The investigation on the pathogenesis of fibrosis using scleroderma fibroblasts

• Project/Area Number: 20591350
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Dermatology
• Research Institution: Kumamoto University
• Principal Investigator: IHN Hironobu Kumamoto University, 生命科学研究部, 教授 (20282634)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: collagen / TGF-β / extracellular matrix / signal transduction / transcriptional regulation

Research Abstract

We investigated scleroderma fibroblasts as an in vitro model of fibrosis. We have shown that scleroderma fibroblasts overexpressed thrombospondin-1 (TSP-1), one of extracellular matrix proteins, and down-regulated CD36, the ligand for TSP-1. These phenomenon were shown to be induced by autocrine transforming growth factor-β (TGF-β) signaling in scleroderma fibroblasts. Furthermore, forced overexpression of TSP-1 or knock-down of CD36 was shown to induce fibrosis.

Research Products

• [Journal Article] Circulating microRNA associated with TNF signaling pathway in patients with plaque psoriasis. (2011)
  • Author(s): Oyama R, Jinnin M, Kakimoto A, Kanemura H, Ichihara A, Fujisawa A, Honda N, Masuguchi S, Fukushima S, Maruo K, Ihn H.
  • Journal Title: J Dermatol Sci 61 Pages: 209-211
  • Peer Reviewed
• [Journal Article] Circulating microRNA-221 level in patients with malignant melanoma as a new tumor marker. (2011)
  • Author(s): Kanemura H, Fukushima S, Yamashita J, Honda N, Oyama R, Kakimoto A, Masuguchi S, Ishihara T, Inoue Y, Jinnin M, Ihn H.
  • Journal Title: J Dermatol Sci 61 Pages: 187-193
  • Peer Reviewed
• [Journal Article] Expression of matrix metalloproteinase-13 is controlled by IL-13 via PI3K/Akt3 and PKC-・ in normal dermal fibroblasts. (2011)
  • Author(s): Moriya C, Jinnin M, Yamane K, Maruo K, Muchemwa FC, Igata T, Makino T, Fukushima S, Ihn H.
  • Journal Title: J Invest Dermatol 131 Pages: 655-661
  • Peer Reviewed
• [Journal Article] Altered dynamics of TGF-・ receptors in scleroderma fibroblasts. (2011)
  • Author(s): Asano Y, Ihn H, Jinnin M, Tamaki K.
  • Journal Title: Ann Rheum Dis 70 Pages: 384-387
  • Peer Reviewed
• [Journal Article] Circulating miR-29a levels in patients with scleroderma spectrum disorder. (2011)
  • Author(s): Kawashita Y, Jinnin M, Makino T, Kajihara I, Makino K, Honda N, Masuguchi S, Fukushima S, Inoue Y, Ihn H.
  • Journal Title: J Dermatol Sci 61 Pages: 67-69
  • Peer Reviewed
• [Journal Article] Circulating miR-29a levels in patients with scleroderma-spectrum disorder. (2011)
  • Author(s): Kawashita Y, Jinnin M, Makino T, Kajihara I, Makino K, Honda N, Masuguchi S, Fukushima S, Inoue Y, Ihn H.
  • Journal Title: J Dermatol Sci Volume: 61 Pages: 67-69
  • Peer Reviewed
• [Journal Article] Altered dynamics of TGF-β receptors in scleroderma fibroblasts. (2011)
  • Author(s): Asano Y, Ihn H, Jinnin M, Tamaki K.
  • Journal Title: Ann Rheum Dis Volume: 70 Pages: 384-387
  • Peer Reviewed
• [Journal Article] Down-regulation of mir-424 contributes to the abnormal angiogenesis via MEK1 and cyclin E1 in senile hemangioma : its implications to therapy. (2010)
  • Author(s): Nakashima T, Jinnin M, Etoh T, Fukushima S, Masuguchi S, Maruo K, Inoue Y, Ishihara T, Ihn H.
  • Journal Title: PloS One 5
  • Peer Reviewed
• [Journal Article] Impaired lymphangiogenesis due to excess VEGF-D/Flt-4 signaling in the skin of patients with systemic sclerosis. (2010)
  • Author(s): Honda N, Jinnin M, Kajihara I, Makino T, Fukushima T, Ihn H.
  • Journal Title: Br J Dermatol 163 Pages: 776-780
  • Peer Reviewed
• [Journal Article] Serum TARC/CCL17 levels are increased in dermatomyositis associated with interstitial lung disease. (2010)
  • Author(s): Kawashima T, Tada Y, Asano Y, Yazawa N, Tomita M, Tamaki Z, Kubo M, Ihn H, Sugaya M, Kadono T, Tamaki K, Sato S.
  • Journal Title: J Dermatol Sci 60 Pages: 52-54
  • Peer Reviewed
• [Journal Article] Characterization of monocyte/macrophage subsets in the skin and peripheral blood derived from patients with systemic sclerosis. (2010)
  • Author(s): Higashi-Kuwata N, Jinnin M, Makino T, Fukushima S, Inoue Y, Muchemwa FC, Yonemura Y, Komohara Y, Takeya M, Mitsuya H, Ihn H.
  • Journal Title: Arhritis Res Ther 12
  • Peer Reviewed
• [Journal Article] Amelanotic malignant melanoma where primary lesion was discovered 5 years after metastasis in the lymph node. (2010)
  • Author(s): Kato T, Inoue Y, Ishihara T, Kageshita T, Ihn H.
  • Journal Title: J Dermatol 37 Pages: 730-734
  • Peer Reviewed
• [Journal Article] PDGFB quantification is a useful tool in the diagnosis of dermatofibrosarcoma protuberans : a study of 10 cases. (2010)
  • Author(s): Muchemwa FC, Wakasugi S, Honda Y, Ihn H.
  • Journal Title: Clin Exp Dermatol 35 Pages: 295-299
  • Peer Reviewed
• [Journal Article] A novel COL1A1 exon 14/PDGFB fusion gene in dermatofibrosarcoma protuberans (2010)
  • Author(s): Muchemwa FC, Jinnin M, Wakasugi S, Sakamoto M, Inoue Y, Ishihara T, Ihn H.
  • Journal Title: Eur J Dermatol 20 Pages: 390-391
  • Peer Reviewed
• [Journal Article] Serum levels of soluble vascular endothelial growth factor receptor-2 in patients with systemic sclerosis. (2010)
  • Author(s): Jinnin M, Makino T, Kajihara I, Honda N, Makino K, Ogata A, Ihn H.
  • Journal Title: Br J Dermatol 162 Pages: 751-758
  • Peer Reviewed
• [Journal Article] Basic fibroblast growth factor stimulates the proliferation of human dermal fibroblasts via the ERK1/2 and JNK pathways. (2010)
  • Author(s): Makino T, Jinnin M, Muchemwa F, Fukushima S, Ihn H.
  • Journal Title: Br J Dermatol 162 Pages: 717-723
  • Peer Reviewed
• [Journal Article] Supression of melanin production by expression of HSP70. (2010)
  • Author(s): Hoshino T, Matsuda M, Yamashita Y, Takehara M, Fukuya M, Mineda K, Maji D, Ihn H, Adachi H, Sobue G, Funasaka Y, Mizushima T.
  • Journal Title: J Biol Chem 285 Pages: 13254-13263
  • Peer Reviewed
• [Journal Article] Up-regulated type I collagen expression by the inhibition of Rac1 signaling pathway in human dermal fibroblasts. (2010)
  • Author(s): Igata T, Jinnin M, Makino T, Moriya C, Muchemwa F, Ishihara T, Ihn H.
