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Analysis for the role of physiological IgE

Research Project

Project/Area Number 20591352
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Dermatology
Research InstitutionKyorin University

Principal Investigator

MIZUKAWA Yoshiko  杏林大学, 医学部, 講師 (50301479)

Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
KeywordsIgE / TLR2 / 自然免疫 / 性差
Research Abstract

The objective of this study was to investigate whether mast cell activated through the TLR on IgE-independent immediate-type hypersensitivity(ITH) response, and whether the physiological level of IgE suppressed this response. We clearly demonstrated that IgE acts not only as a deterioration effect but also as an inhibitory effect on the ITH : IgE is an important factor of regulating the activation of mast cells. In addition, we also showed that scratching would act to convert ITH responses which might otherwise be IgE-independent to IgE-dependent.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (50 results)

All 2011 2010 2009 2008

All Journal Article (29 results) (of which Peer Reviewed: 15 results) Presentation (21 results)

  • [Journal Article] Efficacy of plasmapheresis for the treatment of severe toxic epidermal necrolysis : Is cytokine expression analysis useful in predicting its therapeutic efficacy?2010

    • Author(s)
      Narita Y, Hirahara K, Mizukawa Y, Kano Y, Shiohara T
    • Journal Title

      J Dermatol

      Volume: 38巻 Pages: 236-245

    • NAID

      10029330615

    • Related Report
      2010 Annual Research Report 2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Recognition of immune reconstitution syndrome necessary for better management of patients with severe drug eruptions and those under immunosuppressive therapy2010

    • Author(s)
      Shiohara T, Kurata M, Mizukawa Y, Kano Y
    • Journal Title

      Allergol Int

      Volume: 59巻 Pages: 333-343

    • NAID

      10029670991

    • Related Report
      2010 Final Research Report
  • [Journal Article] The skin is a site of long-term viral persistence associated with retention of antiviral memory T cells2010

    • Author(s)
      Shiohara T, Mizukawa Y, Kano Y
    • Journal Title

      Dermatology

      Volume: 220巻 Pages: 186-188

    • Related Report
      2010 Annual Research Report 2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Nonpigmenting fixed drug eruption as a possible abortive variant of toxic epidermal necrolysis : immunohistochemical and serum cytokine analyses2010

    • Author(s)
      Mizukawa Y, Shiohara T
    • Journal Title

      Clin Exp Dermatol

      Volume: 35 Pages: 493-497

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Recognition of immune reconstitution syndrome necessary for better management of patients with severe drug eruptions and those under immunosuppressive therapy.2010

    • Author(s)
      Shiohara T, Kurata M, Mizukawa Y, Kano Y
    • Journal Title

      Allergol Int

      Volume: 59 Pages: 333-343

    • NAID

      10029670991

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 診断に苦慮したアロマテラピーによる接触皮膚炎.2010

    • Author(s)
      岡暗亜季, 水川良子, 狩野葉子, 塩原哲夫
    • Journal Title

      臨皮 64

      Pages: 8-12

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fixed drug eruption : a prototypic disorder mediated by effecor memory T cells2009

    • Author(s)
      Mizukawa Y, Shiohara T
    • Journal Title

      Curr Allergy Asthma Rep

      Volume: 9巻 Pages: 71-77

    • Related Report
      2010 Final Research Report
  • [Journal Article] Nonpigmenting fixed drug eruption as a possible abortive variant of toxic epidermal necrolysis : immunohistochemical and serum cytokine analyses2009

    • Author(s)
      Mizukawa Y, Shiohara T
    • Journal Title

      Clin Exp Dermatol

      Volume: 182巻 Pages: 8071-8079

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Defective regulatory T cells in patients with severe drug eruption : timing of the dysfunction is associated with the pathological phenotype and outcome2009

    • Author(s)
      Takahashi R, Kano Y, Mizukawa Y, Shiohara T
    • Journal Title

      J Immunol

      Volume: 182巻 Pages: 8071-8079

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Defective regulatory T cells in patients with severe drug eruption : timing of the dysfunction is associated with the pathological phenotype and outcome2009

    • Author(s)
      Takahashi R, Kano Y, Mizukawa Y, Shiohara T
    • Journal Title

