| Project/Area Number |
20591357
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | Fujita Health University |
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Principal Investigator |
ITO Shosuke Fujita Health University, 藤田保健衛生大学, 名誉教授 (70121431)
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| Co-Investigator(Kenkyū-buntansha) |
WAKAMATSU Kazumasa 藤田保健衛生大学, 医療科学部, 教授 (80131259)
広部 知久 独立行政法人放射線医学総合研究所, 生体影響機構研究グループ, チームリーダー (10111238)
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| Co-Investigator(Renkei-kenkyūsha) |
HIROBE Tomohisa 放射線医学総合研究所, 生体影響機構研究, グループ・チームリーダー (10111238)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | メラニン / 遺伝子 / 紫外線 / メラノサイト / ユーメラニン / フェオメラニン / メラノブラスト / ケラチノサイト / メラノソーム / 化学分析 / エストロゲン / recessive yellow / Mclrレセプター / pink-eyed dilution / ミトコンドリア |
|---|
| Research Abstract |
Our present results suggest that melanoblast/melanocyte proliferation and melanocyte differentiation are regulated in a time-and development-dependent manner by many coat color genes, especially Agouti (A), brown (Tyrp1^b/b), albino (Tyr^c/c), dilute (Myo5a^d/d), recessive yellow (Mc1r^e/e), pink-eyed dilution (Oca2^p/p), slaty (Dct^slt/slt) and ruby-eye 2^d(ru2^d/Hps5^ru2-d) otherwise known for their ability to regulate melanosome formation and maturation, pigment switching, melanosome distribution and transfer.
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