  • Journal Title: Biochem Biophys Res Commun 393 Pages: 101-105
  • Peer Reviewed
• [Journal Article] Transglutaminase 1 preferred substrate prptide K5 is an efficient tool in diagnosis of lamellar ichthyosis. (2010)
  • Author(s): Akiyama M, Sakai K, Yanagi T, Fukushima S, Ihn H, Hitomi K, Shimizu H.
  • Journal Title: Am J Pathol 176 Pages: 1592-1599
  • Peer Reviewed
• [Journal Article] The expression of human high molecular weight melanoma-associated antigen in acral lentiginous melanoma. (2010)
  • Author(s): Nishi H, Inoue Y, Kageshita T, Takata M, Ihn H.
  • Journal Title: Bioscience Trends 4 Pages: 86-89
  • Peer Reviewed
• [Journal Article] Prevention of ultraviolet B radiation-induced epidermal damage by expression of heat shock protein 70. (2010)
  • Author(s): Matsuda M, Hoshino T, Yamashita Y, Tanaka KI, Maji D, Sato K, Adachi H, Sobue G, Ihn H, Funasaka Y, Mizushima T.
  • Journal Title: J Biol Chem 285 Pages: 5848-5858
  • Peer Reviewed
• [Journal Article] CD109 expression levels in human malignant melanoma. (2010)
  • Author(s): Ohshima Y, Yajima I, Yanagishita T, Kumasaka MY, Yanagishita T, Watanabe D, Takahashi M, Inoue Y, Ihn H, Matsumoto Y, Kato M.
  • Journal Title: J Dermatol Sci 57 Pages: 132-146
  • Peer Reviewed
• [Journal Article] CD109 expression levels in human malignant melanoma. (2010)
  • Author(s): Ohshima Y, Yajima I, Yanagishita T, Kumasaka MY, Yanagishita T, Watanabe D, Takahashi M, Inoue Y, Ihn H, Matsumoto Y, Kato M.
  • Journal Title: J Dermatol Sci Volume: 57 Pages: 132-146
  • Peer Reviewed
• [Journal Article] Prevention of ultraviolet B radiation-induced epidermal damage by expression of heat shock protein 70. (2010)
  • Author(s): Matsuda M, Hoshino T, Yamashita Y, Tanaka KI, Maji D, Sato K, Adachi H, Sobue G, Ihn H, Funasaka Y, Mizushima T.
  • Journal Title: J Biol Chem Volume: 285 Pages: 5848-5858
  • Peer Reviewed
• [Journal Article] The expression of human high molecular weight melanoma-associated antigen in acral lentiginous melanoma. (2010)
  • Author(s): Nishi H, Inoue Y, Kageshita T, Takata M, Ihn H.
  • Journal Title: Bioscience Trends Volume: 4 Pages: 86-89
  • Peer Reviewed
• [Journal Article] Transglutaminase 1 preferred substrate peptide K5 is an efficient tool in diagnosis of lamellar ichthyosis. (2010)
  • Author(s): Akiyama M, Sakai K, Yanagi T, Fukushima S, Ihn H, Hitomi K, Shimizu H.
  • Journal Title: Am J Pathol Volume: 176 Pages: 1592-1599
  • Peer Reviewed
• [Journal Article] Up-regulated type I collagen expression by the inhibition of Rac1 signaling pathway in human dermal fibroblasts. (2010)
  • Author(s): Igata T, Jinnin M, Makino T, Moriya C, Muchemwa F, Ishihara T, Ihn H.
  • Journal Title: Biochem Biophys Res Commun Volume: 393 Pages: 101-105
  • Peer Reviewed
• [Journal Article] Supression of melanin production by expression of HSP70. (2010)
  • Author(s): Hoshino T, Matsuda M, Yamashita Y, Takehara M, Fukuya M, Mineda K, Maji D, Ihn H, Adachi H, Sobue G, Funasaka Y, Mizushima T.
  • Journal Title: J Biol Chem Volume: 285 Pages: 13254-13263
  • Peer Reviewed
• [Journal Article] Basic fibroblast growth factor stimulates the proliferation of human dermal fibroblasts via the ERK1/2 and JNK pathways. (2010)
  • Author(s): Makino T, Jinnin M, Muchemwa F, Fukushima S, Ihn H.
  • Journal Title: Br J Dermatol Volume: 162 Pages: 717-723
  • Peer Reviewed
• [Journal Article] Serum levels of soluble vascular endothelial growth factor receptor-2 in patients with-systemic sclerosis. (2010)
  • Author(s): Jinnin M, Makino T, Kajihara I, Honda N, Makino K, Ogata A, Ihn H.
  • Journal Title: Br J Dermatol Volume: 162 Pages: 751-758
  • Peer Reviewed
• [Journal Article] A novel COL1A1 exon 14/PDGFB fusion gene in dermatofibrosarcoma protuberans (2010)
  • Author(s): Muchemwa FC, Jinnin M, Wakasugi S, Sakamoto M, Inoue Y, Ishihara T, Ihn H.
  • Journal Title: Eur J Dermatol Volume: 20 Pages: 390-391
  • Peer Reviewed
• [Journal Article] PDGFB quantification is a useful tool in the diagnosis of dermatofibrosarcoma protuberans : a study of 10 cases. (2010)
  • Author(s): Muchemwa FC, Wakasugi S, Honda Y, Ihn H.
  • Journal Title: Clip Exp Dermatol Volume: 35 Pages: 295-299
  • Peer Reviewed
• [Journal Article] Inflixmab monotherapy in Japanese patients with moderate-to-severe plaque psoriasis and psoriatic arthritis.A randomized, double-blind, placebo-controlled multicenter trial. (2010)
  • Author(s): Torii H, Nakagawa H, Iizuka H, Aoyagi S, Okuyama R, Ohtsuki M, Abe M, Takamori K, Matsuba S, Terui T, Igarashi A, Kawashima M, Amagai M, Takae Y, Eto H, Ikeda S, Komine M, Saeki H, Hayakawa K, Kitami A, Watanabe H, Takehara K, Shimade S, Kitajima Y, Takigawa M, Morita A, Yamanaka K, Takahashi K, Tarutani M, Tarsi M, Kubota.Y, Nakayama J, Ihn H.
  • Journal Title: J Dermatol Sci Volume: 59 Pages: 40-49
  • Peer Reviewed
• [Journal Article] Amelanoti malignant melanoma where primary lesion was discovered 5 ears after metastasis in the lymph node. (2010)
  • Author(s): Kato T, Inoue Y, Ishihara T, Kageshita T, Ihn H.
  • Journal Title: J Dermatol Volume: 37 Pages: 730-734
  • Peer Reviewed
• [Journal Article] Characterization of monocyte/macrophage subsets in the skin and peripheral blood derived from patients with systemic sclerosis. (2010)
  • Author(s): Higashi-Kuwata N, Jinnin M, Makino T, Fukushima S, Inoue Y, Muchemwa FC, Yonemura Y, Komohara Y, Takeya M, Mitsuya H, Ihn H.
  • Journal Title: Arhritis Res Ther Volume: 12
  • Peer Reviewed
• [Journal Article] Serum TARC/CCL17 levels are increased in dermatomyositis associated with interstitial lung disease. (2010)
  • Author(s): Kawashima T, Tada Y, Asano Y, Yazawa N, Tomita M, Tamaki Z, Kubo M, Ihn H, Sugaya M, Kadono T, Tamaki K, Sato S.
  • Journal Title: J Dermatol Sci Volume: 60 Pages: 52-54
  • Peer Reviewed
• [Journal Article] Impaired lymphangiogenesis due to excess VEGF-D/Flt-4 signaling in the skin of patients with systemic sclerosis. (2010)
  • Author(s): Honda N, Jinnin M, Kajihara I, Makino T, Fukushima T, Ihn H.