      J Immunol 182

      Pages: 8071-8079

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nonpigmenting fixed drug eruption as a possible abortive variant of toxic epidermal necrolysis : immunohistochemical and serum cytokine analyses2009

    • Author(s)
      Mizukaw Y, Shiohara T
    • Journal Title

      Clin Exp Dermatol (Epub)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 乾燥が増悪因子と考えられた扁平苔癬の1例.2009

    • Author(s)
      堀江千穂、水川良子、塩原哲夫
    • Journal Title

      臨皮 63

      Pages: 8-12

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fixed drug eruption : a prototypic disorder mediated by effecor memory T cells.2009

    • Author(s)
      Mizukaw Y, Shiohara T
    • Journal Title

      Curr Allergy Asthma Rep 9

      Pages: 71-77

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 膠原病と皮膚病2009

    • Author(s)
      水川良子
    • Journal Title

      三鷹醫人往来 31

      Pages: 11-14

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 下肢の紫斑を伴う褐色斑Schamberg病(chronic pigmented purpura, pigmented purpuric dermatosis,_purpura pigmentosa chronica)2009

    • Author(s)
      水川良子
    • Journal Title

      Visual Dermatol 8

      Pages: 607-608

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Fixed drug eruption : a prototypic disorder mediated byeffector memory T cells2009

    • Author(s)
      Mizukawa Y, Shiohara T
    • Journal Title

      Curr Allergy Asthma Rep 9

      Pages: 71-77

    • Related Report
      2008 Annual Research Report
  • [Journal Article] ケブネル現象をめぐって. 全身性疾患 : 膠原病・血管炎 DLE+サルコイドーシス.2009

    • Author(s)
      水川良子
    • Journal Title

      Visual Dermatology 8

      Pages: 42-43

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 疥癬(ステロイド外用・内服後に診断された症例).2009

    • Author(s)
      水川良子
    • Journal Title

      Visual Dermatology 8

      Pages: 270-271

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Pathomechanisms of lichen planus autoimmunity elicited by cross-reactive T cells2008

    • Author(s)
      Shiohara T, Mizukawa Y, Takahashi R
    • Journal Title

      Curr Dir Autoimmun

      Volume: 10巻 Pages: 206-226

    • Related Report
      2010 Final Research Report
  • [Journal Article] In vivo dynamics of intraepidermal CD8+T cells and CD4+T cells during the evolution of fixed drug eruption2008

    • Author(s)
      Mizukawa Y, Yamazaki Y, Shiohara T
    • Journal Title

      Br J Dermatol

      Volume: 158巻 Pages: 1230-1238

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] In vivo dynamics of intraepidermal CD8+ T cells and CD4+ T cells during the evolution of fixed drug eruption2008

    • Author(s)
      Mizukawa Y, Yamazaki Y, Shiohara T
    • Journal Title

      Br J Dermatol 158

      Pages: 1230-1238

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pathomechanisms of lichen planus autoimmunity elicited by cross-reactive T cells2008

    • Author(s)
      Shiohara T, Mizukawa Y, Takahashi R
    • Journal Title

      Curr Dir Autoimmun 10

      Pages: 206-226

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 知らないとはずかしい皮膚疾患(3)頬部の〓痒性紅斑. 好酸球性膿庖性毛包炎2008

    • Author(s)
      水川良子
    • Journal Title

      Visual Dermatology 7

      Pages: 633-634

    • Related Report
      2008 Annual Research Report
  • [Journal Article] In vivo dynamics of intraepidermal CD8+ T cells and CD4+T cells during the evolution of fixed drug eruption2008

    • Author(s)
      Mizukawa Y, Yamazaki Y, Shiohara T
    • Journal Title

      Br J Dermatol 158

      Pages: 1230-1238

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 汗と関連がある意外な皮膚病 汗孔角化症.2008

    • Author(s)
      青田典子, 水川良子, 早川順
    • Journal Title

      Visual Dermatology 7

      Pages: 1000-1001

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 汗の低下を来す意外な原因 ウイルス感染後の発汗障害.2008

    • Author(s)
      水川良子
    • Journal Title

      Visual Dermatology 7

      Pages: 1016-1017

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 蜂窩織炎に続発したアナフィラクトイド紫斑の1例.2008

