日、2011
• [Remarks] ののちゃんのDo科学?なぜ髪がうすくなるの?、朝日新聞、4月25日、2011
• [Remarks] 育毛剤 毎日新聞記者が体験…生える場所は選べず、毎日新聞、5月12日、2011
• [Remarks] ホームページ
  • URL: http://www.r-derma.med.osaka-u.ac.jp/