  • Journal Title: Br J Dermatol Volume: 163 Pages: 776-780
  • Peer Reviewed
• [Journal Article] Down-regulation of mir-424 contributes to the abnormal angiogenesis via MEK1 and cyclin E1 in senile hemangioma : its implications to therapy. (2010)
  • Author(s): Nakashima T, Jinnin M, Etoh T, Fukushima S, Masuguchi S, Maruo K, Inoue Y, Ishihara T, Ihn H.
  • Journal Title: PloS One Volume: 5
  • Peer Reviewed
• [Journal Article] CD109 expression levels in human malignant melanoma (2010)
  • Author(s): Ohshima Y, Yajima I, Yanagishita T, Kumasaka MY, Yanagishita T, Watanabe D, Takahashi M, Inoue Y, Ihn H, Matsumoto Y, Kato M.
  • Journal Title: J Dermatol Sci 57 Pages: 132-146
  • Peer Reviewed
• [Journal Article] Prevention of ultraviolet B radiation-induced epidermal damage by expression of heat shock protein 70 (2010)
  • Author(s): Matsuda M, Hoshino T, Yamashita Y, Tanaka KI, Maji D, Sato K, Adachi H, Sobue G, Ihn H, Funasaka Y, Mizushima T.
  • Journal Title: J Biol Chem 285 Pages: 5848-5858
  • Peer Reviewed
• [Journal Article] 全身性強皮症の基礎的病態―最近の知見― (2010)
  • Author(s): 尹浩信
  • Journal Title: 日本胸部臨床 3 Pages: 183-190
  • Peer Reviewed
• [Journal Article] Decreased serum IL-7 levels in patients with systemic sclerosis. (2009)
  • Author(s): Makino T, Johno T, Fukushima S, Wakasugi S, Inoue Y, Ihn H.
  • Journal Title: Clin Exp Rheumatol 54s Pages: 68-69
  • Peer Reviewed
• [Journal Article] Clinical usefulness of anti-RNA polymerase III antibody measurement by enzyme-linked immunosorbent assay. (2009)
  • Author(s): Satoh T, Ishikawa O, Ihn H, Endo H, Kawaguchi Y, Sasaki T, Goto D, Takahashi K, Takahashi H, Misaki Y, Mimori T, Muro Y, Yazawa N, Sato S, Takehara K, Kuwana M.
  • Journal Title: Rheumatology 48 Pages: 1570-1574
  • Peer Reviewed
• [Journal Article] Alternatively activated macrophages (M2 macrophages) in the skin of patients with localized scleroderma. (2009)
  • Author(s): Higashi-Kuwata N, Makino T, Inoue Y, Takeya M, Ihn H.
  • Journal Title: Exp Dermatol 18 Pages: 727-729
  • Peer Reviewed
• [Journal Article] The expression of SnoN in normal human skin and cutaneous keratinous neoplasms. (2009)
  • Author(s): Zhang X, Egawa K, Xie Y, Ihn H.
  • Journal Title: Int J Dermatol 48 Pages: 579-583
  • Peer Reviewed
• [Journal Article] Multiple antigen-targeted immunotherapy with α-galactosylceramide-loaded and genetically engineered dendritic cells derived from embryonic stem cells. (2009)
  • Author(s): Fukushima S, Hirata S, Motomura Y, Fukuma D, Matsunaga Y, Haruta M, Ikuta Y, Ikeda T, Kageshita T, Ihn H, Nishimura Y, Senju S.
  • Journal Title: J Immunotherapy 32 Pages: 219-231
  • Peer Reviewed
• [Journal Article] The prevalence of melanocytic nevi on the soles in the Japanese population. (2009)
  • Author(s): Kogushi-Nishi H, Kawasaki J, Kageshita T, Ishihara T, Ihn H.
  • Journal Title: J Am Acad Dermatol 60 Pages: 767-771
  • Peer Reviewed
• [Journal Article] Non-radioisotope method for diagnosing photosensitive disorders and a new marker for xeroderma pigmentosum variant. (2009)
  • Author(s): Hashimoto S, Egawa K, Ihn H, Tateishi S.
  • Journal Title: J Dermatol 36 Pages: 130-135
  • Peer Reviewed
• [Journal Article] Non-radioisotope method for diagnosing photosensitive disorders and a new marker for xeroderma pigmentosum variant (2009)
  • Author(s): Hashimoto S, Egawa K, Ihn H, Tateishi S.
  • Journal Title: J Dermatol 36 Pages: 130-135
  • Peer Reviewed
• [Journal Article] A randomized double-blind trial of intravenous immunoglobulin for pemphigus (2009)
  • Author(s): Amagai M, Ikeda S, Shimizu H, Iizuka H, Hanada K, Aiba S, Kaneko F, Izaki S, Tamaki K, Ikezawa Z, Takigawa M, Seishima M, Tanaka T, Miyachi Y, Katayama I, Horiguchi Y, Miyagawa S, Furukawa F, Twatsuki K, Hide M, Tokura Y, Furue M, Hashimoto T, Ihn H, Fujiwara S, Nishikawa T, Ogawa H, Kitajima Y, Hashimoto K.
  • Journal Title: J Am Acad Dermatol 60 Pages: 595-603
  • Peer Reviewed
• [Journal Article] The prevalence of melanocytic nevi on the soles in the Japanese population (2009)
  • Author(s): Kogushi-Nishi H, Kawasaki J, Kageshita T, Ishihara T, Ihn H.
  • Journal Title: J Am Acad Dermatol 60 Pages: 767-771
  • Peer Reviewed
• [Journal Article] Multiple antigen-targeted immunotherapy with α-galactosylcer amide-loaded and genetically engineered dendritic cells derived from embryonic stem cells (2009)
  • Author(s): Fukushima S, Hirata S, Motomura Y, Fukuma D, Matsunaga Y, Haruta M, Ikuta Y, Ikeda T, Kageshita T, Ihn H, Nishimura Y, Senju S.
  • Journal Title: J Immunotherapy 32 Pages: 219-231
  • Peer Reviewed
• [Journal Article] Retrospective study of clinical and laboratory features in Japanese scleroderma patients with cardiac involvement (2009)
  • Author(s): Jinnin M, Ihn H, Asano Y, Yamane K, Yazawa N, Tamaki K.
  • Journal Title: J Dermatol Sci 55 Pages: 70-72
  • Peer Reviewed
• [Journal Article] The expression of SnoN in normal human skin and cutaneous keratinous neoplasms (2009)
  • Author(s): Zhang X, Egawa K, Me Y, Ihn H.
  • Journal Title: Int J Dermatol 48 Pages: 579-583
  • Peer Reviewed
• [Journal Article] Alternatively activated macrophages(M2 macrophages)in the skin of patients with localized scleroderma (2009)
  • Author(s): Higashi-Kuwata N, Makino T, Inoue Y, Takeya M, Ihn H.
  • Journal Title: Exp Dermatol 18 Pages: 727-729
  • Peer Reviewed
• [Journal Article] Clinical and laboratoryu features of scleroderma patients with telangiectasia (2009)
  • Author(s): Ashida R, Ihn H, Mimura Y, Jinnin M, Asano Y, Kubo M, Tamaki K.
  • Journal Title: Clin Exp Dermatol 34 Pages: 781-783
  • Peer Reviewed
• [Journal Article] Cutaneous γ/δ T-cell lymphoma treated with retinoid and narrowband ultraviolet B. (2009)
  • Author(s): Nakashima H, Sugaya M, Minatani T, Ohmatsu H, Asano N, Fujimoto M, Kikuchi K, Ihn H, Tamaki K.