    • Author(s)
      白石由佳, 水川良子, 塩原哲夫
    • Journal Title

      臨皮 62

      Pages: 898-901

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 同じ病気でもこんなに違う! 固定薬疹.2008

    • Author(s)
      水川良子
    • Journal Title

      Visual Dermatology 7

      Pages: 1338-1345

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 星状神経節ブロック後に生じた慢性苔癬状粃糠疹の1例.2008

    • Author(s)
      堀江千穂, 浅野祐介, 水川良子, 塩原哲夫
    • Journal Title

      臨皮 62

      Pages: 984-987

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] マイコプラズマ感染はDIHS発症を抑制する2011

    • Author(s)
      水川良子
    • Organizer
      第53回日本皮膚科学会愛媛地方会
    • Place of Presentation
      松山
    • Year and Date
      2011-03-19
    • Related Report
      2010 Annual Research Report
  • [Presentation] Severity of contact sensitivity in mice with reduced inflammatory threshold to hapten can be attenuated by increasing skin surface hydration2010

    • Author(s)
      Mizukawa Y, Doi T, Shiohara T
    • Organizer
      The 35th Annual Meeting of the Japanese Society for Investigative Dermatology
    • Place of Presentation
      Yakayama
    • Year and Date
      2010-12-04
    • Related Report
      2010 Final Research Report
  • [Presentation] Lichen planus is an inflammatory dermatosis caused by sweating disturbance2010

    • Author(s)
      Kurara M, Mizukawa Y, Yamazaki Y, Doi T, Hayakawa J, Shiohara T
    • Organizer
      The 35th Annual Meeting of the Japanese Society for Investigative Dermatology
    • Place of Presentation
      Yakayama
    • Year and Date
      2010-12-04
    • Related Report
      2010 Final Research Report
  • [Presentation] Severity of contact sensitivity in mice with reduced inflammatory threshold to hapten can be attenuated by increasing skin surface hydration.2010

    • Author(s)
      Mizukawa Y
    • Organizer
      The 35^<th> Annual Meeting of the Japanese Society for Investigative Dermatology.
    • Place of Presentation
      Wakayama
    • Year and Date
      2010-12-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] VZV Ag expression of eccrine epithelium in a patient with linear lichen planus2010

    • Author(s)
      Mizukawa Y, Horie C, Shiohara T
    • Organizer
      9th Meething of the German-Japanese Society of Dermatology
    • Place of Presentation
      Weimar
    • Year and Date
      2010-06-12
    • Related Report
      2010 Final Research Report
  • [Presentation] VZV Ag expression of eccrine epithelium in a patient with linear lichenplanus.2010

    • Author(s)
      Mizukawa Y
    • Organizer
      9^<th> Meeting of the German-Japanese Society of Dermatology
    • Place of Presentation
      Weimar
    • Year and Date
      2010-06-12
    • Related Report
      2010 Annual Research Report
  • [Presentation] 発汗障害を認めた類乾癬.2010

    • Author(s)
      早川順、佐藤洋平、井上桐子、土肥孝彰、平原和久、水川良子、塩原哲夫
    • Organizer
      第73回日本皮膚科学会東京支部学術大会
    • Place of Presentation
      東京
    • Year and Date
      2010-02-20
    • Related Report
      2009 Annual Research Report
  • [Presentation] Depletion of NMU from the epidermis is associated with low skin hydration and directs innate-type responses towards allergic inflammation.2009

    • Author(s)
      Mizukawa Y
    • Organizer
      The 34th Annual Meeting of the Japanese Society for Investigative Dermatology
    • Place of Presentation
      福岡
    • Year and Date
      2009-12-09
    • Related Report
      2009 Annual Research Report
  • [Presentation] Depletion of NMU from the epidermis is associated with low skin hydration and directs innate-type responses towards allergic inflammation2009

    • Author(s)
      Mizukawa Y, Doi T, Shiohara T
    • Organizer
      The 34th Annual Meeting of the Japanese Society for Investigative Dermatology
    • Year and Date
      2009-12-05
    • Related Report
      2010 Final Research Report
  • [Presentation] Herpes simplex virus infection of human Langerhans cells in normal skin : its protective role in the development of HSV skin diseases.2009

