Analysis for the role of physiological IgE
Project/Area Number |
20591352
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Dermatology
|
Research Institution | Kyorin University |
Principal Investigator |
|
Project Period (FY) |
2008 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | IgE / TLR2 / 自然免疫 / 性差 |
Research Abstract |
The objective of this study was to investigate whether mast cell activated through the TLR on IgE-independent immediate-type hypersensitivity(ITH) response, and whether the physiological level of IgE suppressed this response. We clearly demonstrated that IgE acts not only as a deterioration effect but also as an inhibitory effect on the ITH : IgE is an important factor of regulating the activation of mast cells. In addition, we also showed that scratching would act to convert ITH responses which might otherwise be IgE-independent to IgE-dependent.
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Report
(4 results)
Research Products
(50 results)