  • Journal Title: Clin Exp Dermatol 34
  • Peer Reviewed
• [Journal Article] Clinical usefulness of anti-RNA polymerase III antibody measurement by enzyme-linked immunosorbent assay (2009)
  • Author(s): Satoh T, Ishikawa O, Ihn H, Endo H, Kawaguchi Y, Sasaki T, Goto D, Takahashi K, Takahashi H, Misaki Y, Mimori T, Muro Y, Yazawa N, Sato S, Takehara K, Kuwana M.
  • Journal Title: Rheumatology 48 Pages: 1570-1574
  • Peer Reviewed
• [Journal Article] Decreased serum IL-7 levels in patients with systemic sclerosis (2009)
  • Author(s): Makino T, Johno T, Fukushima S, Wakasugi S, Inoue Y, Ihn H.
  • Journal Title: Clin Exp Rheumatol 54s Pages: 68-69
  • Peer Reviewed
• [Journal Article] 主要疾患における研究動向 強皮症 (2009)
  • Author(s): 尹浩信
  • Journal Title: 日本臨床 67 Pages: 519-522
  • Peer Reviewed
• [Journal Article] 全身性強皮症の治療の進歩 (2009)
  • Author(s): 尹浩信
  • Journal Title: 総合臨床 59 Pages: 1275-1276
  • Peer Reviewed
• [Journal Article] 線維化を伴う皮膚疾患の臨床と線維化の分子機序(前編)―全身性強皮症― (2009)
  • Author(s): 尹浩信
  • Journal Title: 西日本皮膚 71 Pages: 428-433
  • NAID: 10026321345
  • Peer Reviewed
• [Journal Article] 全身性強皮症の治療の進歩と研究の動向 (2009)
  • Author(s): 尹浩信
  • Journal Title: 医学のあゆみ 230 Pages: 1008-1012
  • Peer Reviewed
• [Journal Article] 線維化を伴う皮膚疾患の臨床と線維化の分子機序(中編)―限局性強皮症、深在性エリテマトーデス、硬化性萎縮性苔癬、硬化性脂肪織炎、ケロイド/肥厚性瘢痕― (2009)
  • Author(s): 尹浩信
  • Journal Title: 西日本皮膚 71 Pages: 506-511
  • NAID: 10026321529
  • Peer Reviewed
• [Journal Article] 線維化を伴う皮膚疾患の臨床と線維化の分子機序(後編)―皮膚線維化の分子機序― (2009)
  • Author(s): 尹浩信
  • Journal Title: 西日本皮膚 71 Pages: 592-596
  • NAID: 10026321753
  • Peer Reviewed
• [Journal Article] Non-radioisotope method for diagnosing photosensitive disorders and a new marker for xeroderma pigmentosum variant. (2009)
  • Author(s): Hashimoto S.
  • Journal Title: J Dermatol 36 Pages: 130-135
  • Peer Reviewed
• [Journal Article] A randomized double-blind trial of intravenous immunoglobulin for pemphigus. (2009)
  • Author(s): Amagai M.
  • Journal Title: J Am Acad Dermatol 60 Pages: 595-603
  • Peer Reviewed
• [Journal Article] Quick detection of herpes viruses from skin vesicles and exudates without nucleic acid extraction using the multiplex PCR method. (2008)
  • Author(s): Sakai K, Wakasugi S, Muchemwa FC, Ihn H.
  • Journal Title: Bioscience Trends 2 Pages: 164-168
  • Peer Reviewed
• [Journal Article] Adult-onset neurological degeneration in a patient with Cockayne syndrome and a null mutation in the CSB gene. (2008)
  • Author(s): Hashimoto S, Suga T, Kudo E, Ihn H, Uchino M, Tateishi S.
  • Journal Title: J Invest Dermatol 128 Pages: 1597-1599
  • Peer Reviewed
• [Journal Article] Immunohistochemical characterization of the cellular infiltrate in localized scleroderma. (2008)
  • Author(s): Xie Y, Zhang X, Wakasugi S, Makino T, Inoue Y, Ihn H.
  • Journal Title: Int J Dermatol 47 Pages: 438-442
  • Peer Reviewed
• [Journal Article] A new disorder in UV-induced skin cancer with defective DNA repair distinct from xeroderma pigmentosum or Cocyayne syndrome. (2008)
  • Author(s): Hashimoto S, Egawa K, Ihn H, Igarashi A, Matsunaga T, Tateishi S, Yamaizumi M.
  • Journal Title: J Invest Dermatol 128 Pages: 694-701
  • Peer Reviewed
• [Journal Article] Autocrine TGF-β signaling in the pathogenesis of systemic sclerosis. (2008)
  • Author(s): Ihn H.
  • Journal Title: J Dermatol Sci 49 Pages: 103-113
  • Peer Reviewed
• [Journal Article] Expression of CDla and CD86 on scleroderma Langerhans cells. (2008)
  • Author(s): Xie Y.
  • Journal Title: Eur J Dermatol 18 Pages: 50-54
  • Peer Reviewed
• [Journal Article] Autocrine TGF-β signaling the pathogenesis of systemic sclerosis. (2008)
  • Author(s): Ihn H.
  • Journal Title: J Dermatol Sci 19 Pages: 103-113
  • Peer Reviewed
• [Journal Article] Identification and characterization of the novel cetrosomal protoin centlein. (2008)
  • Author(s): Makino K.
  • Journal Title: Biochem Biophys Res Commun 366 Pages: 958-962
  • Peer Reviewed
• [Journal Article] Constitutive activation of the phosphatidyl ionositol 3 kinasesignaling pathway in acral lontinginous melanoma. (2008)
  • Author(s): Muchemwa FC.
  • Journal Title: Br J Dermatol 158 Pages: 411-413
  • Peer Reviewed
• [Journal Article] A new disorder in UV-induced skin cancer with defective DNA repair distinect from xeroderma pigmentosum or Coeyayne syndrome. (2008)
  • Author(s): Hashimoto S.
  • Journal Title: J Invest Dermatol 128 Pages: 694-701
  • Peer Reviewed
• [Journal Article] Epidemiological survey of Vibrio vulnificus infection in japanbetween 1999 and 2003. (2008)
  • Author(s): Tnoue Y.
  • Journal Title: J Dermatol 35 Pages: 129-139
  • Peer Reviewed
• [Journal Article] Immunohistochemical characterization of the cellular infiltrate in localized seleroderma. (2008)
  • Author(s): Xie Y.
  • Journal Title: Int J Dermatol 17 Pages: 438-442
  • Peer Reviewed
• [Journal Article] Clinical relevance of serum levels of matrix metallopeptidase-2, and tissue inhibitor of metalloproteinase-1 and-2 in patie nts with malignant melanoma. (2008)
  • Author(s): Yoshino Y.
  • Journal Title: J Dermatol 35 Pages: 206-214
  • Peer Reviewed
• [Journal Article] Submental perforator flap : location and number of submental perforating vessels. (2008)
  • Author(s): Ishihara T.
  • Journal Title: Sean J Plast Rcconstr Surg Hand Surg 4 2 Pages: 127-131
  • Peer Reviewed
• [Journal Article] Differential expression of heat shock protein 105 in melanomaand melanocytic naevi. (2008)
  • Author(s): Muchemwa FC.
  • Journal Title: Melanoma Res 18 Pages: 166-71
  • Peer Reviewed
• [Journal Article] Alkaline trypan blue as a stain for superficial fungi. (2008)
  • Author(s): Ikeda I.
  • Journal Title: Br J Dermatol 158 Pages: 1371-1401
  • Peer Reviewed
• [Journal Article] Adult-onset meurological degeneration in a patient with Cockaynesyndrome and a null mutation in the CSB gene. (2008)
  • Author(s): Hashimoto S.