    • Author(s)
      Kurata M, Mizukawa Y, Yamazaki Y, Shiohara T
    • Organizer
      The 34th Annual Meeting of the Japanese Society for Investigative Dermatology
    • Place of Presentation
      福岡
    • Year and Date
      2009-12-05
    • Related Report
      2009 Annual Research Report
  • [Presentation] 自然免疫とアレルギー:肥満細胞を中心として2009

    • Author(s)
      水川良子
    • Organizer
      第39回日本皮膚アレルギー・接触皮膚炎学会学術大会
    • Place of Presentation
      京都
    • Year and Date
      2009-11-08
    • Related Report
      2010 Final Research Report
  • [Presentation] マウス接触皮膚炎モデルにおける遅延型過敏反応の強さは皮膚水分量に依存する2009

    • Author(s)
      土肥孝彰, 山崎好美, 水川良子, 塩原哲夫
    • Organizer
      第39回日本皮膚アレルギー・接触皮膚炎学会学術大会
    • Place of Presentation
      京都
    • Year and Date
      2009-11-07
    • Related Report
      2010 Final Research Report
  • [Presentation] マウス接触皮膚炎モデルにおける遅延型過敏反応の強さは皮膚水分量に依存する.2009

    • Author(s)
      土肥孝彰, 山崎好美, 水川良子, 塩原哲夫
    • Organizer
      第39回日本皮膚アレルギー・接触皮膚炎学会学術大会,
    • Place of Presentation
      京都
    • Year and Date
      2009-11-07
    • Related Report
      2009 Annual Research Report
  • [Presentation] 肥満細胞を中心として2009

    • Author(s)
      水川良子
    • Organizer
      第39回日本皮膚アレルギー・接触皮膚炎学会学術大会
    • Place of Presentation
      京都
    • Year and Date
      2009-11-07
    • Related Report
      2009 Annual Research Report
  • [Presentation] カポジ水痘様発疹症(KVE)における水痘・帯状庖疹ウイルスの関与2009

    • Author(s)
      倉田麻衣子、水川良子, 塩原哲夫
    • Organizer
      第825回東京地方会(合同臨床地方会)
    • Place of Presentation
      東京
    • Year and Date
      2009-07-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] VZV antigen expression in eccrine glands of herpes-zoster lesions2009

    • Author(s)
      Horie C, Kurata M, Mizukawa Y
    • Organizer
      Japanese Dermatological Association and Australian College of Dermatologists
    • Place of Presentation
      札幌
    • Year and Date
      2009-07-11
    • Related Report
      2009 Annual Research Report
  • [Presentation] 自然免疫と肥満細胞の接点: IgE依存性反応と自然免疫の関わり2008

    • Author(s)
      水川良子
    • Organizer
      第38回日本皮膚アレルギー・接触皮膚炎学会学術大会
    • Place of Presentation
      大阪
    • Year and Date
      2008-11-09
    • Related Report
      2010 Final Research Report
  • [Presentation] 自然免疫, と肥満細胞の接点 : IgE依存性反応と自然免疫の関わり.2008

    • Author(s)
      水川良子
    • Organizer
      第38回日本皮膚アレルギー・接触皮膚炎学会学術大会
    • Place of Presentation
      大阪
    • Year and Date
      2008-11-09
    • Related Report
      2008 Annual Research Report
  • [Presentation] ウィルス感染とアレルギー : ADと自然免疫異常2008

    • Author(s)
      水川良子
    • Organizer
      第20回日本アレルギー学会春季臨床大会
    • Place of Presentation
      東京
    • Year and Date
      2008-06-13
    • Related Report
      2008 Annual Research Report
  • [Presentation] IgE preferentially protects female mice against hapten-induced immunopathology2008

    • Author(s)
      Mizukawa Y, Yamazaki Y, Shiohara T
    • Organizer
      International Investigative Dermatology
    • Place of Presentation
      Kyoto
    • Year and Date
      2008-05-17
    • Related Report
      2010 Final Research Report
  • [Presentation] IgE preferentially protects female mice against hapten-induced immunopathology2008

    • Author(s)
      Mizukawa Y
    • Organizer
      International Investigative Dermatology
    • Place of Presentation
      京都
    • Year and Date
      2008-05-17
    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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