| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Research Abstract |
The objective of this study was to investigate whether mast cell activated through the TLR on IgE-independent immediate-type hypersensitivity(ITH) response, and whether the physiological level of IgE suppressed this response. We clearly demonstrated that IgE acts not only as a deterioration effect but also as an inhibitory effect on the ITH : IgE is an important factor of regulating the activation of mast cells. In addition, we also showed that scratching would act to convert ITH responses which might otherwise be IgE-independent to IgE-dependent.
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