  • Journal Title: J Invest, Dermatol 128 Pages: 1597-1599
  • Peer Reviewed
• [Journal Article] Fixed drug eruption caused by cashew nut. (2008)
  • Author(s): Fukushima S.
  • Journal Title: Allergol Int 5 7 Pages: 285-287
  • Peer Reviewed
• [Journal Article] Two cases of anti-epiligrin cicatricial pemphigoid with and without associated malignancies. (2008)
  • Author(s): Fukushima S.
  • Journal Title: Acta Dermato Venereol 88 Pages: 484-487
  • Peer Reviewed
• [Journal Article] Juvenile pustular psoriasis associated with steroid withdrawal syndronme due to topical corticosteroid. (2008)
  • Author(s): Saeki H.
  • Journal Title: J Dermatol 35 Pages: 601-603
  • Peer Reviewed
• [Journal Article] Proliferating trichilemmal cystic careinoma : a case containing differentiated and dedifferentiated parts. (2008)
  • Author(s): Masui Y.
  • Journal Title: J Cutan Pathol 35 Pages: 55-58
  • Peer Reviewed
• [Journal Article] Using the Smallest Skin excision without Dog-Ear Formations : Utilizing Histopathology on the Face. (2008)
  • Author(s): I shihara T.
  • Journal Title: Dermatol surg 34 Pages: 1404-1406
  • Peer Reviewed
• [Journal Article] Quick detection of herpes viruses from skin vesicles and exudates without nucleic acid extraction using the multiplex PCR method (2008)
  • Author(s): Sakai K.
  • Journal Title: Bioseience Trends 2 Pages: 164-168
  • Peer Reviewed
• [Journal Article] The expression levels of thrombospondin-1 in dermatofibroma and dermatofibrosarcoma protuberans.
  • Author(s): Maekawa T, Jinnin M, Ihn H.
  • Journal Title: Eur J Dermatol in press.
• [Journal Article] Analysis of adiponectin expression in rheumatic diseases.
  • Author(s): Arakawa H, Jinnin M, Muchemwa FC, Makino T, Kajihara I, Makino K, Honda N, Sakai K, Fukushima S, Ihn H.
  • Journal Title: Exp Dermatol in press.
• [Journal Article] Immunohistochemical characterization of the cellular infiltrate in discoid lupus erythematosus.
  • Author(s): Xie Y, Jinnin M, Zhang X, Wakasugi S, Makino T, Inoue Y, Masuguchi S, Sakai K, Jinnin M, Ihn H.
  • Journal Title: BioScience Trends in press.
• [Journal Article] Clinical significance of cobble stone appearance on the skin of patients with systemic sclerosis.
  • Author(s): Kajihara I, Jinnin M, Makino T, Toihata-Yonemitsu A, Fukushima S, Ihn H.
  • Journal Title: J Eur Acad Dermatol Venereol in press.
• [Journal Article] Expression pattern of new vessels arise related factors, VEGF1,2,3, and D2-40 protein, in the skin of patients with systemic sclerosis.
  • Author(s): Kuwata N, Makino T, Inoue Y, Ihn H.
  • Journal Title: Eur J Dermatol in press.
• [Journal Article] Serum levels of soluble CD163 in patients with systemic sclerosis.
  • Author(s): Nakayama W, Jinnin M, Makino K, Kajihara I, Makino T, Fukushima S, Inoue Y, Ihn H.
  • Journal Title: Rheumatol Int in press.
• [Journal Article] Serum levels of soluble CD21 in patients with sclerosis.
  • Author(s): Tomita M, Kadono T, Yazawa N, Kawashima T, Tamaki Z, Ashida R, Ohmatsu H, Asano Y, Sugaya M, Kubo M, Ihn H, Tamaki K, Sato S.
  • Journal Title: Rheumatol Int in press
• [Presentation] 全身性強皮症と限局性強皮症:臨床・治療と最近の話題 (2010)
  • Author(s): 尹浩信
  • Organizer: 日本皮膚科学会第352回福岡地方会
  • Place of Presentation: 福岡(ホテルニューオータニ博多)
  • Year and Date: 2010-03-13
• [Presentation] 強皮症―臨床と最近の話題― (2010)
  • Author(s): 尹浩信
  • Organizer: 日本皮膚科学会第119回山陰・第15回島根合同地方会
  • Place of Presentation: 島根(ビッグハート出雲)
  • Year and Date: 2010-03-07
• [Presentation] bFGFによる培養ヒト皮膚線維芽細胞の増殖刺激作用に関与するシグナル経路の検討 (2010)
  • Author(s): 牧野貴充, 神人正寿, 伊方敏勝, 藤澤明彦, Faith Muchemwa, 井上雄二, 尹浩信
  • Organizer: 厚生労働省「強皮症における病因解明と根治的治療法の開発」研究班2009年度班会議・第13回強皮症研究会議
  • Place of Presentation: 東京(大正製薬(株)本社2号館)
  • Year and Date: 2010-01-16
• [Presentation] 汎発性強皮症における血清 soluble VEGF2型レセプター濃度の検討 (2010)
  • Author(s): 神人正寿, 牧野貴充, 梶原一亨, 本多教稔, 緒方亜紀, 尹浩信
  • Organizer: 厚生労働省「強皮症における病因解明と根治的治療法の開発」研究班2009年度班会議・第13回強皮症研究会議
  • Place of Presentation: 東京(大正製薬(株)本社2号館)
  • Year and Date: 2010-01-16
• [Presentation] 全身性強皮症における血清 vascular endothelial growth factor-D(VEGF-D)値の検討 (2010)
  • Author(s): 本多教稔, 神人正寿, 梶原一亨, 牧野貴充, 尹浩信
  • Organizer: 厚生労働省「強皮症における病因解明と根治的治療法の開発」研究班2009年度班会議・第13回強皮症研究会議
  • Place of Presentation: 東京(大正製薬(株)本社2号館)
  • Year and Date: 2010-01-16
• [Presentation] 全身性強皮症における血清CD163値の検討 (2010)
  • Author(s): 中山若菜, 神人正寿, 牧野雄成, 梶原一亨, 牧野貴充, 尹浩信
  • Organizer: 厚生労働省「強皮症における病因解明と根治的治療法の開発」研究班2009年度班会議・第13回強皮症研究会議
  • Place of Presentation: 東京(大正製薬(株)本社2号館)
  • Year and Date: 2010-01-16
• [Presentation] 全身性強皮症における血清 Carbonic Anhydrase IX(CA9)値の検討 (2010)
  • Author(s): 牧野雄成, 神人正寿, 中山若菜, 梶原一亨, 牧野貴充, 尹浩信
  • Organizer: 厚生労働省「強皮症における病因解明と根治的治療法の開発」研究班2009年度班会議・第13回強皮症研究会議
  • Place of Presentation: 東京(大正製薬(株)本社2号館)
  • Year and Date: 2010-01-16
• [Presentation] 汎発性強皮症における cobblestone appearance の検討 (2010)
  • Author(s): 梶原一亨, 神人正寿, 牧野貴充, 尹浩信
  • Organizer: 厚生労働省「強皮症における病因解明と根治的治療法の開発」研究班2009年度班会議・第13回強皮症研究会議
  • Place of Presentation: 東京(大正製薬(株)本社2号館)
  • Year and Date: 2010-01-16
• [Presentation] PTAによる血行再建術が奏効した全身性強皮症患者の壊疽 (2010)
  • Author(s): 緒方亜紀, 本多教稔, 牧野公治, 宮下梓, 尹浩信, 山下淳二
  • Organizer: 厚生労働省「強皮症における病因解明と根治的治療法の開発」研究班2009年度班会議・第13回強皮症研究会議
  • Place of Presentation: 東京(大正製薬(株)本社2号館)
  • Year and Date: 2010-01-16
• [Presentation] 全身性強皮症の病因について (2010)
  • Author(s): 尹浩信
  • Organizer: 第54回日本リウマチ学会総会・学術集会
  • Place of Presentation: 神戸ポートピアホテル・神戸
• [Presentation] Molecular mechanism of fibrosis. (Invited Lecture) (2010)
  • Author(s): 尹浩信
  • Organizer: The 21th Academic Meeting of Korean Society for Investigative Dermatology
  • Place of Presentation: Auditorium, 1st Floor, Clinical Research Institute Seoul National University Hospital, Seoul, Korea
• [Presentation] PTAによる血行再建術が奏効した全身性強皮症患者の壊疽 (2010)
  • Author(s): 緒方亜紀, 本多教稔, 牧野公治, 宮下梓, 尹浩信, 山下淳二
  • Organizer: 第33回皮膚脈管膠原病研究会
  • Place of Presentation: 東京(文京シビックホール)
• [Presentation] Altered dynamics of TGF-β receptors in scleroderma fibroblasts (2010)
  • Author(s): Asano Y, Ihn H, Jinnin M, Mimura Y, Tamaki K, Sato S.
  • Organizer: 1^<st> Systemic Sclerosis World Congress
  • Place of Presentation: Florence, Italy(PALAZZO DEI CONGRESSI)
• [Presentation] Effects of the immunosuppressant rapamycin on human α2(I)collagen in scleroderma fibroblasts (2010)
  • Author(s): Tamaki Z, Asano Y, Kubo M, Ihn H, Yazawa N, Ashida R, Tomita M, Kawashima T, Tamaki K, Sato S.
  • Organizer: 1^<st> Systemic Sclerosis World Congress
  • Place of Presentation: Florence, Italy(PALAZZO DEI CONGRESSI)
• [Presentation] Decreased serum IL-7 levels in patients with systemic sclerosis (2010)
  • Author(s): Makino T, Fukushima S, Jinnin M, Ihn H.
  • Organizer: 1^<st> Systemic Sclerosis World Congress
  • Place of Presentation: Florence, Italy(PALAZZO DEI CONGRESSI)
• [Presentation] MRI、筋電図で筋炎所見を認めず筋生検にて筋炎の存在を診断した皮膚筋炎・全身性強皮症 overlap 症候群の1例 (2009)
  • Author(s): 宮下梓, 本多教稔, 牧野公治, 神人正寿, 尹浩信
  • Organizer: 日本皮膚科学会第199回熊本地方会
  • Place of Presentation: 熊本(熊本全日空ホテルニュースカイホテル)
  • Year and Date: 2009-12-06
• [Presentation] 両側性の顔而血管腫を認めたSturge-Weber症候群の一例 (2009)
  • Author(s): 山下淳二
  • Organizer: 日本形成外科学会九州支部学術集会第79回例会
  • Place of Presentation: 福岡
  • Year and Date: 2009-03-14
• [Presentation] 自然消退のみられた悪性黒色腫の2例 (2009)
  • Author(s): 井上雄二
  • Organizer: 第169回日本皮膚科学会信州地方会・総会
  • Place of Presentation: 長野
  • Year and Date: 2009-03-08
• [Presentation] 肺塞栓が疑われた重症熱傷の1例 (2009)
  • Author(s): 江崎由佳
  • Organizer: 第19回日本熱傷学会九州地方会
  • Place of Presentation: 熊本
  • Year and Date: 2009-02-21
• [Presentation] 転移性皮膚癌の2例 (2009)
  • Author(s): 問端 文
  • Organizer: 日本皮膚科学会第197回熊本地方会
  • Place of Presentation: 熊木
  • Year and Date: 2009-02-08
• [Presentation] 神経鞘腫が多発した神経鞘腫症2型の1例 (2009)
  • Author(s): 本多教稔
  • Organizer: 日本皮膚科学会第197回熊本地方会
  • Place of Presentation: 熊本
  • Year and Date: 2009-02-08
• [Presentation] プロカルシトニン(PCT)測定が病勢把握に有用と思われた壊死性筋膜炎の1例 (2009)
  • Author(s): 高橋亜紀
  • Organizer: 日本皮膚科学会第197回熊本地方会
  • Place of Presentation: 熊本
  • Year and Date: 2009-02-08
• [Presentation] ネクサバールによる薬疹の1例 (2009)
  • Author(s): 中山若菜
  • Organizer: 日本皮膚科学会第197回熊本地方会
  • Place of Presentation: 熊本
  • Year and Date: 2009-02-08
• [Presentation] 尋常性乾癖に水庖性類天庖塘を合併した1例 (2009)
  • Author(s): 原田美穂
  • Organizer: 日本皮膚科学会第197回熊本地方会
  • Place of Presentation: 熊本
  • Year and Date: 2009-02-08
• [Presentation] 外陰部悪性黒色腫のI例 (2009)
  • Author(s): 江崎由佳
  • Organizer: 日本皮膚科学会第197回熊本地方会
  • Place of Presentation: 熊本
  • Year and Date: 2009-02-08
• [Presentation] 高圧駿素療法が有効であった全身性強皮症に伴う指趾潰瘍の4例 (2009)
  • Author(s): 青井 淳
  • Organizer: 厚生労働省「強皮症における病囚解明と根治的治疸法の開発」研究班2008年度別会議・第12回強皮症研究会議
  • Place of Presentation: 東京
  • Year and Date: 2009-01-17
• [Presentation] 強皮症皮膚由来線維芽細胞におけるα2(l) colalgen遺伝子転写活性化に寄与する調節配列の検討 (2009)
  • Author(s): 神人正寿
  • Organizer: 厚生労仙省「強皮症における病因解明と根治的治療法の開発」研究班2008年度班会議・第12回強皮症研究会議
  • Place of Presentation: 東京
  • Year and Date: 2009-01-17
• [Presentation] bFGFによる培養ヒト皮膚線維芽細胞増殖刺激の機序について (2009)
  • Author(s): 牧野貴充
  • Organizer: 厚生労働省「強皮症における病因解明と根治的治療法の開発」研究班2008年度班会議・第12回強皮症研究会議
  • Place of Presentation: 東京
  • Year and Date: 2009-01-17
• [Presentation] 膠原病の臨床症状と治療 (2009)
  • Author(s): 尹浩信
  • Organizer: 第73回日本皮膚科学会東部支部学術大会
  • Place of Presentation: 山梨(甲府富士屋ホテル)
• [Presentation] Basic FGF stimulates the proliferation of human dermal fibroblasts via the ERK1/2 and JNK pathways (2009)
  • Author(s): Makino T, Jinnin M, Ihn H
  • Organizer: The 34th Annual Meeting of the Japanese Society for Investigative Dermatology
  • Place of Presentation: Fukuoka(JALリゾートシーホークホテル福岡)
• [Presentation] Inhibition of Rho family GTPase Rac1 signaling increased expression levels of type I collagen in human dermal fibroblasts in vitro (2009)
  • Author(s): Igata T, JInnin M, Makino T, Moriya C, Muchemwa FC, Ishihara T, Ihn H.
  • Organizer: The 34th Annual Meeting of the Japanese Society for Investigative Dermatology
  • Place of Presentation: Fukuoka(JALリゾートシーホークホテル福岡)
• [Presentation] The effect of IL-13 on MMP-13 expression in cultured normal human dermal fibroblasts (2009)
  • Author(s): Moriya C, Jinnin M, Maruo K, Muchemwa FC, Makino T, Igata T, Ihn H.
  • Organizer: The 34th Annual Meeting of the Japanese Society for Investigative Dermatology
  • Place of Presentation: Fukuoka(JALリゾートシーホークホテル福岡)
• [Presentation] 問質性肺炎を合併した全身性エリテマトーデス (2009)
  • Author(s): 宮下 梓
  • Organizer: 第32回皮膚脈管膠原病研究会
  • Place of Presentation: 京都
• [Presentation] 全身性強皮症における血清lL-7値と臨床症状の検討 (2009)
  • Author(s): 牧野貴充
  • Organizer: 第32回皮膚脈管膠原病研究会
  • Place of Presentation: 京都
• [Presentation] LDLアフェレーシスを試行したコレステロール結晶塞栓症の1例 (2008)
  • Author(s): 梶原一亨
  • Organizer: 日本皮膚科学会第196回熊本地方会
  • Place of Presentation: 熊本
  • Year and Date: 2008-12-14
• [Presentation] 有棘細胞癌がC. tetaniの侵入路となり破傷風が発症したと思われる1例 (2008)
  • Author(s): 間端 文
  • Organizer: 日本皮膚科学会第196回熊本地方会
  • Place of Presentation: 熊本
  • Year and Date: 2008-12-14
• [Presentation] 被爆歴のある、胸膜中皮種を合併したCTCLの1例 (2008)
  • Author(s): 中山若菜
  • Organizer: 日本皮膚科学会第196回熊本地方会
  • Place of Presentation: 熊本
  • Year and Date: 2008-12-14
• [Presentation] 生下時より腰部に腫瘤を認めたCongenita1 self-healing Langerhanscell histiocytosis (CSLCH) (2008)
  • Author(s): 高橋亜紀
  • Organizer: 日本皮膚科学会第196回熊本地方会
  • Place of Presentation: 熊本
  • Year and Date: 2008-12-14
• [Presentation] 当院で経験した乾癬性紅皮症の3例 (2008)
  • Author(s): 山下淳二
  • Organizer: 日本皮膚科学会第196回熊本地方会
  • Place of Presentation: 熊本
  • Year and Date: 2008-12-14
• [Presentation] 靴ずれよりsccを生じた1例 (2008)
  • Author(s): 江崎由佳
  • Organizer: 靴ずれよりsecを生じた1例
  • Place of Presentation: 熊本
  • Year and Date: 2008-12-14
• [Presentation] もどし植皮を行った慢性臀部膿皮症の1例 (2008)
  • Author(s): 牧野公治
  • Organizer: 第130回日本皮膚科学会徳島地方会
  • Place of Presentation: 徳島
  • Year and Date: 2008-11-22
• [Presentation] 後頭部に生じた骨肉腫の1例 (2008)
  • Author(s): 増口信一
  • Organizer: 日本形成外科学会九州支部学術集会第78回例会
  • Place of Presentation: 鹿児島
  • Year and Date: 2008-10-25
• [Presentation] in situ病変を繰り返し、 8年後に皮膚転移を来したALMの1例-ALMの切除範囲についての検討 (2008)
  • Author(s): 井上雄二
  • Organizer: 平成20年度厚生労働省がん助成金(山崎班)第2回会議
  • Place of Presentation: 東京
  • Year and Date: 2008-10-25
• [Presentation] シクロフォスフアミドパルス療法が奏効したアレルギー性肉芽腫性血管炎のl例 (2008)
  • Author(s): 中嶋泰治
  • Organizer: 日本皮膚科学会第346回福岡地方会
  • Place of Presentation: 北九州
  • Year and Date: 2008-09-28
• [Presentation] 下限瞼悪性腫瘍に対する皮膚外科的再建 (2008)
  • Author(s): 加藤裕史
  • Organizer: 第245回日本皮膚科学会東海地方会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-09-15
• [Presentation] 全身性強皮症と限局性強皮症 (2008)
  • Author(s): 尹 浩信
  • Organizer: 第52回日本皮膚科学会高知地方会例会
  • Place of Presentation: 高地
  • Year and Date: 2008-09-13
• [Presentation] 日本人のacral lentiginous melanoma症例のホルマリン固定切片におけるHuman High Molecular Weight-Mclanoma-Associated Antigenの発現率 (2008)
  • Author(s): 西 葉月
  • Organizer: 平成20年度厚生労働省がん研究助成金 第1回班会議
  • Place of Presentation: 東京
  • Year and Date: 2008-08-02
• [Presentation] 後頭部に生じた骨浸潤性皮下腫瘍の1例 (2008)
  • Author(s): 城野剛充
  • Organizer: 第24回日本皮膚病理組織学会
  • Place of Presentation: 東京
  • Year and Date: 2008-07-26
• [Presentation] Molecular mechanism of skin fibrosis (2008)
  • Author(s): Ihn H.
  • Organizer: The 3^<rd>Annual Meeting of Taiwanese Societyfor lnvestigative Dermatology
  • Place of Presentation: 台中
  • Year and Date: 2008-05-31
• [Presentation] Clinical aspects and pathogenesis of skin fibrosis (2008)
  • Author(s): Ihn H.
  • Organizer: 2008 Spring Meeting of Taiwanese Dermatological Association
  • Place of Presentation: 台中
  • Year and Date: 2008-05-31
• [Presentation] 熊本大学附属病院皮膚科・形成再建科外来患者の感染症に関するサーベイランス (2008)
  • Author(s): 恵濃明子
  • Organizer: 第5回日本褥瘡学会九州地方会学術集会
  • Place of Presentation: 長崎
  • Year and Date: 2008-05-24
• [Presentation] 卒前教肖 : 熊本大学における皮膚科学卒前教育 (2008)
  • Author(s): 尹 浩信
  • Organizer: 第107回日本皮膚科学会総会
  • Place of Presentation: 京都
• [Presentation] MultiplexリアルタイムPCRによるヘルペスウイルスの検出 (2008)
  • Author(s): 境 恵祐
  • Organizer: 第107回日本皮膚科学会総会
  • Place of Presentation: 京都
• [Presentation] 当院におけるamelanotic Malignant Melanoma16例の検討 (2008)
  • Author(s): 加膝裕史
  • Organizer: 第107回日本皮膚科学会総会
  • Place of Presentation: 京都
• [Presentation] 5-S-cysteindopa(5-S-CD) value in malignant melanoma case at Kumamoto University (2008)
  • Author(s): Inolle Y.
  • Organizer: Merger of Molecular Biology with Pigmentary diseases & Malignant Melanoma
  • Place of Presentation: 札幌
• [Presentation] A case of atopic dermatitis with infective endocarditis (2008)
  • Author(s): Maruo K.
  • Organizer: 5^<th> George Rajka International Symposium on Atopic Dermatitis
  • Place of Presentation: 京都
• [Presentation] Lupus erythematosus profundus : clinical and pathological features of 12 cases (2008)
  • Author(s): Miyashita A.
  • Organizer: 2^<nd> International Conference on Cutancous Lupus Erythematosus
  • Place of Presentation: 京都
• [Presentation] Molecular analysis of the genetic aberrations in dermatofibros arcoma protuberans (2008)
  • Author(s): Chikwanha FC.
  • Organizer: International lnvestigative Dermatology 2008
  • Place of Presentation: 京都
• [Presentation] Identification and characterization of a novel centrosomal protein (2008)
  • Author(s): Makino K.
  • Organizer: International lnvestigative Dermatology 2008
  • Place of Presentation: 京都
• [Presentation] Basie fibroblast growth factor stimulates the proliferation of dermal fibroblasts via activation of ERK1/2-dependent pathway (2008)
  • Author(s): Makino T.
  • Organizer: International Investigative Dermatology 2008
  • Place of Presentation: 京都
• [Presentation] Effective immunotherapy with a-GalCer-loaded embryonic stem ce11-derived dendric cells expressing multiple antigens against B16 melanoma (2008)
  • Author(s): Fukushima S.
  • Organizer: International Investigaltive Dermatology 2008
  • Place of Presentation: 京都
• [Presentation] A case report of epidermolysis bullosa acquisita (2008)
  • Author(s): Sakai K
  • Organizer: Post llD 2008 Satellite lnternational Meeting on Autoimmune Bullous Diseases
  • Place of Presentation: 大津
• [Presentation] 菊池恵楓園人所者における抗核抗体と臨床症状の検討 (2008)
  • Author(s): 牧野貴充
  • Organizer: 第81回日本ハンセン病学会総会・学術大会
  • Place of Presentation: 熊本
• [Presentation] 国立療養所菊池恵楓園と熊本大学附属病院皮膚科形成外科外来患者における足・爪白癬の現状比較 (2008)
  • Author(s): 城野剛充
  • Organizer: 第81回日本ハンセン病学会総会・学術大会
  • Place of Presentation: 熊本
• [Presentation] 膠原病における皮膚潰瘍治療 (2008)
  • Author(s): 尹 浩信
  • Organizer: 第81回日本ハンセン病学会総会・学術大会
  • Place of Presentation: 熊本
• [Presentation] ヒト母乳および脂肪組織から検出された人工香料の蓄積特性 (2008)
  • Author(s): 森部南
  • Organizer: 第17回環境化学討論会
  • Place of Presentation: 神戸
• [Presentation] CK上昇なく, MRIにて筋炎の存在が確認された小児皮膚筋炎の1例 (2008)
  • Author(s): 水廣利恵
  • Organizer: 第32回日本小児皮膚科学会
  • Place of Presentation: 東京
• [Presentation] 急速に増大したAngiomatoid fibrous histiocytomaの1例 (2008)
  • Author(s): 増口信一
  • Organizer: 第24回日本皮膚悪性腫瘍学会学術大会
  • Place of Presentation: 岐阜
• [Presentation] 背部表皮嚢腫より生じた有棘細胞癌の1例 (2008)
  • Author(s): 牧野貴充
  • Organizer: 第24回日本皮膚悪性腫瘍学会学術大会
  • Place of Presentation: 岐阜
• [Presentation] 爪甲変形を伴わなかった爪下メラノーマの2例 (2008)
  • Author(s): 井上雄二
  • Organizer: 第24回日本皮膚悪性腫瘍学会学術大会
  • Place of Presentation: 岐阜
• [Presentation] Primary culaneous anaplastic large cell lymphomaの1例 (2008)
  • Author(s): 宮下 梓
  • Organizer: 第24回日本皮膚悪性腫瘍学会学術大会
  • Place of Presentation: 岐阜
• [Presentation] 陰部基底細胞癌の一例 (2008)
  • Author(s): 宮下梓
  • Organizer: 第6回南九州地区別司皮膚科地方会
  • Place of Presentation: 宮崎
• [Presentation] Lymphoepithelial carcinomaの1例 (2008)
  • Author(s): 城野剛充
  • Organizer: 第6回南九州地区合同皮膚科地方会
  • Place of Presentation: 宮崎
• [Presentation] スボロトリコーシスの1例 (2008)
  • Author(s): 牧野公治
  • Organizer: 第6回南九州地区合同皮膚科地方会
  • Place of Presentation: 宮崎
• [Presentation] クラインフェルター症候群に合併しか難治性下腿潰瘍の3例 (2008)
  • Author(s): 牧野公治
  • Organizer: 第23回日木皮膚外科学会総会・学術大会
  • Place of Presentation: 京祁
• [Presentation] 局所麻酔下、短時問で出来る褥瘡手術について (2008)
  • Author(s): 井上雄二
  • Organizer: 第10回日本褥瘡学会
  • Place of Presentation: 神戸
• [Presentation] インフリキシマブ療法により出現した乾癬様皮疹の一例 (2008)
  • Author(s): 藤澤明彦
  • Organizer: 第23回日本乾癬学会学術大会
  • Place of Presentation: 旭川
• [Presentation] lmmunotherapy with multiple antigen-targeted and a-galactosylceramide-loaded dendritic cells derived from embryonic stem cells. (2008)
  • Author(s): Fukushima S.
  • Organizer: The 10th lnternational Symposium on DendritiC Cells
  • Place of Presentation: 神戸
• [Presentation] The amount of rain and salinity of the seawater are importantfor occurrence of Vibrio vulnificus infection (2008)
  • Author(s): 1noue Y.
  • Organizer: The 8th Asian Dermatological Congress
  • Place of Presentation: Seoul, Korea
• [Presentation] 複数抗原を標的としa-GalCerを負荷した遺伝子導人ES細胞由来樹状細胞を用いた癌免疫療法 (2008)
  • Author(s): 福島聡
  • Organizer: 第36回日本臨床免疫学会総会
  • Place of Presentation: 東京
• [Presentation] Bellign symmetrical. lipomatosis (BSL)の2例 (2008)
  • Author(s): 西 葉月
  • Organizer: 第60回目木皮膚科学会西部支部学術大会
  • Place of Presentation: 福岡
• [Presentation] Balloon cell melanomaの1例 (2008)
  • Author(s): 本多教稔
  • Organizer: 第60回日本皮膚科学会西部支部学術大会
  • Place of Presentation: 福岡
• [Presentation] 過去10年問の熊本大学皮膚科形成再建科におけるcutaneous B-cell lymphomaの検討 (2008)
  • Author(s): 城野剛充
  • Organizer: 第60回日本皮膚科学会西部支部学術大会
  • Place of Presentation: 福岡
• [Presentation] A case of actinomycosis (2008)
  • Author(s): Maruo K.
  • Organizer: The 10th China-Japan Joint Meeting of Dermatology
  • Place of Presentation: Hangzhou, China
• [Book] 強皮症2009(リウマチ病セミナーXXI) (2011)
  • Author(s): 尹浩信
  • Publisher: 永井書店
• [Book] 全身性強皮症(皮膚疾患最新の治療2009-2010) (2009)
  • Author(s): 尹浩信
  • Publisher: 南江堂
• [Book] 皮膚疾患最新の治療2009-2010 (2009)
  • Author(s): 尹浩信
  • Total Pages: 278
  • Publisher: 南江堂
• [Book] 皮膚疾斑最新の治療2009-2010 (2009)
  • Author(s): 尹 浩信, 他
  • Total Pages: 278
  • Publisher: 南江堂
• [Book] 今日の治療指針2009 (2009)
  • Author(s): 尹 浩信, 他
  • Total Pages: 1812
  • Publisher: 医学書院
• [Book] 今日の治療指針2008 (2008)
  • Author(s): 尹 浩信, 他
  • Total Pages: 1758
  • Publisher: 医学書院
• [Book] 最新皮膚科学体系2008-2009 (2008)
  • Author(s): 尹 浩信, 他
  • Total Pages: 325
  • Publisher: 中山書店
• [Book] 第7回アレルギー・臨床免疫医を目指す人達の為の研修会Text Book (2008)
  • Author(s): 尹 浩信, 他
  • Total Pages: 200
  • Publisher: 日本アレルギー協会九州支部
• [Book] 強皮症のすべてがわかる本 (2008)
  • Author(s): 尹 浩信, 他
  • Total Pages: 156
  • Publisher: 保健同人社
• [Book] 現場の疑問に答える皮膚病治療薬 (2008)
  • Author(s): 尹 浩信, 他
  • Total Pages: 345
  • Publisher: 中外医学社